@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2015: (2016-02-03 )
MTYPSLNFALGETIDMLRDQVRGFVAAELQPRAAQIDQDNQFPMDMWRKFGEMGLLGITVDEEYGGSALGYLAHAVVMEEISRASASVALSYGAHSNLCVNQIKRNGNAEQKARYLPALVSGEHIGALAMSEPNAGSDVVSMKLRADRVGDRFVLNGSKMWITNGPDAHTYVIYAKTDADKGAHGITAFIVERDWKGFSRGPKLDKLGMRGSNTCELIFQDVEVPEENVLGAVNGGVKVLMSGLDYERVVLSGGPVGIMQACMDVVVPYIHDRRQFGQSIGEFQLVQGKVADMYTALNASRAYLYAVAAACDRGETTRKDAAGVILYSAERATQMALDAIQILGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR
Atome Classification :
(37 SA)
.........10........20........30........40..--......50........60........---70--.........80........90.....-...100.......110.......120.......130.......140.......-150........160.......170......--.----180.----..---.-.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...-....320.......330.......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTYPSL
N
F
A
L
G
E
T
I
D
M
L
R
D
Q
V
R
G
F
V
A
AELQP
R
A
AQIDQDNQF
P
--
M
D
M
W
R
K
FGEM
G
L
L
G
I
T
VDEEYG
G
S
A
L
---
G
---
Y
L
A
H
A
V
V
M
E
E
I
S
RAS
A
S
V
A
L
S
YGAHS-
N
L
C
V
N
Q
I
K
RNG
N
A
E
Q
K
A
R
Y
L
P
A
L
VSGE
H
I
G
A
L
AMSEPNAGS
D
V
V
S
M
K
L
R
ADRV-G
D
-
R
F
V
LNG
S
K
M
W
I
TNGPDA
H
T
Y
V
I
Y
A
KTD--A----D--K----GA---H-G
I
T
A
F
I
V
ERDWKGFSRGPKLDKLGMRGS
N
T
C
E
L
I
F
QDVEVPEENVLGAVNG
G
V
K
V
L
M
SGL
D
Y
E
R
V
VLSGG
P
V
G
I
M
Q
A
C
M
D
V
V
V
P
Y
I
H
D
R
R
Q
F
G
Q
S
IGE
F
Q
L
V
Q
G
K
V
A
D
M
Y
T
A
LNAS
R
A
Y
L
Y
A
V
A
A
ACDRGE-TTRKDA
A
G
V
I
L
Y
SA
E
R
A
T
Q
M
A
L
D
A
I
Q
ILGGNGYINEFPTGR
L
L
RD
A
K
L
Y
EIGA
G
T
S
E
I
R
R
M
L
I
G
R
E
L
FNETR
21
PsiBlast_CBE
94.31
74%
-102
- C2 -
4O5M
2
?
D:
[9-390]
-----
M
N
F
G
L
G
E
E
I
E
A
L
R
D
T
V
R
R
F
A
E
S
R
I
A
P
L
A
A
E
T
D
R
N
N
Q
F
P
--
M
H
L
W
R
E
F
G
E
L
G
V
L
G
I
T
A
P
E
D
Y
G
G
A
G
M
---
G
---
Y
L
A
H
C
I
A
M
E
E
I
S
R
A
S
A
S
I
G
L
S
Y
G
A
H
S
-
N
L
C
V
N
Q
I
T
R
N
G
S
P
E
Q
R
A
K
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
----------
M
K
L
A
A
E
K
R
-
G
D
-
R
Y
V
L
N
G
N
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
-----------------------
G
I
S
A
F
I
I
E
K
G
F
K
G
F
S
T
A
Q
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
V
F
E
D
C
E
V
P
A
E
N
L
L
G
T
E
G
K
G
V
N
V
L
M
S
G
L
D
Y
E
R
V
V
L
A
G
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
V
H
E
R
K
Q
F
D
Q
P
I
G
E
F
Q
L
M
Q
C
K
L
A
D
M
Y
V
T
F
N
A
S
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
E
-
T
T
R
K
D
A
A
G
C
I
L
Y
S
A
E
N
A
T
Q
M
A
L
Q
A
I
Q
S
L
G
G
N
G
---
D
Y
P
T
G
R
L
L
R
D
A
K
L
Y
E
I
--------
R
M
L
I
G
R
E
L
F
Q
E
T
R
2
PsiBlast_PDB
92.45
72%
-98
- C2 -
4KTO
4
?
