@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2260: (2016-02-05 )
MSLHPVSISLSSYGADLVRSRGQASFLPLLAMAGAQRVELREELFAGPPDTEALTAAIQLQGLECVFSSPLELWREDGQLNPELEPTLRRAEACGAGWLKVSLGLLPEQPDLAALGRRLARHGLQLLVENDQTPQGGRIEVLERFFRLAERQQLDLAMTFDIGNWRWQEQAADEAALRLGRYVGYVHCKAVIRNRDGKLVAVPPSAADLQYWQRLLQHFPEGVARAIEYPLQGDDLLSLSRRHIAALARLGQPQEERQHG
Atome Classification :
(20 SA)
.........10..-......----20-........30........40--.....-------------.-----..50........60.....-.-.-.-70---------.----.-.-------------.---....-------.-80-.---...-.....90......-...100......----------------.-------110-------.---------.......-------.120.......130-----.--------.---.-....140......--.150.......160..-.....-170.........-180-........190..----..--------------.-------.--------------.200.....-.-.210........220...----.....230.----.------.--------------------....240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSL
H
P
V
S
I
S
L
S
SY-
G
A
D
L
V
R
----SR-GQ
A
S
F
L
P
L
L
A
MAG
A
Q
R
V
E
L
R
--
E
E
LFA-------------G-----PP
D
T
E
A
L
T
A
A
I
Q
L
QG
L
E
C
V
-
F
-S-S-
P
----------
L
----
E
-
L
-------------
W
---
R
EDG-------Q-L--N---PE
L
-
E
P
T
L
R
R
-
A
E
ACGA-
G
W
L
K
V
S
LGLLPE----------------Q-------P---------
D
---------
L
A
A
L
G
R
R
-------
L
A
R
H
G
L
Q
L
LVENDQ-----T--------P---Q-G
G
R
I
E
V
L
E
R
F
F
R
L
--
A
E
R
QQL
D
L
A
M
T
F
DIGN-
W
R
W
Q
E
-Q--A
A
D
E
A
A
L
R
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
RN----RD--------------G-------
K
--------------
L
V
A
VPPS
A
A
-
D
-
L
Q
Y
-
W
Q
R
L
L
Q
H
F
P
E
-
G
V
A
----
R
A
IEYPLQG----
D
------
D
--------------------
L
L
S
L
S
R
R
H
I
A
A
L
A
RLGQ
P
Q
E
E
RQHG
22
PsiBlast_CBE
99.41
99%
-123
- C3 -
1YX1
2
?
B:
[5-255]
--
L
H
P
V
S
I
S
L
S
S
Y
-
G
A
D
L
V
R
----
S
R
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G
Q
A
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P
L
L
A
M
A
G
A
Q
R
V
E
L
R
--
E
E
L
F
A
-------------
G
-----
P
P
D
T
E
A
L
T
A
A
I
Q
L
Q
G
L
E
C
V
-
F
-
S
-
S
-
P
----------
L
----
E
-
L
-------------
W
---
R
E
D
G
-------
Q
-
L
--
N
---
P
E
L
-
E
P
T
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A
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A
-
G
W
L
K
V
S
L
G
L
L
P
E
----------------
Q
-------
P
---------
D
---------
L
A
A
L
G
R
R
-------
L
A
R
H
G
L
Q
L
L
V
E
N
D
Q
-----
T
--------
P
---
Q
-
G
G
R
I
E
V
L
E
R
F
F
R
L
--
A
E
R
Q
Q
L
D
L
A
M
T
F
D
I
G
N
-
W
R
W
Q
E
-
Q
--
A
A
D
E
A
A
L
R
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
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N
----
R
D
--------------
G
-------
K
--------------
L
V
A
V
P
P
S
A
A
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D
-
L
Q
Y
-
W
Q
R
L
L
Q
H
F
P
E
-
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V
A
----
R
A
I
E
Y
P
L
Q
G
----
D
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D
--------------------
L
L
S
L
S
R
R
H
I
A
A
L
A
R
L
G
Q
P
-------
1
PsiBlast_PDB
99.01
99%
-124
- C3 -
1YX1
2
?
