@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0399: (2016-01-03 )
MTSDSRPAVLDLIGNTPLVRVTRFDTGPCTLYLKLESQNPGGSIKDRIGVAMIEAAERDGRLRPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKMSTEKVLHLRAMGAEVHITRSDVGKGHPEYYQDVAARLAQDIPGAFFADQFNNPANPLAHECGTGPELWAQTGHDLDAIVVGVGSSGTLTGLTRFFQKVQPELEMVLADPEGSIMAEYSRSGTLGTPGSWAVEGIGEDFVPAIADLSSVRHAYSISDEESFAMARELLRVEGIPGGSSTGTLLAAALRFCREQKEPKRVVSFVCDTGTRYLSKIYNDQWMTDQGLLQRKHYGDLRDIIARRFEEGRVISVGPDDTLLTAFQRMRLADVSQLPVLDDGKLVGVIDESDILLGVHADAPRFRDAVSSAMNAAPETLAPGASLAQLQAVLDRGLVAIVADASGFHGLITRFDLLNHLRRKLA
Atome Classification :
(39 SA)
----------------------------------.........10........20...---...---..30.---........40........50........60.....--..-.70........80........90........100.......110.......120-.......----130.......140.......150.......160.......170.......180.......190...--....200......-.210......-.220--.......230.......240.......250.......260.......270.......280.....-.-.290-..-.....300.......310.......----320.....----..330--.......-.340---.......350.......360.......370--.--.-.....380.......390.......400.......410.......420.......430..-.-----...---.440---.........450.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------MTSDSR
P
A
V
L
DLIGNT
P
L
V
R
V
T
RF---DTG---
P
C
T
-
L
---
Y
L
K
L
ESQNPGG
S
I
K
D
R
I
G
V
A
M
I
E
AAERDGRLRPG
G
--
T
I
-
V
E
ATAGNTG
L
G
L
A
L
V
GRAKG
Y
R
V
V
L
V
VPDKM
S
T
E
K
V
L
H
L
R
AMG
A
E
V
H
I
T
RSDVG-KG
H
P
E
Y
Y
----
Q
D
V
A
A
R
L
A
Q
DI
P
G
A
F
F
A
D
QFNNPANP
L
A
H
ECGT
G
P
E
L
W
A
QTGHD
L
D
A
I
V
V
GVGSS
G
T
L
T
G
L
T
R
F
F
Q
--
K
VQPE
L
E
M
V
L
ADP-EG
S
I
M
A
E
YSR-SGTL--GTPG
S
W
A
V
EGIG
E
D
F
V
P
A
I
A
D
L
S
S
V
R
H
AYSIS
D
E
E
S
F
A
M
A
R
E
L
L
R
VEGIPGGSS
T
G
T
L
L
A
A
A
L
R
F
-
C
-
R
EQK-
E
P
-
K
R
V
V
S
F
VCD
T
G
T
R
Y
L
S
K
I
YNDQWM
T
----
D
Q
G
L
L
Q
R
K----HYG
D
---
L
R
D
I
I
A
R
-
R
F
EE---G
R
V
I
S
VGPD
D
T
L
L
T
A
F
Q
R
M
R
LADVSQLPVL--D--D-G
K
L
V
G
V
IDES
D
I
L
L
G
VHAD
A
P
R
F
R
D
A
V
S
S
A
M
NAAPETLAPG
A
S
L
A
Q
L
Q
A
V
L
DRG
L
V
A
I
V
A-D-----ASG---
F
H
-----
G
L
I
T
R
F
D
L
L
N
H
L
R
R
KLA-
23
PsiBlast_CBE
95.65
35%
-84
- C2 -
4COO
9
CBS_HUMAN
B:
[100-555]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
--------------
K
P
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
Q
M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
1
PsiBlast_PDB
95.54
35%
-84
- C2 -
4L0D
2
CBS_HUMAN
A:
[78-531]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
-
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LG
L
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
-M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
22
PsiBlast_CBE
94.86
35%
-86
- C2 -
4L0D
2
CBS_HUMAN
B:
[78-531]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LG
L
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
-M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
2
PsiBlast_PDB
94.62
35%
-84
- C2 -
4COO
12
CBS_HUMAN
A:
[100-555]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
-M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
26
PsiBlast_CBE
94.29
35%
-83
- C2 -
4L3V
2
CBS_HUMAN
A:
[77-540]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LG
L
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-------------RQMVF
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
3
PsiBlast_PDB
94.05
35%
-81
- C2 -
4L28
2
CBS_HUMAN
A:
[77-540]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
-
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LG
L
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
N
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-------------QMVF-
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
24
PsiBlast_CBE
94.00
35%
-84
- C2 -
4PCU
4
CBS_HUMAN
B:
[78-531]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
S
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
---------
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
Q
RQM
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
--
5
PsiBlast_PDB
93.64
35%
-81
- C2 -
4L3V
2
CBS_HUMAN
B:
[77-540]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
FGL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-------------RQMVF