A:
[29-408]
-----
L
N
F
A
L
G
E
E
I
D
A
L
R
A
S
V
R
R
F
A
S
E
R
I
A
P
L
A
D
D
A
D
R
S
N
A
F
P
--
M
S
L
W
R
E
M
G
E
L
G
L
L
G
I
T
A
D
E
A
H
G
G
A
G
L
---
G
---
Y
L
A
H
C
V
A
M
E
E
I
S
R
A
S
A
S
V
G
L
S
Y
G
A
H
S
-
N
L
C
V
N
Q
I
N
R
N
G
K
P
A
Q
K
S
R
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
E
P
G
-----
V
S
M
K
L
K
A
D
K
R
-
G
D
-
R
Y
V
L
N
G
S
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
D
--
P
-------------
P
---
R
-
G
I
T
A
F
L
V
E
K
A
F
P
G
F
S
A
G
Q
K
L
D
K
L
G
M
R
G
S
N
T
S
E
L
I
F
T
D
C
E
V
P
E
E
N
V
L
G
G
V
G
E
G
V
K
V
L
M
S
G
L
D
Y
E
R
V
V
L
S
A
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
L
H
E
R
K
Q
F
G
Q
P
I
G
E
F
Q
L
M
Q
G
K
L
A
D
M
Y
V
T
M
N
A
A
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
E
-
T
A
R
K
D
A
A
G
C
I
L
Y
A
A
E
K
A
T
A
M
A
L
E
A
I
Q
A
L
G
G
N
G
Y
T
N
D
Y
P
A
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
A
E
--
22
PsiBlast_CBE
91.27
74%
-101
- C2 -
4O5M
1
?
C:
[9-390]
-----
M
N
F
G
L
G
E
E
I
E
A
L
R
D
T
V
R
R
F
A
E
S
R
I
A
P
L
A
A
E
T
D
R
N
N
Q
F
P
--
M
H
L
W
R
E
F
G
E
L
G
V
L
G
I
T
A
P
E
D
Y
G
G
A
G
M
---
G
---
Y
L
A
H
C
I
A
M
E
E
I
S
R
A
S
A
S
I
G
L
S
Y
G
A
H
S
-
N
L
C
V
N
Q
I
T
R
N
G
S
P
E
Q
R
A
K
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
S
----------
M
K
L
A
A
E
K
R
-
G
D
-
R
Y
V
L
N
G
N
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
D
-----------------------
I
S
A
F
I
I
E
K
G
F
K
G
F
S
T
A
Q
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
V
F
E
D
C
E
V
P
A
E
N
L
L
G
T
E
G
K
G
V
N
V
L
M
S
G
L
D
Y
E
R
V
V
L
A
G
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
V
H
E
R
-------
G
E
F
Q
L
M
Q
C
K
L
A
D
M
Y
V
T
F
N
A
S
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
E
-
T
T
R
K
D
A
A
G
C
I
L
Y
S
A
E
N
A
T
Q
M
A
L
Q
A
I
Q
S
L
G
G
N
G
Y
I
N
D
Y
P
T
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
I
R
R
M
L
I
G
R
E
L
F
Q
E
T
R
23
PsiBlast_CBE
91.06
74%
-103
- C2 -
4O5M
1
?
