@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3540: (2016-02-18 )
MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLINQGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVSFICVGTPSKKNGDLDLGYIETVCREIGFAIREKSERHTVVVRSTVLPGTVNNVVIPLIEDCSGKKAGVDFGVGTNPEFLRESTAIKDYDFPPMTVIGELDKQTGDLLEEIYRELDAPIIRKTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGREVMDVICQDHKLNLSRYYMRPGFAFGGSCLPKDVRALTYRASQLDVEHPMLGSLMRSNSNQVQKAFDLITSHDTRKVGLLGLSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYARVHGANKEYIESKIPHVSSLLVSDLDEVVASSDVLVLGNGDELFVDLVNKTPSGKKLVDLVGFMPHTTTAQAEGICW
Atome Classification :
(21 SA)
----.........10........20..--.--.....30..----......40.....--...50........60........70........80........---90.-----.-----.......100.......110--........120.......130.--......140.......150.......160.......170.......180---.------.---......190..------.---.--...200------........210.......220.......230.......240.......250.......---260.......270.......280---.--...---.--...290-------.........300.......310-------.--------...--.....320.......330.......340.......350.-......360.......-.--370-...-.--...380.......390.......400..-----...-..-----410.......-.420...--.-.-.---.430....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
ARG--
H
--
E
V
I
G
V
DVSS----
T
K
I
D
L
INQGKSP
I
--
V
E
P
G
L
E
A
L
L
Q
QGRQTGRLSG
T
T
D
F
K
K
A
V
LDSDV
S
F
I
C
VGTPSK---K-N-----G-----DL
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R---EKSER
H
T
V
V
V
R
STVLPGTVN
N
V
--
V
I
P
L
IEDCSGKKAGVDFGVGT
N
P
E
F
L
R
ESTAIKDYDFP
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
EL------D---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
CNVW
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
VGVD
G
R
E
V
M
D
V
I
CQDHKL
N
L
S
R
Y
YMR---PGFAFGGSCL
P
K
D
V
R
A
L
T
YRAS----Q--LDV---E--H
P
M
L
---------
G
S
L
M
RSN
S
N
Q
V
Q
K
A
F
D
L
I
TS---------H--------DT
R
--
K
V
G
L
L
G
L
S
FKAGT
D
D
LRES
P
L
V
E
L
A
E
M
L
IGKG
Y
E
L
R
I
F
D-RNV
E
Y
A
R
-VHGA
N
K
E
Y
-
I
--
E
S
K-I
P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
VASS
D
V
L
V
LGNG
D
E
L
F
V
-----
D
L
V
-NK-----T-PSG
K
K
L
V
D
-
L
V
GFMPH--T-T-T---AQAEGICW-------
22
PsiBlast_CBE
97.90
100%
-120
- C2 -
1MV8
7
ALGD_PSEAE
C:
[1-436]
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
---
E
K
S
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
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T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
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L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
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G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
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L
R
I
F
D
-
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N
V
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Y
A
R
-
V
H
G
A
N
K
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Y
-
I
--
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S
K
-
I
P
H
-
V
--
S
S
L
L
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D
L
D
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V
V
A
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S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
1
PsiBlast_PDB
97.80
100%
-120
- C2 -
1MV8
4
ALGD_PSEAE
A:
[1-436]
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
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A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
---
E
K
S
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
-
R
N
V
E
Y
A
R
-
V
H
G
A
N
K
E
Y
-
I
--
E
S
K
-
I
P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
23
PsiBlast_CBE
97.54
100%
-119
- C2 -
1MV8
5
ALGD_PSEAE
B:
[1-436]
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
---
E
K
S
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
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I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
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P
L
V
E
L
A
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L
I
G
K
G
Y
E
L
R
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N
V