A:
[5-254]
--
L
H
P
V
S
I
S
L
S
S
Y
-
G
A
D
L
V
R
----
S
R
-
G
Q
A
S
F
L
P
L
L
A
M
A
G
A
Q
R
V
E
L
R
--
E
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L
F
A
-------------
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-----
P
P
D
T
E
A
L
T
A
A
I
Q
L
Q
G
L
E
C
V
-
F
-
S
-
S
-
P
----------
L
----
E
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L
-------------
W
---
R
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D
G
-------
Q
-
L
--
N
---
P
E
L
-
E
P
T
L
R
R
-
A
E
A
C
G
A
-
G
W
L
K
V
S
L
G
L
L
P
E
----------------
Q
-------
P
---------
D
---------
L
A
A
L
G
R
R
-------
L
A
R
H
G
L
Q
L
L
V
E
N
D
Q
-----
T
--------
P
---
Q
-
G
G
R
I
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V
L
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R
F
F
R
L
--
A
E
R
Q
Q
L
D
L
A
M
T
F
D
I
G
N
-
W
R
W
Q
E
-
Q
--
A
A
D
E
A
A
L
R
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
R
N
----
R
D
--------------
G
-------
K
--------------
L
V
A
V
P
P
S
A
A
-
D
-
L
Q
Y
-
W
Q
R
L
L
Q
H
F
P
E
-
G
V
A
----
R
A
I
E
Y
P
L
Q
G
----
D
------
D
--------------------
L
L
S
L
S
R
R
H
I
A
A
L
A
R
L
G
Q
--------
21
PsiBlast_CBE
98.67
99%
-121
- C3 -
1YX1
1
?
C:
[5-254]
--
L
H
P
V
S
I
S
L
S
S
Y
-
G
A
D
L
V
R
----
S
R
-
G
Q
A
S
F
L
P
L
L
A
M
A
G
A
Q
R
V
E
L
R
--
E
E
L
F
A
-------------
G
-----
P
P
D
T
E
A
L
T
A
A
I
Q
L
Q
G
L
E
C
V
-
F
-
S
-
S
-
P
----------
L
----
E
-
L
-------------
W
---
R
E
D
G
-------
Q
-
L
--
N
---
P
E
L
-
E
P
T
L
R
R
-
A
E
A
C
G
A
-
G
W
L
K
V
S
L
G
L
L
P
E
----------------
Q
-------
P
---------
D
---------
L
A
A
L
G
R
R
-------
L
A
R
H
G
L
Q
L
L
V
E
N
D
Q
-----
T
--------
P
---
Q
-
G
G
R
I
E
V
L
E
R
F
F
R
L
--
A
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R
Q
Q
L
D
L
A
M
T
F
D
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G
N
-
W
R
W
Q
E
-
Q
--
A
A
D
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A
A
L
R
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
R
N
----
R
D
--------------
G
-------
K
--------------
L
V
A
V
P
P
S
A
A
-
D
-
L
Q
Y
-
W
Q
R
L
L
Q
H
F
P
E
-
G
V
A
----
R
A
I
E
Y
P
L
Q
G
----
D
------
D
--------------------
L
L
S
L
S
R
R
H
I
A
A
L
A
R
L
G
Q
--------
23
HHSearch
98.30
99%
-122
- C3 -
1YX1
2
?
A:
[5-254]
--
L
H
P
V
S
I
S
L
S
S
Y
-
G
A
D
L
-
V
----
R
S
R
G
Q
A
S
F
L
P
L
L
A
M
A
G
A
Q
R
V
E
L
R
--
E
E
L
F
A
-------------
G
-----
P
P
D
T
E
A
L
T
A
A
I
Q
L
Q
G
L
E
C
V
-
F
-
S
-
S
-
P
----------
L
----
E
-
L
-------------
W
---
R
E
D
G
-------
Q
-
L
--
N
---
P
E
L
-
E
P
T
L
R
R
-
A
E
A
C
G
A
-
G
W
L
K
V
S
L
G
L
L
P
E
----------------
Q
-------
P
---------
D
---------
L
