@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2158: (2016-02-05 )
MKAVVFHDIGDIRLEDVAEPRLQEPTDAIVRLTASAICGTDLHFVRGSVGGMRPGTILGHEGVGIVEALGDEVRNLQVGDRVVIPSTIACGNCVYCRAGYYAQCDVANPGGSQAGTAFFGGPRANGGFHGLQAEKARIPYANIGLIRLPSSISDDQAILLSDIFPTGYFGAELAGIAPGNTVAVFGCGPVGQFAIASALLLGAARVFAIDRHPDRLHMARQQGAEVIDFEREDPVQALRWLTAGIGVDRAIDAVGVDAEHSHGTATPAPRQEGTSWSPGNAPAQALEWAVQGLAKAGTLSIIGVYAEDSRQFPIGLAMNRNLTIRMGNCHHRKYIPLLLEHVLSGRIDPAKILTQVKPIGDAIEAFEAFDRRETGWIKVELVPQKRQVEGSEERLDERAVDELARRPTPESGARG
Atome Classification :
(20 SA)
-.........10........20...-------..------.------..30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....----..----.160.......170.......180.......190.......200.......210.......220..-.....230...-..-..240.......250.......260.......270.......280.......290...-....300...------------..----.------------.310..---.-----...-----------..320.......-330........340.......350.-.-...-..360.......370.......380.......390.......400.......410...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
K
A
V
V
F
HDIGDI
R
L
E
DVAEPRLQE-------
P
T
------
D
------
A
I
V
R
L
T
A
S
AICGT
D
L
H
F
V
RGSVGGMRPG
T
I
LGHEG
V
G
I
V
E
A
L
G
D
E
V
RNLQVG
D
R
V
VIPSTIACG
N
C
V
Y
CRAG
Y
Y
A
QCDVANPGGSQAGT
A
F
FGGPRANGGFHGLQAEKARIPYA
N
I
G
L
I
RLPSSISDD
Q
----
A
I
----
L
L
S
DIFPTGYFG
A
E
LAGIAPG
N
T
V
A
V
F
GCG
P
V
G
Q
F
A
I
A
S
A
L
L
L
G
A
A
R
V
F
A
IDRH
P
D
R
L
H
M
A
R
QQGA-
E
V
I
DFERE
D
P
V
-
Q
A
-
L
R
W
L
T
AGIGVDRAI
D
A
VGVDAEHSHGTATPAPRQEGTSWSPGN
A
P
A
Q
A
L
E
W
A
V
Q
G
L
AK-AG
T
L
S
I
I
G
V
Y------------AE----D------------SR-QFP---
I
-----
G
L
A
-----------MNR
N
L
T
I
R
MGNC-H-H
R
K
Y
I
P
L
L
L
E
H
V
LSGRI
D
P
A
K
I
L
-
T
-QVK-P
I
G
D
A
I
E
A
F
E
A
F
DRRET
G
W
I
K
V
E
LVP
Q
K
RQVEG
S
E
E
R
L
D
E
R
A
V
D
E
L
ARRPTPESGARG
22
PsiBlast_CBE
91.69
38%
-112
- C1 -
4CPD
3
?
C:
[1-344]
-
M
R
A
V
V
F
E
N
K
E
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
-------
P
L
------
D
------
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
H
L
Y
H
G
K
I
P
V
L
-
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
-
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
--------
R
G
G
V
Y
G
Y
G
P
M
F
-
G
N
L
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
----
A
I
----
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
-
I
P
I
N
A
E
Q
E
N
P
V
-
R
R
-
V
R
S
E
T
N
D
E
G
P
D
L
V
L
E
A
V
G
-------
G
A
A
T
-------------------
L
S
L
A
L
E
M
V
R
P
-
G
G
R
V
S
A
V
G
V
D
------------
N
A
----
P
------------
S
F
-
P
F
P
---
L
-----
A
S
G
-----------
L
V
K
D
L
T
F
R
I
G
L
A
-
N
-
V
H
L
Y
I
D
A
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
-
S
-
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
D
R
K
E
A
--
L
K
V
L
L
V
V
R
-------------------------------
23
PsiBlast_CBE
90.87
38%
-111
- C1 -
4CPD
2
?
