@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2796: (2016-02-11 )
MTSKLEQLKQYTTVVADTGDFDAIARLKPVDATTNPSLLLKAAALPRYAEHLRQATAGSGGDAGLACDRFAVAVGKDILGVIPGRISTEVDARLSFDSEATLARAHRLIELYDEQGIDRERVLIKIASTWEGIRAAEILEREGIQTNLTLLFSFAQAVACADAGVFLISPFVGRIYDWYKKSENRDYAGAEDPGVQSVSRIYRYYKANGYKTVVMGASFRNLGQIEQLAGCDRLTISPDLLQQLADAQGELPRLLLPGEGEPRQVLDESAFRWQMNEDAMATEKLAEGIRLFARDQEKLEYQLATRH
Atome Classification :
(35 SA)
.........10.-........20.....---...-30........40....-....-------50......------.-.----------60-------.--.-..-------.--------...70--------........80........90........100.......110.......120.......130....-...140.-.......150.......160.......170.......-180-...-.--..--..190.......200.......210.......220.....--..230.......240.......250..--..-...---.----260-.---...--.------....270.......280.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
K
L
E
Q
L
K
Q
-
Y
-
T
T
VVADTG
D
F
D
A
I
AR---LKP-VDATT
N
P
S
L
L
L
K
A
AAL-
P
R
Y
A
-------
E
H
L
R
Q
ATA------G-S----------GG-------D--A-GL-------
A
--------
C
D
R
F
A
--------
V
A
V
G
K
D
I
L
G
VIPGRIST
E
V
D
A
R
L
SFDS
E
A
T
L
A
R
A
H
R
L
I
E
L
Y
D
EQGIDR
E
R
V
L
I
K
I
ASTWE
G
I
R
A
A
-
E
I
L
E
-RE-GI
Q
T
N
L
T
L
L
F
S
F
A
Q
A
V
A
C
ADA
G
V
F
L
I
S
P
F
V
G
R
I
Y
D
W
Y
-K-K-SEN-R--DY--AGAEDP
G
V
Q
S
V
S
R
I
Y
R
Y
Y
KANG
Y
K
T
V
V
MGASFRNL
G
Q
I
E
Q
--
L
AGCDRLTI
S
P
D
L
L
Q
Q
L
A
D
AQGEL-
P
R
--
L
L-LPG---E----G---
E
---
P
R
Q
--
V
------
L
D
ESA
F
R
WQMN
E
D
A
M
A
T
E
K
L
A
E
G
I
R
L
F
AR
D
Q
E
K
L
E
Y
Q
LATRH
2
PsiBlast_PDB
91.86
60%
-84
- C5 -
1UCW
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
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T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
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L
Y
N
D
A
G
I
S
N
D
R
I
L
I
-
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
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A
P
A
L
L
K
E
L
A
E
S
E
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A
I
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R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
23
PsiBlast_CBE
91.77
57%
-81
- C5 -
2E1D
1
TALDO_MOUSE
B:
[8-326]
M
E
S
A
L
D
Q
L
K
Q
-
F
-
T
T
V
V
A
D
T
G
D
F
N
A
I
D
E
---
Y
K
P
-
Q
D
A
T
T
N
P
S
L
I
L
A
A
A
Q
M
-
P
A
Y
Q
-------
E
L
V
E
E
A
I
A
------
Y
-
G
----------
K
K
-------
L
--
G
-
G
P
Q
E
E
Q
I
K
N
A
--------
I
D
K
L
F
--------
V
L
F
G
A
E
I
L
K
K
I
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
D
A
M
V
A
R
A
R
R
L
I
E
L
Y
K
E
A
G
V
G
K
D
R
I
L
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L
S
S
T
W
