@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2968: (2016-02-12 )
MSASLAFVFPGQGSQSLGMLAELGAQQALVRDTFAEASEALGYDLWALVQNGPEERLNQTDKTQPAILTVSIALWRLWLAEGGARPAFVAGHSLGEYSALVAAESLAFADAVKLVERRGQLMQQAVPAGQGGMAAILGLEDADVLAACAEAAQGEVVSAVNFNAPGQVVIAGAAAAVERAIEACKARGAKRAVALPVSVPSHCELMRPAAEQFAASVESLQWQAPKISLVQNVSAAVPADLDTLRRDLLAQLYSPVRWVESIQLLAEKGVTELVECGPGKVLAGLNRRCAKGINTHGLDGVEAFAATRAALA
Atome Classification :
(27 SA)
.........10........20........30........40........50........60....-----....70.----.-.....--.80...-...----.------..90-.........100.......110.......120.......130.......140...-------....150--------........160.......170.......180.......190.......200.......210.......220.......230-----...-....240.......250.......260.....----.----.270.......280.......290.......300.......310---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSA
S
L
A
F
V
FPGQGS
Q
S
L
G
M
L
A
E
LG
A
Q
Q
A
L
V
R
D
T
F
A
E
A
S
E
AL
G
Y
D
L
W
A
L
V
QN
G
P
E
E
RLNQTDKTQ
P
-----
A
I
L
T
V
S
I
----
A
-
L
W
R
L
W
--
L
A-EGG-AR
P
----
A
------
F
V
A--GHSLG
E
Y
S
A
L
V
A
A
E
S
L
A
F
A
D
A
V
K
L
V
E
R
R
G
Q
L
M
Q
Q
AVPAGQG
G
M
A
A
I
LGLE
D
A
D
V
L
-------
A
A
C
A
E
-A--------AQG
E
V
V
S
A
V
NFNAPG
Q
V
V
I
A
G
A
A
A
A
V
E
R
A
I
E
A
C
K
ARGAK
R
A
V
A
L
PVSVP
S
H
C
E
L
M
R
P
A
A
E
Q
F
A
A
S
V
E
SLQWQAP
K
I
S
L
V
Q
N-----
V
S
A-AVPA
D
L
D
T
L
R
R
D
L
L
A
Q
L
Y
S
P
V
R
W
V
E
S
I
Q
L
L
A
E
----K----
G
V
T
E
L
V
ECGP
G
K
V
L
A
G
L
N
R
R
C
AKGINTHGL
D
G
V
E
A
F
A
A
T
R
A
ALA---
9
PsiBlast_PDB
97.32
56%
-105
- C1 -
3H0P
1
FABD_SALTY
A:
[7-308]
----
F
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
A
E
M
A
A
N
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
W
R
V
W
--
Q
Q
-
Q
G
G
-
K
M
P
----
A
------
L
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
N
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
G
M
S
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
S
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
S
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
D
A
A
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
F
I
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
A
A
L
S
A
---------
1
PsiBlast_PDB
96.93
57%
-109
- C1 -
1MLA
-
FABD_ECOLI
A:
[4-305]
----
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
---------
5
PsiBlast_PDB
95.75
57%
-107
- C1 -
2G2Z
2
FABD_ECOLI
A:
[3-304]
----
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
---------
4
PsiBlast_PDB
95.40
57%
-105
- C1 -
2G2Y
1
FABD_ECOLI
A:
[3-304]
----
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
---------
30
HHSearch
95.20
58%
-109
- C1 -
1MLA
-
FABD_ECOLI
A:
[3-298]
---
Q
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
----------------
37
HHSearch
95.00
56%
-104
- C1 -
3K89
1
?
A:
[3-311]
-
E
S
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
-----
A
L
L
A
A
G
V
----
A
-
V
W
R
L
W
--
T
A
Q
R
-
G
-
Q
R
P
----
A
------
L
L
A
--
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-------
E
V
C
A
E
-
A
--------
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
-----
V
D
A
-
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
----
Q
----
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
L
D
A
-----
6
PsiBlast_PDB
94.95
55%
-102
- C1 -
3HJV
18
?