A
A
L
G
R
R
-------
L
A
R
H
G
L
Q
L
L
V
E
N
D
Q
-----
T
--------
P
---
Q
-
G
G
R
I
E
V
L
E
R
F
F
R
L
--
A
E
R
Q
Q
L
D
L
A
M
T
F
D
I
G
N
-
W
R
W
Q
E
-
Q
--
A
A
D
E
A
A
L
R
L
-
G
R
--
Y
V
G
Y
V
H
C
K
A
V
I
R
N
----
R
D
--------------
G
-------
K
--------------
L
V
A
V
P
P
S
A
A
-
D
-
L
Q
Y
-
W
Q
R
L
L
Q
H
F
P
E
-
G
V
A
----
R
A
I
E
Y
P
L
Q
G
----
D
------
D
--------------------
L
L
S
L
S
R
R
H
I
A
A
L
A
R
L
G
Q
--------
26
HHSearch
55.88
15%
-82
- C3 -
3CNY
2
IOLE_LACPL
A:
[7-300]
E
K
D
I
K
W
G
I
A
P
I
G
W
-
R
N
D
D
I
P
SIGK
D
N
-
N
L
Q
Q
L
L
S
D
I
V
V
A
G
F
Q
G
T
E
V
G
--
G
F
F
P
----------------------
G
P
E
K
L
N
Y
E
L
K
L
R
N
L
E
I
A
-
G
-
Q
-
W
F
S
----------
S
----
Y
-
I
-------------
I
---
R
D
G
I
-------
E
-
K
--
A
S
--
E
A
F
-
E
K
H
C
Q
Y
-
L
K
A
I
N
A
-
P
V
A
V
V
S
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Q
T
Y
T
I
QRSDTANIF
K
D
K
P
Y
F
T
D
-------
K
---------
E
W
D
E
V
C
K
G
--
L
N
H
Y
G
E
I
-------
A
A
K
Y
G
L
K
V
A
Y
H
H
H
M
-----
G
--------
T
---
G
-
I
Q
T
K
E
E
T
D
R
L
M
A
N
--
T
D
--
P
K
L
V
G
L
L
Y
D
T
G
H
-
I
A
V
S
D
-
G
--
D
Y
M
A
L
L
N
A
H
-
I
D
--
R
V
V
H
V
H
F
K
D
V
R
R
S
----
K
E
--------------
E
-------
E
C
R
A
K
GLT
F
Q
G
S
F
L
N
G
M
F
T
V
P
G
D
G
-
D
-
L
-
D
-
F
K
P
V
Y
D
K
L
I
A
-
N
N
Y
K
G
W
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I
V
V
E
A
E
Q
D
P
----
S
KA----
N
--------------------
P
L
E
M
A
Q
I
A
H
R
Y
I
K
Q
H
L
I
E
-------
27
HHSearch
55.84
14%
-88
- C3 -
3P6L
4
?
A:
[7-260]
K
N
G
W
R
L
G
M
Q
S
Y
S
F
-
H
L
F
----------
P
L
T
E
A
L
D
K
T
Q
E
L
G
L
K
Y
I
E
I
Y
--
P
G
H
K
L
GGKWGDKVFDFNL
D
-----
A
Q
T
Q
K
E
I
K
E
L
A
A
S
K
G
I
K
I
V
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G
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T
-
G
-
V
----------
Y
----
V
-
A
----------------------------
E
-
K
--
S
---
S
D
W
-
E
K
M
F
K
F
-
A
K
A
M
D
L
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F
I
T
C
E
P
A
L
S
------------------------------------
D
---------
W
D
L
V
E
K
L
-------
S
K
Q
Y
N
I
K
I
S
V
H
N
H
P
-----
Q
--------
P
---
S
D
Y
W
K
P
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N
L
L
K
A
I
S
G
---
R
--
S
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S
L
G
S
C
S
D
V
G
H
-
W
R
R
E
G
-
L
--
N
Q
I
D
C
L
K
Q
L
-
K
G
--
R
I
I
S
L
H
F
K
D
I
A
P
K
----
K
A
--------------
G
EN-----
E
--------------
Q
H
D
V
I
W
G
T
G
-
I
-
L
-
D
-
V
K
G
M
L
K
E
L
K
S
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N
F
K
G
V
-
F
S
I
E
Y
E
Y
N
W
----
E
------
N
--------------------
S
V
P
D
I
K
E
C
I
Q
Y
F
N
K
T
A
N
E
-------
25
HHSearch
55.62
16%
-87
- C3 -
3U0H
5
?