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
25
PsiBlast_CBE
93.59
35%
-81
- C2 -
4L3V
2
CBS_HUMAN
C:
[77-540]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
FGL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-------------RQMVF
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
21
PsiBlast_CBE
93.22
35%
-83
- C2 -
4L27
2
CBS_HUMAN
D:
[77-532]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
-
F
D
S
P
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
-
T
E
---
K
K
P
W
W
W
H
L
R
V
Q
E
LG
L
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
N
Q
A
P
V
V
-----
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
-M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
-
4
PsiBlast_PDB
92.00
35%
-81
- C2 -
4PCU
4
CBS_HUMAN
A:
[78-531]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
--
A
R
-
F
D
S
P
S
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
E
----
D
L
-----
K
K
P
W
W
W
H
L
R
V
Q
E
LGL
S
A
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
--
D
--
E
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
-
H
-----
E
Q
-M--
V
F
-----
G
V
V
T
A
I
D
L
L
N
F
V
A
A
----
101
HHSearch
91.69
34%
-74
- C2 -
3PC3
2
?
A:
[48-512]
------------------------------------
Q
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
---
P
A
S
D
GI
E
C
E
-
M
---
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
-
Y
D
S
P
E
G
L
----
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
L
A
R
P
A
E
-
L
N
K
T
---
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
-
A
-
R
K
L
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
----
A
R
N
F
K
E
P
V
NEHG
H
W
W
W
---
S
L
A
I
A
E
L
-
E
L
P
----
A
P
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
--
D
Q-
D
D
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
V
D
P
S
V
L
I
L
G
K
N
PAG-
K
V
E
---
L
K
-----
A
L
A
T
K
L
D
V
T
T
F
I
A
A
G
K
Q
-
121
Fugue
90.69
33%
-72
- C2 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
A
H
R
Q
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
---
P
A
S
D
GI
E
C
E
-
M
---
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
-
Y
D
S
P
E
G
L
----
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
L
A
R
P
A
E
-
L
N
K
---
T
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
-
A
-
R
K
L
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
----
A
R
N
F
K
E
P
V
----
N
E
H
G
HWW
W
S
L
A
I
A
E
-
L
E
L
P
---
A
P
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
--
D
QD
D
-
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
V
D
P
S
V
L
I
L
-
G
K
N
PAG
K
V
E
---
L
K
-----
A
L
A
T
K
L
D
V
T
T
F
I
A
A
G
K
Q
K
10
PsiBlast_PDB
87.71
35%
-73
- C2 -
3PC3
2
?
A:
[52-478]
----------------------------------------
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
G
I
---
E
C
E
-
M
---
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
-
Y
D
S
P
E
G
L
----
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
L
A
R
P
A
E
-
L
N
K
T
--
D
V
-
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
-
A
-
R
K
L
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
N
E
H
G
----
H
W
W
W
---
S
L
A
I
A
E
L
-
E
L
P
A
---
P
P
V
I
-
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
--
D
-
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
V
D
P
S
V
L
I
L
-
G
-----
K
N
P
---
A
G
-----
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
-
9
PsiBlast_PDB
87.66
35%
-74
- C2 -
3PC2
2
?
A:
[52-478]
----------------------------------------
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
G
I
---
E
C
E
-
M
---
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
-
Y
D
S
P
E
G
L
----
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
L
A
R
P
A
E
-
L
N
K
T
--
D
V
-
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
-
A
-
R
K
L
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
N
E
H
G
----
H
W
W
W
---
S
L
A
I
A
E
L
-
E
L
P
A
---
P
P
V
I
-
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
--
D
-
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
V
D
P
S
V
L
I
L
-
G
-----
K
N
P
---
A
G
-----
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
-
11
PsiBlast_PDB
86.63
35%
-73
- C2 -
3PC4
3
?