A:
[6-312]
-
M
S
K
F
A
I
V
F
P
G
Q
G
S
Q
A
V
G
M
L
A
D
L
A
E
Q
Y
A
V
V
K
Q
T
F
A
E
A
S
E
V
L
G
Y
D
L
W
A
L
V
Q
D
G
P
V
E
D
L
N
Q
T
F
R
T
Q
P
-----
A
L
L
A
A
S
V
----
A
-
I
W
R
V
W
--
Q
Q
-
L
G
L
-
E
Q
P
----
A
------
V
L
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
K
Q
A
I
K
L
V
E
L
R
G
Q
L
M
Q
Q
A
V
P
A
G
T
G
A
M
Y
A
I
I
G
L
E
D
E
A
I
A
-------
K
A
C
A
D
-
A
--------
A
Q
G
E
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
Q
K
D
A
V
E
R
A
G
V
L
C
K
E
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
E
L
A
K
T
L
A
E
L
E
F
N
A
P
Q
I
P
V
I
N
N
-----
V
D
V
-
V
A
E
T
D
P
V
K
I
K
D
A
L
I
R
Q
L
Y
S
P
V
R
W
T
E
C
V
E
Q
M
S
A
----
Q
----
G
V
E
K
L
I
E
M
G
P
G
K
V
L
T
G
L
T
K
R
I
V
K
T
L
E
G
V
A
V
N
D
V
A
S
L
D
A
V
K
-------
3
PsiBlast_PDB
94.92
57%
-105
- C1 -
2G2O
1
FABD_ECOLI
A:
[3-304]
----
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
---------
2
PsiBlast_PDB
94.66
57%
-106
- C1 -
2G1H
1
FABD_ECOLI
A:
[3-304]
----
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
-----
A
L
L
T
A
S
V
----
A
-
L
Y
R
V
W
--
Q
Q
-
Q
G
G
-
K
A
P
----
A
------
M
M
A
--
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-------
K
A
C
E
E
-
A
--------
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
-----
V
D
V
-
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
----
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
---------
8
PsiBlast_PDB
93.65
57%
-110
- C1 -
3R97
1
?
A:
[4-299]
--
S
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
-----
A
L
L
A
A
G
V
----
A
-
V
W
R
L
W
--
T
A
-
Q
R
G
-
Q
R
P
----
A
------
L
L
A
--
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-------
E
V
C
A
E
-
A
--------
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
-----
V
D
A
-
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
----
Q
----
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
-----------------
7
PsiBlast_PDB
93.30
57%
-108
- C1 -
3K89
1
?
A:
[4-299]
--
S
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
-----
A
L
L
A
A
G
V
----
A
-
V
W
R
L
W
--
T
A
-
Q
R
G
-
Q
R
P
----
A
------
L
L
A
--
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-------
E
V
C
A
E
-
A
--------
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
-----
V
D
A
-
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
----
Q
----
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
-----------------
32
HHSearch
89.85
51%
-107
- C1 -
3TQE
3
?
A:
[4-308]
M
P
Q
S
F
A
F
V
F
P
G
Q
G
S
Q
H
L
G
M
L
A
E
L
G
L
Q
Q
P
I
V
L
E
T
F
Q
Q
A
S
S
A
L
A
Y
D
L
W
A
L
V
Q
H
G
P
Q
E
R
L
D
Q
T
Q
F
T
Q
P
-----
A
L
L
T
A
D
V
----
A
-
I
F
R
C
W
--
E
A
-
L
-
G
G
P
K
P
----
Q
------
V
M
A
--
G
H
S
L
G
E
Y
A
A
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
V
G
E
G
A
M
G
A
I
I
G
L
N
E
A
E
I
E
-------
S
I
C
E
N
-
A
--------
A
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
Q
T
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
E
G
A
K
I
A
K
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
V
P
V
I
H
N
-----
V
D
V
-
V
D
H
N
E
A
N
I
I
R
G
A
L
I
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
E
E
----
Q
----
G
I
K
V
F
M
E
C
G
P
D
N
K
L
A
G
L
I
K
R
I
D
R
Q
S
E
I
L
P
L
T
T
T
E
L
I
L
----------
11
PsiBlast_PDB
86.27
51%
-109
- C1 -
3TQE
3
?