A:
[3-281]
--
A
M
E
P
C
L
H
P
T
L
V
-
D
E
T
----------
S
L
V
L
Y
L
D
L
A
R
E
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Y
R
Y
V
D
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--
F
H
W
L
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-------------
A
E
A
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--
R
H
G
D
A
A
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E
A
M
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Q
R
R
G
L
V
L
A
N
L
-
G
-
L
-
P
----------
L
----
N
-
L
-------------
Y
---
D
S
E
P
-------
V
-
F
L
R
E
L
--
S
L
L
-
P
D
R
A
R
L
-
C
A
R
L
G
A
-
R
S
V
T
A
F
L
W
P
S
M
D
----------------
E
-------
E
P
V
R
Y
I
----
S
Q
L
A
R
R
----
I
R
Q
V
A
V
E
-------
L
L
P
L
G
M
R
V
G
L
E
Y
V
G
-----
P
HHLRHRRY
P
---
F
-
V
Q
S
L
A
D
L
K
T
F
W
E
A
--
I
G
--
A
P
N
V
G
A
L
V
D
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Y
H
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W
Y
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--
H
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D
D
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--
K
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Y
V
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I
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D
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R
D
A
----
P
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--------------
D
AH-----
D
--------------
G
K
R
L
L
P
G
D
G
-
R
-
I
-
P
-
L
V
P
F
L
R
G
L
Y
L
-
A
G
Y
R
G
P
-
V
A
A
E
V
L
H
E
T
----
P
LDG---
T
--------------------
G
E
S
R
A
R
L
V
R
E
R
L
E
K
L
I
A
L
A
K
G
----
29
HHSearch
53.81
18%
-71
- C3 -
2Q02
5
?
A:
[5-272]
-
E
K
T
R
F
C
I
N
R
K
I
A
-
P
G
L
----------
S
I
E
A
F
F
R
L
V
K
R
L
E
F
N
K
V
E
L
R
--
N
D
M
P
S
GSVT---------
D
-----
D
L
N
Y
N
Q
V
R
N
L
A
E
K
Y
G
L
E
I
V
-
T
-
I
-
N
-
A
----------
V
----
Y
-
P
-------------
F
---
N
Q
L
T
-------
E
-
E
V
-
V
---
K
K
T
-
E
G
L
L
R
D
-
A
Q
G
V
G
A
-
R
A
L
V
L
C
P
L
N
D
G
T
----------------
I
-------
V
P
P
E
V
T
V
E
--
A
---------
I
K
R
L
S
D
L
-------
F
A
R
Y
D
I
Q
G
L
V
E
P
L
G
-----
F
--------
R
VS-
S
-
L
R
S
A
V
W
A
Q
Q
L
I
R
E
--
A
G
--
S
P
-
F
K
V
L
L
D
T
F
H
-
H
H
L
Y
E
-
E
--
A
E
K
E
F
A
S
R
I
D
I
S
--
A
I
G
L
V
H
L
S
G
V
E
D
T
----
R
P
--------------
T
EALA---
D
--------------
E
Q
R
I
M
L
S
E
K
D
V
-
M
-
Q
-
N
Y
Q
Q
V
Q
R
L
E
N
-
M
G
Y
R
G
I
-
Y
A
F
E
P
F
S
S
Q
----
L
ASWS
E
A
E
--------------------
I
E
E
Q
I
N
R
S
V
S
L
L
L
Q
-----------
46
Fugue
53.52
20%
-68
- C3 -
3TVA
4
?
A:
[9-290]
-
P
Y
W
P
I
G
V
F
T
S
V
D
-
A
------------
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
AP
H
P
H
T
R
-------------
T
-----
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
-
V
-
I
-
F
-
G
G
F
D
GESYAD
I
P
----
T
-
T
-------------
A
---
R
T
V
G
LVPLET
R
A
-
S
--
R
---
V
A
E
M
K
E
I
S
D
F
-
A
S
W
V
G
C
-
P
A
I
G
L
H
I
G
F
V
P
E
SS--------------
S
-------
P
---------
D
---------
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
-----
E
--------
S
---
A
-
D
H
L
L
E
F
I
E
D
V
--------
N
R
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
