@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2272: (2016-02-06 )
MSSQRRNYRFILVVTLFVLASLAVSGRLVYLQVHDHEFLADQGDLRSIRDLPIPVTRGMITDRNGEPLAVSTEVASIWCNPREMAAHLDEVPRLAGALHRPAAALLAQLQANPNKRFLYLERGLSPIEASEVMALGITGVHQIKEYKRFYPSSELTAQLIGLVNIDGRGQEGTELGFNDWLSGKDGVREVAINPRGSLVNSIKVLKTPKASQDVALSIDLRLQFIAYKALEKAVLKFGAHSGSAVLVNPKSGQILAMANFPSYNPNNRASFAPAFMRNRTLTDTFEPGSVIKPFSMSAALASGKFDENSQVSVAPGWMTIDGHTIHDVARRDVLTMTGVLINSSNIGMSKVALQIGPKPILEQLGRVGFGAPLSLGFPGENPGYLPFHEKWSNIATASMSFGYSLAVNTAELAQAYSVFANDGKLVPLSLLRDNPQNQVRQAMDPQIARRIRAMLQTVVEDPKGVVRARVPGYHVAGKSGTARKASGRGYADKSYRSLFVGMAPASDPQLVLAVMIDSPTRIGYFGGLVSAPTFSDIMAGSLRALAIPPDNLQDSPAVADRQHHG
Atome Classification :
(20 SA)
-------------------------------------------------------------.........10........20.........30........40....--------....50........60........70........80..---------...----...90........100--.........110---------------------------------------------------------.--.------...-...120........130-....--..-------...140.......150.......160.----..---------------------.-----------------..--------.170.......180.......190.......-200...--.....210.......220.......230......------.240.......250.......260.......270-----------.....-...280.-----------......290.......300.......310..-....----.320.--......---330.-----------.......340.......350....-----------------...360.......370.......380.......390.......400..-.-.....410.......420....-.---..430-----------..--------...-.------------.440--------.....---------..450.......460.---------......-.470.......480....--..--.490-.--.......--500.......510.......520-.......530.......------540.--......550.......560...---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------MSSQRR
N
Y
R
F
I
L
V
V
T
L
F
V
L
A
-
S
L
AVS
G
R
L
V
Y
L
Q
VHDHEFLADQGDL--------
R
S
IRDLPIPVTRGMITDRNGE
P
L
A
V
S
T
E
V
A
S
I
WC
N
P
R
E
---------
M
A
A
----
H
L
D
E
V
P
R
L
A
G
A
LH
R
----
P
A
A
A
L
L
A
Q
L
QA----------------------------------------------------------N--P------NK
R
-
F
L
Y
LE-RGLSPI
E
A
S
---
E
V
M
A
--
L
G
-------
I
T
G
V
H
Q
I
K
E
Y
K
R
FYP
S
S
E
L
T
A
Q
L
I
G
L
V
----NI---------------------D-----------------GR--------GQEGTELGFNDWLSGKDG
V
R
E
V
A
INPR
G
S
L
V
-
N
-
S
I
K
V
--LKTPKASQ
D
V
A
L
S
I
D
L
R
L
Q
F
I
A
Y
K
A
L
E
K
A
V
L
K
FG------AHSG
S
A
V
L
V
NPKS
G
Q
I
L
A
M
ANFPSYNPNNRASF------------
A
P
A
F
M-RNRTLTD-----------TFEPGSVIKPFSM
S
A
A
LASGKFDENS
Q
V
S
VA-P
G
W
M
----
T
IDG
H
--
T
I
H
D
V
A
---
R
R
-
D
-----------
V
L
T
M
T
G
V
L
I
NSSNIG
M
S
K
V
A
L
QIG-----------------
P
K
P
I
L
E
Q
L
G
RVGFGAPLSLGFPGENPGYL
P
F
H
E
K
W
SNI
A
T
A
S
MS-F
G
Y
-
S
-
L
AV
N
T
A
E
L
A
Q
A
Y
S
V
FANDG
K
L
V
-
P
---
L
S
L
LR-----------DN--------
P
Q
N
-
Q
------------
V
R
Q
A--------M
D
P
Q
I
---------
A
R
R
I
R
A
M
L
Q
T
V
VED-P---------KG
V
V
R
A-RVP
G
Y
H
VAGKSGTARKAS--GR--GYA--
D
--
K
S
Y
R
S
L
F
--
V
GMAPASD
P
Q
L
V
L
A
V
M
IDSPT
R
I
-
G
YFGGLVSAP
T
F
S
D
I
M
A------GS
L
R
--
A
L
AIPPDNLQDSPAVADRQHHG---------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
98.98
49%
-82
- C2 -
4KQQ
5
?