A:
[7-294]
---
S
F
A
F
V
F
P
G
Q
G
S
Q
H
L
G
M
L
A
E
L
G
L
Q
Q
P
I
V
L
E
T
F
Q
Q
A
S
S
A
L
A
Y
D
L
W
A
L
V
Q
H
G
P
Q
E
R
L
D
Q
T
Q
F
T
Q
P
-----
A
L
L
T
A
D
V
----
A
-
I
F
R
C
W
--
E
A
-
L
G
G
-
P
K
P
----
Q
------
V
M
A
--
G
H
S
L
G
E
Y
A
A
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
V
G
E
G
A
M
G
A
I
I
G
L
N
E
A
E
I
E
-------
S
I
C
E
N
-
A
--------
A
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
Q
T
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
E
G
A
K
I
A
K
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
V
P
V
I
H
N
-----
V
D
V
-
V
D
H
N
E
A
N
I
I
R
G
A
L
I
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
E
E
----
Q
----
G
I
K
V
F
M
E
C
G
P
D
N
K
L
A
G
L
I
K
R
I
D
R
------------------------
10
PsiBlast_PDB
84.85
55%
-105
- C1 -
3EZO
-
?
A:
[1-284]
---
K
F
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
N
A
F
-
A
D
V
A
V
V
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
I
G
K
L
I
A
D
G
P
A
D
E
L
N
L
T
T
N
T
Q
P
-----
V
M
L
T
A
A
Y
----
A
-
C
Y
R
A
W
--
Q
Q
-
A
G
G
-
A
Q
P
----
S
------
I
V
A
--
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
V
G
V
G
G
M
A
A
I
L
G
L
D
D
D
T
V
R
-------
A
V
C
A
E
-
A
--------
S
A
T
G
V
V
E
A
V
N
F
N
A
P
A
Q
V
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
K
G
A
K
R
A
L
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
I
S
V
V
N
N
-----
I
D
V
-
A
V
V
S
D
P
A
A
I
K
D
A
L
V
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
A
R
----
E
----
G
V
T
H
V
I
E
C
G
P
G
K
V
L
A
G
L
T
K
R
---------------------------
33
HHSearch
81.24
38%
-102
- C1 -
3IM9
3
FABD_STAAM
A:
[9-313]
-
G
S
H
M
A
I
I
F
P
G
Q
G
A
Q
K
V
G
M
A
Q
D
L
F
N
N
N
D
Q
A
T
E
I
L
T
S
A
A
K
T
L
D
F
D
I
L
E
T
M
F
T
D
E
E
G
K
L
G
E
T
E
N
T
Q
P
-----
A
L
L
T
H
S
S
----
A
-
L
L
A
A
L
--
K
N
-----
L
N
P
----
D
------
F
T
M
--
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
T
G
V
G
S
M
A
A
V
L
G
L
D
F
D
K
V
D
-------
E
I
C
K
S
-
L
S-------
S
D
D
K
I
I
E
P
A
N
I
N
C
P
G
Q
I
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
L
G
A
K
R
V
M
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
F
P
V
V
Q
N
-----
V
N
A
-
Q
G
E
T
D
K
E
V
I
K
S
N
M
V
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
----
Q
----
G
V
D
H
F
I
E
I
G
P
G
K
V
L
S
G
L
I
K
K
I
N
R
D
V
K
L
T
S
I
Q
T
L
E
D
V
K
G
W
N
-------
12
PsiBlast_PDB
80.23
38%
-98
- C1 -
3IM9
3
FABD_STAAM
A:
[10-307]
--
S
H
M
A
I
I
F
P
G
Q
G
A
Q
K
V
G
M
A
Q
D
L
F
N
N
N
D
Q
A
T
E
I
L
T
S
A
A
K
T
L
D
F
D
I
L
E
T
M
F
T
D
E
E
G
K
L
G
E
T
E
N
T
Q
P
-----
A
L
L
T
H
S
S
----
A
-
L
L
A
-----
A
-
L
K
N
-
L
N
P
----
D
------
F
T
M
--
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
T
G
V
G
S
M
A
A
V
L
G
L
D
F
D
K
V
D
-------
E
I
C
K
S
L
S
--------
S
D
D
K
I
I
E
P
A
N
I
N
C
P
G
Q
I
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
L
G
A
K
R
V
M
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
F
P
V
V
Q
N
-----
V
N
A
-
Q
G
E
T
D
K
E
V
I
K
S
N
M
V
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
----
Q
----
G
V
D
H
F
I
E
I
G
P
G
K
V
L
S
G
L
I
K
K
I
N
R
D
V
K
L
T
S
I
Q
T
L
E
-------------
27
HHSearch
79.89
41%
-103
- C1 -
3QAT
2
?