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G
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Q
A
G
K
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L
E
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I
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C
N
M
T
L
L
F
S
F
A
Q
A
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A
C
A
E
A
G
V
T
L
I
S
P
F
V
G
R
I
L
D
W
H
V
A
-
N
-
T
D
K
-
K
--
S
Y
--
E
P
Q
G
D
P
G
V
K
S
V
T
K
I
Y
N
Y
Y
K
K
F
G
Y
K
T
I
V
M
G
A
S
F
R
N
T
G
E
I
K
A
--
L
A
G
C
D
F
L
T
I
S
P
K
L
L
G
E
L
L
K
D
N
S
K
L
A
P
A
--
L
S
-
V
K
A
A
Q
T
S
----
D
---
S
---
E
K
I
--
H
------
L
D
E
K
A
F
R
W
L
H
N
E
D
Q
M
A
V
E
K
L
S
D
G
I
R
K
F
A
A
D
A
I
K
L
E
R
M
L
T
E
R
-
66
HHSearch
91.75
60%
-78
- C5 -
3CWN
2
TAL_ECO1E
A:
[22-336]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
K
Q
Q
SND
R
---
A
Q
-------
Q
--
I
-
V
D
-------
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
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L
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Y
D
T
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A
S
I
A
K
A
K
R
L
I
K
L
Y
N
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A
G
I
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N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
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G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
Y
V
G
R
I
L
D
W
Y
-
K
-
A
-
N
T
D
-
K
K-
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
T
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
-
S
Y
T
---
G
----
E
V
K
-
A
---
R
P
A
--
R
------
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
K
M
I
G
D
L
-
22
PsiBlast_CBE
91.71
60%
-82
- C5 -
3KOF
2
TALB_ECOLI
B:
[22-330]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
RAQQIVD
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
Y
V
G
E
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
T
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
1
PsiBlast_PDB
91.68
60%
-79
- C5 -
3CWN
2
TAL_ECO1E
A:
[22-330]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
Y
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
T
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
3
PsiBlast_PDB
91.61
60%
-81
- C5 -
1ONR
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
13
PsiBlast_PDB
91.56
57%
-82
- C5 -
2CWN
-
TALDO_MOUSE
A:
[15-329]
----
L
D
Q
L
K
Q
-
F
-
T
T
V
V
A
D
T
G
D
F
N
A
I
D
E
---
Y
K
P
-
Q
D
A
T
T
N
P
S
L
I
L
A
A
A
Q
M
-
P
A
Y
Q
-------
E
L
V
E
E
A
I
A
------
Y
-
G
----------
K
K
-------
L
--
G
-
G
P
Q
E
E
Q
I
K
N
A
--------
I
D
K
L
F
--------
V
