@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2243: (2016-02-05 )
MTSAAVETTPLTCDVLVVGSGAAGLAAAVTAAWHGRRVVLVEKDPVFGGASAWSGGWAWLPRNPLARRAGIEEDIEQPRTYLRHELGERYDAARIDAFLEACPHMVAFFERHTHLRFVDGNGIPDMHGDTPGAAEGGHQLVAAPYDARQLGPLLPRLRKTLRETSFMGMPIMAGADLAAFLDLTRSLPAFLHVARRFSSHLWHLLRYGRAMHLVNGVALVARLAKSAEALGVRLIESAPARELLLRDGKVVGALVESAEGLLRIEAGAVVLACGGFPHDPQRRAELAPTLDTLLPLPPPGCNGDGLRLGESAGGRVADDLRSPIAWAPVSRVPHGDGETGHFPHIIERGKPGLIGVLANGRRFVNEAHGYHDYVAALLEATPPGQPARSWLVCDRRFLRRYGLGYVRPAPLPIAAHLRSGYLKRGTSLDQLARSCGIDPSGLAATVAEYNRHAREGRDPEFGRGGTAFNRKQGDPAYPGPNPCVAPIERGPYYAVQVEPGCFGTFAGLKTDAQARVLDGGGQPIPGLYAAGADMASLFAGHYPSGGINLGPALTFGYIAGRHIAGALGYEQEQAQRG
Atome Classification :
(20 SA)
-------------.........10.....-----...20.....---...30........40.---------------------------.......50........60-........70--------------------.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200......-----.210...----....220.......230........240...-..-..250....-.--.-.260.....-.-.270.......280.......290.......300-.......310.-......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530...-....540.......550.......560.......570.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MTSAAVETTP
L
T
C
D
V
L
-----
V
VGSGA
A
G
L
A
---
A
A
V
T
A
AWHG
R
R
V
V
L
V
E---------------------------KDPVFGGASAWSG
G
W
AWLP-RNP
L
A
R
RAG---------------------
I
E
E
D
I
E
Q
P
R
T
Y
L
R
H
E
L
G
E
RY
D
A
A
R
I
D
A
F
L
E
A
C
P
H
M
V
A
F
F
E
RHT
H
L
R
F
VDGNGIPDMHGDTPGAAEGG
H
Q
L
V
AAPY
D
A
R
Q
L
G
P
L
L
P
R
L
R
K
T
L
R
ETSFMGMPIMAG
A
D
L
A
A
F
L
D
L
T
R
S
L
P
A
F
L
H
V
A
R
R
F
S
S
H
L
W
H
L
L
R
YG-----
R
A
M
H
L
V
N
----
G
V
A
L
V
A
R
L
A
K
S
A
E
A
L
G
-
V
R
L
IESAP
A
R
E
L
L
L-RD-G
K
V
V
G
A
L
V
E
-S--A-E
G
L
L
R
I
EA
G
-
A
-
V
V
L
ACGGFPH
D
P
Q
R
R
A
E
LA
P
T
L
D
T
LLPLPPPGCN-GDGLRLGESAG-GR
V
A
D
D
L
RSPIAWAPVSRVPHGDGETGHF
P
H
I
I
ERGKP
G
L
I
G
V
LAN
G
R
R
F
V
N
EAH
G
Y
H
D
Y
V
A
A
L
L
EATPPGQP
A
R
S
W
L
V
C
D
R
R
F
L
R
R
YGLGYVRPAP
L
P
I
A
A
H
L
R
S
G
Y
L
KRGT
S
L
D
Q
L
A
R
SCGID
P
S
G
L
A
A
T
V
A
E
Y
N
R
H
AREGRDPEFGRGGTAFNRKQGDPAYPGPNPCVAPIERG
P
Y
Y
A
V
Q
VEPG
C
F
G
TFAGLKTDA
Q
A
R
V
LDGGGQPIP
G
L
YAAG
A
D
M
A
-
S
L
F
AGHYPSGGINLGP
A
L
T
F
G
Y
I
A
G
R
H
I
A
G
ALGY
E
Q
E
Q
AQRG
133
Fugue
94.54
33%
-88
- C2 -
4C3X
9
?
