@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2266: (2016-02-06 )
MKPTAFLALSALACGIAQAAAAPDPALVRQGEYLARAGDCVACHTARDGKPFAGGLPMETPIGAVYSTNITPDRKTGIGDYSFEDFDRAVRHGVARSGDTLYPAMPYPSYARVSEADMRALYAYFMHGVEPVEQPNKASDIPWPLSMRWPLAFWRWTFAPEVKDFQAAAGQDPVLARGAYLVEGLGHCGACHTPRGLGMQEKALAASDGAAYLSGSAPLENWIAKSLRGDHRTGLGSWSEADLVSFLRTGRSERSAVFGGMSDVVVHSMQYMTDADLTAIARYLKSLPPADPADQPHVYDESVAQALFHGDDSKTGAALYVDNCGACHRTDGKGYARVFPALAGNPVVTGSDPTSLVHIVLKGGTLPATHQAPSSFTMPPFGWRMNDQEIADVVNFIRTSWGNQAPSVSVDEVRRLRKDTGAAAVGDIPPPGSAAADRG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80--........90........----100.......110.......120.......130.......140.......150.......160.......170.......180..------.....190.......200.......210.......220.......230......--.240.......250...-----....260.......270.......280.......290.......300.......310.-......320-------.--------.......330...-----.-..-.340...--.-.-..350.......360.--....-..370....--...380.......390.......400...-----....410.......420.......430.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKP
T
A
F
L
A
L
S
A
L
A
C
G
I
A
Q
AAAAP
D
P
A
L
V
RQG
E
Y
L
ARAG
D
C
V
A
C
HTARDGKPFAGGLPMETPIG
A
V
Y
STNITPDRKTGIGDY--
S
F
E
D
F
D
R
A
V
R
HGVARSGD----TLYPAMPYPSYARV
S
E
A
D
M
R
A
L
Y
A
Y
F
M
HGVEPVEQPNKASDIPWPLSMRWP
L
A
F
W
R
W
TFAPEV
K
D
F
Q
AAAGQDP
V
L
AR
G
A
Y
L
V
E
G------LGHCGACHTPRGLG
M
Q
E
K
ALAASDG
A
A
YLSGS
A
P
L
E
N
W
I
A
K
S
LRGDHRTGLGSW--
S
E
A
D
L
V
S
F
L
R
TGRS
E
R
S
-----
A
V
FG
G
M
S
D
V
V
V
H
S
M
Q
Y
MTDA
D
L
T
A
I
A
R
Y
L
K
SLPPADPADQPH
V
Y
D
E
S
V
A
Q
A
L
FHGDDS-KT
G
A
A
L
Y
V--------D--------NCGACHRTDGK
G
Y
-----
A
-
R
V
-
F
PALAGN--P-
V
-
V
TGSDP
T
S
L
V
H
I
V
LKG--GTLP-ATHQAPSSF--TMPPFGWRM
N
D
Q
E
I
A
D
V
V
N
F
I
R
T
SWGNQA-----PSV
S
V
D
E
V
R
R
L
R
K
DTGAAAVGDIPPPGSAAADRG
57
Fugue
78.23
15%
-51
- C1 -
3MK7
3
CCOP1_PSEST
C:
[1-303]
M
S
T
F
W
S
G
Y
I
A
L
L
T
L
G
T
I
V
A
L
F
W
L
I
F
A
T
R
K
G
E
S
A
G
T
T
D
Q
T
--------
M
G
H
A
F
D
G
I
E
E
Y
D
N
P
L
P
R
W
W
F
L
L
F
I
G
T
L
V
F
G
I
L
Y
L
--
V
L
Y
P
G
L
G
N
W
K
G
V
L
P
G
Y
E
G
----
G
W
T
Q
E
K
Q
W
E
R
E
V
A
Q
A
D
E
K
Y
G
P
I
F
A
K
Y
A
A
-----------------------------------
M
S
V
E
E
V
A
Q
D
P
Q
A
V
K
M
G
A
R
L
F
A
N
------
Y
--
C
S
I
C
H
G
S
D
A
K
G
S
L
--------------
G
F
P
N
L
A
D
----------
Q
D
W
R
W
G
G
--
D
A
A
S
I
K
T
S
I
L
N
G
R
I
-----------
A
A
M
P
A
----
W
G
Q
A
I
G
E
E
G
V
K
N
V
A
A
F
V
R
K
D
L
A
G
L
P
L
P
E
G
T
------------
D
A
D
L
-
S
A
G
K
N
V
Y
A
--------
Q
--------
T
C
A
V
C
H
G
Q
G
G
E
G
M
-----
A
-
A
L
G
A
P
K
L
N
S
A
--
A
-
G
W
I
Y
G
S
S
L
G
Q
L
Q
Q
T
I
R
H
G
-------------
R
N
G
--
Q
M
P
A
Q
Q
Q
Y
L
G
D
D
K
V
H
L
L
A
A
Y
V
Y
S
L
S
Q
------------------------------------------
4
PsiBlast_PDB
75.60
31%
-54
- C1 -
2ZOO
3
?