L
F
G
A
E
I
L
K
K
I
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
D
A
M
V
A
R
A
R
R
L
I
E
L
Y
K
E
A
G
V
G
K
D
R
I
L
I
K
L
S
S
T
W
E
G
I
Q
A
G
K
E
L
E
E
-
Q
H
-
G
I
H
C
N
M
T
L
L
F
S
F
A
Q
A
V
A
C
A
E
A
G
V
T
L
I
S
P
F
V
G
R
I
L
D
W
H
V
A
-
N
-
T
D
K
-
K
--
S
Y
--
E
P
Q
G
D
P
G
V
K
S
V
T
K
I
Y
N
Y
Y
K
K
F
G
Y
K
T
I
V
M
G
A
S
F
R
N
T
G
E
I
K
A
--
L
A
G
C
D
F
L
T
I
S
P
K
L
L
G
E
L
L
K
D
N
S
K
L
A
P
A
--
L
S
-
V
K
A
A
Q
T
S
----
D
---
S
---
E
K
I
--
H
------
L
D
E
K
A
F
R
W
L
H
N
E
D
Q
M
A
V
E
K
L
S
D
G
I
R
K
F
A
A
D
A
I
K
L
E
R
M
L
T
E
R
-
6
PsiBlast_PDB
91.56
60%
-82
- C5 -
1I2Q
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
A
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
21
PsiBlast_CBE
91.40
60%
-79
- C5 -
3CWN
2
TAL_ECO1E
B:
[22-330]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
RAQQIVD
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
Y
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
T
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
4
PsiBlast_PDB
91.39
60%
-85
- C5 -
3KOF
2
TALB_ECOLI
A:
[22-330]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
Y
V
G
E
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
T
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
85
Fugue
91.34
60%
-81
- C5 -
1ONR
-
TALB_ECOLI
A:
[2-317]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
Q
SND
R
A
Q
Q
--
I
-
V
D
-------
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
-
E
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
-
A
N
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
-
S
Y
T
------------
G
---
E
V
K
--
A
R
P
A
R--
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
K
M
I
G
D
L
L
84
Fugue
91.34
60%
-79
- C5 -
1ONR
-
TALB_ECOLI
A:
[2-317]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
Q
SND
R
A
Q
Q
--
I
-
V
D
-------
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
-
A
-
N
T
D
K
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
-
S
Y
T
---
G
----
E
---
V
---
K
A
R
P
A
R
------
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
K
M
I
G
D
L
L
11
PsiBlast_PDB
91.32
57%
-84
- C5 -
1F05
-
TALDO_HUMAN
A:
[11-329]
M
E
S
A
L
D
Q
L
K
Q
-
F
-
T
T
V
V
A
D
T
G
D
F
H
A
I
D
E
---
Y
K
P
-
Q
D
A
T
T
N
P
S
L
I
L
A
A
A
Q
M
-
P
A
Y
Q
-------
E
L
V
E
E
A
I
A
Y
G
R
K
L
G
G
-
S
----------
Q
E
-------
D
--
Q
I
K
N
-------
A
--------
I
D
K
L
F
--------
V
L
F
G
A
E
I
L
K
K
I
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
D
A
M
V
A
R
A
R
R
L
I
E
L
Y
K
E
A
G
I
S
K
D
R
I
L
I
K
L
S
S
T
W
E
G
I
Q
A
G
K
E
L
E
E
-
Q
H
-
G
I
H
C
N
M
T
L
L
F
S
F
A
Q
A
V
A
C
A
E
A
G
V
T