B:
[1-344]
-
M
R
A
V
V
F
E
N
K
E
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
-------
P
L
------
D
------
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
H
L
Y
H
G
K
I
P
V
L
-
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
Q
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
--------
R
G
G
V
Y
G
Y
G
P
M
F
-
G
N
L
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
----
A
I
----
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
-
I
P
I
N
A
E
Q
E
N
P
V
-
R
R
-
V
R
S
E
T
N
D
E
G
P
D
L
V
L
E
A
V
G
-------
G
A
A
T
-------------------
L
S
L
A
L
E
M
V
R
P
-
G
G
R
V
S
A
V
G
V
D
------------
N
A
----
P
------------
S
F
-
P
F
P
---
L
-----
A
S
G
-----------
L
V
K
D
L
T
F
R
I
G
L
A
-
N
-
V
H
L
Y
I
D
A
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
-
S
-
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
D
R
K
E
A
--
L
K
V
L
L
V
V
R
-------------------------------
1
PsiBlast_PDB
90.81
38%
-110
* C1 *
4CPD
3
?
A:
[1-344]
-
M
R
A
V
V
F
E
N
K
E
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
-------
P
L
------
D
------
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
H
L
Y
H
G
K
I
P
V
L
-
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
Q
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
--------
R
G
G
V
Y
G
Y
G
P
M
F
-
G
N
L
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
----
A
I
----
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
-
I
P
I
N
A
E
Q
E
N
P
V
-
R
R
-
V
R
S
E
T
N
D
E
G
P
D
L
V
L
E
A
V
G
-------
G
A
A
T
-------------------
L
S
L
A
L
E
M
V
R
P
-
G
G
R
V
S
A
V
G
V
D
------------
N
A
----
P
------------
S
F
-
P
F
P
---
L
-----
A
S
G
-----------
L
V
K
D
L
T
F
R
I
G
L
A
-
N
-
V
H
L
Y
I
D
A
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
-
S
-
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
D
R
K
E
A
--
L
K
V
L
L
V
V
R
-------------------------------
21
PsiBlast_CBE
90.44
38%
-110
- C1 -
4CPD
3
?
D:
[1-344]
-
M
R
A
V
V
F
------
A
V
K
E
V
N
A
P
R
L
Q
H
-------
P
L
------
D
------
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
H
L
Y
H
G
K
I
P
V
L
-
P
-
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
-
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
--------
R
G
G
V
Y
G
Y
G
P
M
F
-
G
N
L
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
----
A
I
----
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
V
L
G
A
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
-
I
P
I
N
A
E
Q
E
N
P
V
-
R
R
-
V
R
S
E
T
N
D
E
G
P
D
L
V
L
E
A
V
G
-------
G
A
A
T
-------------------
L
S
L
A
L
E
M
V
R
P
-
G
G
R
V
S
A
V
G
V
D
------------
N
A
----
P
------------
S
F
-
P
F
P
---
L
-----
A
S
G
-----------
L
V
K
D
L
T
F
R
I
G
L
A
-
N
-
V
H
L
Y
I
D
A
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
-
S
-
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
D
R
K
E
A
--
L
K
V
L
L
V
V
R
-------------------------------
3
PsiBlast_PDB
89.98
34%
-99
- C1 -
1KOL
4
FADH_PSEPU
A:
[4-380]
--
R
G
V
V
Y
L
G
S
G
K
V
E
V
Q
K
I
D
Y
P
K
M
Q
D
-------
P
R
------
G
KKIEH
G
V
I
L
K
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
-
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
D
W
T
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
----
K
I
R
D
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
E
G
A
K
H
E
A
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVD
A
A
A
K
I
G
S
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
I
N
I
A
E
V
V
G
V
-
Q
V
I
-
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
K
T
F
S
A
----------------------------
25
PsiBlast_CBE
89.35
33%
-104
- C1 -
4JLW
6
?
C:
[5-381]
--
R
G
V
V
Y
L
G
P
G
K
V
E
V
Q
N
I
P
Y
P
K
M
Q
D
-------
P
Q
------
G
RQIDHG
V
I
L
R
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
P
E
-
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
G
W
V
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
----
K
I
RDLT
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
S
G
S
Q
Q
E
A
P
A
T
V
L
N
-
S
L
M
G
I
T
R
V
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVDAAAKHG
A
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
I
K
I
A
D
I
V
G
V
-
E
V
I
-
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-----------------------------
26
PsiBlast_CBE
88.38
33%
-104
- C1 -
4JLW
6
?