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A
R
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V
H
G
A
N
K
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Y
-
I
--
E
S
K
-
I
P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
21
PsiBlast_CBE
97.41
100%
-117
- C2 -
1MV8
5
ALGD_PSEAE
D:
[1-436]
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
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P
I
--
V
E
P
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A
L
L
Q
Q
G
R
Q
T
G
R
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G
T
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D
F
K
K
A
V
L
D
S
D
V
S
F
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V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
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V
C
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G
F
A
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R
---
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K
S
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P
G
T
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N
N
V
--
V
I
P
L
I
E
D
C
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G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
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S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
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G
N
I
A
K
A
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V
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R
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V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
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L
V
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L
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L
I
G
K
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N
V
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H
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A
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K
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Y
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I
--
E
S
K
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P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
3
PsiBlast_PDB
96.87
98%
-117
- C2 -
1MUU
4
ALGD_PSEAE
A:
[2-436]
-----
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
---
E
K
S
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
-
R
N
V
E
Y
A
R
-
V
H
G
A
N
K
E
Y
-
I
--
E
S
K
-
I
P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
60
HHSearch
96.83
99%
-119
- C2 -
1MV8
4
ALGD_PSEAE
A:
[1-436]
----
M
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
EKS
E
R
---
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
D-----
A
---
P
--
I
I
-
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
-
R
N
V
E
Y
A
R
-
V
H
G
A
N
K
E
Y
-
I
--
E
S
K
-
I
P
H
-
V
S
S
L
-
L
-
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
T
T
-----
A
Q
A
E
G
I
C
W
-------
2
PsiBlast_PDB
96.64
98%
-118
- C2 -
1MFZ
2
ALGD_PSEAE
A:
[2-436]
-----
R
I
S
I
F
G
L
G
Y
V
G
A
V
C
A
G
C
L
S
A
R
G
--
H
--
E
V
I
G
V
D
V
S
S
----
T
K
I
D
L
I
N
Q
G
K
S
P
I
--
V
E
P
G
L
E
A
L
L
Q
Q
G
R
Q
T
G
R
L
S
G
T
T
D
F
K
K
A
V
L
D
S
D
V
S
F
I
C
V
G
T
P
S
K
---
K
-
N
-----
G
-----
D
L
D
L
G
Y
I
E
T
V
C
R
E
I
G
F
A
I
R
---
E
K
S
E
R
H
T
V
V
V
R
S
T
V
L
P
G
T
V
N
N
V
--
V
I
P
L
I
E
D
C
S
G
K
K
A
G
V
D
F
G
V
G
T
N
P
E
F
L
R
E
S
T
A
I
K
D
Y
D
F
P
P
M
T
V
I
G
E
L
D
K
----
Q
------
T
---
G
D
L
L
E
E
I
Y
R
E
L
------
D
---
A
--
P
I
I
R
K
-------
T
V
E
V
A
E
M
I
K
Y
T
C
N
V
W
H
A
A
K
V
T
F
A
N
E
I
G
N
I
A
K
A
V
G
V
D
G
R
E
V
M
D
V
I
C
Q
D
H
K
L
N
L
S
R
Y
Y
M
R
---
P
G
F
A
F
G
G
S
C
L
P
K
D
V
R
A
L
T
Y
R
A
S
----
Q
--
L
D
V
---
E
--
H
P
M
L
---------
G
S
L
M
R
S
N
S
N
Q
V
Q
K
A
F
D
L
I
T
S
---------
H
--------
D
T
R
--
K
V
G
L
L
G
L
S
F
K
A
G
T
D
D
L
R
E
S
P
L
V
E
L
A
E
M
L
I
G
K
G
Y
E
L
R
I
F
D
-
R
N
V
E
Y
A
R
-
V
H
G
A
N
K
E
Y
-
I
--
E
S
K
-
I
P
H
-
V
--
S
S
L
L
V
S
D
L
D
E
V
V
A
S
S
D
V
L
V
L
G
N
G
D
E
L
F
V
-----
D
L
V
-
N
K
-----
T
-
P
S
G
K
K
L
V
D
-
L
V
G
F
M
P
H
--
T
-
T
-
T
---
A
Q
A
E
G
I
C
W
-------
58
HHSearch
76.77
36%
-94
- C2 -
3VTF
2
?