L
I
S
P
F
V
G
R
I
L
D
W
H
V
A
-
N
-
T
D
K
-
K
--
S
Y
--
E
P
L
E
D
P
G
V
K
S
V
T
K
I
Y
N
Y
Y
K
K
F
S
Y
K
T
I
V
M
G
A
S
F
R
N
T
G
E
I
K
A
--
L
A
G
C
D
F
L
T
I
S
P
K
L
L
G
E
L
L
Q
D
N
A
K
L
-
V
P
--
V
L
-
S
A
K
---
A
----
A
---
Q
---
A
S
D
--
L
E
K
I
H
--
L
D
E
K
S
F
R
W
L
H
N
E
D
Q
M
A
V
E
K
L
S
D
G
I
R
K
F
A
A
D
A
V
K
L
E
R
M
L
T
E
R
-
5
PsiBlast_PDB
91.25
60%
-81
- C5 -
1I2R
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
A
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
8
PsiBlast_PDB
91.22
60%
-82
- C5 -
1I2P
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
A
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
7
PsiBlast_PDB
91.07
60%
-81
- C5 -
1I2O
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
N
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
A
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
65
HHSearch
90.92
55%
-88
- C5 -
3HJZ
16
TAL_PROM9
A:
[2-321]
M
K
S
I
L
E
Q
L
S
S
-
M
-
T
V
V
V
A
D
T
G
D
L
D
S
I
K
K
---
F
Q
P
-
R
D
A
T
T
N
P
S
L
I
L
A
A
A
K
N
-
P
D
Y
V
-------
K
L
I
D
K
A
I
E
------
S
-
S
E
N
T
LPNGFS
E
I
E
-------
L
--
I
-
K
E
-------
T
--------
V
D
Q
V
S
--------
V
F
F
G
K
E
I
L
K
I
I
S
G
R
V
S
T
E
V
D
A
R
L
S
F
D
T
E
A
T
V
K
K
A
R
K
L
I
N
L
Y
K
N
F
G
I
E
K
E
R
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
E
I
L
E
-
K
E
-
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
L
I
S
P
F
V
G
R
I
L
D
W
H
-
K
-
A
-
K
T
G
-
K
T-
S
F
--
I
G
A
E
D
P
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
G
F
K
T
E
V
M
G
A
S
F
R
N
L
D
E
I
K
E
--
L
A
G
C
D
L
L
T
I
A
P
K
F
L
E
E
L
K
R
E
K
G
V
L
-
I
R
--
K
L
-
D
A
S
---
T
----
K
INN
S
---
I
D
Y
--
K
------
F
E
E
K
D
F
R
L
S
M
L
E
D
Q
M
A
S
E
K
L
S
E
G
I
T
G
F
S
K
A
I
E
E
L
E
E
L
L
I
E
R
-
68
HHSearch
90.81
59%
-81
- C5 -
2E1D
1
TALDO_MOUSE
A:
[9-326]
-
E
S
A
L
D
Q
L
K
Q
-
F
-
T
T
V
V
A
D
T
G
D
F
N
A
I
D
E
---
Y
K
P
-
Q
D
A
T
T
N
P
S
L
I
L
A
A
A
Q
M
-
P
A
Y
Q
-------
E
L
V
E
E
A
I
A
------
Y
-
G
K
K
L
GGP
Q
---
E
E
-------
Q
--
I
-
K
N
-------
A
--------
I
D
K
L
F
--------
V
L
F
G
A
E
I
L
K
K
I
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
D
A
M
V
A
R
A
R
R
L
I
E
L
Y
K
E
A
G
V
G
K
D
R
I
L
I
K
L
S
S
T
W
E
G
I
Q
A
G
-
K
E
L
E
E
Q
H
-
G
I
H
C
N
M
T
L
L
F
S
F
A
Q
A
V
A
C
A
E
A
G
V
T
L
I
S
P
F
V
G
R
I
L
D
W
H
-
V
-
A
-
N
T
D
-
K
K-
S
Y
--
E
P
Q
G
D
P
G
V
K
S
V
T
K
I
Y
N
Y
Y
K
K
F
G
Y
K
T
I
V
M
G
A
S
F
R
N
T
G
E
I
K
A
--
L
A
G
C
D
F
L
T
I
S
P
K
L
L
G
E
L
L
K
D
N
S
K
L
-
A
P
--
A
L
-
S
V
K
---
A
A
Q
T
S
D
---
S
---
E
K
I
--
H
------
L
D
E
K
A
F
R
W
L
H
N
E
D
Q
M
A
V
E
K
L
S
D
G
I
R
K
F
A
A
D
A
I
K
L
E
R
M
L
T
E
R
-
9