A:
[36-553]
-------------------------------------------------------------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
A
T
E
Q
Q
Q
-----------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.43
49%
-81
- C2 -
4KQR
10
?
B:
[38-553]
---------------------------------------------------------------------------------------------------------------------
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
A
T
E
Q
Q
Q
-----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
98.40
49%
-81
- C2 -
4KQR
11
?
A:
[36-553]
-------------------------------------------------------------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
A
T
E
Q
Q
Q
-----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.77
49%
-83
- C2 -
4KQO
3
?
A:
[35-547]
----------------------------------------------------------------------------------------------------------
A
--------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
-----------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.17
49%
-82
- C2 -
4KQQ
6
?
B:
[42-553]
-------------------------------------------------------------------------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
-----------------
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
A
T
E
Q
Q
Q
-----------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.41
49%
-80
- C2 -
3OCN
1
?
A:
[35-545]
----------------------------------------------------------------------------------------------------------
A
--------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
------------
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
----------------------------------------------------------------------------------------------------------------------
65
Fugue
96.29
50%
-81
- C2 -
3OC2
3
?
A:
[35-545]
----------------------------------------------------------------------------------------------------------
A
--------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
-
K
-
D
V
Q
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
S
R
-----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
-----------------
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
------
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
94.95
49%
-84
- C2 -
4KQO
5
?
B:
[43-548]
--------------------------------------------------------------------------------------------------------------------------
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
---------
L
M
T
----
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
----
D
T
K
L
F
A
D
R
I
E
Q
----------------------------------------------------------
N
--
A
------
E
R
E
-
F
I
Y
L
V
-
R
G
L
T
P
E
Q
G
E
---
G
V
I
A
--
L
K
-------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
V
---------------------
D
-----------------
D
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
------------------
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
------------
Q
P
A
A
M
-
R
N
R
A
M
I
D
-----------
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
-
P
G
T
L
----
Q
I
G
R
Y
--
T
I
R
D
V
S
---
R
N
-
S
R----------
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
-----------------
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
-
Y
G
Y
-
G
-
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
---
L
S
M
T
R
-----------
V
D
--------
R
V
P
-
D
------------
G
V
Q
V
--------
I
S
P
E
V
---------
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
-
Q
---------
G
G
V
F
R
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
S
VG
T
K
--
G
Y
R
--
E
--
N
A
Y
R
S
L
F
--
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
-
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
------
G
A
L
R
--
L
M
N
V
P
P
D
N
L
---
P
T
A
----------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.09
38%
-70
- C2 -
3EQV
9
PBP2_NEIGO
A:
[14-529]
------------------------------------------------------------------------------------------------
T
Y
N
F
L
K
E
Q
G
D
N
--------
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
I
---------------------
D
-----------------
G
K
--------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
-
D
-
S
L
D
S
PR
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
-
P
--
Y
----
K
I
G
P
S
--
P
V
R
D
T
H
---
V
Y
-
P
-----------
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
-----------------
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