A:
[22-443]
----
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
--
H
--
R
V
V
G
Y
D
V
N
P
----
S
I
V
E
R
L
R
A
G
R
P
H
I
--
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
---
P
-
D
-----
G
-----
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
---
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
--
V
A
R
A
V
A
E
--
E
-
A
G
G
V
K
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
E
----
R
------
A
---
A
S
F
L
L
D
V
Y
K
A
V
------
D
---
A
--
P
K
L
V
M
-------
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
--
I
G
R
H
Y
F
G
---
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
----
S
--
L
G
L
---
E
--
M
A
I
S
---------
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
E
---------
R
L
GGL----
R
G
R
--
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
-
P
M
A
M
E
K
A
-
R
A
V
L
------------
G
D
S
-
V
--
T
-
Y
-
V
E
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
-----
G
L
D
----------
Y
R
G
K
V
V
V
D
-
G
R
Y
V
K
K
A
--
R
-
E
-
A
---
K
I
Y
E
G
V
A
W
-------
62
HHSearch
74.02
30%
-86
- C2 -
3GG2
4
?
A:
[3-436]
----
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
----
N
K
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
---
E
-
D
-----
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
---
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
--
R
K
A
I
Q
E
E
L
D
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
D
----
R
------
A
---
R
E
L
I
T
S
L
Y
K
P
M
L-----
L
---
N
NF
R
V
L
F
M
-------
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
--
I
G
S
K
F
L
Y
---
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
----
D
--
N
G
Y
---
R
--
M
E
V
L
---------
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
T
---------
Y
Y
K
GNV---
Q
G
R
--
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
-
P
V
A
M
K
E
A
-
Q
K
R
L
------------
G
D
K
-
V
--
E
-
Y
-
T
T
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
-----
M
P
D
W
S
A
L
S
Q
--
A
-
M
A
A
S
L
V
I
D
-
G
R
N
V
Y
E
L
--
P
-------
F
T
L
L
N
I
G
--------
4
PsiBlast_PDB
72.95
39%
-88
- C2 -
3VTF
1
?
A:
[24-392]
------
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
--
H
--
R
V
V
G
Y
D
V
N
P
----
S
I
V
E
R
L
R
A
G
R
P
H
I
--
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
---
P
-
D
-----
G
-----
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
---
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
--
V
A
R
A
V
A
E
E
A
G
---
G
V
K
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
E
----
R
------
A
---
A
S
F
L
L
D
V
Y
K
A
V
------
D
---
A
--
P
K
L
V
M
-------
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
--
R
H
Y
F
G
---
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
----
S
--
L
G
L
---
E
--
M
A
I
S
---------
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
E
---------
R
L
GGL----
R
G
R
--
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
M
A
M
E
K
A
R
A
V
L
G
D
S
V
T
Y
-
V
--
E
-------------------------------------------------------------------------------------------------
55
HHSearch
71.59
31%
-82
- C2 -
2Y0C
11
?
A:
[9-459]
----
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
---
E
-
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
---
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
--
R
A
A
V
A
E
E
L
A
K
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
R
------
A
---
R
E
L
M
K
K
L
Y
A
P
F
N-----
R
NH-
E
--
R
T
L
Y
M
-------
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
--
I
G
Y
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
----
E
--
H
G
Q
---
S
--
L
Q
I
L
---------
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
A
---------
R
FGEDL---
T
G
R
--
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
-
P
V
A
Q
E
E
A
-
R
R
V
I
A
L
D
L
-
A
DH
P
S
W
-
L
E
R
-
L
--
S
-
F
-
V
D
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
-----
S
P
D
F
V
A
L
G
R
--
L
-
W
K
T
P
V
I
F
D
-
G
R
N
L
Y
E
P
--
E
-
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
-------
11
PsiBlast_PDB
70.77
27%
-85
- C2 -
4XR9
3
?