A:
[5-316]
--
M
G
A
A
F
T
F
P
G
Q
G
S
Q
L
I
G
M
G
K
V
L
T
E
Q
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
F
E
G
P
A
D
V
L
T
L
T
A
N
A
Q
P
-----
A
L
M
A
V
S
M
----
A
-
V
I
R
V
M
--
E
Q
-
L
-
G
-
L
N
V
EKKV
K
------
F
V
A
--
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
-------
E
I
C
E
I
-
V
--------
A
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
K
G
A
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
-----
V
S
V
-
I
P
E
S
D
P
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
----
N
----
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
----
15
PsiBlast_PDB
77.83
35%
-100
- C1 -
3PTW
-
?
A:
[2-308]
--
A
K
L
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
M
G
K
E
F
F
D
N
F
E
E
S
K
E
V
F
K
R
S
S
E
A
L
G
I
D
M
E
E
L
C
F
N
D
P
E
G
L
L
N
K
T
E
F
T
Q
P
-----
A
I
I
T
T
N
M
----
A
-
I
L
T
-
A
--
L
D
-
K
L
G
-
V
K
S
----
H
------
I
S
C
--
G
L
S
L
G
E
Y
S
A
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
E
G
I
G
G
M
V
A
V
L
R
M
T
P
E
Q
V
D
-------
E
I
I
E
K
-
S
--------
S
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
V
G
G
-
R
A
I
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
G
I
V
M
S
N
-----
V
K
G
-
E
A
Y
L
E
D
D
N
I
I
E
L
L
T
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
----
S
----
G
V
D
T
F
I
E
I
G
P
G
K
A
L
S
G
F
V
K
K
I
N
K
N
V
T
V
L
N
V
E
D
L
K
S
L
E
K
T
L
S
K
L
----
42
HHSearch
76.84
42%
-108
- C1 -
3IM8
1
?
A:
[3-294]
---
K
T
A
F
L
F
A
G
Q
G
A
Q
Y
L
G
M
G
R
D
F
Y
D
Q
Y
P
I
V
K
E
T
I
D
R
A
S
Q
V
L
G
Y
D
L
R
Y
L
I
D
T
E
-
E
D
K
L
N
Q
T
R
Y
T
Q
P
-----
A
I
L
A
T
S
V
----
A
-
I
Y
R
L
L
--
Q
E
-
K
-
G
-
Y
Q
P
----
D
------
M
V
A
--
G
L
S
L
G
E
Y
S
A
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
A
D
S
G
K
M
V
A
V
L
N
T
P
V
E
V
I
E
-------
E
A
C
Q
K
-
A
--------
S
E
L
G
V
V
T
P
A
N
Y
N
T
P
A
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
A
G
A
K
R
L
I
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
Q
V
S
F
S
D
F
T
C
P
L
V
G
N
-----
T
E
A
-
A
V
M
Q
K
-
E
D
I
A
Q
L
L
T
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
----
A
----
G
I
S
N
F
I
E
I
G
P
G
K
V
L
S
G
F
V
K
K
I
D
Q
T
A
H
L
A
H
V
-----------------
35
HHSearch
76.53
40%
-99
* C1 *
2CUY
-
?