A:
[340-441]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
G
Q
R
V
Y
E
--------
A
--------
N
C
M
A
C
H
Q
A
N
G
E
G
I
-----
P
-
G
A
-
F
P
P
L
A
K
S
--
D
-
Y
-
L
N
-
N
N
P
L
L
G
V
N
A
I
I
K
G
--
L
S
G
P
I
K
V
N
N
V
N
Y
N
G
--
V
M
P
--
A
M
N
L
N
D
E
D
I
A
N
V
I
T
F
V
L
N
N
W
D
N
A
G
-----
G
K
V
S
A
E
Q
V
A
K
Q
R
----------------------
21
PsiBlast_CBE
75.42
33%
-39
- C1 -
4AX3
1
?
D:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
LN
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
8
PsiBlast_PDB
75.40
28%
-40
- C1 -
1R0Q
1
CY552_THETH
A:
[4-112]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
I
Y
A
-----------------
Q
C
A
G
C
H
Q
Q
N
G
Q
G
I
-----
P
-
G
A
-
F
P
P
L
A
G
H
V
A
E
-
I
-
L
A
K
E
G
G
R
E
Y
L
I
L
V
L
L
Y
--
G
L
Q
G
-
Q
I
E
V
K
G
M
K
Y
N
G
V
M
S
S
F
A
-
Q
L
K
D
E
E
I
A
A
V
L
N
H
I
A
T
A
W
G
D
A
K
KVK
G
F
K
P
F
T
A
E
E
V
K
K
L
R
----------------------
7
PsiBlast_PDB
74.97
28%
-37
- C1 -
1QYZ
1
CY552_THETH
A:
[4-112]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
I
Y
A
-----------------
Q
C
A
G
C
H
Q
Q
N
G
Q
G
I
-----
P
-
G
A
-
F
P
P
L
A
G
H
V
A
E
-
I
-
L
A
K
E
G
G
R
E
Y
L
I
L
V
L
L
Y
--
G
L
Q
G
-
Q
I
E
V
K
G
M
K
Y
N
G
V
M
S
S
F
A
-
Q
L
K
D
E
E
I
A
A
V
L
N
H
I
A
T
A
W
G
D
A
K
K
V
KGF
K
P
F
T
A
E
E
V
K
K
L
R
----------------------
2
PsiBlast_PDB
74.87
33%
-43
- C1 -
4AX3
1
?
A:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
L
N
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
6
PsiBlast_PDB
74.52
28%
-40
- C1 -
3VNW
1
CY552_THETH
A:
[2-110]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
I
Y
A
-----------------
Q
C
A
G
C
H
Q
Q
N
G
Q
G
I
-----
P
-
G
A
-
F
P
P
L
A
G
H
V
A
E
-
I
-
L
A
K
E
G
G
R
E
Y
L
I
L
V
L
L
Y
--
G
L
Q
G
-
Q
I
E
V
K
G
M
K
Y
N
G
V
M
S
S
F
A
-
Q
L
K
D
E
E
I
A
A
V
L
N
H
I
A
T
A
W
G
D
A
K
KVKGF
K
P
F
T
A
E
E
V
K
K
L
R
----------------------
5
PsiBlast_PDB
74.09
28%
-40
- C1 -
1DT1
1
CY552_THET8
A:
[2-110]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
I
Y
A
-----------------
Q
C
A
G
C
H
Q
Q
N
G
Q
G
I
-----
P
-
G
A
-
F
P
P
L
A
G
H
V
A
E
-
I
-
L
A
K
E
G
G
R
E
Y
L
I
L
V
L
L
Y
--
G
L
Q
G
-
Q
I
E
V
K
G
M
K
Y
N
G
V
M
S
S
F
A
-
Q
L
K
D
E
E
I
A
A
V
L
N
H
I
A
T
A
W
G
D
A
K
KVKGF
K
P
F
T
A
E
E
V
K
K
L
R
----------------------
22
PsiBlast_CBE
73.92
33%
-37
- C1 -
4AX3
1
?
C:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
L
N
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
23
PsiBlast_CBE
73.86
33%
-41
- C1 -
4AX3
1
?
B:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
L
N
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
1
PsiBlast_PDB
73.15
33%
-40
- C1 -
2YQB
1
?
A:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
L
N
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
30
HHSearch
73.05
24%
-63
- C1 -
3MK7
2
CCOP1_PSEST
C:
[128-303]
-----------------------
D
P
Q
A
V
K
M
G
A
R
L
F
A
-
N
Y
C
S
I
C
H
G
S
D
A
K
----
G
S
---------
L
G
F
P
N
L
A
D
Q
D
----
W
R
W
GG
D
A
A
S
I
K
T
S
I
L
N
G
R
I
-----------
A
A
M
P
A
-
W
G
Q
A
I
G
E
E
G
V
K
N
V
A
A
F
V
R
K
-
D
L
A
G
L
P
L
P
--------------------------------
E
G
T
D
A
D
L
S
A
G
K
N
V
Y
A
--------
Q
T
C
A
V
C
H
G
Q
G
G
E
G
M
A
A
--------------------
L
G
A
P
K
L
N
S
A
A
G
-
W
I
Y
G
S
--
S
L
G
Q
L
Q
Q
T
I
R
H
G
R
N
-----------
G
Q
M
P
A
Q
Q
----
Q
Y
L
G
D
D
K
V
H
L
L
A
A
Y
V
Y
S
L
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.78
33%
-40
- C1 -
3ZBM
1
?
A:
[342-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
S
G
T
L
T
V
Q
D
Q
V
-
Q
A
G
R
A
L
F
A
--------
G
--------
T
C
S
V
C
H
Q
G
N
G
A
G
L
-----
P
-
G
V
-
F
P
P
L
A
K
S
--
D
-
F
-
L
A
-
A
D
P
K
R
A
M
N
I
V
L
H
G
L
N
G
K
I
K
-
V
N
G
Q
E
Y
D
S
---
V
M
P
P
M
-
T
Q
L
N
D
D
E
V
A
N
I
L
T
Y
V
L
N
S
W
D
N
P
G
-----
G
R
V
S
A
E
D
V
K
K
V
R
----------------------
31
HHSearch
72.47
20%
-37
- C1 -
1M70
3
CYC4_PSEST
A:
[2-190]
-------------------------
G
D
A
E
A
G
Q
G
K
V
--
A
V
C
G
A
C
H
G
V
D
G
N
----
S
P
--------
A
P
N
F
P
K
L
A
G
Q
G
----
E
R
Y
--
L
L
K
Q
-
L
Q
D
I
K
A
G
S
T
P
G
A
P
EGVG
R
K
V
L
E
M
T
G
-
M
L
D
P
L
S
D
Q
D
L
E
D
I
A
A
Y
F
S
S
-
Q
K
G
S
V
G
Y
A
----------------------------------
D
P
A
L
A
K
Q
G
E
K
L
F
R
G
GKLDQG
M
P
A
C
T
G
C
H
A
P
N
G
V
G
N
D
L
--------------------
A
G
F
P
K
L
G
G
Q
H
A
----
A
Y
--
T
A
K
Q
L
T
D
F
-
R
E
G
N
R
T
N
D
-----
G
D
T
M
I
M
R
G
V
A
----
A
K
L
S
N
K
D
I
E
A
L
S
S
Y
I
Q
G
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
71.94
24%
-39
- C1 -
1H1O
10
CY552_ACIFR
A:
[12-183]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
--------
S
D
C
M
V
C
H
G
M
T
G
R
D
T
L
Y
--------------------
P
I
V
P
R
L
A
G
Q
H
K
----
S
Y
--
M
E
A
Q
L
K
A
Y
-
K
D
H
S
R
A
D
Q
-----
N
G
E
I
Y
M
W
P
V
A
----
Q
A
L
D
S
A
K
I
T
A
L
A
D
Y
F
N
A
Q
K
P
P
M
Q
S
S
G
------------
I
K
H
A
G
A
-
K
E
G
K
A
I
F
N
--------
Q
GVTNEQIP
A
C
M
E
C
H
G
S
D
G
Q
G
A
-----
G
--
P
-
F
P
R
L
A
G
Q
--
R
-
Y
-
G
------
Y
I
I
Q
Q
L
T
Y
F
--
H
N
G
------
T
R
V
N
T
--
L
M
N
Q
I
A
K
N
I
T
V
A
Q
M
K
D
V
A
A
Y
L
S
S
L
--------------------------------------------
9
PsiBlast_PDB
71.05
28%
-50
- C1 -
1FOC
2
CY552_THET8
A:
[5-113]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
I
Y
A
-----------------
Q
C
A
G
C
H
Q
Q
N
G
Q
G
I
-----
P
-
G
A
-
F
P
P
L
A
G
H
V
A
E
-
I
-
L
A
K
E
G
G
R
E
Y
L
I
L
V
L
L
Y
--
G
L
Q
G
-
Q
I
E
V
K
G
M
K
Y
N
G
V
M
S
S
F
A
-