A:
[16-414]
----
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
L
A
V
T
L
A
G
R
G
--
A
--
E
V
V
A
V
D
S
D
P
----
G
T
V
A
D
L
R
A
G
R
C
R
L
--
P
E
P
G
L
A
G
A
V
R
D
L
A
A
T
G
R
L
T
A
S
T
S
Y
D
P
-
V
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
---
A
-
G
-----
H
-----
E
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
---
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
L
--
V
A
P
L
L
E
S
-
G
G
L
V
H
E
R
D
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
-
V
V
G
G
C
G
P
----
R
------
S
---
A
A
A
A
E
R
F
W
R
S
A
------
L
---
G
--
V
D
V
R
Q
V
P-----
S
A
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
---
V
L
D
V
I
G
A
A
N
T
L
P
K
G
S
S
M
V
N
LLL
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
R
----
D
--
R
G
V
---
S
--
L
R
T
V
---------
E
T
A
R
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
GRDR
N
--------
D
T
---
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
R
D
S
G
F
R
V
R
I
F
D
-
P
L
A
D
P
A
E
-
I
---------------
V
A
R
-
F
--
G
T
A
P
A
A
S
L
D
E
A
V
S
G
A
G
C
L
A
F
L
A
G
H
R
Q
F
H
-----
E
L
----------------------------------------------------
59
HHSearch
70.43
26%
-83
- C2 -
2Q3E
3
UGDH_HUMAN
A:
[6-465]
----
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
PE
I
--
R
V
T
V
V
D
V
N
E
----
S
R
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C
R
-
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
---
T
-
Y
GMGKG
R
-----
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
---
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
--
R
R
I
F
D
A
N
--
T
-
K
P
N
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
T
P
E
G
Q
R
------
A
---
V
Q
A
L
C
A
V
Y
E
H
W
V-----
P
R--
E
--
K
I
L
T
T
-------
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
--
I
G
N
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
----
A
--
L
N
L
---
P
E
V
A
R
Y
W
---------
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
---------
S
L
FNTV---
T
D
K
--
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
-
P
K
V
P
R
E
Q
-
I
V
V
D
L
S
H
------
D
Q
V
S
R
L
-
V
--
T
-
I
-
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
-----
E
L
D
Y
E
R
I
H
K
K
-
M
-
L
K
P
A
F
I
F
D
-
G
R
R
V
L
D
G
L
H
N
-
E
L
Q
T
I
G
F
Q
I
E
T
I
G
K
-------
57
HHSearch
68.48
27%
-83
- C2 -
2O3J
4
UGDH_CAEEL
A:
[10-467]
----
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
PH
I
--
T
V
T
V
V
D
M
N
T
----
A
K
I
A
E
W
N
S
D
K
L
P
I
--
Y
E
P
G
L
D
E
I
V
F
A
A
R
-
G
R
N
L
F
F
S
S
D
I
P
K
A
I
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
---
M
-
Y
-----
G
RGKGM
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
P
---
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
--
G
C
I
L
R
E
A
--
Q
K
---
L
K
F
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
E
S
S
P
---
E
G
L
Q
---
A
---
V
A
E
L
V
R
I
Y
E
N
W
VP----
R
---
N
--
R
I
I
T
T
-------
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
--
I
G
S
K
F
L
Q
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
E
----
S
--
L
N
L
---
P
Q
V
A
D
Y
W
---------
Q
G
V
I
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
---------
E
L
FNTV---
T
D
K
--
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
M
E
E
H
A
K
L
S
V
Y
D
-
P
K
V
Q
K
S
Q
-
M
L
N
D
L
A
S
V
T
S
--
A
Q
D
-
V
E
R
L
I
--
T
-
V
-
E
S
D
P
Y
A
A
A
R
G
A
H
A
I
V
V
L
T
E
W
D
E
F
V
-----
E
L
N
Y
S
Q
I
H