B:
[9-390]
-----
M
N
F
G
L
G
E
E
I
E
A
L
R
D
T
V
R
R
F
A
E
S
R
I
A
P
L
A
A
E
T
D
R
N
N
Q
F
P
--
M
H
L
W
R
E
F
G
E
L
G
V
L
G
I
T
A
P
E
D
Y
G
G
A
G
M
---
G
---
Y
L
A
H
C
I
A
M
E
E
I
S
R
A
S
A
S
I
G
L
S
Y
G
A
H
S
-
N
L
C
V
N
Q
I
T
R
N
G
S
P
E
Q
R
A
K
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
----------------------
D
-
R
Y
V
L
N
G
N
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
-------------------------
S
A
F
I
I
E
K
G
F
K
G
F
S
T
A
Q
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
V
F
E
D
C
E
V
P
A
E
N
L
L
G
T
E
G
K
G
V
N
V
L
M
S
G
L
D
Y
E
R
V
V
L
A
G
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
V
H
E
R
--------
E
F
Q
L
M
Q
C
K
L
A
D
M
Y
V
T
F
N
A
S
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
E
-
T
T
R
K
D
A
A
G
C
I
L
Y
S
A
E
N
A
T
Q
M
A
L
Q
A
I
Q
S
L
G
G
N
G
Y
I
N
D
Y
P
T
G
R
L
L
R
D
A
K
L
Y
E
I
-----
E
I
R
R
M
L
I
G
R
E
L
F
Q
E
T
R
24
PsiBlast_CBE
90.69
64%
-98
- C2 -
1IVH
5
IVD_HUMAN
D:
[13-387]
---------
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
NL
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
LA
A
----
V
--
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
1
PsiBlast_PDB
90.28
74%
-105
- C2 -
4O5M
2
?
A:
[9-389]
-----
M
N
F
G
L
G
E
E
I
E
A
L
R
D
T
V
R
R
F
A
E
S
R
I
A
P
L
A
A
E
T
D
R
N
N
Q
F
P
--
M
H
L
W
R
E
F
G
E
L
G
V
L
G
I
T
A
P
E
D
Y
G
G
A
G
M
---
G
---
Y
L
A
H
C
I
A
M
E
E
I
S
R
A
S
A
S
I
G
L
S
Y
G
A
H
S
-
N
L
C
V
N
Q
I
T
R
N
G
S
P
E
Q
R
A
K
Y
L
P
K
L
I
S
G
E
H
V
G
A
L
A
M
------------
K
L
A
A
E
K
R
-
G
D
-
R
Y
V
L
N
G
N
K
M
W
I
T
N
G
P
D
A
D
V
L
V
V
Y
A
K
T
-----------------------
G
I
S
A
F
I
I
E
K
G
F
K
G
F
S
T
A
Q
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
V
F
E
D
C
E
V
P
A
E
N
L
L
G
------------
L
D
Y
E
R
V
V
L
A
G
G
P
L
G
I
M
A
A
C
L
D
V
V
V
P
Y
V
H
E
R
K
Q
F
D
Q
P
-
G
E
F
Q
L
M
Q
C
K
L
A
D
M
Y
V
T
F
N
A
S
R
A
Y
V
Y
A
V
A
A
A
C
D
R
G
E
-
T
T
R
K
D
A
A
G
C
I
L
Y
S
A
E
N
A
T
Q
M
A
L
Q
A
I
Q
S
L
G
G
N
G
Y
I
N
D
Y
P
T
G
R
L
L
R
D
A
K
L
Y
E
I
G
A
G
---
I
R
R
M
L
I
G
R
E
L
F
Q
E
T
-
115
HHSearch
90.22
63%
-95
- C2 -
1IVH
5
IVD_HUMAN
A:
[11-392]
-------
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
--
L
----
A
AV
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
3
PsiBlast_PDB
89.88
64%
-96
- C2 -
1IVH
5
IVD_HUMAN
A:
[13-387]
---------
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
LA
A
----
V
--
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
25
PsiBlast_CBE
89.20
64%
-98
- C2 -
1IVH
5
IVD_HUMAN
C:
[13-387]
---------
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
NL
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
LA
A
----
V
--
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
26
PsiBlast_CBE
89.07
64%
-97
- C2 -
1IVH
5
IVD_HUMAN
B:
[13-387]
---------
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
NL
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
L
---
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
N
-
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
LA
A
----
V
--
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
104
Fugue
88.51
62%
-94
- C2 -
1IVH
5
IVD_HUMAN
A:
[6-392]
--
V
D
D
A
I
N
G
L
S
E
E
Q
R
Q
L
R
Q
T
M
A
K
F
L
Q
E
H
L
A
P
K
A
Q
E
I
D
R
S
N
E
F
K
N
L
R
E
F
W
K
Q
L
G
N
L
G
V
L
G
I
T
A
P
V
Q
Y
G
G
S
G
-L--
G
---
Y
L
E
H
V
L
V
M
E
E
I
S
R
A
S
G
A
V
G
L
S
Y
G
A
H
S
-
N
L
C
I
N
Q
L
V
R
N
G
N
E
A
Q
K
E
K
Y
L
P
K
L
I
S
G
E
Y
I
G
A
L
A
M
S
E
P
N
A
G
S
D
V
V
S
M
K
L
K
A
E
K
K
-
G
-N
H
Y
I
L
N
G
N
K
F
W
I
T
N
G
P
D
A
D
V
L
I
V
Y
A
K
T
D
--
L
----
A
AV
P
----
A
S
---
R
-
G
I
T
A
F
I
V
E
K
G
M
P
G
F
S
T
S
K
K
L
D
K
L
G
M
R
G
S
N
T
C
E
L
I
F
E
D
C
K
I
P
A
A
N
I
L
G
H
E
N
K
G
V
Y
V
L
M
S
G
L
D
L
E
R
L
V
L
A
G
G
P
L
G
L
M
Q
A
V
L
D
H
T
I
P
Y
L
H
V
R
E
A
F
G
Q
K
I
G
H
F
Q
L
M
Q
G
K
