@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3312: (2016-02-15 )
MSASLPSLAFAGLGLMGVPMCRRLLAAGYPLAVWNRSPGKRELLAAEGAKAVEVPAELAADAEILMLCLADTAAVREVVFGAGGIVENARPGQLLVDFSSAEPAATREMAAELEARCGVRWVDAPVSGGTPGAESGSLAIMAGGRAADIERLRPVLSRLGQRLTRMGEVGAGQVTKVCNQMIVACNALVIAEVVALAERAGVDASLVAPALAGGFADSKPLQILAPQMAESRYEPVKWHVRTLLKDLDTAVKLSREQGAATPMSGLAAQLMRLHGSQGYLERDPATLVEQYRTAVE
Atome Classification :
(24 SA)
.........10........20........30........40......-..50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-........220.-...-------..-----.230---.........240.......250.......260.......270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSASL
P
S
L
A
F
A
G
L
GLM
G
V
P
M
C
R
R
L
L
AAGY
P
L
A
V
WNRSPGKR
E
L
L
AAE-GA
K
A
VE
V
P
A
E
LAA
D
A
E
I
L
M
LCLA
D
T
A
A
V
R
E
V
V
FGAGGIVENARP
G
Q
L
L
V
DFSSAEP
A
A
T
R
E
M
A
A
E
L
E
A
RCG
V
R
W
VDAPVSGGTPGAESG
S
L
A
I
M
AGGRAA
D
I
E
R
L
R
P
V
L
S
R
L
G
Q
R
L
T
RMGEVG
A
G
Q
V
T
K
V
C
N
Q
M
I
V
A
C
N
A
L
V
I
A
E
V
V
A
L
A
E
RAGV
D
A
S
L
V
A
P
A
L
--AGGFADSK
P
L
Q
I-L
A
P
-------
Q
M
-----
A
E
-----SRYE
P
V
K
W
H
V
R
T
L
L
K
D
L
D
T
A
V
K
L
SREQGAAT
P
M
S
G
L
A
A
Q
L
M
R
L
HGSQGYLER
D
P
A
T
L
V
E
Q
Y
R
T
AVE
37
HHSearch
92.93
35%
-98
- C2 -
1VPD
2
?
A:
[6-292]
-----
M
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
-
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
-
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
H
T
G
D
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
--
R
G
G
L
A
G
S
T
V
L
D
A
-
K
A
P
-------
M
V
-----
M
D
-----
R
N
F
K
-
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
L
--
4
PsiBlast_PDB
91.96
34%
-99
- C2 -
1VPD
2
?
A:
[8-290]
-------
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
-
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
-
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
H
T
G
D
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
--
R
G
G
L
A
G
S
T
V
L
D
A
-
K
A
P
-------
M
V
-----
M
D
-----
R
N
F
K
P
-
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
----
3
PsiBlast_PDB
90.81
41%
-98
- C2 -
4DLL
1
?
A:
[34-293]
-------
I
T
F
L
G
T
G
S
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
Q
V
W
N
R
T
P
A
R
A
A
S
L
A
A
L
-
G
A
T
I
H
E
Q
A
R
A
A
A
R
D
A
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
L
F
-
A
Q
G
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
-
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
-
R
A
T
H
V
G
P
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
I
--
T
G
G
F
A
D
S
R
V
L
Q
L
-
H
G
Q
-------
R
M
-----
V
E
-----
R
D
F
A
P
-
R
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
G
L
F
E
Q
L
Y
-------------------------
32
HHSearch
90.67
32%
-94
- C2 -
3OBB
5
SERDH_PSEAE
A:
[3-298]
----
M
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
-
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
-
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
P
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
--
R
R
S
S
G
G
N
W
A
L
E
V
-
Y
N
P
WPGVMEN
A
P
-----
A
S
-----
R
D
Y
S
-
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
T
Q
-
42
HHSearch
90.55
35%
-98
- C2 -
3WS7
3
?