A:
[2-299]
----
Y
A
A
L
F
P
G
Q
G
S
H
R
V
G
M
G
R
A
L
Y
E
A
S
P
A
A
K
E
V
L
D
R
A
E
A
A
L
P
G
L
L
-
K
L
M
W
E
G
P
E
E
A
L
T
L
T
E
N
Q
Q
P
-----
A
L
L
A
A
G
Y
----
A
-
A
Y
R
A
F
--
L
E
-
A
G
G
-
K
P
P
----
A
------
L
A
A
--
G
H
S
L
G
E
W
T
A
H
V
A
A
G
T
L
E
L
E
D
A
L
R
L
V
R
L
R
G
R
Y
M
Q
E
A
V
P
V
G
E
G
A
M
A
A
V
L
K
L
P
L
E
E
I
Q
-------
K
A
L
E
G
------------
L
E
G
V
E
I
A
N
L
N
A
P
E
Q
T
V
I
S
G
R
R
Q
A
V
E
E
A
A
E
R
L
K
E
R
R
A
-
R
V
V
F
L
P
V
S
A
P
F
H
S
S
L
M
A
P
A
R
K
R
L
A
E
D
L
A
Q
V
P
L
R
R
P
R
F
P
V
Y
S
N
-----
V
T
A
-
R
P
E
E
D
P
E
R
I
R
A
L
L
L
E
Q
I
T
A
P
V
R
W
V
E
I
L
R
D
M
E
A
----
R
----
G
V
K
R
F
L
E
F
G
S
G
E
V
L
K
G
L
V
L
R
T
L
K
E
A
E
A
L
S
V
Q
D
P
D
S
L
R
K
A
--------
36
HHSearch
64.91
32%
-94
- C1 -
2QC3
1
FABD_MYCTU
A:
[1-302]
--
H
M
I
A
L
L
A
P
G
Q
G
S
Q
T
E
G
M
L
S
P
W
L
Q
-
L
P
G
A
A
D
Q
I
A
A
W
S
K
A
A
D
L
D
L
A
R
L
G
T
T
A
S
T
E
E
I
T
D
T
A
V
A
Q
P
-----
L
I
V
A
A
T
L
L
A
H
Q
E
-
L
A
R
R
C
--
V
L
-
A
-
G
--
K
D
----
V
------
I
V
A
--
G
H
S
V
G
E
I
A
A
Y
A
I
A
G
V
I
A
A
D
D
A
V
A
L
A
A
T
R
G
A
E
M
A
K
A
C
A
T
E
P
T
G
M
S
A
V
L
G
G
D
E
T
E
V
L
-------
S
R
L
E
Q
-------------
L
D
L
V
P
A
N
R
N
A
A
G
Q
I
V
A
A
G
R
L
T
A
L
E
K
L
A
E
D
P
P
A
-
K
A
-
R
V
R
A
L
G
V
A
G
A
F
H
T
E
F
M
A
P
A
L
D
G
F
A
A
A
A
A
N
I
A
T
A
D
P
T
A
T
L
L
S
N
-----
R
D
G
-
K
P
V
T
S
A
A
A
A
M
D
T
L
V
S
Q
L
T
Q
P
V
R
W
D
L
C
T
A
T
L
R
E
----
H
----
T
V
T
A
I
V
E
F
P
P
A
G
T
L
S
G
I
A
K
R
E
L
R
G
V
P
A
R
A
V
K
S
P
A
D
L
D
E
L
A
N
------
23
PsiBlast_CBE
63.20
31%
-96
- C1 -
2C2N
8
FABD_HUMAN
A:
[23-325]
M
G
Q
C
S
V
L
L
F
P
G
Q
G
S
Q
V
V
G
M
G
R
G
L
-
L
N
Y
P
R
V
R
E
L
Y
A
A
A
R
R
V
L
G
Y
D
L
L
E
L
S
L
H
G
P
Q
E
T
L
D
R
T
V
H
C
Q
P
-----
A
I
F
V
A
S
L
----
A
A
V
E
K
L
H
--
H
L
-
Q
P
S
-
V
I
E
----
N
------
C
V
A
A
A
G
F
S
V
G
E
F
A
A
L
V
F
A
G
A
M
E
F
A
E
G
L
Y
A
V
K
I
R
A
E
A
M
Q
E
A
S
E
A
V
P
S
G
M
L
S
V
L
G
Q
P
Q
S
K
F
N
-------
F
A
C
L
E
-
A
R
E
H
C
K
S
L
G
I
E
N
P
V
C
E
V
S
N
Y
L
F
P
D
C
R
V
I
S
G
H
Q
E
A
L
R
F
L
Q
K
N
S
S
K
F
H
F
R
R
T
R
M
L
P
V
S
G