M
A
D
M
Y
T
R
L
M
A
C
R
Q
Y
V
Y
N
V
A
K
A
C
D
E
G
H
-
C
T
A
K
D
C
A
G
V
I
L
Y
S
A
E
C
A
T
Q
V
A
L
D
G
I
Q
C
F
G
G
N
G
Y
I
N
D
F
P
M
G
R
F
L
R
D
A
K
L
Y
E
I
G
A
G
T
S
E
V
R
R
L
V
I
G
R
A
F
N
A
D
--
59
PsiBlast_CBE
79.09
34%
-87
- C2 -
1EGD
3
ACADM_HUMAN
C:
[12-395]
-----
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
K
T
G
E
Y
P
--
V
P
L
I
R
R
A
W
E
L
G
L
M
N
T
H
I
P
E
N
C
G
G
L
G
L
---
G
---
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
S
--
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
-
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
--
P
----
D
--
P
----
K
A
PAN
K
-
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
27
PsiBlast_CBE
77.83
40%
-90
- C2 -
1JQI
4
ACADS_RAT
B:
[10-387]
---------
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
--
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
--
R
----
S
--
R
----
Q
N
---
K
-
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
4
PsiBlast_PDB
77.26
40%
-89
- C2 -
1JQI
4
ACADS_RAT
A:
[10-387]
---------
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
--
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
---
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
--
R
----
S
--
R
----
Q
N
---
K
-
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
32
PsiBlast_CBE
76.98
40%
-88
- C2 -
2VIG
6
ACADS_HUMAN
D:
[6-383]
---------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
--------------------
K
-
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
29
PsiBlast_CBE
76.92
40%
-88
- C2 -
2VIG
7
ACADS_HUMAN
G:
[6-383]
---------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
---------------
Q
N
---
K
-
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
119
HHSearch
76.89
40%
-87
- C2 -
2VIG
5
ACADS_HUMAN
A:
[6-383]
---------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
--
R
----
A
--
L
----
Q
N
---
K
-
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
5
PsiBlast_PDB
76.89
40%
-87
- C2 -
2VIG
5
ACADS_HUMAN
A:
[6-383]
---------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
--
R
----
A
--
L
----
Q
N
---
K
-
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
34
PsiBlast_CBE
76.64
40%
-88
- C2 -
2VIG
6
ACADS_HUMAN
B:
[6-383]
---------
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
--
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
---
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
-
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
-----------------------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
117
HHSearch
76.36
35%
-91
- C2 -
2JIF
9
ACDSB_HUMAN
A:
[24-404]
----
A
P
L
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
--
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
---
F
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
-
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
--
P
----
T
--
I
----
G
Y
---
K
-
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
-
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
Y
-
15
PsiBlast_PDB
75.40
38%
-92
- C2 -
2DVL
2
?
A:
[9-372]
---------------
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
--
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
-
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
V
-
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
--------------------
K
-
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
-
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
---
43
PsiBlast_CBE
75.05
37%
-85
- C2 -
1UKW
3
?
B:
[1-377]
-----
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
-
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
--
P
----
E
--
L
----
R
H
---
K
-
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
A
--
6
PsiBlast_PDB
75.02
36%
-87
- C2 -
4L1F
7
?