-
G
--
N
P
I
E
A
L
R
K
V
-
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
----
P
V
--------------
N
ERGK
S
W
G
Q
--------------
E
V
A
L
G
T
G
D
V
-
G
M
E
A
Y
-
L
T
T
L
W
E
I
G
Y
R
-
G
-
P
----
L
T
I
E
R
E
-
I
P
----
H
------
D
--------------------
P
V
Q
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
N
C
24
HHSearch
53.07
12%
-86
- C3 -
3DX5
5
ASBF_BACAN
A:
[1-274]
---
M
K
Y
S
L
C
T
I
S
F
-
R
H
Q
L
-------
I
-
S
F
T
D
I
V
Q
F
A
Y
E
N
G
F
E
G
I
E
L
W
--
G
T
H
A
Q
-------------
N
L
Y
M
QE
Y
E
T
T
E
R
E
L
N
C
L
K
D
K
T
L
E
I
T
-
M
-
I
-
S
-
D
----------
Y
----
L
-
D
-------------
I
---
S
L
S
A
-------
D
-
F
E
K
T
I
--
E
K
C
-
E
Q
L
A
I
L
-
A
N
W
F
K
T
-
N
K
I
R
T
F
A
G
Q
K
G
S
----------------
A
DFS
Q
---
Q
---------
E
R
Q
E
Y
V
N
R
--
I
R
M
I
C
E
L
-------
F
A
Q
H
N
M
Y
V
L
L
E
T
H
P
-----
N
--------
T
---
L
-
T
D
T
L
P
S
T
L
E
L
L
G
E
--
V
D
--
H
P
N
L
K
I
N
L
D
F
L
H
-
I
W
E
S
G
-
A
--
D
P
V
D
S
F
Q
Q
L
-
R
P
--
W
I
Q
H
Y
H
F
K
N
I
S
S
A
----
D
Y
LHVFE
P
N
N
V
Y
AAAG
N
-------
R
--------------
T
G
M
V
P
L
F
E
G
-
I
-
V
-
N
-
Y
D
E
I
I
Q
E
V
R
D
T
D
H
F
----
A
S
L
E
W
F
G
H
N
--------------------------------
A
K
D
I
L
K
A
E
M
K
V
L
T
N
R
N
---------
34
HHSearch
52.64
12%
-92
- C3 -
3QC0
12
?
A:
[2-274]
M
Q
V
E
G
L
S
I
N
L
A
T
I
-
R
E
Q
C
---------
G
F
A
E
A
V
D
I
C
L
K
H
G
I
T
A
I
A
P
W
--
R
D
Q
V
A
-------------------
A
I
G
L
G
E
A
G
R
I
V
R
A
N
G
L
K
L
T
-
G
-
L
-
C
-
R
----------
G
----
G
-
F
-------------
F
P--
A
P
D
A
S
------
G
-
R
E
K
A
I
--
D
D
N
-
R
R
A
V
D
E
-
A
A
E
L
G
A
-
D
C
L
V
L
V
A
G
G
L
P
G
----------------
G
SKN
I
D
--
A
A
R
R
M
V
V
E
--
G
---------
I
A
A
V
L
P
H
-------
A
R
A
A
G
V
P
L
A
I
E
P
L
H
-----
P
MYAADR--
A
---
C
-
V
N
T
L
G
Q
A
L
D
I
C
E
T
--
L
G
---
P
G
V
G
V
A
I
D
V
Y
H
-
V
W
W
D
P
----
D
L
A
N
Q
I
A
R
A
-
G
K
M
K
A
I
L
A
H
H
I
C
D
W
L
V
P
----
T
K
D-------------
M
-------
L
--------------
T
D
R
G
M
M
G
D
G
-
V
-
I
-
D
-
L
K
G
I
R
R
R
I
E
A
-
A
G
F
H
G
A
-
Q
E
V
E
I
F
S
A
D
NWWK
R
------
P
--------------------
A
D
E
V
I
A
T
C
V
E
R
Y
R
N
C
----------
36
HHSearch
52.20
18%
-78
- C3 -
3TVA
4
?
A:
[9-289]
-
P
Y
W
P
I
G
V
F
T
S
V
D
---
A
----------
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
--
A
P
H
P
H
-------------
T
RT---
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
-
V
-
I
-
F
-
G
----------
G
----
F
-
D
GESYAD
I
P
T
T
A
R
T
V
G--
L
V
P
L
E------
T
-
R
A
S
R
V
--
A
E
M
-
K
E
I
S
D
F
-
A
S
W
V
G
C
-
P
A
I
G
L
H
I
G
F
V
P
E
----------------
S
-------
S
---------
S
P
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
-------
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
---------------------
E
S
A
D
H
L
L
E
F
I
E
D
--
V
N
--
R
P
N
L
G
I
N
F
D
P
A
N
-
M
I
L
Y
G
T
G
--
N
P
I
E
A
L
R
K
V
-
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
----
P
V
NERGK---------
S
-------
W
--------------
G
Q
E
V
A
L
G
T
G
-
D
-
V
-
G
-
M
E
A
Y
L
T
T
L
W
E
-
I
G
Y
RGP-
L
T
I
E
R
E
I
P
H
----
D
P
V
----
Q
--------------------
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
N
----
41
HHSearch
51.01
12%
-88
* C3 *
3VNI
1
?