-
F
G
Y
-
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
---
L
S
F
E
K
-----------
Q
A
--------
V
A
P
-
Q
------------
G
K
R
I
--------
F
K
E
S
T
---------
A
R
E
V
R
N
L
M
V
S
V
T
E
--
P
---------
G
G
T
G
T
A
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
R
K
----------------
N
K
H
V
G
T
F
--
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
H
-
G
Y
Y
G
G
V
V
A
G
S
P
F
K
K
I
M
G
------
G
S
L
N
--
I
L
G
I
S
P
-------------------------------------------------------------------------------------------------------------------------
41
HHSearch
81.23
38%
-73
* C2 *
3EQU
11
PBP2_NEIGO
A:
[24-534]
----------------------------------------------------------------------------------------------------------
N
--------
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
I
---------------------
D
-----------------
G
K
--------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
-
D
-
S
L
D
S
PR
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
---
P
Y
----
K
I
G
P
S
--
P
V
R
D
T
H
---
V
Y
-
P
-----------
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
-----------------
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
-
F
G
Y
-
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
---
L
S
F
E
K
-----------
Q
A
--------
V
A
P
-
Q
------------
G
K
R
I
--------
F
K
E
S
T
---------
A
R
E
V
R
N
L
M
V
S
V
T
E
P
-
G
---------
G
T
G
T
A
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
-------------------
K
H
V
A
T
F
--
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
H
-
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
------
G
S
L
N
--
I
L
G
I
S
P
T
K
P
L
T
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.24
37%
-74
- C2 -
3EQU
11
PBP2_NEIGO
A:
[24-529]
----------------------------------------------------------------------------------------------------------
N
--------
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
I
---------------------
D
-----------------
G
K
--------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
-
D
-
S
L
D
S
PR
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
------------
D
S
E
Q
R
-
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
-
P
--
Y
----
K
I
G
P
S
--
P
V
R
D
T
H
---
V
Y
-
P
-----------
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
-----------------
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
-
F
G
Y
-
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
---
L
S
F
E
K
-----------
Q
A
--------
V
A
P
-
Q
------------
G
K
R
I
--------
F
K
E
S
T
---------
A
R
E
V
R
N
L
M
V
S
V
T
E
P
-
G
---------
G
T
G
T
A
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
-------------------
K
H
V
A
T
F
--
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
H
-
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
------
G
S
L
N
--
I
L
G
I
S
P
-------------------------------------------------------------------------------------------------------------------------
66
Fugue
77.39
27%
-61
- C2 -
1QME
3
PBPX_STRPN
A:
[23-702]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
----
Q
L
---------------------
H
-----------------
E
N
EDG
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
-
E
--
L
----
K
I
A
D
A
--
T
I
R
D
W
D
---
V
N
-
E
GLTG
G
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
-----------------
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
---
A
D
N
I
V
N
I
A
Q
S
S
-
F
G
Q
-
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
-
E
---
P
K
F
I
S
A
I
Y
D
PNDQ
T
A
R
K
S
--------
Q
K
E
-
I
------------
V
G
N
P
--------
V
S
K
D
A
---------
A
S
L
T
R
T
N
M
V
L
V
G
T
D
-
P
VYGTMYNHS
T
G
K
P
T
V
-
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
--
E
K
NG
G
Y
L
--
V
GL
T
D
Y
I
F
S
A
--
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
------
M
K
D
S
LN-------
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
67
Fugue
76.83
27%
-59
- C2 -
1QME
3
PBPX_STRPN
A:
[23-702]
-------------------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
I
A
E
D
A
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
----
Q
L
---------------------
H
-----------------
E
N
EDG
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
---
S
S
E
L
----
K
I
A
D
A
--
T
I
R
D
W
D
---
V
N
-
E
GLTG
G
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
-----------------
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
---
A
D
N
I
V
N
I
A
Q