A
F
H
T
R
L
M
E
P
A
V
E
P
L
T
Q
A
L
K
A
V
D
I
K
K
P
L
V
S
V
Y
S
N
-----
V
H
G
-
H
R
Y
R
H
P
G
H
I
H
K
L
L
A
Q
Q
L
V
S
P
V
K
W
E
Q
T
M
H
A
I
Y
E
RKKG
R
----
G
F
P
Q
T
F
E
V
G
P
G
R
Q
L
G
A
I
L
K
S
C
--------------------------
43
HHSearch
62.50
31%
-100
- C1 -
2C2N
8
FABD_HUMAN
A:
[24-330]
-
G
Q
C
S
V
L
L
F
P
G
Q
G
S
Q
V
V
G
M
G
R
G
L
L
N
-
Y
P
R
V
R
E
L
Y
A
A
A
R
R
V
L
G
Y
D
L
L
E
L
S
L
H
G
P
Q
E
T
L
D
R
T
V
H
C
Q
P
-----
A
I
F
V
A
S
L
----
A
-
A
V
E
K
L
--
H
----
H
-
L
Q
P
----
S
V
I
E
N
CV
A
A
A
--
G
F
S
V
G
E
F
A
A
L
V
F
A
G
A
M
E
F
A
E
G
L
Y
A
V
K
I
R
A
E
A
M
Q
E
A
S
E
A
V
P
S
G
M
L
S
V
L
G
Q
P
Q
S
K
F
N
F
A
C
L
E
A
R
E
H
C
K
S
L
G
--------
I
E
N
P
V
C
E
V
S
N
Y
L
F
P
D
C
R
V
I
S
G
H
Q
E
A
L
R
F
L
Q
K
N
S
S
K
F
H
F
R
R
T
R
M
L
P
V
S
G
A
F
H
T
R
L
M
E
P
A
V
E
P
L
T
Q
A
L
K
A
V
D
I
K
K
P
L
V
S
V
Y
S
N
-----
V
H
G
-
H
R
Y
R
H
P
G
H
I
H
K
L
L
A
Q
Q
L
V
S
P
V
K
W
E
Q
T
M
H
A
I
Y
E
----
R
KKG
R
G
F
P
Q
T
F
E
V
G
P
G
R
Q
L
G
A
I
L
K
S
C
N
M
Q
A
W
---------------------
47
Fugue
60.00
31%
-93
- C1 -
1NM2
3
?
A:
[1-315]
--
H
M
L
V
L
V
A
P
G
Q
G
A
Q
T
P
G
F
L
T
D
W
L
A
L
P
G
-
A
A
D
R
V
A
A
W
S
D
A
I
G
L
D
L
A
H
F
G
T
K
A
D
A
D
E
I
R
D
T
S
V
A
Q
P
-----
L
L
V
A
A
G
I
----
L
-
S
A
A
A
L
-----
G
T
G
-
F
T
P
----
G
------
A
V
A
--
G
H
S
V
G
E
I
T
A
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
V
T
E
T
G
M
S
A
L
L
G
G
D
P
E
V
S
V
-------
A
H
L
E
R
-
L
--------
G
----
L
T
P
A
N
V
N
G
A
G
Q
I
V
A
A
G
T
M
E
Q
L
A
A
L
N
E
D
-
K
P
E
G
V
R
K
V
V
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
V
T
Y
V
S
N
-----
K
D
G
-
R
A
V
A
S
G
T
E
V
L
D
R
L
V
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
----
L
----
G
V
T
A
I
I
E
V
C
P
G
G
T
L
T
G
L
A
K
R
A
L
P
G
V
K
T
L
A
L
K
T
P
D
D
L
D
A
A
R
E
L
V
A
E
H
T
26
PsiBlast_CBE
59.09
34%
-96
- C1 -
2QC3
1
FABD_MYCTU
A:
[3-286]
----
I
A
L
L
A
P
G
Q
G
S
Q
T
E
G
M
L
S
P
W
-
L
Q
L
P
G
A
A
D
Q
I
A
A
W
S
K
A
A
D
L
D
L
A
R
L
G
T
T
A
S
T
E
E
I
T
D
T
A
V
A
Q
P
-----
L
I
V
A
A
T
L
L
A
H
Q
E
-
L
A
R
R
C
--
V
L
-
A
G
---