A:
[2-290]
---
M
K
H
G
I
Y
Y
A
Y
W
-
E
Q
E
W
------
E
A
-
D
Y
K
Y
Y
I
E
K
V
A
K
L
G
F
D
I
L
E
I
A
--
A
S
P
L
P
-------------
F
YS---
D
I
Q
I
N
E
L
K
A
C
A
H
G
N
G
I
T
L
T
-
V
G
H
-
G
-
P
----------
S
AEQ-
N
-
L
-------------
S
---
S
P
D
P
-------
D
I
R
--
K
N
A
K
A
F
Y
-
T
D
L
L
K
R
-
L
Y
K
L
D
V
-
H
L
I
G
G
A
L
Y
S
Y
W
P
IDYTKTID
K
-------
K
-------
G
---------
D
W
E
R
S
V
E
S
--
V
R
E
V
A
K
V
-------
A
E
A
C
G
V
D
F
C
L
E
V
L
N
RFE--
N
--------
Y
---
L
-
I
N
T
A
Q
E
G
V
D
F
V
K
Q
--
V
D
--
H
N
N
V
K
V
M
L
D
T
F
H
-
M
N
I
E
E
-
D
--
S
I
G
G
A
I
R
T
A
-
G
S
--
Y
L
G
H
L
H
T
G
E
C
N
-----------------------------------------------
R
K
V
P
G
R
G
-
R
-
I
-
P
-
W
V
E
I
G
E
A
L
A
D
-
I
G
Y
N
G
S
-
V
V
M
E
P
F
V
R
M
----
G
------
G
T
V
G
S
N
I
KVWRDISNGAD
E
K
M
L
D
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
C
-------
52
Fugue
50.93
12%
-74
- C3 -
3P6L
4
?
A:
[1-262]
G
Q
T
K
A
E
K
N
G
W
R
L
G
M
Q
S
Y
S
F
H
----
L
F
-
P
L
T
E
A
L
D
K
T
Q
E
L
G
L
K
Y
I
E
I
Y
--
P
G
H
K
L
-------------
G
-----
G
---
K
W
G
D
K
V
F
D
F
N
L
D
A
Q
T
-
Q
-
K
-
E
-
I
----------
K
----
E
-
L
-------------
A
---
A
S
K
G
IKIVGTG
V
-
Y
--
V
---
A
E
K
-
S
S
D
W
E
K
M
F
K
F
A
K
A
M
D
L
E
F
I
T
C
E
P
A
------------------
L
-------
S
---------
D
---------
W
D
L
V
E
K
L
-------
S
K
Q
Y
N
I
K
I
S
V
H
N
H
P
-----
Q
--------
P
---
S
-
D
--
Y
W
K
P
E
N
L
L
K
A
--
I
S
G
R
S
Q
S
L
G
S
C
S
D
V
G
H
-
W
R
R
E
G
-
L
--
N
Q
I
D
C
L
K
Q
L
-
K
G
--
R
I
I
S
L
H
F
K
D
I
A
P
K
KAGE
N
E
--------------
Q
-------
H
--------------
D
V
I
W
G
T
G
I
L
-
D
-
V
K
G
M
L
K
E
L
K
S
Q
N
F
K
-
G
V
F
-----
S
I
E
Y
E
Y
N
W
----
E
------
N
--------------------
S
V
P
D
I
K
E
C
I
Q
Y
F
N
K
T
A
N
E
I
L
-----
32
HHSearch
50.46
13%
-87
- C3 -
3KWS
4
?