S
S
-
F
G
Q
-
G
-
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
-
E
PKF
I
S
A
I
Y
-----------
D
P
NDQ
T
A
R
K
S
Q
K
E
-
I
------------
V
G
N
P
--------
V
S
K
D
A
---------
A
S
L
T
R
T
N
M
V
L
V
G
T
D
-
P
VYGTMYNHS
T
G
K
P
T
V
-
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
--
E
K
NG
G
Y
L
--
V
GL
T
D
Y
I
F
S
A
--
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
------
R
A
S
A
--
M
K
D
S
L
N
L
Q
-
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
9
PsiBlast_PDB
76.37
25%
-72
- C2 -
1RP5
1
PBPX_STRPN
A:
[24-544]
--------------------------------------------------------------------------------------------------------------------------
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
NYKSATGKI
L
Y
V
----
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
YLDM
E
E
S
Y
V
R
E
Q
L
-
S
----------------------------------------------------------
Q
--
P
------
N
L
K
-
Q
V
S
F
G
-
A
K
G
N
G
I
T
Y
A
---
N
M
M
S
--
I
K
K
E
L
E
T
A
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
---------------------
D
-----------------
G
S
K
S
L
L
----
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
-
T
E
Q
V
--
S
Q
Q
T
V
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
----------
P
G
G
E
----
V
F
N
S
S
E
L
K
I
A
D
A
T
---
I
R
-
D
W
D
V
N
E
GLTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
-----------------
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
----
D
N
I
V
N
I
A
M
S
A
F
G
Q
-
G
-
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
-
E
PKF
I
S
A
L
Y
-----------
D
P
--------
N
D
Q
-
S
------------
V
R
K
S
Q
KEIVGNP
V
S
K
E
A
---------
A
S
V
T
R
D
H
M
V
M
V
G
T
D
-
P
TYGTMYNHS
T
G
K
A
T
V
-
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
--
E
K
NG
G
Y
L
--
T
--
G
S
T
N
N
I
F
S
V
V
S
M
H
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.66
36%
-75
- C2 -
4U3T
-
PBP2_NEIGO
A:
[5-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
G
---------------------------
R
N
R
A
V
T
D
-----------
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
-
P
-
Y
K
----
I
G
P
S
P
--
V
R
D
D
T
H
---
V
Y
-
P
-----------
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
-----------------
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
-
F
G
Y
-
G
-
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
---
L
S
F
E
K
-----------
Q
A
--------
V
A
P
-
Q
------------
G
K
R
I
--------
F
K
E
S
T
---------
A
R
E
V
R
N
L
M
V
S
V
T
E
P
-
G
---------
G
T
G
T
A
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
R
K
L
V
--
N
G
--
R
Y
V
--
D
--
N
K
H
V
G
T
F
--
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
H
-
G
----
V
V
A
G
S
P
F
K
K
I
M
G
------
G
S
L
N
--
I
L
G
I
S
P
-------------------------------------------------------------------------------------------------------------------------
70
Fugue
70.04
26%
-49
- C2 -
1K25
-
?
A:
[67-750]
---------------------------------------------------------------------------------------------------------------------
Q
I
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------
Y
N
V
Y
A
V
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
----
Q
L
---------------------
H
-----------------
E
N
EDGSKSLL
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
G
N
I
V
P
G
T
E
L
-
V
-
S
------
Q
Q
T
V
D
G
K
D
V
Y
T
T
L
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
L
E
K
V
K
------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
N
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
A
M
K
V
M
T
L
A
S
S
I
D
N
N
T
F
P
S
G
E
Y
F
N
S
S
-
E
-----------------------------------------------
L
S
S
N
V
G
M
S
L
L
E
Q
K
M
G
-----------------
D
A
T
W
L
D
Y
L
K
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
I
V
S
I
A
Q
S
S
-
F
G
Q
-
G
-
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
-
E
---
P
K
F
I
S
A
I
Y
D
TNNQ
S
V
R
K
S
--------
Q
K
E
-
I
------------
V
G
N
P
--------
V
S
K
E
A
---------
A
S
T
T
R
N
H
M
I
L
V
G
T
D
-
P
---------
L
---
I
I
-
T
V
P
G
Q
N
V
A
V
K
S
G
T
A
Q
I
A
D
--
E
K
NG
G
Y
L
VG
S
--
T
N
Y
I
F
S
A
--
V
T
M
N
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
T
P
I
L
E
R
A
S
A
M
KESLN
L
Q
S
P
--
A
K
N
L
D
K
V
T
T
E
S
S
Y
A
M
P
S
I
K
D
I
S
P
G
E
L
A
E
A
L
R
R
N
I
V
Q
P
I
V
V
G
TGTKIKETSVEEGTNLAPN
Q
Q
V
L
L
L
S
DKVEEIPDMYGWK
K
E
T
A
E
T
F
A
K
W
L
D
I
E
L
E
F
E
G
SGSVVQKQDVRTNTAIKNIK
K
I
K
L
T
L
G
D
44
HHSearch
68.30
19%
-61
- C2 -
1VQQ
9
?