A:
[52-478]
----------------------------------------
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
G
I
---
E
C
E
-
M
---
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
Y
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
-
Y
D
S
P
E
G
L
----
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
L
A
R
P
A
E
-
L
N
K
T
--
D
V
-
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
-
A
-
R
K
L
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
N
E
H
G
----
H
W
W
W
---
S
L
A
I
A
E
L
-
E
L
P
A
---
P
P
V
I
-
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
--
D
-
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
V
D
P
S
V
L
I
L
-
G
-----
K
N
P
---
A
G
-----
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
-
8
PsiBlast_PDB
83.60
41%
-87
- C2 -
4OFX
2
?
A:
[9-319]
------------------------------------------
I
L
Q
V
I
G
K
T
P
V
V
R
L
H
R
I
G--
Q
S
L
---
P
C
E
-
L
---
Y
G
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
A
A
M
I
E
S
A
E
K
Q
G
K
I
K
P
G
D
--
T
L
-
I
E
P
T
S
G
N
T
G
I
G
I
A
L
A
G
A
V
K
G
Y
R
V
I
I
T
M
P
E
K
M
S
H
E
K
Q
V
V
L
E
A
L
G
A
T
I
Y
R
T
P
---------
E
S
H
----
I
S
L
A
K
R
L
N
Q
E
I
P
N
S
Y
I
L
D
Q
Y
S
N
A
E
N
P
D
I
H
Y
Q
T
T
G
Q
E
I
L
D
D
M
G
E
N
L
S
M
V
V
M
G
V
G
T
G
G
T
I
I
G
V
A
K
K
L
K
--
E
V
N
P
S
I
Q
I
I
G
V
D
P
-
I
G
S
I
L
G
-----
G
G
D
------------------------
N
N
L
I
D
E
Y
I
K
I
N
D
K
D
S
F
L
M
A
R
R
L
I
R
E
E
G
L
L
V
G
G
S
S
G
S
A
V
W
A
A
C
Q
A
-
A
-
Q
R
L
K
-
E
G
-
E
R
C
L
V
I
L
P
D
A
I
R
N
Y
L
T
K
F
V
D
D
A
W
M
K
----
A
Q
G
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.06
42%
-73
- C2 -
1JBQ
2
CBS_HUMAN
D:
[100-419]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
FGL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
--------
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
82.61
42%
-71
- C2 -
1JBQ
2
CBS_HUMAN
E:
[100-421]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
FGL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
--------
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.41
42%
-73
- C2 -
1JBQ
2
CBS_HUMAN
A:
[100-419]
----------------------------------------
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
F
GL
K
C
E
-
L
---
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
G
D
--
T
I
-
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
--------
E
S
H
----
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
C
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
L
A
E
P
E
E
L
N
Q
T
E
--
Q
T
--
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
-
A
-
Q
E
L
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
R
W
M
L
----
Q
K
G
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
78.33
38%
-72
- C2 -
1OAS
1
CYSK_SALTY
B:
[11-315]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.91
38%
-72
- C2 -
1OAS
1
CYSK_SALTY
A:
[11-315]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
76.94
39%
-81
- C2 -
2ECQ
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V--
E
P
D
---
M
A
E
-
V
---
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
--------
D
P
E
R
R
M
L
A
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
---------
A
R
-
S
N
V
L
SG
G
K
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
-
R
E
L
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.85
39%
-81
- C2 -
2BHS
1
CYSM_ECOLI
A:
[8-288]
----------------------------------------------
I
G
N
T
P
L
V
K
L
Q
R
M
GP-
D
N
G
----
S
E
-
V
---
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
-
M
---
E
G
A
----
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
R
R
------------
W
P
T
E
-----
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
-
A
-
K
A
N
P
-
D
A
-
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.81
39%
-77
- C2 -
2BHS
1
CYSM_ECOLI
B:
[8-288]
----------------------------------------------
I
G
N
T
P
L
V
K
L
Q
R
M
GP-
D
N
G
----
S
E
-
V
---
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
-
M
---
E
G
A
----
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
R
R
------------
W
P
T
E
-----
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
-
A
-
K
A
N
P
-
D
A
-
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.24
39%
-82
- C2 -
2ECO
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V--
E
P
D
---
M
A
E
-
V
---
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
--------
D
P
E
R
R
M
L
A
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
---------
A
R
-
S
N
V
L
SG
G
K
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
-
R
E
L
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
76.14
39%
-78
- C2 -
2BHS
1
CYSM_ECOLI
C:
[8-288]
----------------------------------------------
I
G
N
T
P
L
V
K
