@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3455: (2016-02-17 )
MFESAEVGHSIDKDTYEKAVIELREALLEAQFELKQQARFPVIILINGIEGAGKGETVKLLNEWMDPRLIEVQSFLRPSDEELERPPQWRFWRRLPPKGRTGIFFGNWYSQMLYARVEGHIKEAKLDQAIDAAERFERMLCDEGALLFKFWFHLSKKQLKERLKALEKDPQHSWKLSPLDWKQSEVYDRFVHYGERVLRRTSRDYAPWYVVEGADERYRALTVGRILLEGLQAALATKERAKRQPHAAPLVSSLDNRGLLDSLDLGQYLDKDAYKEQLAAEQARLAGLIRDKRFRQHSLVAVFEGNDAAGKGGAIRRVTDALDPRQYHIVPIAAPTEEERAQPYLWRFWRHIPARRQFTIFDRSWYGRVLVERIEGFCAPADWLRAYGEINDFEEQLSEYGIIVVKFWLAIDKQTQMERFKEREKTPYKRYKITEEDWRNRDKWDQYVDAVGDMVDRTSTEIAPWTLVEANDKRFARVKVLRTINDAIEAAYKKDK
Atome Classification :
(20 SA)
.........10........20........30.......----.40........50........60......-..70........80----.----.--------.-----.----------...--------------------.-----.90----.---..-----------......100.......110.......120.......130......---.140.......150.......160.......170.......180.......190.......200.-------......210.......220.......230.......240.......250.......260.......270.......280.......290...-----...------.300.......310.......320...----....330...--...-----.--------340---------.--------.-------.--------------------.-------..--.-----.---350.-------..-....360.......-370..---..---...380.......390--.......400.......410.......420.......430.......440.......450.......-460-----.........470.....-..480.......490....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFESAEVGHSI
D
K
D
T
Y
E
K
A
V
I
E
L
R
E
A
L
L
E
A
Q
F
E
L
K
Q
QA----RF
P
V
I
I
L
I
NGIEGAGKG
E
T
V
K
L
L
N
EWMD
P
-
R
L
I
E
V
Q
S
F
LRP
S
D
-----
E
----
E
--------L-----E----------RPP--------------------Q-----
W
R
-----
F
---
W
R-----------RLPPKGR
T
G
I
F
F
G
N
W
Y
S
Q
M
L
Y
A
R
V
EG
H
I
K
E
A
K
L
D
Q
A
I
D
A
A
E
R
F
E
R
---
M
L
CDE
G
A
L
L
F
K
F
W
F
H
L
S
K
K
Q
L
K
E
R
L
K
A
L
EKDPQHSWKLSPLDW
K
Q
S
E
V
Y
D
R
F
V
H
Y
G
E
R
V
L
R
R
TSR-------DYA
P
W
Y
V
V
EGADE
R
Y
R
A
L
T
V
G
R
I
L
L
E
G
L
Q
A
A
L
A
T
K
E
R
AKRQPHA
A
P
L
V
S
SLDNRGLLDS
L
D
L
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
I
R
D
K
RFR-----QH
S
------
L
V
A
V
F
EGNDAAGKGG
A
I
R
R
V
T
DALDPR----
Q
Y
H
I
V
PIAAP--
T
E
E
-----E--------R-A---------Q--------
P
-------
Y
--------------------
L
-------
W
R
--
F
-----
W
---
R
HIP-------AR-R
Q
F
T
IFDR
S
W
Y
G
R
V
-
L
V
E
R
I
---
E
G
---FCA
P
A
D
W
L
R
AYGEI
N
D
--
F
E
E
Q
L
S
EY
G
I
I
V
V
K
F
W
L
AID
K
Q
T
Q
M
E
R
F
K
E
R
EKTPYKRYKI
T
E
E
D
WRN
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
DRTS-T-------EIA
P
W
T
L
V
EANDK
R
F
A
R
-
V
K
V
L
R
T
I
N
D
A
I
E
A
A
YKKDK
36
HHSearch
97.24
100%
-109
- C3 -
3CZP
11
?