A:
[98-638]
---------------------------------------------------------------------------------------
D
G
M
W
K
L
D
W
D
H
S
V
I
I
P
G
M
Q
K
D
--------
Q
S
I
H
I
E
N
L
K
S
E
R
G
K
I
L
D
R
N
N
V
E
L
A
N
T
G
T
A
Y
E
I
G
I
V
P
K
N
---------
V
S
K
-----
K
D
-
Y
K
A
I
A
K
E
L
S
I
----
S
E
D
Y
I
K
Q
Q
M
D
Q
----------------------------------------------------------
N
WV
Q
------
D
D
T
-
F
V
P
L
K
-
T
-
V
K
K
M
D
E
Y
---
L
S
D
F
--
A
K
-------
K
F
H
L
T
T
N
E
T
E
S
R
N
Y
P
L
E
K
A
T
S
H
L
L
G
Y
V
----
G
P
---------------------
I
N
S
E
E
L
K
QKEYKGYKD
D
A
V
I
--------
G
K
K
G
L
E
K
L
Y
D
K
K
L
Q
H
E
D
G
Y
R
V
T
I
V
D
D
-
S
N
T
I
-
A
H
T
L
I
---
E
K
K
K
K
D
G
K
D
I
Q
L
T
I
D
A
K
V
Q
K
S
I
Y
N
N
M
K
-------------
N
D
Y
G
S
G
T
A
I
H
P
Q
T
G
E
L
L
A
L
V
S
T
P
S
Y
D
V
Y
P
F
M
Y
G
MS
N
E
E
Y
N
K
L
T
E
D
K
K
E
P
L
-
L
N
K
-
F
Q
I
-----------
T
T
S
P
G
S
T
Q
K
I
L
T
A
M
I
G
L
N
N
K
T
L
D
D
K
T
S
Y
K
I
D
-
G
K
G
W
QKDK
S
W
G
G
Y
--
N
V
T
R
Y
E
V
--
V
N
-
G
-----------
N
I
D
L
K
Q
A
I
E
S
S
D
N
I
F
F
A
R
V
A
L
E
L
G
-----------------
S
K
K
F
E
K
G
M
K
K
L
G
V
G
E
D
I
P
S
D
Y
P
F
Y
N
A
-
Q
I
S
N
K
N
L
D
N
E
I
L
L
A
D
S
G
-
Y
G
Q
-
G
E
I
L
I
N
P
V
Q
I
L
S
I
Y
S
A
L
E
N
N
G
N
I
N
-
A
---
P
H
L
L
K
-----------
D
T
--------
K
N
K
V
W
------------
K
K
N
I
--------
I
S
K
E
N
---------
I
N
L
L
T
D
G
M
Q
Q
V
V
N
--
K
---------
T
H
K
E
D
I
-
Y
R
S
Y
A
N
L
I
G
K
S
G
T
A
E
L
K
---------------
G
R
Q
I
G
W
F
--
I
S
Y
D
K
D
-
N
P
N
M
M
M
A
I
N
V
K
D
V
Q
D
K
---
G
M
A
S
Y
N
A
K
I
S
G
K
V
Y
D
------
E
L
Y
E
--
N
G
-----------------------------------------------------------------------------------------------------------------------------
42
HHSearch
66.77
20%
-53
- C2 -
3VSK
-
?