A:
[1-380]
-----
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
--
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
-
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
--
K
----
S
--
Q
----
G
V
---
H
-
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
-
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
--
35
PsiBlast_CBE
74.79
36%
-88
- C2 -
4L1F
5
?
B:
[1-380]
-----
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
--
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
---
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
-
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
-
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
--
K
----
S
--
Q
----
G
V
---
H
-
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
-
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
--
123
HHSearch
74.60
36%
-86
- C2 -
1BUC
3
ACDS_MEGEL
A:
[2-383]
------
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
---
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
-
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
--
K
----
S
--
K
----
G
N
---
H
-
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
---
57
PsiBlast_CBE
74.16
38%
-89
- C2 -
2DVL
2
?
B:
[9-372]
---------------
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
--
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
---
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
-
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
V
-
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
--------------------
K
-
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
-
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
---
126
HHSearch
73.17
37%
-87
- C2 -
1UKW
2
?
A:
[1-378]
-----
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
A
S
D
--
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
--
P
----
E
--
L
----
R
H
---
K
-
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
A
--
128
HHSearch
72.82
38%
-85
- C2 -
2D29
2
?
A:
[3-387]
-----
L
W
F
E
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
-
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
--
P
----
P
--
P
SPER
K
H
---
Q
-
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
-
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
A
V
-
64
PsiBlast_CBE
72.80
37%
-84
- C2 -
1BUC
3
ACDS_MEGEL
B:
[19-382]
-----------------------
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
-
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
--
K
----
S
--
K
----
G
N
---
H
-
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
---
89
PsiBlast_CBE
72.46
35%
-90
- C2 -
2PG0
2
?
B:
[10-383]
---------
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
-
V
G
I
G
L
H
N
-
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
--
P
----
Q
A-
K
----
P
P
---
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
K
-
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
D
----
90
PsiBlast_CBE
72.30
35%
-90
- C2 -
2PG0
2
?
A:
[10-383]
---------
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
-
V
G
I
G
L
H
N
-
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
--
P
----
Q
A-
K
----
P
P
---
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
K
-
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
D
L
---
91
PsiBlast_CBE
72.21
38%
-87
- C2 -
2D29
2
?
B:
[19-385]
---------------------
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
-
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
--
P
PPSP
E
--
R
----
K
H
---
Q
-
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
-
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
A
V
-
10
PsiBlast_PDB
72.01
37%
-85
- C2 -
1UKW
2
?
A:
[1-377]
-----
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
P
--
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
---
M
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
-
Y
T
I
P
M
A
S
-
D
L
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
-
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
--
P
----
E
--
L
----
R
H
---
K
-
G
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
A
--
18
PsiBlast_PDB
71.65
37%
-83
- C2 -
1BUC
3
ACDS_MEGEL
A:
[19-382]
-----------------------
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
I
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
-
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
-
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
--
K
----
S
--
K
----
G
N
---
H
-
G
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
---
120
HHSearch
71.06
35%
-86
- C2 -
2PG0
2
?
A:
[6-383]
-----
T
A
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
I
I
P
--
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
---
D
---
F
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
L
V
G
I
-
G
L
H
N
-
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
-
G
D
-
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
--
P
----
Q
--
A
KP--
P
H
---
R
-
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
K
-
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
D
L
---
92
PsiBlast_CBE
70.83
38%
-84
- C2 -
2D29
2
?
A:
[19-385]
---------------------
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
G
A
F
P
--
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
---
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
A
L
T
V
A
S
H
N
-
S
L
A
T
G
H
I
L
L
A
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
-
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
--
P
PPSP
E
--
R
----
K
H
---
Q
-
G
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
-
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
A
V
-
130
HHSearch
68.20
32%
-85
- C2 -
3P4T
3
?
A:
[23-399]
------
S
I
W
T
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
R
A
G
E
I
P
--
R
E
L
H
R
K
A
A
E
L
G
L
L
G
A
G
F
P
E
D
A
G
G
S
G
G
---
D
---
G
A
D
P
V
V
I
C
E
E
M
H
Y
A
G
S
P
G
G
V
Y
A
S
L
F
T
C
G
I
A
V
P
H
M
I
A
S
G
D
Q
R
L
I
D
T
Y
V
R
P
T
L
R
G
E
K
I
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
-
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
--
G
----
P
-------
G
A
---
G
-
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
E
T
N
L
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
G
F
Q
S
-