A:
[3-497]
M
F
E
S
A
E
V
G
H
S
I
D
K
D
T
Y
E
K
A
V
I
E
L
R
E
A
L
L
E
A
Q
F
E
L
K
Q
Q
A
----
R
F
P
V
I
I
L
I
N
G
I
E
G
A
G
K
G
E
T
V
K
L
L
N
E
W
M
D
P
-
R
L
I
E
V
Q
S
F
L
R
P
S
D
-----
E
----
E
--------
L
-----
E
----------
R
P
P
--------------------
Q
-----
W
R
-----
F
---
W
R
-----------
R
L
P
P
K
G
R
T
G
I
F
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G
N
W
Y
S
Q
M
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Y
A
R
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E
G
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I
K
E
A
K
L
D
Q
A
I
D
A
A
E
R
F
E
R
---
M
L
C
D
E
G
A
L
L
F
K
F
W
F
H
L
S
K
K
Q
L
K
E
R
-------------
L
S
P
L
D
W
K
Q
S
E
V
Y
D
R
F
V
H
Y
G
E
R
V
L
R
R
T
S
R
-------
D
Y
A
P
W
Y
V
V
E
G
A
D
E
R
Y
R
A
L
T
V
G
R
I
L
L
E
G
L
Q
A
A
L
A
T
-----------------
D
N
R
G
L
L
D
S
L
D
L
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
I
R
D
K
R
F
R
-----
Q
H
S
------
L
V
A
V
F
E
G
N
D
A
A
G
K
G
G
A
I
R
R
V
T
D
A
L
D
P
R
----
Q
Y
H
I
V
P
I
A
A
P
--
T
E
E
-----
E
--------
R
-
A
---------
Q
--------
P
-------
Y
--------------------
L
-------
W
R
--
F
-----
W
---
R
H
I
P
-------
A
R
-
R
Q
F
T
I
F
D
R
S
W
Y
G
R
V
-
L
V
E
R
I
---
E
G
---
F
C
A
P
A
D
W
L
R
A
Y
G
E
I
N
D
--
F
E
E
Q
L
S
E
Y
G
I
I
V
V
K
F
W
L
A
I
D
K
Q
T
Q
M
E
R
F
K
E
R
E
K
T
P
Y
K
R
Y
K
I
T
E
E
D
W
R
N
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
D
R
T
S
-
T
-------
E
I
A
P
W
T
L
V
E
A
N
D
K
R
F
A
R
-
V
K
V
L
R
T
I
N
D
A
I
E
A
A
Y
K
K
D
-
1
PsiBlast_PDB
94.30
98%
-108
- C3 -
3CZP
11
?
A:
[4-498]
-
F
E
S
A
E
V
G
H
S
I
D
K
D
T
Y
E
K
A
V
I
E
L
R
E
A
L
L
E
A
Q
F
E
L
K
Q
Q
A
----
R
F
P
V
I
I
L
I
N
G
I
E
G
A
G
K
G
E
T
V
K
L
L
N
E
W
M
D
P
-
R
L
I
E
V
Q
S
F
L
R
P
S
D
-----
E
----
E
--------
L
-----
E
----------
R
P
P
--------------------
Q
-----
W
R
-----
F
---
W
R
-----------
R
L
P
P
K
G
R
T
G
I
F
F
G
N
W
Y
S
Q
M
L
Y
A
R
V
E
G
H
I
K
E
A
K
L
D
Q
A
I
D
A
A
E
R
F
E
R
---
M
L
C
D
E
G
A
L
L
F
K
F
W
F
H
L
S
K
K
Q
L
K
E
R
-------------
L
S
P
L
D
W
K
Q
S
E
V
Y
D
R
F
V
H
Y
G
E
R
V
L
R
R
T
S
R
-------
D
Y
A
P
W
Y
V
V
E
G
A
D
E
R
Y
R
A
L
T
V
G
R
I
L
L
E
G
L
Q
A
A
L
A
T
-----------------
D
N
R
G
L
L
D
S
L
D
L
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
I
R
D
K
R
F
R
-----
Q
H
S
------
L
V
A
V
F
E
G
N
D
A
A
G
K
G
G
A
I
R
R
V
T
D
A
L
D
P
R
----
Q
Y
H
I
V
P
I
A
A
P
--
T
E
E
-----
E
--------
R
-
A
---------
Q
--------
P
-------
Y
--------------------
L
-------
W
R
--
F
-----
W
---
R
H
I
P
-------
A
R
-
R
Q
F
T
I
F
D
R
S
W
Y
G
R
V
-
L
V
E
R
I
---
E
G
---
F
C
A
P
A
D
W
L
R
A
Y
G
E
I
N
D
--
F
E
E
Q
L
S
E
Y
G
I
I
V
V
K
F
W
L
A
I
D
K
Q
T
Q
M
E
R
F
K
E
R
E
K
T
P
Y
K
R
Y
K
I
T
E
E
D
W
R
N
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
D
R
T
S
-
T
-------
E
I
A
P
W
T
L
V
E
A
N
D
K
R
F
A
R
-
V
K
V
L
R
T
I
N
D
A
I
E
A
A
Y
K
K
D
K
41
HHSearch
64.13
29%
-79
- C3 -
3CZP
3
?