A:
[23-530]
--------------------
D
W
T
S
E
C
D
V
L
-----
V
V
G
S
G
G
G
A
L
T
---
G
A
Y
T
A
A
A
Q
G
L
T
T
I
V
L
E
---------------------------
K
T
D
R
F
G
G
T
S
A
Y
S
G
A
S
I
W
L
P
-
G
T
Q
V
Q
E
R
A
G
---------------------
L
P
D
S
T
E
N
A
R
T
Y
L
R
A
L
L
G
D
A
-
E
S
E
R
Q
D
A
Y
V
E
T
A
P
A
V
V
A
L
L
E
Q
N
P
N
I
E
F
E
F
-
R
A
F
P
D
Y
Y
-
K
A
E
G
R
M
D
T
G
R
S
I
N
P
L
D
L
D
P
A
D
I
G
D
L
A
G
K
V
R
P
E
L
D
Q
D
R
-
T
G
Q
D
H
A
P
G
P
------------------------------------------
M
I
G
----
G
R
A
L
I
G
R
L
L
A
A
V
Q
S
T
G
K
A
E
L
R
T
E
S
V
L
T
S
L
I
V
-
E
D
-
G
R
V
V
G
A
E
V
E
-
S
--
G
-
G
E
T
Q
R
I
K
A
N
-
R
G
V
L
M
A
A
G
G
I
E
G
N
A
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
S
M
G
P
F
G
A
N
T
G
D
A
I
S
A
G
I
A
V
G
-
G
A
T
A
--
L
L
D
Q
A
W
F
C
P
G
V
E
Q
P
D
G
S
-----
A
A
F
M
V
--
G
V
R
G
G
L
V
V
D
S
A
G
E
R
Y
L
N
E
S
L
P
Y
D
Q
F
G
R
A
M
D
A
H
D
D
N
G
S
A
V
P
S
F
M
I
F
D
S
R
--
E
G
G
G
L
P
A
I
C
I
P
N
T
A
P
A
K
H
L
E
A
G
T
W
V
G
A
D
T
L
E
E
L
A
A
K
T
G
L
P
A
D
A
L
R
S
T
V
E
K
F
N
D
A
A
K
L
G
V
D
E
E
F
H
R
G
E
D
P
Y
D
A
F
F
C
P
P
-
N
G
G
A
N
A
A
L
T
A
I
E
N
G
P
F
Y
A
A
R
I
V
L
S
D
L
G
T
K
G
G
L
V
T
D
V
N
G
R
V
L
R
A
D
G
S
A
I
D
G
L
Y
A
A
G
N
T
S
A
-
S
L
S
G
R
F
Y
P
G
P
G
V
P
L
G
T
A
M
V
F
S
Y
R
A
A
Q
D
M
A
K
------------
1
PsiBlast_PDB
92.46
30%
-86
- C2 -
4C3X
9
?
A:
[28-529]
-------------------------
C
D
V
L
-----
V
V
G
S
G
G
G
A
L
T
---
G
A
Y
T
A
A
A
Q
G
L
T
T
I
V
L
E
---------------------------
K
T
D
R
F
G
G
T
S
A
Y
S
G
A
S
I
W
L
P
-
G
T
Q
V
Q
E
R
A
G
---------------------
L
P
D
S
T
E
N
A
R
T
Y
L
R
A
L
L
G
D
A
-
E
S
E
R
Q
D
A
Y
V
E
T
A
P
A
V
V
A
L
L
E
Q
N
P
N
I
E
F
-
E
F
R
A
F
P
D
Y
Y
-
K
A
E
G
R
M
D
T
G
R
S
I
N
P
L
D
L
D
P
A
D
I
G
D
L
A
G
K
V
R
P
E
L
D
Q
D
R
-------
T
G
Q
D
H
A
---------
P
G
---------------------------
P
M
I
G
----
G
R
A
L
I
G
R
L
L
A
A
V
Q
S
T
G
K
A
E
L
R
T
E
S
V
L
T
S
L
I
V
-
E
D
-
G
R
V
V
G
A
E
V
E
-
S
--
G
-
G
E
T
Q
R
I
K
A
N
R
G
-
V
L
M
A
A
G
G
I
E
G
N
A
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
S
M
G
P
F
G
A
N
T
G
D
A
I
S
A
G
I
A
V
G
-
G
A
T
A
--
L
L
D
Q
A
W
F
C
P
G
V
E
Q
P
--
D
G
S
A
A
F
M
V
G
V
----
R
G
G
L
V
-
V
D
S
A
G
E
R
Y
L
N
E
S
L
P
Y
D
Q
F
G
R
A
M
D
A
H
D
D
N
G
S
A
V
P
S
F
M
I
F
D
S
R
--
E
G
G
G
L
P
A
I
C
I
P
N
T
A
P
A
K
H
L
E
A
G
T
W
V
G
A
D
T
L
E
E
L
A
A
K
T
G
L
P
A
D
A
L
R
S
T
V
E
K
F
N
D
A
A
K
L
G
V
D
E
E
F
H
R
G
E
D
P
Y
D
A
F
F
C
-
P
P
N
G
G
A
N
A
A
L
T
A
I
E
N
G
P
F
Y
A
A
R
I
V
L
S
D
L
G
T
K
G
G
L
V
T
D
V
N
G
R
V
L
R
A
D
G
S
A
I
D
G
L
Y
A
A
G
N
T
S
A
-
S
L
S
G
R
F
Y
P
G
P
G
V
P
L
G
T
A
M
V
F
S
Y
R
A
A
Q
D
M
A
-------------
2
PsiBlast_PDB
92.35
30%
-85
- C2 -
4C3Y
6
?