A:
[17-302]
-
R
G
S
H
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
-
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
--
T
---
A
R
S
G
A
I
E
L
-
Y
L
P
-------
K
L
-----
L
K
-----
G
D
L
S
-
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
G
F
-------
38
HHSearch
87.64
28%
-99
- C2 -
3DOJ
1
GLYR1_ARATH
A:
[18-309]
-
G
S
H
M
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
-
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
-
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
--
D
L
G
A
M
T
N
P
M
F
K
G
-
K
G
P
-------
S
M
-----
N
K
-----
S
S
Y
P
-
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
7
PsiBlast_PDB
87.60
30%
-99
- C2 -
2I9P
1
3HIDH_HUMAN
A:
[23-314]
----
M
P
-
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
-
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
-
P
V
P
-------
G
V
-----
M
D
GVPSA
N
N
Y
Q
G
-
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
----
51
Fugue
87.48
28%
-98
- C2 -
3DOJ
1
GLYR1_ARATH
A:
[18-309]
-
G
S
H
M
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
-
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
-
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
--
D
L
G
A
M
T
N
P
M
F
K
G
-
K
G
P
-------
S
M
-----
N
K
-----
S
S
Y
P
P
-
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
35
HHSearch
87.30
30%
-97
- C2 -
2GF2
-
3HIDH_HUMAN
A:
[40-333]
-----
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
-
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
--
N
M
S
S
G
R
C
W
S
S
D
T
-
Y
N
P
VP-----
G
V
MDGVP
S
A
-----
N
N
Y
Q
-
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
E
--
1
PsiBlast_PDB
86.99
37%
-108
- C2 -
3WS7
3
?
A:
[23-285]
-------
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
-
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
--
T
---
A
R
S
G
A
I
E
L
-
Y
L
P
-------
K
L
-----
L
K
-----
G
D
L
S
P
-
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
------------------------
8
PsiBlast_PDB
86.81
30%
-103
- C2 -
2GF2
-
3HIDH_HUMAN
A:
[42-331]
-------
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
-
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
-
P
V
P
-------
G
V
-----
M
D
GVPSA
N
N
Y
Q
G
-
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
----
13
PsiBlast_PDB
86.69
29%
-99
- C2 -
3DOJ
1
GLYR1_ARATH
A:
[24-309]
-------
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
-
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
-
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
--
D
L
G
A
M
T
N
P
M
F
K
G
-
K
G
P
-------
S
M
-----
N
K
-----
S
S
Y
P
P
A
-
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
17
PsiBlast_PDB
86.35
31%
-95
- C2 -
3OBB
5
SERDH_PSEAE
A:
[6-286]
-------
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
-
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
-
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
P
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
--
R
R
S
S
G
G
N
W
A
L
E
V
-
Y
N
P
WPGVME-
N
A
-----
P
A
-----
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
-------------
2
PsiBlast_PDB
86.17
36%
-106
- C2 -
3W6Z
1
?
A:
[23-285]
-------
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
-
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
M
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
--
T
R
G
A
A
R
S
G
A
I
E
L
-
Y
L
P
-------
K
L
-----
L
K
-----
G
D
L
S
P
-
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
------------------------
31
HHSearch
86.10
31%
-98
- C2 -
3PDU
3
?
A:
[1-286]
----
M
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
-
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
C
F
G
A
N
G
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
-
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
--
D
A
G
A
M
A
N
P
M
F
K
G
-
K
G
Q
-------
M
L
-----
L
S
-----
G
E
F
P
-
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
Q
P
L
H
G
A
A
T
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
----
33
HHSearch
85.97
29%
-99
- C2 -
3PEF
6
?
A:
[1-286]
----
S
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
-
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
-
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
--
G
A
G
A
M
A
N
P
M
F
A
L
-
K
G
G
-------
L
I
-----
R
D
-----
R
N
F
A
-
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
----
10
PsiBlast_PDB
85.30
30%
-92
- C2 -
3PEF
6
?