A:
[266-498]
-----
D
L
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
I
R
D
-
K
R
F
R
----
Q
H
S
L
V
A
V
F
E
G
N
D
A
A
G
K
G
G
A
I
R
R
V
T
D
A
L
D
P
-
R
Q
Y
H
I
V
P
I
A
A
P
T
E
-----
E
----
E
--------
R
-----
A
----------
Q
P
Y
--------------------
L
-----
W
R
-----
F
---
W
R
-----------
H
I
P
A
R
R
Q
F
T
I
F
D
R
S
W
Y
G
R
V
L
V
E
R
I
E
G
F
C
A
P
A
D
W
L
R
A
Y
G
E
I
N
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F
E
E
---
Q
L
S
E
Y
G
I
I
V
V
K
F
W
L
A
I
D
K
Q
T
Q
M
E
R
F
K
E
R
E
K
T
P
Y
K
R
Y
K
I
T
E
E
D
W
R
N
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
D
R
T
S
T
-------
E
I
A
P
W
T
L
V
E
A
N
D
K
R
F
A
R
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K
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R
T
I
N
D
A
I
E
A
A
Y
K
K
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
58.66
27%
-78
- C3 -
3RHF
5
?
A:
[41-274]
----------
G
V
K
A
D
G
K
A
L
L
A
A
Q
D
A
R
L
A
E
L
Q
E
K
L
F
A
E
G
K
F
GN
P
K
R
L
L
L
I
L
Q
A
M
D
T
A
G
K
G
G
I
V
S
H
V
V
G
A
M
D
P
-
Q
G
V
Q
L
T
A
F
K
A
P
T
D
-----
E
----
E
--------
K
-----
S
----------
H
D
F
--------------------
L
-----
W
R
-----
I
---
E
K
-----------
Q
V
P
A
A
G
M
V
G
V
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S
Q
Y
E
D
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L
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V
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G
W
A
D
A
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E
L
E
R
R
Y
A
A
I
N
D
F
E
S
---
R
L
T
E
Q
G
T
T
I
V
K
V
M
L
N
I
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D
E
Q
K
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R
L
I
A
R
L
D
D
P
S
K
H
W
K
Y
S
R
G
D
L
A
E
R
A
Y
W
D
D
Y
M
D
A
Y
S
V
A
F
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K
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S
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-------
E
I
A
P
W
H
V
V
P
A
N
K
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Y
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R
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A
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L
L
L
D
A
L
G
G
L
Q
L
D
W
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
53.51
39%
-66
- C3 -
3RHF
5
?
A:
[42-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
D
G
K
A
L
L
A
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Q
D
A
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A
E
G
K
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GN
P
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R
------
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--
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-----
E
--------
K
-
S
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--------
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-------
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-------
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---
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A
A
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E
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P
A
N
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A
R
-
I
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Q
Q
L
L
L
D
A
L
G
G
L
Q
----
38
HHSearch
53.51
27%
-63
- C3 -
3CZQ
1
?
A:
[49-285]
--
D
D
Y
P
Y
K
K
K
L
D
R
E
E
Y
E
E
T
L
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-
M
Q
A
T
----
G
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M
A
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R
D
A
A
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G
G
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V
A
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K
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-----
T
----
E
--------
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-----
G
----------
Q
W
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--------------------
F
-----
Q
R
-----
Y
---
V
A
-----------
T
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A
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C
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K
E
A
P
R
F
E
E
---
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
T
-------
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
I
N
V
I
R
H
M
L
T
K
L
D
Y
D
G
K
D
E
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
53.16
39%
-68
- C3 -
3RHF
5
?