L
Q
R
M
GP-
D
N
G
----
S
E
-
V
---
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
-
M
---
E
G
A
----
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
R
R
------------
W
P
T
E
-----
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
-
A
-
K
A
N
P
-
D
A
-
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
76.09
38%
-69
- C2 -
1FCJ
3
CYSK_SALTY
C:
[11-304]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
75.99
39%
-80
- C2 -
2BHS
1
CYSM_ECOLI
D:
[8-288]
----------------------------------------------
I
G
N
T
P
L
V
K
L
Q
R
M
GP-
D
N
G
----
S
E
-
V
---
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
D
--
V
L
-
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
-
M
---
E
G
A
----
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
R
R
------------
W
P
T
E
-----
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
-
A
-
K
A
N
P
-
D
A
-
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
75.96
38%
-69
- C2 -
1FCJ
3
CYSK_SALTY
B:
[11-304]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.93
38%
-71
- C2 -
1FCJ
3
CYSK_SALTY
D:
[11-302]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
75.76
38%
-61
- C2 -
1D6S
2
CYSK_SALTY
B:
[11-322]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
T
----
E
K
E
L
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.20
38%
-68
- C2 -
1FCJ
3
CYSK_SALTY
A:
[11-302]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
75.15
38%
-60
- C2 -
1D6S
2
CYSK_SALTY
A:
[11-322]
----------------------------------------------
I
G
H
T
P
L
V
R
L
N
R
I
---
G
N
G
-----
R
-
I
---
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
V
--
E
L
-
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
--
A
-
K
G
M
K
G
A
I
----
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
A
Q
A
L
-
A
G
E
E
--
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
-
Q
-
E
D
E
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
T
----
E
K
E
L
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
75.13
38%
-64
- C2 -
4LMA
2
?
B:
[14-313]
------------------------------------------
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
---
P
Q
A
---
E
G
C
-
L
GRI
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E
T
--
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
K
G
A
I
L
R
A
----
Q
Q
I
V
----
D
S
I
P
G
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
K
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
V
I
-----
S
G
----
G
N
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
-
A
Q
R
P
E
N
-
E
G
-
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
N
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
75.02
39%
-61
- C2 -
4LMB
3
?
A:
[14-311]
------------------------------------------
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
---
P
V
A
E
GV
K
A
R
-
I
---
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D
K
--
T
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
Q
G
-
M
---
E
G
A
----
I
T
R
A
E
E
I
V
E
N
T
P
N
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
R
P
Q
F
Q
A
I
A
V
E
P
-
S
N
S
P
V
L
-----
S
G
----
G
Q
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
-
R
P
E
N
-
E
D
-
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.95
39%
-69
- C2 -
3ZEI
4
CYSK_MYCTU
A:
[7-300]
------------------------------------------
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
V
A
D
I
---
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
-
M
S
G
A
I
A
K
----
A
E
E
L
A
K
T
D
Q
R
Y
---
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
L
-----
S
G
----
G
Q
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
-
A
-
R
R
P
E
-
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.86
39%
-81
- C2 -
2EFY
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V--
E
P
D
---
M
A
E
-
V
---
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
-
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
--------
D
P
E
R
R
M
L
A
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
---------
A
R
-
S
N
V
L
SG
G
K
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
-
R
E
L
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
73.05
39%
-59
- C2 -
2Q3D
2
CYSK_MYCTU
A:
[10-304]
------------------------------------------
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
V
A
D
I
---
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
T
--
I
I
-
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
-
M
S
G
A
I
A
K
----
A
E
E
L
A
K
T
D
Q
R
Y
---
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
L
-----
S
G
----
G
Q
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
-
A
-
R
R
P
E
-
N
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------