A:
[23-286]
D
L
E
L
K
L
S
F
Q
E
G
I
A
-
P
G
E
----------
S
L
N
E
K
L
D
F
M
E
K
L
G
V
V
G
F
E
P
G
--
G
G
G
L
--------------------
A
G
R
V
N
E
I
K
Q
A
L
N
G
R
N
I
K
V
S
-
A
-
I
C
A
-
G
----------
F
K---
G
F
I
-------------
L
---
S
T
D
P
A
------
I
-
R
--
K
E
C
M
D
T
M
-
K
E
I
I
A
A
-
A
G
E
L
G
S
-
T
G
V
I
I
V
P
A
F
N
G
Q
----------------
V
PALPHT
M
E
T
R
-------
D
F
L
C
E
Q
----
F
N
E
M
G
T
F
-------
A
A
Q
H
G
T
S
V
I
F
E
P
L
N
-----
R
--------
K
ECF
Y
-
L
R
Q
V
A
D
A
A
S
L
C
R
D
--
I
N
--
N
P
G
V
R
C
M
G
D
F
W
H
-
M
T
W
E
E
-
T
--
S
D
M
G
A
F
I
S
G
-
G
E
--
Y
L
Q
H
V
H
V
A
S
R
K
R
---------------------------------------------
R
S
M
P
G
E
D
G
-
D
-
A
D
N
-
Y
I
N
G
F
K
G
L
K
M
-
I
G
Y
NNY-
V
S
F
E
C
G
C
Q
G
-----------
D
--------------------
R
N
V
V
V
P
A
A
V
K
L
L
R
E
Q
W
E
Q
-------
30
HHSearch
49.79
16%
-79
- C3 -
3CQJ
2
ULAE_ECO57
A:
[16-290]
--
Q
I
P
L
G
I
Y
E
K
A
L
-
P
A
G
E
---------
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
--
V
D
E
T
D
E
R
L
S
R
LDW-----
S
-----
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
-
L
-
S
----------
A
H
R
R
F
P
-
L
-------------
G
---
S
E
D
D
A
------
V
-
R
A
Q
G
L
--
E
I
M
-
R
K
A
I
Q
F
-
A
Q
D
V
G
I
-
R
V
I
Q
L
A
G
Y
D
V
Y
Y
----------------
Q
E
A
N
N
---
E
---------
T
R
R
R
F
R
D
G
--
L
K
E
S
V
E
M
-------
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
-
M
N
S
I
S
K
A
L
G
Y
A
H
Y
--
L
N
--
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
--
D
V
Q
M
E
L
Q
A
G
-
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
G
----
V
--------------------------------------
F
K
N
V
P
F
G
E
G
-
V
-
V
-
D
-
F
E
R
C
F
E
T
L
K
Q
-
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
E
T
A---
E
------
D
--------------------
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
-----
38
HHSearch
48.67
13%
-78
- C3 -
1K77
5
YGBM_ECOLI
A:
[1-258]
--
M
P
R
F
A
A
N
L
S
M
M
-
F
T
E
V
---------
P
F
I
E
R
F
A
A
A
R
K
A
G
F
D
A
V
E
F
L
--
F
P
Y
N
---------------------
Y
S
T
L
Q
I
Q
K
Q
L
E
Q
N
H
L
T
L
A
-
L
-
F
-
N
-
T
A
---------
P
----
G
-
D
INAGEWG------
L
---
S
A
L
P
-------
G
R
E
H
E
A
H
--
A
D
I
-
D
L
A
L
E
Y
-
A
L
A
L
N
C
-
E
Q
V
H
V
M
A
G
V
V
P
A
----------------
G
ED-----
A
E
R
Y
R
A
V
F
I
D
N
---------
I
R
Y
A
A
D
R
-------
F
A
P
H
G
K
R
I
L
V
E
A
L
S
PGVKP
H
--------
Y
---
L
-
F
S
S
Q
Y
Q
A
L
A
I
V
E
E
--
V
A
--
R
D
N
V
F
I
Q
L
D
T
F
H
-
A
Q
K
V
D
-
G
--
N
L
T
H
L
I
R
D
Y
-
A
G
--
K
Y
A
H
V
Q
I
A
G
L
P
D
----------------------------------------------
R
H
E
P
D
D
G
-
E
-
I
-
N
-
Y
P
W
L
F
R
L
F
D
E
-
V
G
Y
Q
G
W
-
I
G
C
E
Y
K
P
R
G
----
L
-------------------------------
T
E
E
G
L
G
W
F
D
A
W
R
---------
33
HHSearch
48.42
12%
-72
- C3 -
2G0W
1
?