K
D
----
V
------
I
V
A
--
G
H
S
V
G
E
I
A
A
Y
A
I
A
G
V
I
A
A
D
D
A
V
A
L
A
A
T
R
G
A
E
M
A
K
A
C
A
T
E
P
T
G
M
S
A
V
L
G
G
D
E
T
E
V
L
----------
S
R
-
L
--------
E
Q
L
D
L
V
P
A
-
N
R
N
A
A
G
Q
I
V
A
A
G
R
L
T
A
L
E
K
L
A
E
D
P
P
A
K
A
--
R
V
R
A
L
G
V
A
G
A
F
H
T
E
F
M
A
P
A
L
D
G
F
A
A
A
A
A
N
I
A
T
A
D
P
T
A
T
L
L
S
N
RDGKP
V
T
S
-
A
A
A
A
-
M
D
T
----
L
V
S
Q
L
T
Q
P
V
R
W
D
L
C
T
A
T
L
R
E
----
H
----
T
V
T
A
I
V
E
F
P
P
A
G
T
L
S
G
I
A
K
R
E
L
R
G
V
----------------------
24
PsiBlast_CBE
58.37
32%
-92
- C1 -
1NM2
3
?
A:
[3-308]
----
L
V
L
V
A
P
G
Q
G
A
Q
T
P
G
F
L
T
D
W
L
A
L
P
G
-
A
A
D
R
V
A
A
W
S
D
A
I
G
L
D
L
A
H
F
G
T
K
A
D
A
D
E
I
R
D
T
S
V
A
Q
P
L
L
V
A
A
G
I
L
S
A
A
A
----
L
-
G
T
----------
G
-
F
T
P
----
G
------
A
V
A
--
G
H
S
V
G
E
I
T
A
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
V
T
E
T
G
M
S
A
L
L
G
-
G
D
P
E
V
S
-------
V
A
H
L
E
-
R
--------
L
G
---
L
T
P
A
N
V
N
G
A
G
Q
I
V
A
A
G
T
M
E
Q
L
A
-
A
L
N
E
D
K
P
E
G
V
R
K
V
V
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
V
T
Y
V
S
N
-----
K
D
G
R
A
V
A
S
G
T
E
V
L
D
R
-
L
V
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
----
L
----
G
V
T
A
I
I
E
V
C
P
G
G
T
L
T
G
L
A
K
R
A
L
P
G
V
K
T
L
A
L
K
T
P
D
D
L
D
A
A
R
-------
34
HHSearch
58.17
31%
-95
- C1 -
1NM2
3
?
A:
[1-312]
--
H
M
L
V
L
V
A
P
G
Q
G
A
Q
T
P
G
F
L
T
D
W
L
A
-
L
P
G
A
A
D
R
V
A
A
W
S
D
A
I
G
L
D
L
A
H
F
G
T
K
A
D
A
D
E
I
R
D
T
S
V
A
Q
P
-----
L
L
V
A
A
G
I
----
L
-
S
A
A
A
L
G
T-----
G
-
F
T
P
----
G
------
A
V
A
--
G
H
S
V
G
E
I
T
A
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
V
T
E
T
G
M
S
A
L
L
G
G
D
P
E
V
S
V
-------
A
H
L
E
-------------
R
L
G
L
T
P
A
N
V
N
G
A
G
Q
I
V
A
A
G
T
M
E
Q
L
A
A
L
N
E
D
K
P
E
G
V
R
-
K
V
V
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
V
T
Y
V
S
N
-----
K
D
G
-
R
A
V
A
S
G
T
E
V
L
D
R
L
V
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
----
L
----
G
V
T
A
I
I
E
V
C
P
G
G
T
L
T
G
L
A
K
R
A
L
P
G
V
K
T
L
A
L
K
T
P
D
D
L
D
A
A
R
E
L
V
A
---