PsiBlast_PDB
90.55
60%
-81
- C5 -
1I2N
-
TALB_ECOLI
A:
[2-310]
-
T
D
K
L
T
S
L
R
Q
-
Y
-
T
T
V
V
A
D
T
G
D
I
A
A
M
K
L
---
Y
Q
P
-
Q
D
A
T
T
A
P
S
L
I
L
N
A
A
Q
I
-
P
E
Y
R
-------
K
L
I
D
D
A
V
A
------
W
-
A
----------
K
Q
-------
Q
--
S
-
N
D
R
A
Q
Q
I
V
D
A
--------
T
D
K
L
A
--------
V
N
I
G
L
E
I
L
K
L
V
P
G
R
I
S
T
E
V
D
A
R
L
S
Y
D
T
E
A
S
I
A
K
A
K
R
L
I
K
L
Y
N
D
A
G
I
S
N
D
R
I
L
I
K
L
A
S
T
W
Q
G
I
R
A
A
-
E
Q
L
E
-
K
E
-
G
I
N
C
N
L
T
L
L
F
S
F
A
Q
A
R
A
C
A
E
A
G
V
F
L
I
S
P
F
V
G
R
I
L
D
W
Y
-
K
A
N
-
T
D
K
-
K
--
E
Y
--
A
P
A
E
D
P
G
V
V
S
V
S
E
I
Y
Q
Y
Y
K
E
H
G
Y
E
T
V
V
M
G
A
S
F
R
N
I
G
E
I
L
E
--
L
A
G
C
D
R
L
T
I
A
P
A
L
L
K
E
L
A
E
S
E
G
A
I
-
E
R
--
K
L
S
Y
T
G
---
E
----
V
---
K
---
A
R
P
--
A
R-----
I
T
E
S
E
F
L
W
Q
H
N
Q
D
P
M
A
V
D
K
L
A
E
G
I
R
K
F
A
I
D
Q
E
K
L
E
-------
12
PsiBlast_PDB
90.25
57%
-82
- C5 -
2E1D
1
TALDO_MOUSE
A:
[9-326]
-
E
S
A
L
D
Q
L
K
Q
-
F
-
T
T
V
V
A
D
T
G
D
F
N
A
I
D
E
---
Y
K
P
-
Q
D
A
T
T
N
P
S
L
I
L
A
A
A
Q
M
-
P
A
Y
Q
-------
E
L
V
E
E
A
I
A
------
Y
-
G
----------
K
K
-------
L
--
G
-
G
P
Q
E
E
Q
I
K
N
A
--------
I
D
K
L
F
--------
V
L
F
G
A
E
I
L
K
K
I
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
D
A
M
V
A
R
A
R
R
L
I
E
L
Y
K
E
A
G
V
G
K
D
R
I
L
I
K
L
S
S
T
W
E
G
I
Q
A
G
K
E
L
E
E
-
Q
H
-
G
I
H
C
N
M
T
L
L
F
S
F
A
Q
A
V
A
C
A
E
A
G
V
T
L
I
S
P
F
V
G
R
I
L
D
W
H
V
A
-
N
-
T
D
K
-
K
--
S
Y
--
E
P
Q
G
D
P
G
V
K
S
V
T
K
I
Y
N
Y
Y
K
K
F
G
Y
K
T
I
V
M
G
A
S
F
R
N
T
G
E
I
K
A
--
L
A
G
C
D
F
L
T
I
S
P
K
L
L
G
E
L
L
K
D
N
S
K
L
A
P
A
--
L
S
-
V
K
A
A
Q
T
S
----
D
---
S
---
E
K
I
--
H
------
L
D
E
K
A
F
R
W
L
H
N
E
D
Q
M
A
V
E
K
L
S
D
G
I
R
K
F
A
A
D
A
I
K
L
E
R
M
L
T
E
R
-
14
PsiBlast_PDB
88.32
52%
-95
- C5 -
3HJZ
16
TAL_PROM9
A:
[4-309]
--
S
I
L
E
Q
L
S
S
-
M
-
T
V
V
V
A
D
T
G
D
L
D
S
I
K
K
---
F
Q
P
-
R
D
A
T
T
N
P
S
L
I
L
A
A
A
K
N
-
P
D
Y
V
-------
K
L
I
D
K
A
I
E
------
S
-
S
----------
E
N
-------
T
LP
N
-
G
F
-------
S
E
I
E
L
I
K
E
T
V
D
Q
V
S
--------
V
F
F
G
K
E
I
L
K
I
I
S
G
R
V
S
T
E
V
D
A
R
L
S
F
D
T
E
A
T
V
K
K
A
R
K
L
I
N
L
Y
K
N
F
G
I
E
K
E
R
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
E
I
L
E
-
K
E
-
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
L
I
S
P
F
V
G
R
I
L
D
W
H
-
K
A
K
-
T
G
K
-
T
--
S
F
--
I
G
A
E
D
P
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
G
F
K
T
E
V
M
G
A
S
F
R
N
L
D
E
I
K
E
--
L
A
G
C
D
L
L
T
I
A
P
K
F
L
E
E
L
K
R
E
K
G
V
L
-
I
R
--
K
L
-
D
A
S
---
T
----
K
---
I
---
N
N
S
--
I
D
Y
K
---
F
E
E
K
D
F
R
L
S
M
L
E
D
Q
M
A
S
E
K
L
S
E
G
I
T
G
F
S
K
-------------
69
HHSearch
88.24
51%
-82
* C5 *
3TKF
6
?