A:
[28-529]
-------------------------
C
D
V
L
-----
V
V
G
S
G
G
G
A
L
T
---
G
A
Y
T
A
A
A
Q
G
L
T
T
I
V
L
E
---------------------------
K
T
D
R
F
G
G
T
S
A
Y
S
G
A
S
I
W
L
P
-
G
T
Q
V
Q
E
R
A
G
---------------------
L
P
D
S
T
E
N
A
R
T
Y
L
R
A
L
L
G
D
A
-
E
S
E
R
Q
D
A
Y
V
E
T
A
P
A
V
V
A
L
L
E
Q
N
P
N
I
E
F
-
E
F
R
A
F
P
D
Y
Y
-
K
A
E
G
R
M
D
T
G
R
S
I
N
P
L
D
L
D
P
A
D
I
G
D
L
A
G
K
V
R
P
E
L
D
Q
D
R
-------
T
G
Q
D
H
A
---------
P
G
---------------------------
P
M
I
G
----
G
R
A
L
I
G
R
L
L
A
A
V
Q
S
T
G
K
A
E
L
R
T
E
S
V
L
T
S
L
I
V
-
E
D
-
G
R
V
V
G
A
E
V
E
-
S
--
G
-
G
E
T
Q
R
I
K
A
N
R
G
-
V
L
M
A
A
G
G
I
E
G
N
A
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
S
M
G
P
F
G
A
N
T
G
D
A
I
S
A
G
I
A
V
G
-
G
A
T
A
--
L
L
D
Q
A
W
F
C
P
G
V
E
Q
P
--
D
G
S
A
A
F
M
V
G
V
----
R
G
G
L
V
-
V
D
S
A
G
E
R
Y
L
N
E
S
L
P
Y
D
Q
F
G
R
A
M
D
A
H
D
D
N
G
S
A
V
P
S
F
M
I
F
D
S
R
--
E
G
G
G
L
P
A
I
C
I
P
N
T
A
P
A
K
H
L
E
A
G
T
W
V
G
A
D
T
L
E
E
L
A
A
K
T
G
L
P
A
D
A
L
R
S
T
V
E
K
F
N
D
A
A
K
L
G
V
D
E
E
F
H
R
G
E
D
P
Y
D
A
F
F
C
-
P
P
N
G
G
A
N
A
A
L
T
A
I
E
N
G
P
F
Y
A
A
R
I
V
L
S
D
L
G
T
K
G
G
L
V
T
D
V
N
G
R
V
L
R
A
D
G
S
A
I
D
G
L
Y
A
A
G
N
T
S
A
-
S
L
S
G
R
F
Y
P
G
P
G
V
P
L
G
T
A
M
V
F
S
Y
R
A
A
Q
D
M
A
-------------
112
HHSearch
81.91
30%
-85
* C2 *
1Y0P
5
FRDA_SHEFR
A:
[122-568]
--------------------
A
P
H
D
T
V
D
V
V
-----
V
V
G
S
G
G
A
G
F
S
---
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
---------------------------
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
-
W
T
D
Q
Q
K
A
K
K
---------------------
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
-
G
A
D
L
T
D
V
G
--------
M
M
G
G
A
S
V
N
-------------------------
R
A
-----------------------------------------
H
R
P
------
T
G
G
A
G
V
----
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
M-
Y
-
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
--
V
---
M
V
-
T
E
A
V
R
G
N
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
----
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
---------
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
P
N
-----------------
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
-
G
V
H
G
A
N
R
L
-
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----------
113
HHSearch
81.09
27%
-84
- C2 -
1QO8
3
FRD2_SHEFN
A:
[114-564]
-----------------
I
A
A
G
P
S
E
T
T
Q
V
L
-----
V
V
G
A
G
S
A
G
F
N
---
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
---------------------------
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
N
A
V
-
G
T
K
Q
Q
T
A
H
G
---------------------
V
E
D
K
V
E
W
F
I
E
D
A
M
K
G
G
R
Q
Q
N
D
I
K
L
V
T
I
L
A
E
Q
S
A
D
G
V
Q
W
L
E
S
L
-
G
A
N
L
D
D
L
K
------
R
--
S
G
G
A
R
V
D
-------------------------
R
T
-----------------------------------------
H
R
P
------
H
G
G
K
S
S
----
G
P
E
I
I
D
T
L
R
K
A
A
K
E
Q
G
-
I
D
T
R
L
N
S
R
V
V
K
L
V
V
-
N
D
D
H
S
V
V
G
A
V
V
H
-
G
K-
H
-
T
G
Y
Y
M
I
G
A
K
-
S
-
V
V
L
A
T
G
G
Y
G
M
N
K
E
M
I
A
Y
Y
R
P
T
M
K
D
M
T
S
S
N
N
I
T
A
T
-
G
D
G
V
L
M
A
K
E
I
G
-
A
S
M
T
D
--
I
D
W
V
Q
A
H
P
T
V
G