Q
L
K
D
E
E
I
A
A
V
L
N
H
I
A
T
A
W
G
D
A
K
KVKGF
K
P
F
T
A
E
E
V
K
K
L
R
----------------------
25
HHSearch
70.67
20%
-66
- C1 -
3MK7
2
CCOP1_PSEST
C:
[128-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
Q
A
V
K
M
G
A
R
L
F
A
--------
N
Y
C
S
I
C
H
G
S
D
A
K
G
S
L
----------------------
G
F
P
N
L
A
D
Q
D
W
----
R
W
GG
D
A
A
S
I
K
T
S
I
L
N
G
R
I
-----------
A
A
M
P
A
W
G
----
Q
A
I
G
E
E
G
V
K
N
V
A
A
F
V
R
K
D
L
A
G
L
P
L
P
E
-------------
G
T
D
A
D
L
S
A
G
K
N
V
Y
A
--------
Q
--------
T
C
A
V
C
H
G
Q
G
G
E
G
M
-----
A
A
L
G
-
A
P
K
L
N
S
A
--
A
G
W
-
I
Y
G
S
S
L
G
Q
L
Q
Q
T
I
R
H
G
--
R
N
-----------
G
--
Q
M
P
A
Q
Q
Q
Y
L
G
D
D
K
V
H
L
L
A
A
Y
V
Y
S
L
S
Q
------------------------------------------
59
Fugue
62.85
17%
-18
- C1 -
4WQD
6
TSDA_ALLVD
A:
[5-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
L
T
V
P
A
A
A
L
L
P
D
G
A
L
G
E
S
I
V
R
G
R
R
Y
L
S
D
------
T
P
A
Q
L
P
D
F
V
G
N
G
L
A
C
R
H
C
H
P
G
R
D
G
E
V
G
T
E
A
N
A
A
P
F
V
G
V
V
G
R
F
P
Q
Y
S
A
R
H
G
R
L
I
T
--
L
E
Q
R
I
G
D
C
F
E
R
S
L
N
G
R
A
-----
L
A
L
D
--------------
H
P
A
L
I
D
M
L
A
Y
M
S
W
L
S
Q
G
V
P
V
G
A
V
V
A
G
H
G
I
P
T
L
T
L
E
R
E
P
D
G
-
V
H
G
E
A
L
Y
Q
--------
A
--------
R
C
L
A
C
H
G
A
D
G
S
G
T
L
D
ADG
R
-
Y
L
-
F
P
P
L
W
G
P
--
R
-
S
-
F
N
T
G
-----------------
A
-
G
M
N
R
Q
A
T
A
A
--
G
F
I
K
H
G
M
S
L
S
D
E
E
A
W
D
V
A
G
F
V
L
T
H
P
R
P
L
F
---------------------------------------
27
HHSearch
62.01
21%
-31
- C1 -
1M70
3
CYC4_PSEST
A:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
A
E
A
G
Q
G
K
V
---------
A
V
C
G
A
C
H
G
V
D
G
N
S
P
A
P
---------------------
N
F
P
K
L
A
G
Q
G
E
----
R
Y
--
L
L
K
Q
L
Q
D
I
-
K
A
G
S
T
P
G
A
PEGVG
R
K
V
L
E
M
T
G
M
L
----
D
P
L
S
D
Q
D
L
E
D
I
A
A
Y
F
S
S
Q
K
G
S
V
G
Y
A
D
--------------
P
A
L
A
-
K
Q
G
E
K
L
F
R
GGKLDQGM
P
--------
A
C
T
G
C
H
A
P
N
G
V
G
N
-----
D
L
A
G
-
F
P
K
L
G
G
Q
--
H
-
A
-
A
Y
T
A
---
K
Q
L
T
D
F
R
E
G
--
N
R
T
N
-
D
----
G
D
T
M
--
I
M
R
G
V
A
A
K
L
S
N
K
D
I
E
A
L
S
S
Y
I
Q
G
L
--------------------------------------------
33
HHSearch
61.53
20%
-49
- C1 -
1H1O
10
CY552_ACIFR
A:
[12-183]
----------------------------------
V
S
-
S
D
C
M
V
C
H
G
M
T
G
R
----
D
T
L
-------
Y
P
I
V
P
R
L
A
G
Q
----
H
K
S
Y
--
M
E
A
Q
-
L
K
A
Y
K
D
H
S
R
A
D
-
Q
----
N
G
E
I
Y
M
W
P
-
V
A
Q
A
L
D
S
A
K
I
T
A
L
A
D
Y
F
N
A
-
Q
K
P
P
M
Q
S
S
--------------------------------
G
I
K
H
A
G
A
K
E
G
K
A
I
F
N
Q
GVTNEQ
I
P
A
C
M
E
C
H
G
S
D
G
Q
G
A
G
----------------------
P
F
P
R
L
A
G
Q
R
Y
----------
G
Y
I
I
Q
Q
L
T
Y
F
H
N
G
T
------
R
V
N
T
L
M
N
Q
I
A
----
K
N
I
T
V
A
Q
M
K
D
V
A
A
Y
L
S
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------