A:
[22-289]
--
K
C
P
I
T
I
S
S
Y
T
L
-
G
T
E
V
---------
S
F
P
K
R
V
K
V
A
A
E
N
G
F
D
G
I
G
L
R
--
A
E
N
Y
V
-------------
D
A
L
A
A
-
G
L
T
D
E
D
M
L
R
I
L
D
E
H
N
M
K
V
T
-
E
-
V
-
E
-
Y
----------
I
----
T
-
Q
-------------
W
---
G
T
A
E
D------
R
-
T
A
E
Q
Q
--
K
K
E
-
Q
T
T
F
H
M
-
A
R
L
F
G
V
-
K
H
I
N
C
G
L
L
E
K
I
P
----------------
E
-------
E
Q
I
I
V
-----
A
---------
L
G
E
L
C
D
R
-------
A
E
E
L
I
--
I
G
L
E
F
M
P
-----
Y
--------
S
---
G
-
V
A
D
L
Q
A
A
W
R
V
A
E
A
--
C
G
--
R
D
N
A
Q
L
I
C
D
T
W
H
-
W
A
R
A
N
-
Q
--
T
A
E
S
I
K
N
V
P
-
A
D
--
R
I
V
S
I
Q
L
C
D
V
H
E
T
----
P
Y
--------------
K
E
L
R
E
E
S
-
L
--------------
H
D
R
L
A
P
G
E
G
-
Y
-
G
-
D
-
T
V
G
F
A
K
I
L
K
E
-
H
G
V
NPRV
M
G
V
E
V
I
S
D
S
----
M
V
A
T
---
G
--------------------
L
E
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
A
------
31
HHSearch
48.27
9%
-80
- C3 -
3LMZ
3
?
A:
[16-257]
-
N
P
F
H
L
G
M
A
G
Y
T
F
-
V
N
F
----------
D
L
D
T
T
L
K
T
L
E
R
L
D
I
H
Y
L
C
I
K
--
D
F
H
L
P
LNS----------
T
-----
D
E
Q
I
R
A
F
H
D
K
C
A
A
H
K
V
T
G
Y
-
A
-
V
-
G
-
P
----------
I
----
Y
-------------------
M
----------
K
-
S
--
E
---
E
E
I
-
D
R
A
F
D
Y
-
A
K
R
V
G
V
-
K
L
I
V
G
V
P
N
Y
E
------------------------------------
L
---------
L
P
Y
V
D
K
K
-------
V
K
E
Y
D
F
H
Y
A
I
H
L
H
G
-----
P
--------
D
---
I
--
K
T
Y
P
D
A
T
D
V
W
V
H
T
K
D
L
--
D
P
R
I
G
M
C
L
D
V
G
H
-
D
L
R
N
G
-
C
--
D
P
V
A
D
L
K
K
Y
-
H
T
--
R
V
F
D
M
H
I
K
D
V
T
D
S
----
S
K
----------------------
A
--------------
G
V
G
I
E
I
G
R
G
-
K
-
I
-
D
-
F
P
A
L
I
R
M
M
R
E
-
V
N
Y
TGM-
C
S
L
E
Y
E
K
D
M
----
K
------
D
--------------------
P
F
L
G
I
A
E
S
I
G
Y
F
K
A
V
S
D
L
T
------
35
HHSearch
47.35
15%
-69
- C3 -
3WQO
2
Y1311_METJA
A:
[16-286]
--
D
M
K
F
G
V
S
S
L
V
F
-
L
P
E
----------
S
L
T
S
S
M
E
K
I
A
E
H
N
F
D
A
W
E
I
V
--
C
E
G
T
H
YL-----------
S
-----
P
K
N
I
K
Y
L
M
E
L
R
D
R
Y
E
V
E
I
V
-
V
-
H
-
A
-
P
----------
F
----
S
-
D
-------------
L
NPA
S
M
N
E
R
------
V
-
R
--
K
L
T
V
E
C
I
-
R
D
A
I
E
G
-
A
F
E
L
D
S
-
E
V
V
V
V
H
P
G
Y
I
P
E
----------------
L
-------
W
SNY
V
S
E
---
I
L
D
N
N
F
S
T
--
L
S
E
I
V
E
I
-------
A
E
D
Y
G
I
K
I
G
L
E
N
M
P
-----
N
--------
F
RGV
L
-
G
I
T
P
E
S
L
L
E
I
V
K
D
--
I
D
--
S
K
N
L
G
I
T
F
D
I
G
H
-
A
N
T
A
G
-
N
PA
E
F
V
E
K
L
Q
N
I
-
G
I
--
G
I
I
H
V
H
A
H
D
N
N
G
Y
----
D
--------------------------------------
D
E
H
L
K
I
G
E
G
-
N
-
I
-
N
-
F
I
E
V
L
E
K
L
K
E
-
I
G
Y
DGV-
I
S
I
E
N
K
N
I
R
----
D
A
V
----
K
--------------------
S
K
E
I
L
K
E
Y
L
E
I
V
N
E
K
V
A
--------