K
D
S
R
--
I
--
L
I
--
S
E
T
V
R
G
V
G
A
V
M
V
N
K
D
G
N
R
F
I
S
E
L
T
T
R
D
K
A
S
D
A
I
L
K
Q
P
----
G
Q
F
A
W
I
I
F
D
N
Q
L
Y
K
K
A
K
M
V
---------
R
G
Y
D
H
L
E
M
L
Y
K
G
D
T
V
E
Q
L
A
K
S
T
G
M
K
V
A
D
L
A
K
T
V
S
D
Y
N
G
Y
V
A
S
G
K
D
T
A
F
G
R
A
D
M
-----------------
P
L
N
M
T
Q
S
P
Y
Y
A
V
K
V
A
P
G
I
H
H
T
M
G
G
V
A
I
N
T
T
A
S
V
L
D
L
Q
S
K
P
I
D
G
L
F
A
A
G
E
V
T
G
-
G
V
H
G
Y
N
R
L
-
G
G
N
A
I
A
D
T
V
V
F
G
R
I
A
G
D
N
A
A
K
H
A
L
---------
135
Fugue
78.10
25%
-71
- C2 -
1QJD
8
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQE
C
D
S
C
H
T
P
D
G
E
L
S
N
D
S
L
-----
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
K
H
E
H
Y
N
A
H
---------------------------
A
S
H
F
P
G
E
V
A
C
T
S
C
H
S
A
H
E
K
-
S
M
V
Y
C
D
S
C
H
SFDFNMPYAK
K
W
L
R
D
E
P
T
IAE
L
A
K
D
K
S
E
R
Q
A
A
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
---
G
G
N
A
K
L
A
A
G
G
---
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
--
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
GASVN
R
A
H
R
P
T
G
GAG
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
D
K
-
G
T
V
K
G
I
L
V
K
G
M
--
Y
-
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
-------
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
----
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
---------
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------------
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
-
G
V
H
-
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----------
134
Fugue
77.59
24%
-72
- C2 -
1JRX
7
FRDA_SHEFR
A:
[1-568]
------------A
D
N
L
A
E
F
H
V
Q
N
Q
E
C
D
S
C
HTPDG
E
L
S
N
D
S
L
T
Y
E
---
N
T
Q
C
V
S
C
H
G
T
L
A
E
V
A
E
T
T
KHEHYNAHASHFPGEVACTSCHSAH
E
K
S
M
V
Y
C
D
S
C
H
S
F
D
F
N
M
P
Y
-
A
K
K
W
L
R
D
E
P
T
IAE-----------------
L
A
K
D
K
S
E
R
Q
A
A
L
A
S
A
P
H
D
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
---
G
G
N
A
K
L
A
A
G
G
---
M
N
A
A
W
T
D
Q
Q
K
A
K
K
I
T
D
S
P
E
L
M
F
E
D
T
M
K
G
G
Q
N
I
N
--
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
V
D
W
M
T
A
M
G
A
D
L
T
D
V
G
M
M
G
GASVN
R
A
H
R
P
T
G
GAG
V
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
D
D
K
-
G
T
V
K
G
I
L
V
K
G
M
--
Y
-
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
-------
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
----
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
---------
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------------
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
-
G
V
H
-
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
----------
13
PsiBlast_PDB
66.48
32%
-80
- C2 -
1JRX
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
4
PsiBlast_PDB
66.36
32%
-83
- C2 -
1E39
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
A
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
23
PsiBlast_CBE
66.32
32%
-83
- C2 -
1JRX
5
FRDA_SHEFR
B:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
116
HHSearch
66.21
19%
-88
- C2 -
2BS2
3
FRDA_WOLSU
A:
[2-430]
---------------------
K
V
Q
Y
C
D
S
L
-----
V
I
G
G
G
L
A
G
L
R
---
A
A
V