A:
[47-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
L
A
A
Q
D
A
R
L
A
E
L
-
Q
E
K
L
F
A
-----
E
G
K
F
GNP
K
R
L
L
L
I
L
Q
A
M
D
T
A
G
K
G
G
I
V
S
H
V
V
G
A
M
D
P
Q
----
G
V
Q
L
T
A
F
K
A
P
--
T
D
E
-----
E
--------
K
-
S
---------
H
--------
D
-------
F
--------------------
L
-------
W
R
--
I
-----
E
---
K
Q
V
P
-------
A
A
-
G
M
V
G
V
F
D
R
S
Q
Y
E
D
V
-
L
I
H
R
V
---
H
G
---
W
A
D
A
A
E
L
E
R
R
Y
A
A
I
N
D
--
F
E
S
R
L
T
E
Q
G
T
T
I
V
K
V
M
L
N
I
S
K
D
E
Q
K
K
R
L
I
A
R
L
D
D
P
S
K
H
W
K
Y
S
R
G
D
L
A
E
R
A
Y
W
D
D
Y
M
D
A
Y
S
V
A
F
E
K
T
S
-
T
-------
E
I
A
P
W
H
V
V
P
A
N
K
K
W
Y
A
R
-
I
A
V
Q
Q
L
L
L
D
A
L
--------
2
PsiBlast_PDB
52.51
38%
-63
- C3 -
3CZQ
1
?
A:
[57-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
E
E
Y
E
E
T
L
T
K
L
Q
I
E
L
V
K
V
Q
F
W
M
Q
A
T
-----
G
K
R
------
V
M
A
V
F
E
G
R
D
A
A
G
K
G
G
A
I
H
A
T
T
A
N
M
N
P
R
----
S
A
R
V
V
A
L
T
K
P
--
T
E
T
-----
E
--------
R
-
G
---------
Q
--------
W
-------
Y
--------------------
F
-------
Q
R
--
Y
-----
V
---
A
T
F
P
-------
T
A
-
G
E
F
V
L
F
D
R
S
W
Y
N
R
A
-
G
V
E
P
V
---
M
G
---
F
C
T
P
D
Q
Y
E
Q
F
L
K
E
A
P
R
--
F
E
E
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
-
T
-------
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
-
I
N
V
I
R
--------------
37
HHSearch
50.11
36%
-64
- C3 -
3CZQ
1
?
A:
[47-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
D
D
Y
P
Y
K
K
K
L
D
R
E
E
Y
E
E
T
L
T
K
L
Q
I
E
L
V
K
V
Q
F
W
M
Q
A
T
-----
G
K
R
------
V
M
A
V
F
E
G
R
D
A
A
G
K
G
G
A
I
H
A
T
T
A
N
M
N
P
R
----
S
A
R
V
V
A
L
T
K
P
--
T
E
T
-----
E
--------
R
-
G
---------
Q
--------
W
-------
Y
--------------------
F
-------
Q
R
--
Y
-----
V
---
A
T
F
P
-------
T
A
-
G
E
F
V
L
F
D
R
S
W
Y
N
R
A
-
G
V
E
P
V
---
M
G
---
F
C
T
P
D
Q
Y
E
Q
F
L
K
E
A
P
R
--
F
E
E
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
-
T
-------
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
-
I
N
V
I
R
H
M
L
T
K
L
D
Y
D
G
K
---
53
HHSearch
47.80
14%
-66
- C3 -
1NN5
3
KTHY_HUMAN
A:
[7-207]
------------------------------------------
R
R
G
A
L
I
V
L
E
G
V
D
R
A
G
K
S
T
Q
S
R
K
L
V
E
A
L
C
A
-
A
G
H
R
A
E
L
L
R
F
P
E
R
-----
S
T
E
I
G
K
--------
L
-----
L
----------
S
S
Y
L
Q
KKSDVE
D
H
S
V
H
L
L
F
S
---
A
N
R
W
E
Q
V
P
-----
L
---
I
K
-----------
E
K
L
S
Q
G
V
T
L
V
V
D
R
Y
A
F
S
G
V
A
F
T
G
A
K
E
N
F
-
S
---
L
D
---
W
C
K
Q
P
D
V
---
G
L
P
K
P
D
---
L
V
L
F
L
Q
L
Q
L
A
D
A
A
K
R
-----
E
------
R
---
Y
E
--
N
G
A
F
Q
E
R
A
L
R
C
F
H
Q
L
M
K
D
----------
T
T
L
N
W
K
M
V
D
A
S
K
S
---
I
E
A
V
H
E
D
I
R
V
L
S
E
D
A
I
A
T
A
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