A:
[3-285]
------
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
-
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
-
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
--
G
A
G
-
A
M
A
N
P
M
F
A
-
L
K
G
-------
G
L
-----
I
R
-----
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
-----
27
PsiBlast_CBE
84.44
35%
-95
- C2 -
3PDU
5
?
B:
[2-259]
-----
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
-
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
C
F
G
A
N
G
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
-
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
--
D
A
G
-
A
M
A
N
P
M
F
K
-
G
K
G
-------
Q
M
-----
L
L
-----
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
--
Q
P
L
H
G
A
A
-----------------------------
26
PsiBlast_CBE
83.80
35%
-95
- C2 -
3PDU
3
?
C:
[2-259]
-----
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
-
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
C
F
G
A
N
G
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
-
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
--
D
A
G
-
A
M
A
N
P
M
F
K
-
G
K
G
-------
Q
M
-----
L
L
-----
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
--
Q
P
L
H
G
A
A
-----------------------------
40
HHSearch
83.75
27%
-95
* C2 *
2UYY
2
GLYR1_HUMAN
A:
[27-316]
-
T
P
T
D
K
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
E
-
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
T
F
A
C
V
S
D
P
K
A
A
K
D
L
V
L
G
P
S
G
V
L
Q
G
I
R
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
-
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
S
F
F
L
G
E
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
L
--
N
Q
G
Q
L
A
S
I
F
L
D
Q
-
K
C
Q
-------
N
I
-----
L
Q
-----
G
N
F
K
-
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
A
A
A
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
H
---
41
HHSearch
81.80
31%
-86
- C2 -
2CVZ
1
?
A:
[2-283]
-----
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
A
R
-
R
F
P
T
L
V
W
N
R
T
F
E
K
A
L
R
H
Q
E
E
F
G
S
E
--
A
V
P
L
E
R
V
A
E
A
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
A
E
A
---
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
-
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
Y
-
A
K
K
V
V
H
V
G
P
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
--
N
A
S
S
G
R
S
N
A
T
E
N
L
I
P
Q
-------
R
V
-----
L
T
-----
R
A
F
P
-
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
A
K
R
E
L
G
P
D
A
D
H
V
E
A
L
R
L
L
E
R
W
--
28
PsiBlast_CBE
80.48
34%
-91
- C2 -
1WP4
3
?
D:
[1-262]
----
M
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
-
A
R
R
F
P
T
L
V
W
N
R
T
-
F
E
K
A
L
R
H
Q
E
-
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
---
A
E
A
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
-
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
-
Y
A
K
K
V
V
H
V
G
P
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
--
N
A
S
S
G
R
S
N
A
T
E
N
-
L
I
P
-------
Q
R
-----
V
L
-----
T
R
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
-----------------------
30
PsiBlast_CBE
78.39
34%
-85
- C2 -
1WP4
3
?
B:
[2-262]
-----
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
-
A
R
R
F
P
T
L
V
W
N
R
T
-
F
E
K
A
L
R
H
Q
E
-
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
---
A
E
A
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
-
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
-
Y
A
K
K
V
V
H
V
G
P
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
--
N
A
S
S
G
R
S
N
A
T
E
N
-
L
I
P
-------
Q
R
-----
V
L
-----
T
R
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
-----------------------
29
PsiBlast_CBE
77.70
34%
-86
- C2 -
1WP4
2
?
C:
[1-262]
----
M
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
-
A
R
R
F
P
T
L
V
W
N
R
T
-
F
E
K
A
L
R
H
Q
E
-
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
---
A
E
A
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
-
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
-
Y
A
K
K
V
V
H
V
G
P
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
--
N
A
S
S
G
R
S
N
A
T
E
N
-
L
I
P
-------
Q
R
-----
V
L
-----
T
R
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
-----------------------