A
T
Q
Q
K
G
L
S
T
I
V
L
S
---------------------------
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
------------------------
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
-
G
V
P
W
T
R
I
H
K
-
G
D
R
M
----
A
I
I
N
A
Q
K
T
T
-
I
T
E
E
D
----------
F
R
H
G
--
L
I
H
S
R
------------
D
F
G
G
T
K
K
W
----------------
R
T
C
Y
T
--------
A
D
A
T
----
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
-
V
S
I
Q
D
R
K
E
A
I
A
L
I
H
-
Q
D
-
G
K
C
Y
G
A
V
V
R
-
D
LV
T
-
G
D
I
I
A
Y
V
A
K
-
G
-
T
L
I
A
T
G
G
Y
G
R
I
------
Y
K
N
------
T
T
N
A
V
V
C
E
-
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
--
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
------
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
P
E
K
K
---
E
L
A
S
----------
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
------
G
V
Q
S
P
-
Y
G
Q
H
L
W
-
L
-
D
I
S
I
L
G
R
------
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
-----
F
A
G
-----------------------
I
D
P
A
E
K
W
-
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
D
Y
R
G
E
A
------
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
-
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
--------
12
PsiBlast_PDB
66.17
32%
-83
- C2 -
1Y0P
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
15
PsiBlast_PDB
66.14
32%
-82
- C2 -
1KSU
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
Y
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
10
PsiBlast_PDB
66.09
32%
-83
- C2 -
1P2H
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
7
PsiBlast_PDB
66.02
32%
-83
- C2 -
1JRY
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
K
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
5
PsiBlast_PDB
65.92
32%
-83
- C2 -
1KSS
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
A
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
16
PsiBlast_PDB
65.90
32%
-81
- C2 -
1M64
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
F
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
11
PsiBlast_PDB
65.80
32%
-83
- C2 -
1QJD
6
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
14
PsiBlast_PDB
65.78
32%
-83
- C2 -
1P2E
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------
9
PsiBlast_PDB
65.74
32%
-85
- C2 -
1Q9I
5
FRDA_SHEFR
A:
[254-565]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
V
V
Q
V
L
Y
D
N
A
V
K
R
N
-
I
D
L
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K
G
T
V
K
G
I
L
V
K
-
G
--
M
Y
K
G
Y
Y
W
V
K
A
D
-
A
-
V
I
L
A
T
G
G
F
A
K
N
N
E
R
V
A
K
L
D
P
S
L
K
G
F
I
S
T
N
Q
P
G
A
V
-
G
D
G
L
D
V
A
E
N
A
G
-
G
A
L
K
D
--
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
V
T
E
A
V
-----
R
G
N
-
G
A
I
L
V
N
R
E
G
K
R
F
V
N
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
--
G
K
S
A
--
Y
L
I
F
D
D
S
---------
V
R
K
S
L
C
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
G
K
D
T
D
F
E
R
-----------
P
N
L
P
------
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
N
A
K
K
Q
V
I
P
G
L
Y
G
A
G
-
E
V
T
-
G
G
V
H
G
A
N
R
L
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
-------------