44.17
13%
-61
- C3 -
2V54
1
KTHY_VACCC
A:
[2-190]
------------------------------------------
S
R
G
A
L
I
V
F
E
G
L
D
K
S
G
K
T
T
Q
C
M
N
I
M
E
S
I
P
A
-
N
T
I
K
Y
L
N
F
P
Q
R
S
T
V
T
---
G
----
K
--------
M
I
----
D
D
Y
L
T
RK
K
T
Y
-
N
D
H
I
V
N
L
L
F
C
-------------
A
N
R
W
E
F
A
S
-----
F
---
I
Q
-----------
E
Q
L
E
Q
G
I
T
L
I
V
D
R
Y
A
F
S
G
V
A
Y
A
A
A
K
G
A
--
S
M
T
------
L
S
K
S
Y
E
S
---
G
L
P
K
P
D
---
L
V
I
F
L
E
S
G
S
K
E
I
N
R
N
V
G
-
E
--
E
-----
I
---
Y
E
--
D
V
T
F
Q
Q
K
V
L
Q
E
Y
K
K
M
I
E
E
G
----------
D
I
H
W
Q
I
I
S
S
E
F
E
E
D
V
K
K
E
L
I
K
N
I
V
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
42.88
13%
-50
* C3 *
3TMK
1
KTHY_YEAST
A:
[2-209]
-------------------------------------
M
----
G
R
G
K
L
I
L
I
E
G
L
D
R
T
G
K
T
T
Q
C
N
I
L
Y
K
K
L
Q
P
-
N
C
-
K
L
L
K
F
P
E
R
S
T
R
I
G
--
G
----
L
--------
I
-----
N
E
Y
L
T
D
DSFQL
S
D
Q
A
I
H
L
L
F
S
-------------
A
-----
N
R
W
E
---
I
V
D
K
I
K
-----------
K
D
L
L
E
G
K
N
I
V
M
D
R
Y
V
Y
S
G
V
A
Y
S
A
A
K
G
T
N
-
G
-
M
---
D
L
D
W
C
L
Q
P
D
V
---
G
L
L
K
P
D
---
L
T
L
F
L
S
T
Q
D
V
D
N
N
A
E
K
S
G
F
G
D
E
R
--------
Y
--
E
T
V
K
F
Q
E
K
V
K
Q
T
F
M
K
L
L
D
K
E
I
R
K
------
G
D
E
S
I
T
I
V
D
V
T
N
K
--
G
I
Q
E
V
E
A
L
I
W
Q
I
V
E
P
V
L
S
T
H
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
40.35
18%
-39
- C3 -
1GTV
16
KTHY_MYCTU
A:
[1-198]
---------------------------------------------
M
L
I
A
I
E
G
V
D
G
A
G
K
R
T
L
V
E
K
L
S
G
A
F
R
A
-
A
G
R
S
V
A
T
L
A
F
P
R
Y
GQS
V
A
A
----
D
--------
I
-----
A
----------
A
E
A
L
H
GEHGDLASS
V
Y
A
M
A
T
L
F
A
L
-----
D
R
A
G
A
V
H
T
---
I
Q
-----------
G
L
C
R
G
Y
D
V
V
I
L
D
R
Y
V
A
S
N
A
A
Y
S
A
A
R
L
H
E
--
N
A
A
G
K
A
A
A
W
V
Q
R
I
E
F
ARL
G
L
P
K
P
D
---
W
Q
V
L
L
A
V
S
A
E
L
A
G
E
R
S
R
G
R
A
Q
R
D
P
G
R
A
-
R
D
N
Y
E
-
R
D
A
E
L
Q
Q
R
T
G
A
V
Y
A
E
L
A
A
Q
G
---------
W
G
G
R
W
L
V
V
G
A
D
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
40.26
14%
-51
- C3 -
3TMK
1
KTHY_YEAST
A:
[2-205]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
G
R
G
------
K
L
I
L
I
E
G
L
D
R
T
G
K
T
T
Q
C
N
I
L
Y
K
K
L
Q
P
N
-----
C
--
K
L
L
K
F
P
ER
S
T
R
I
G
---
G
--------
L
-
I
---------
N
--------
E
-------
Y
L
T
D
DSFQLS
D
Q
A
I
H
L
L
F
S
--
A
-------
N
R
--
W
E
I
V
D
K
I
---
K
K
D
L
-------
L
E
-
G
K
N
I
V
M
D
R
Y
V
Y
S
G
V
-
A
Y
S
A
A
---
K
G
---
T
N
-
G
M
----
D
L
D
W
C
L
Q
--
P
D
V
G
L
---
L
K
P
D
L
T
L
F
L
S
T
Q
D
V
D
N
N
A
E
K
S
G
F
G
D
E
R
----------
Y
E
T
V
K
F
Q
E
K
V
K
Q
T
F
M
K
L
L
D
K
E
I
R
K
-------
G
D
E
S
I
T
I
V
D
V
T
N
K
G
--
I
-
Q
E
V
E
A
L
I
W
Q
I
V
E
P
V
L
S
---
50
HHSearch
39.84
16%
-60
- C3 -
2JAQ
1
?