A:
[27-344]
-
K
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
-
V
K
A
N
N
PDLN
S
-
D
D
-------
L
--
V
-
K
E
-------
I
--------
A
I
E
I
L
--------
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
KT
F
P
--
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
K
L
T
--------------------------
Q
------
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
N
I
I
K
Q
N
-
67
HHSearch
87.28
52%
-82
- C5 -
3CQ0
17
TAL2_YEAST
A:
[13-332]
-
T
S
S
L
E
Q
L
K
K
A
G
-
T
H
V
V
A
D
S
G
D
F
E
A
I
S
K
---
Y
E
P
-
Q
D
S
T
T
N
P
S
L
I
L
A
A
S
K
L
-
E
K
Y
A
-------
R
F
I
D
A
A
V
E
------
Y
-
G
R
K
H
GKT
D
---
H
E
-------
K
--
I
-
E
N
-------
A
--------
M
D
K
I
L
--------
V
E
F
G
T
Q
I
L
K
V
V
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
K
A
T
V
K
K
A
L
H
I
I
K
L
Y
K
D
A
G
V
P
K
E
R
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
-
R
E
L
E
V
K
H
-
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
L
I
S
P
F
V
G
R
I
M
D
F
Y
-
K
-
A
-
L
------
D
Y
--
T
A
E
T
D
P
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
G
Y
A
T
E
V
M
A
A
S
F
R
N
L
D
E
L
K
A
--
L
A
G
I
D
N
M
T
L
P
L
N
L
L
E
Q
L
Y
E
S
T
D
P
I
-
E
N
--
K
L
-
N
S
E
---
S
----
A
KEE
G
V
E
K
V
S
F
--
I
------
N
D
E
P
H
F
R
Y
V
L
N
E
D
Q
M
A
T
E
K
L
S
D
G
I
R
K
F
S
A
D
I
E
A
L
Y
K
L
V
E
E
K
-
26
PsiBlast_CBE
87.01
52%
-89
- C5 -
3TNO
2
?
B:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
K
N
-----------------
T
Q
--
S
PQ----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
16
PsiBlast_PDB
86.51
52%
-87
- C5 -
3TNO
2
?
A:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
K
N
---
D
----
D
---
V
---
V
T
Q
--
S
P
Q
----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
31
PsiBlast_CBE
86.39
51%
-84
- C5 -
3CQ0
17
TAL2_YEAST
A:
[13-328]
-
T
S
S
L
E
Q
L
K
K
-
A
G
T
H
V
V
A
D
S
G
D
F
E
A
I
S
K
---
Y
E
P
-
Q
D
S
T
T
N
P
S
L
I
L
A
A
S
K
L
-
E
K
Y
A
R
F
I
D
A
A
V
E
Y
G
R
K
H
G
K
------
T
-
D
----------
H
E
-------
K
--
I
-
E
N
-------
A
--------
M
D
K
I
L
--------
V
E
F
G
T
Q
I
L
K
V
V
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
K
A
T
V
K
K
A
L
H
I
I
K
L
Y
K
D
A
G
V
P
K
E
R
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
-
R
E
L
E
V
K
H
-
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
L
I
S
P
F
V
G
R
I
M
D
F
Y
-
K
-
A
-
L
------
D
Y
--
T
A
E
T
D
P
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
G
Y
A
T
E
V
M
A
A
S
F
R
N
L
D
E
L
K
A
--
L
A
G
I
D
N
M
T
L
P
L
N
L
L
E
Q
L
Y
E
S
T
D
P
I
-
E
N
--
K
L
-
N
S
E
---
S
----
A
---
K
---
E
E
G
--
V
E
K
V
S
F
I
N
D
E
P
H
F
R
Y
V
L
N
E
D
Q
M
A
T
E
K
L
S
D
G
I
R
K
F
S
A
D
I
E
A
L
-
Y
K
L
----
28
PsiBlast_CBE
86.23
51%
-88
- C5 -
3TKF
8
?
B:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
-----------------------
S
PQ----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
30
PsiBlast_CBE
85.86
51%
-81
- C5 -
3CQ0
11
TAL2_YEAST
B:
[13-328]
-
T
S
S
L
E
Q
L
K
K
-
A
G
T
H
V
V
A
D
S
G
D
F
E
A
I
S
K
---
Y
E
P
-
Q
D
S
T
T
N
P
S
L
I
L
A
A
S
K
L
-
E
K
Y
A
R
F
I
D
A
A
V
E
Y
G
R
K
H
G
K
------
T
-
D
----------
H
E
-------
K
--
I
-
E
N
-------
A
--------
M
D
K
I
L
--------
V
E
F
G
T
Q
I
L
K
V
V
P
G
R
V
S
T
E
V
D
A
R
L
S
F
D
K
K
A
T
V
K
K
A
L
H
I
I
K
L
Y
K
D
A
G
V
P
K
E
R
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
-
R
E
L
E
V
K
H
-
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
L
I
S
P
F
V
G
R
I
M
D
F
Y
-
K
-
A
---------
Y
--
T
A
E
T
D
P
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
G
Y
A
T
E
V
M
A
A
S
F
R
N
L
D
E
L
K
A
--
L
A
G
I
D
N
M
T
L
P
L
N
L
L
E
Q
L
Y
E
S
T
D
P
I
-
E
N
--
K
L
-
N
S
E
---
S
----
A
---
K
---
E
E
G
--
V
E
K
V
S
F
I
N
D
E
P
H
F
R
Y
V
L
N
E
D
Q
M
A
T
E
K
L
S
D
G
I
R
K
F
S
A
D
I
E
A
L
-
Y
K
L
----
27
PsiBlast_CBE
85.38
52%
-84
- C5 -
3TK7
1
?
B:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
K
N
-----------------
T
Q
--
S
PQ----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
20
PsiBlast_PDB
85.07
51%
-89
- C5 -
3TKF
6
?
A:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
------------------------Q-----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
15
PsiBlast_PDB
84.97
52%
-87
- C5 -
3TK7
1
?
A:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
K
N
---
D
----
D
---
V
---
V
T
Q
--
S
P
Q
----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
17
PsiBlast_PDB
84.87
52%
-86
- C5 -
3UPB
4
?
A:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
------------------------Q-----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
25
PsiBlast_CBE
84.74
52%
-88
- C5 -
3UPB
4
?
B:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
------------------------Q-----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
19
PsiBlast_PDB
84.12
51%
-87
- C5 -
3TE9
3
?
A:
[28-338]
--
S
V
L
E
Q
L
K
Q
-
V
-
T
M
V
V
A
D
T
G
D
F
E
L
I
K
K
---
Y
K
P
-
V
D
A
T
T
N
P
S
L
I
L
K
A
V
K
E
-
Q
K
Y
S
-------
N
L
V
A
E
T
I
S
------
K
V
K
----------
A
N
-------
N
--
P
-
D
L
-------
N
--------
S
D
D
L
V
K
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
I
E
G
K
V
S
S
E
V
D
A
R
V
S
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
E
S
N
G
I
P
K
D
R
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
-
K
L
L
Q
-
K
E
-
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
L
V
S
P
F
V
G
R
I
T
D
W
Q
-
M
-
Q
-
Q
N
N
-
L
--
K
T
FP
A
I
A
D
D
D
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
G
F
K
T
I
V
M
G
A
S
F
R
N
V
E
Q
V
I
A
--
L
A
G
C
D
A
L
T
I
S
P
V
L
L
E
E
L
K
N
R
D
E
H
L
-
E
V
--
K
L
-
T
------------------------Q-----
I
S
E
A
D
F
R
W
L
M
N
E
N
A
M
A
T
H
K
L
A
E
G
I
R
L
F
T
K
D
T
I
E
L
E
-------
73
HHSearch
66.01
33%
-93
- C5 -
3S1X
1
TAL_THEAC
A:
[2-199]
--------------
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
A
V
N
G
K
K
Y
G
-------
D
I
I
R
E
-------------------------------------------------------------------------
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
---
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
-------
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
-
K
T
L
S
-
S
E
-
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
-
E
-
D
------------------
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
------------------------------------------------------------------------------------