B:
[5-381]
--
R
G
V
V
Y
L
G
P
G
K
V
E
V
Q
N
I
P
Y
P
K
M
Q
D
-------
P
Q
------
G
RQIDHG
V
I
L
R
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
P
E
-
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
G
W
V
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
----
K
I
RDLT
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
S
G
S
Q
Q
E
A
P
A
T
V
L
N
-
S
L
M
G
I
T
R
V
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVDAAAKHG
A
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
I
K
I
A
D
I
V
G
V
-
E
V
I
-
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-----------------------------
27
PsiBlast_CBE
87.40
34%
-97
- C1 -
1KOL
4
FADH_PSEPU
B:
[4-380]
--
R
G
V
V
Y
L
G
S
G
K
V
E
V
Q
K
I
D
Y
P
K
M
Q
D
-------
P
R
------
G
KKIEHG
V
I
L
K
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
-
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
D
W
T
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
----
K
I
RDLT
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
E
G
A
K
H
E
A
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVDAAAKIG
S
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
I
N
I
A
E
V
V
G
V
-
Q
V
I
-
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
K
T
F
S
A
----------------------------
24
PsiBlast_CBE
86.27
33%
-103
- C1 -
4JLW
5
?
D:
[5-381]
--
R
G
V
V
Y
L
G
P
G
K
V
E
V
Q
N
I
P
Y
P
K
M
Q
D
-------
P
Q
------
G
RQIDHG
V
I
L
R
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
P
E
-
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
G
W
V
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
----
K
I
RDLT
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
S
G
S
Q
Q
E
A
P
A
T
V
L
N
-
S
L
M
G
I
T
R
V
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVDAAAKHG
A
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
I
K
I
A
D
I
V
G
V
-
E
V
I
-
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-----------------------------
108
Fugue
86.16
34%
-90
- C1 -
1KOL
4
FADH_PSEPU
A:
[2-397]
G
N
R
G
V
V
Y
L
G
S
G
K
V
E
V
Q
K
I
D
Y
P
K
M
Q
D
-------
P
R
GKKIEH
G
------
V
I
L
K
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
-
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
T
V
N
P
A
R
A
----
G
G
A
Y
G
Y
V
D
M
G
D
W
T
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
K
I
R
D
L
T
----
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
-
E
I
A
D
L
S
L
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
R
G
H
G
H
E
G
A
K
-----------
H
E
A
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
G
K
I
G
I
P
G
L
Y
VTEDPGAVD
A
A
A
K
I
----
G
------------
S
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
I
N
I
A
E
V
V
-
G
-
V
Q
V
I
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
V
P
--
K
K
F
V
I
D
P
H
K
T
F
S
A
--------------------------
2
PsiBlast_PDB
85.33
33%
-102
- C1 -
4JLW
5
?
A:
[5-381]
--
R
G
V
V
Y
L
G
P
G
K
V
E
V
Q
N
I
P
Y
P
K
M
Q
D
-------
P
Q
------
G
RQIDH
G
V
I
L
R
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
A
P
E
-
G
L
V
L
G
H
E
I
T
G
E
V
V
E
I
G
R
G
V
E
T
M
K
I
G
D
L
V
S
V
P
F
N
V
A
C
G
H
C
R
T
C
K
E
Q
H
T
G
V
C
L
T