A:
[1-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
I
F
G
T
V
G
A
G
K
S
T
I
S
A
E
I
S
K
K
L
-------
G
Y
E
I
--
F
K
E
P
--
V
E
E
N----
P
--------
Y
-
F
---------
E
--------
Q
-------
Y
YKDLKKT
V
F
K
M
Q
I
Y
M
L
----
T
-------
A
R
--
S
K
Q
---
L
---
K
---------------
N
I
I
F
D
R
T
L
L
E
D
P
-
I
F
M
K
V
---
N
Y
D
L
N
N
V
D
Q
T
D
Y
N
T
Y
I
D
F
Y
N
N
VV
L
E
N
----
K
L
S
F
D
I
V
I
Y
L
R
V
S
T
K
T
A
I
S
R
I
K
K
R
G
R
S
E
E
L
--------
L
I
G
E
E
Y
W
E
T
L
N
K
N
Y
E
E
F
Y
K
Q
N
V
---------
Y
D
F
P
F
F
V
V
D
A
E
L
---
D
V
-
K
T
Q
I
E
L
I
M
N
K
L
N
S
I
-----
49
HHSearch
39.78
13%
-50
- C3 -
2V54
1
KTHY_VACCC
A:
[2-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
G
------
A
L
I
V
F
E
G
L
D
K
S
G
K
T
T
Q
C
M
N
I
M
E
S
I
P
A
N
----
T
I
K
Y
L
--
N
F
P
--
Q
R
S
T
V
T
G
-
K
--------
M
I
D
D
Y
L
T
RK
K
T
Y
N
--------
D
-------
H
--------------------
I
V
N
L
L
F
C
A
N
R
W
E
F
-----
A
S
F
I
Q
E
Q
L
-------
E
Q
-
G
I
T
L
I
V
D
R
Y
A
F
S
G
V
-
A
Y
A
A
A
---
K
G
---
A
--
S
M
T
------
L
S
K
S
--
Y
E
S
G
L
P
---
K
P
D
L
V
I
F
L
E
S
G
S
K
E
I
N
R
N
V
G
-
E
--
E
I
--------
Y
E
--
D
V
T
F
Q
Q
K
V
L
Q
E
Y
K
K
M
I
E
E
-----------
G
D
I
H
W
Q
I
I
S
S
E
F
E
E
D
V
K
-
K
E
L
I
K
N
I
V
I
----------
44
HHSearch
37.75
16%
-43
- C3 -
2OCP
1
DGUOK_HUMAN
A:
[1-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
------
R
R
L
S
I
E
G
N
I
A
V
G
K
S
T
F
V
K
L
L
T
K
T
Y
P
------
E
W
--
H
V
A
T
E
P
--
V
A
T
-----
W
Q
N
IQLGN
L
L
-
D
M
M
Y
R
E
P
AR-
W
--------
S
Y
T
F
Q
T
F
S
F
--------------------
L
-------
S
R
--
L
-----
K
---
V
Q
L
E
PFP
E
K
L
L
Q
A
R
K
P
V
Q
I
F
E
R
S
V
Y
S
D
R
Y
I
F
A
K
N
L
F
E
N
G
---
S
L
S
D
I
E
W
H
I
Y
Q
D
W
H
S
F
--
L
L
W
E
F
A
S
R
I
T
L
H
G
F
I
Y
L
Q
A
S
P
Q
V
C
L
K
R
L
Y
Q
R
A
R
E
E
E
K
-------
G
-
I
E
L
A
Y
L
E
Q
L
H
G
Q
H
E
A
W
L
I
H
K
T
-
T
KLHFEAL
M
N
I
P
V
L
V
L
D
V
N
D
-
D
F
S
E
E
V
T
K
Q
E
D
L
M
R
E
V
N
T
F
V
K
---
54
HHSearch
37.25
13%
-42
- C3 -
3V9P
5
KTHY_BURTA