A:
[47-678]
------------------------------------------------------------------------------------------------
Q
G
S
H
Y
K
Q
I
I
K
N
--------
D
E
N
I
T
V
N
E
S
V
P
R
G
R
I
L
D
R
N
G
K
V
L
V
D
N
A
S
K
M
A
I
T
Y
T
R
G
R
---------
K
T
T
Q
S
E
M
L
D
T
-
A
E
K
L
S
K
L
I
K
M
----
D
T
K
K
I
T
E
R
D
K
K
D
F
W
I
Q
L
H
P
K
K
A
K
A
M
M
T
K
E
Q
A
M
L
A
DGSIK
Q
D
Q
Y
D
K
Q
L
L
S
K
IRKSQLDELS
S
K
D
L
Q
V
L
A
I
F
--
R
E
M
N
AGT
V
L
D
P
Q
M
I
K
N
-
E
D
V
S
E
K
E
Y
A
---
A
V
S
Q
Q
L
S
K
-------
L
P
G
V
N
T
S
M
D
W
D
R
K
Y
P
Y
G
D
T
L
R
G
I
F
G
D
V
----
S
T
PAEGIPKEL
T
E
H
Y
L
S
K
GYSRN
D
-----------------
R
V
--------
G
K
S
Y
L
E
Y
Q
Y
E
D
V
L
R
G
K
K
K
E
M
K
Y
T
T
D
K
S
G
K
V
T
-
S
-
S
E
V
---
L
N
P
G
A
R
G
Q
D
L
K
L
T
I
D
I
D
L
Q
K
E
V
E
A
L
L
D
K
Q
I
K
K
L
R
SQGAKD
M
D
N
A
M
M
V
V
Q
N
P
K
N
G
D
I
L
A
L
A
G
K
Q
I
N
K
S
G
K
M
T
-----------------
D
Y
-
D
I
G
T
F
T
S
-----------
Q
F
A
V
G
S
S
V
K
G
G
T
L
L
A
G
Y
Q
N
K
A
I
K
V
G
E
T
M
V
D
E
-
P
L
H
F
----
Q
-
G
G
L
--
T
K
R
S
Y
F
NKN
G
H
-
V
-----------
S
I
N
D
K
Q
A
L
M
H
S
S
N
V
Y
M
F
K
T
A
L
K
L
A
GDPYYSGMALPSDI
S
S
P
A
Q
K
L
R
R
G
L
N
Q
V
G
L
G
V
K
T
G
I
D
L
P
N
E
T
R
G
Q
I
E
P
L
-
T
N
N
P
G
N
Y
L
D
L
S
-
I
G
Q
-
Y
-
D
T
Y
T
P
L
Q
L
S
Q
Y
V
S
T
I
A
N
D
G
Y
R
I
-
Q
---
P
H
I
G
L
-----------
T
I
--------
H
E
S
-
T
NKDEVGPLK
K
K
I
N
G
T
V
LNKVN---
N
T
E
K
E
---------
I
K
Q
I
Q
E
G
F
K
M
A
F
N
D
K
D
---------
G
T
G
Y
V
S
F
K
D
T
V
V
P
T
A
G
K
T
G
T
A
E
V
F
Q
-----------
E
--
P
R
V
N
S
T
Y
--
I
G
Y
A
P
I
D
D
P
K
L
A
F
S
I
V
Y
T
N
Q
P
V
P
-
P
--
P
W
L
T
G
G
D
L
G
R
D
V
I
N
------
Y
Y
F
K
---------------------------------------------------------------------------------------------------------------------------------
69
Fugue
66.03
18%
-60
- C2 -
4DKI
13
?