V
N
P
--
A
R
A
G
G
A
Y
--
G
Y
V
D
M
G
G
W
V
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
N
R
E
A
A
M
E
----
K
I
R
D
L
T
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
I
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
V
N
P
T
R
L
A
H
A
K
K
Q
G
F
-
E
I
A
D
L
S
K
D
T
P
L
H
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
-----------
R
G
H
G
H
S
G
S
Q
Q
E
A
P
A
T
V
L
N
-
S
L
M
G
I
T
R
V
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
DPGAVD
A
A
A
K
H
G
A
L
-
S
I
R
---
F
-----
G
L
G
-----------
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
Q
L
M
Q
A
I
M
W
D
R
I
K
I
A
D
I
V
G
V
-
E
V
I
-
T
L
D
D
A
P
K
G
Y
G
E
F
D
A
G
V
P
K
K
F
V
I
D
P
H
N
L
F
R
-----------------------------
95
HHSearch
82.89
34%
-88
- C1 -
1KOL
4
FADH_PSEPU
A:
[3-394]
-
N
R
G
V
V
Y
L
G
S
G
K
V
E
V
Q
K
I
D
Y
P
K
-
M
Q
DPRGKKI
E
H
------
G
------
V
I
L
K
V
V
S
T
N
I
C
G
S
D
Q
H
M
V
R
G
R
T
T
-
A
Q
V
G
L
V
L
G
H
E
I
T
G
E
V
I
E
K
G
R
D
V
E
N
L
Q
I
G
D
L
V
S
V
P
F
N
V
A
C
G
R
C
R
S
C
K
E
M
H
T
G
V
C
L
T
V
N
P
A
R
---
A
G
G
A
Y
G
Y
V
-
D
M
G
D
W
T
G
G
Q
A
E
Y
V
L
V
P
Y
A
D
F
N
L
L
K
L
P
D
R
D
K
A
M
E
K
I
R
D
L
T
----
C
L
S
D
I
L
P
T
G
Y
H
G
A
V
T
A
G
V
G
P
G
S
T
V
Y
V
A
G
A
G
P
V
G
L
A
A
A
A
S
A
R
L
L
G
A
A
V
V
I
V
G
D
L
N
P
A
R
L
A
H
A
K
A
Q
G
F
E
I
A
D
L
S
L
D
T
P
L
H
-
E
Q
-
I
A
A
L
L
G
E
P
E
V
D
C
A
V
D
A
V
G
F
E
A
R
G
H
G
H
E
G
-----------
A
K
H
E
A
P
A
T
V
L
N
S
L
M
Q
V
T
R
V
-
A
G
K
I
G
I
P
G
L
Y
------------
V
T
----
E
------------
D
P
G
A
V
D
---
A
-----
A
A
K
I
GSLSIR
F
G
L
G
W
A
K
S
H
S
F
H
T
G
Q
T
-
P
-
V
M
K
Y
N
R
A
L
M
Q
A
I
M
W
D
R
I
N
I
A
E
V
V
-
G
V
Q
V
I
-
S
L
D
D
A
P
R
G
Y
G
E
F
D
A
G
V
--
P
K
K
F
V
I
D
P
H
K
T
F
S
A
--------------------------
9
PsiBlast_PDB
76.41
30%
-105
- C1 -
3FTN
9
ADH_CLOBE (first)
A:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
M
G
S
S
V
V
V
I
G
I
G
A
V
G
L
M
G
I
A
G
A
K
L
R
G
A
G
R
I
I
G
V
G
S
R
P
I
C
V
E
A
A
K
F
Y
G
A
T
D
I
L
N
Y
K
N
G
H
I
V
-
D
Q
-
V
M
K
L
T
N
G
K
G
V
D
R
V
I
M
A
G
G
--------------------------
G
S
E
T
L
S
Q
A
V
K
M
V
K
P
-
G
G
I
I
S
N
I
N
Y
H
------------
G
S
G---
D
------------
A
L
-
L
I
P
RVE
W
-----
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
6
PsiBlast_PDB
76.07
31%
-101
- C1 -
1BXZ
4
ADH_THEBR
A:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
L
G
A
T
V
A
V
L
G
I
G
P
V
G
L
M
A
V
A
G
A
K
L
R
G
A
G
R
I
I
A
V
G
S
R
P
V
C
V
D
A
A
K
Y
Y
G
A
-
T
D
I
V
N
Y
K
D
G
P
I
-
E
S
Q
I
M
N
L
T
E
G
K
G
V
D
A
A
I
I
A
------------------------
G
G
N
A
D
I
M
A
T
--
A
V
K
I
V
K
P
-
G
G
T
I
A
N
V
N
Y
F
------------
G
E
-----------------
G
E
-
V
L
P
---
V
P
RLEW
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
36
PsiBlast_CBE
75.15
31%
-100
- C1 -
1BXZ
4
ADH_THEBR
B:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
L
G
A
T
V
A
V
L
G
I
G
P
V
G
L
M
A
V
A
G
A
K
L
R
G
A
G
R
I
I
A
V
G
S
R
P
V
C
V
D
A
A
K
Y
Y
G
A
-
T
D
I
V
N
Y
K
D
G
P
I
-
E
S
Q
I
M
N
L
T
E
G
K
G
V
D
A
A
I
I
A
------------------------
G
G
N
A
D
I
M
A
T
--
A
V
K
I
V
K
P
-
G
G
T
I
A
N
V
N
Y
F
------------
G
E
-----------------
G
E
-
V
L
P
---
V
PRLEW
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