A:
[23-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
G
------
K
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
W
F
C
D
R
L
Q
E
R
L
G
P
A
G
R
H
V
V
V
T
R
E
P
--
G
G
T
-----
R
L
G
E
T
----
L
-
R
---------
E
I
L
L
N
Q
P
M
D
L
-------
E
T
E
A
L
L
M
F
A
G
R
R
E
H
-------
L
-------
A
L
--
V
-----
I
---
E
P
A
L
-------
A
R
-
G
D
W
V
V
S
D
R
F
T
D
A
T
F
-
A
Y
Q
G
G
---
G
R
---
G
L
P
R
D
K
-------
L
E
A
--
L
E
R
W
V
Q
G
G
F
Q
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
R
G
A
V
R
M
P
----------
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
-----------
A
P
H
R
F
V
I
V
D
S
S
E
P
---
I
-
A
Q
I
R
K
Q
L
E
G
V
L
--------
46
HHSearch
35.95
13%
-35
- C3 -
1P5Z
3
DCK_HUMAN
B:
[23-261]
-------------------------------------------
R
I
K
K
I
S
I
E
G
N
I
A
A
G
K
S
T
F
V
N
I
L
K
Q
L
C
E
D
W
E
V
V
P
E
P
V
A
R
W
C
N
V
QST--------NGGNVLQM
M
YEKPE
R
----------
W
S
F
TFQTYAC-------------
L
-----
S
R
-----
I
RAQ
L
A
SLNGKLKDAEK
P
V
L
F
F
E
R
S
V
Y
S
D
R
Y
I
F
A
S
N
L
Y
E
S
E
C
M
N
--
E
T
E
W
T
I
Y
Q
D
W
H
D
W
M
N
N
QFG
Q
S
L
E
L
D
---
G
I
I
Y
L
Q
A
T
P
E
T
C
L
H
R
I
Y
L
R
G
R
N
E
E
Q
-------
G
-
I
P
L
E
Y
L
E
K
L
H
Y
K
H
E
S
W
L
L
H
R
T
L
KTNFDYL
Q
E
V
P
I
L
T
L
D
V
N
E
D
-
F
K
--
D
K
Y
E
S
L
V
E
K
V
K
E
F
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
35.34
16%
-25
- C3 -
1GTV
16
KTHY_MYCTU
A:
[1-198]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
I
A
I
E
G
V
D
G
A
G
K
R
T
L
V
E
K
L
S
G
A
F
R
A
A
----
G
R
S
V
A
T
L
A
F
P
--
R
Y
G
QS
V
A
A
D
--------
I
-
A
---------
A
--------
E
-------
A
L
H
GEHGDLASS
V
Y
A
M
A
T
L
F
A
L
-------
D
R
--
A
G
A
V
H
T
I
---
Q
G
L
C
-------
R
G
-
Y
D
V
V
I
L
D
R
Y
V
A
S
N
A
-
A
Y
S
A
A
---
R
L
---
H
--
E
N
A
A
G
K
A
A
A
W
V
Q
R
--
I
E
F
A
R
L
G
L
P
K
P
D
W
Q
V
L
L
A
V
S
A
E
L
A
G
E
R
S
R
G
R
A
Q
R
D
P
G
R
A
R
-
D
N
Y
E
-
R
D
A
E
L
Q
Q
R
T
G
A
V
Y
A
E
L
A
A
Q
G
----------
W
G
G
R
W
L
V
V
G
A
D
V
-------------------------