A:
[3-646]
SKD
K
E
I
N
N
T
I
D
A
I
E
D
KN
F
K
Q
V
Y
K
D
SS
Y
I
S
K
S
D
N
GEVEMT
E
R
P
I
K
I
Y
N
S
L
GVKDINIQD
R
K
I
K
K
V
S
K
N
K
K
R
V
D
A
Q
Y
K
I
K
T
N
Y
G
N
I
D
R
N
V
Q
F
N
F
V
K
E
D
G
M
W
K
L
D
W
D
H
S
V
IIPGMQKD
Q
S
I
H
I
E
N
L
K
S
E
R
G
K
I
L
D
R
N
N
V
E
L
A
N
T
G
T
A
Y
E
I
G
I
V
P
K
N
---------
V
------
S
K
K
D
Y
K
A
I
A
K
E
L
S
I
----
S
E
D
Y
I
K
Q
Q
M
D
Q
----------------------------------------------------------
N
--
W
------
V
Q
D
-
D
T
F
V
P
L
K
T
V
K
K
M
D
E
Y
---
L
S
D
F
--
A
K
-------
K
F
H
L
T
T
N
E
T
E
S
R
N
Y
P
L
E
K
A
T
S
H
L
L
G
Y
V
----
G
P
IN
S
E
E
L
K
QKEYKGYKDD----
A
-----------------
V
I
--------
G
K
K
G
L
E
K
L
Y
D
K
K
L
Q
H
E
D
G
Y
R
V
T
I
V
D
D
N
S
N
T
I
-
A
-
H
T
L
I
--
E
K
K
K
K
D
G
K
D
I
Q
L
T
I
D
A
K
V
Q
K
S
I
Y
N
N
M
K
N
-------------
D
Y
G
S
G
T
A
I
H
P
Q
T
G
E
L
L
A
L
V
S
T
P
S
Y
D
V
Y
P
F
M
Y
G
------------
M
S
N
E
E
-
Y
N
K
L
T
E
D
KKEPLLNKFQI
T
T
S
P
G
S
T
Q
K
I
L
T
A
M
I
G
L
N
N
K
T
L
D
D
K
T
S
Y
K
I
D
G
K
G
W
Q
----
K
D
K
S
W
--
G
G
Y
N
V
T
---
R
Y
-
E
V
V
N
G
-------
N
I
D
L
K
Q
A
I
E
S
S
D
N
I
F
F
A
R
V
A
L
E
L
G
-----------------
S
K
K
F
E
K
G
M
K
K
L
G
V
G
E
D
I
P
S
D
Y
P
F
Y
N
A
Q
I
S
N
K
N
L
D
-
N
E
I
L
L
A
D
S
G
-
Y
G
Q
G
E
-
I
L
I
N
P
V
Q
I
L
S
I
Y
S
A
L
E
N
N
G
N
I
N
A
P
---
H
L
L
K
D
-----------
T
K
--------
N
K
V
-
W
------------
K
K
N
I
--------
I
S
K
E
N
---------
I
N
L
L
T
D
G
M
Q
Q
V
V
N
K
-
T
---------
H
-
K
E
D
I
-
Y
R
S
Y
A
N
L
I
G
K
S
G
T
A
E
L
K
M
--
K
Q
--
E
T
G
--
R
--
Q
--
I
G
W
F
--
I
S
Y
D
K
-
D
N
P
N
M
M
M
A
I
N
V
K
D
V
Q
D
M
-
A
S
Y
N
A
K
I
S
G
K
V
Y
D
E
L
Y
E
------
N
G
N
K
--
K
Y
D
I
D
E
-------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.99
25%
-64
- C2 -
1PYY
2
PBPX_STRR6
A:
[25-544]
---------------------------------------------------------------------------------------------------------------------------
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
-------------------------
N
K
V
A
E
V
F
H
K
YLDM
E
E
S
Y
V
R
E
Q
L
--------------------------------------------------------------------------
V
S
F
G
A
-
K
G
N
G
I
T
Y
A
N
MMS------------------------
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
---------------------
D
-----------------
G
S
K
S
L
L
----
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
----------------------------
D
G
K
D
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Y
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I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
------------
T
E
D
F
V
W
R
D
I
L
Y
Q
S
-----------
N
Y
E
P
G
S
A
F
K
V
M
M
L
A
A
A
I
D
N
N
T
F
----------
P
G
G
E
----
V
F
N
S
S
E
L
K
I
A
D
A
T
---
I
R
-
D
W
D
VNEGLTGG
R
M
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F
S
Q
G
F
A
H
S
S
N
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M
T
L
L
E
Q
K
M
G
-----------------
D
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-
E
PKF
I
S
A
I
Y
-----------
D
---------
P
N
D
-
Q
------------
T
A
R
K
--------
S
Q
K
E
I
VGNPVS
K
D
A
A
S
L
T
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T
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M
V
L
V
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T
D
-
P
VYGTMYNHS
T
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P
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V
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G
Q
N
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A
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--
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NG
G
Y
L
--
V
--
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------