10
PsiBlast_PDB
75.12
30%
-103
- C1 -
3FSR
6
ADH_THEBR
A:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
Q
M
G
S
S
V
V
V
I
G
I
G
A
V
G
L
M
G
I
A
G
A
K
L
R
G
A
G
R
I
I
G
V
G
S
R
P
I
C
V
E
A
A
K
F
Y
G
A
T
D
I
L
N
Y
K
N
G
H
I
V
-
D
Q
-
V
M
K
L
T
N
G
K
G
V
D
R
V
I
M
A
G
G
--------------------------
G
S
E
T
L
S
Q
A
V
S
M
V
K
P
-
G
G
I
I
S
N
I
N
Y
H
------------
G
S
G---
D
------------
A
L
-
L
I
P
RVE
W
-----
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
32
PsiBlast_CBE
75.06
31%
-102
- C1 -
1YKF
2
ADH_THEBR
C:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
L
G
A
T
V
A
V
L
G
I
G
P
V
G
L
M
A
V
A
G
A
K
L
R
G
A
G
R
I
I
A
V
G
S
R
P
V
C
V
D
A
A
K
Y
Y
G
A
-
T
D
I
V
N
Y
K
D
G
P
I
-
E
S
Q
I
M
N
L
T
E
G
K
G
V
D
A
A
I
I
A
------------------------
G
G
N
A
D
I
M
A
T
--
A
V
K
I
V
K
P
-
G
G
T
I
A
N
V
N
Y
F
------------
G
E
-----------------
G
E
-
V
L
P
---
V
PRLEW
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
33
PsiBlast_CBE
74.39
31%
-101
- C1 -
1YKF
2
ADH_THEBR
B:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
L
G
A
T
V
A
V
L
G
I
G
P
V
G
L
M
A
V
A
G
A
K
L
R
G
A
G
R
I
I
A
V
G
S
R
P
V
C
V
D
A
A
K
Y
Y
G
A
-
T
D
I
V
N
Y
K
D
G
P
I
-
E
S
Q
I
M
N
L
T
E
G
K
G
V
D
A
A
I
I
A
------------------------
G
G
N
A
D
I
M
A
T
--
A
V
K
I
V
K
P
-
G
G
T
I
A
N
V
N
Y
F
------------
G
E
-----------------
G
E
-
V
L
P
---
V
PRLEW
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
30
PsiBlast_CBE
74.34
31%
-98
- C1 -
2NVB
3
ADH_THEBR
B:
[1-342]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
-----
G
G
M
L
A
G
W
K
F
------
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
D
I
E
L
G
A
T
V
A
V
L
G
I
G
P
V
G
L
M
A
V
A
G
A
K
L
R
G
A
G
R
I
I
A
V
G
S
R
P
V
C
V
D
A
A
K
Y
Y
G
A
-
T
D
I
V
N
Y
K
D
G
P
I
-
E
S
Q
I
M
N
L
T
E
G
K
G
V
D
A
A
I
I
A
------------------------
G
G
N
A
D
I
M
A
T
--
A
V
K
I
V
K
P
-
G
G
T
I
A
N
V
N
Y
F
------------
G
E
GEVL
D
------------
V
P
-
R
L
E
---
W
-----
G
C
G
-----------
M
A
H
K
-
T
I
K
G
G
L
C
P
G
-
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
----------
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
---------------------
97
HHSearch
74.26
31%
-103
- C1 -
3FPC
6
ADH1_ENTHI (first)
A:
[1-351]
-
M
K
G
F
A
M
L
S
I
G
K
V
G
W
I
E
K
E
K
P
A
-
P
G
-------
P
F
------
D
------
A
I
V
R
P
L
A
V
A
P
C
T
S
D
I
H
T
V
F
E
G
A
I
G
E
R
H
N
M
I
L
G
H
E
A
V
G
E
V
V
E
V
G
S
E
V
K
D
F
K
P
G
D
R
V
V
V
P
A
I
T
P
D
W
R
T
S
E
V
Q
R
G
Y
H
Q
H
S
G
G
M
L
----------
A
G
W
K
-
F
S
N
V
K
D
G
V
F
G
E
F
F
H
V
N
D
A
D
M
N
L
A
H
L
P
K
E
I
P
L
E
A
----
A
V
----
M
I
P
D
M
M
T
T
G
F
H
G
A
E
L
A
N
I
K
L
G
D
T
V
C
V
I
G
I
G
P
V
G
L
M
S
V
A
G
A
N
H
L
G
A
G
R
I
F
A
V
G
S
R
K
H
C
C
D
I
A
L
E
Y
G
A
T
D
I
I
N
Y
K
N
G
D
I
V
-
E
Q
-
I
L
K
A
T
D
G
K
G
V
D
K
V
V
I
A
G
G
D
V
H
--------------------------
T
F
A
Q
A
V
K
M
I
K
P
-
G
S
D
I
G
N
V
N
Y
L
------------
G
E
----
G
D-----------
N
I
-
D
I
P
---
R
SE---
W
G
V
-----------
G
M
G
H
K
H
I
H
G
G
L
C
-
P
G
G
R
L
R
M
E
R
L
I
D
L
V
F
Y
K
R
V
D
P
S
K
L
V
-
T
-
H
V
F
R
G
F
D
N
I
E
K
A
F
M
L
M
K
D
K
P
K
D
L
I
K
P
V
V
I
L
A
-------------------------------