N
--
D
M
Q
H
P
A
A
I
F
D
-
G
R
L
I
L
D
Q
--
K
-
A
L
R
E
I
G
F
R
T
F
A
I
G
T
-------
45
Fugue
67.54
26%
-78
* C2 *
2Q3E
3
UGDH_HUMAN
A:
[2-467]
MFEI
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
--
P
E
I
R
V
T
V
V
D
V
N
E
----
S
R
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C
R
G
-
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
---
T
-
Y
-----
G
MGKGR
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
------
N
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
--
R
R
I
F
D
A
N
---
T
K
P
N
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
T
----
P
------
E
---
G
Q
R
A
V
Q
A
L
C
A
V
Y
E
H
WVP
R
---
E
--
K
I
L
T
T
-------
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
--
N
K
F
L
K
---
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
----
A
L
N
L
P
E
---
V
--
A
R
Y
W
---------
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
---------
S
L
FNTV---
T
D
K
--
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
-
P
K
V
P
-----
R
E
Q
I
V
V
D
-
L
--
S
H
D
-
Q
V
S
-
R
--
L
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
LD
Y
E
R
I
H
-
K
K
-----
M
-
L
K
P
A
F
I
F
D
G
R
R
V
L
D
G
L
--
H
-
N
-
E
---
L
Q
T
I
G
F
Q
I
E
T
I
GKKV
64
HHSearch
66.94
24%
-88
- C2 -
1DLJ
8
UDG_STRPY
A:
[1-393]
----
M
K
I
A
V
A
G
S
G
Y
V
G
L
S
L
G
V
L
L
S
-
L
Q
--
N
--
E
V
T
I
V
D
I
L
P
----
S
K
V
D
K
I
N
N
G
L
S
P
I
--
Q
D
E
Y
I
E
Y
Y
L
K
S
K
--
Q
L
S
I
K
A
T
L
D
S
K
A
A
Y
K
E
A
E
L
V
I
I
A
T
P
T
N
Y
N
---
S
-
R
I----
N
-----
Y
F
D
T
Q
H
V
E
T
V
I
K
E
V
L
S
V
-
N
---
S
H
---
A
T
L
I
I
K
S
T
I
P
I
G
F
I
T
E
M
--
R
Q
K
F
Q
----------
T
D
R
I
I
F
S
P
E
F
L
R
E
S
K
A
L
Y
D
N
L
Y
P
S
R
I
I
V
S
C
E
E
N
----
D
S
P
K
V
K
A
D
---
A
E
K
F
A
L
L
L
K
S
A
A-----
K
KN
N
V
--
P
V
L
I
M
-------
G
A
S
E
A
E
A
V
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
T
Y
A
E
S
R
K
L
N
S
H
M
I
I
Q
G
I
S
Y
D
D
R
--
I
G
M
H
Y
N
N
---
P
S
F
G
Y
G
G
Y
S
L
P
K
D
T
K
Q
L
L
A
--
N
----
Y
--
N
N
I
---
P
--
Q
T
L
I
---------
E
A
I
V
S
S
N
N
V
R
K
S
Y
I
A
K
Q
I
I
N
---------
V
L
K
E
QES--
P
V
K
--
V
V
G
V
Y
R
L
I
M
K
S
N
S
D
N
F
R
E
S
A
I
K
D
V
I
D
I
L
K
S
K
D
I
K
I
I
I
Y
E
-
P
M
L
N
K
L
E
-
S
E
D
Q
----------------
S
--
V
-
L
-
V
N
D
L
E
N
F
K
K
Q
A
N
I
I
V
T
N
R
Y
D
N
E
L
Q
-----
D
V
K
N
K
V
------------------------------------------------
61
HHSearch
66.91
25%
-89
- C2 -
3G79
-
?
A:
[19-470]
----
K
K
I
G
V
L
G
M
G
Y
V
G
I
P
A
A
V
L
F
A
D
A
P
CF
E
--
K
V
L
G
F
Q
R
N
S
KSS
G
Y
K
I
E
M
L
N
R
G
E
S
P
L
K
G
E
E
P
G
L
E
E
L
I
G
K
V
V
K
A
G
K
F
E
C
T
P
D
F
-
S
R
I
S
E
L
D
A
V
T
L
A
I
Q
T
P
F
A
---
N
-
P
KD---
L
-----
E
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L
K
---
P
G
---
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
M
--
A
K
Q
I
L
E
E
E
S
G
L
K
A
G
E
D
F
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
V
G
G
I
-
D
E
----
A
------
S
---
T
K
R
A
V
E
L
Y
S
P
V
L-----
T
V--
G
--
Q
V
I
P
M
-------
S
A
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
R
T
G
V
D
S
L
K
G
E
G
I
T
R
A
V
L
W
---
P
G
A
G
V
G
G
H
C
L
T
K
D
T
Y
H
L
E
R
G
V
K
IGR
G
E
--
L
D
Y
P
E
G
A
--
D
S
I
Y
---------
V
L
A
R
K
V
N
D
F
M
P
A
H
M
Y
N
L
T
V
A
---------
A
L
E
R
L
GKKM
D
G
S
--
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
E
P
Y
R
D
L
C
L
K
A
G
A
S
V
M
V
H
D
-
P
Y
V
V
N
Y
P
-
G
-------------------
V
--
E
-
I
-
S
D
N
L
E
E
V
V
R
N
A
D
A
I
V
V
L
A
G
H
S
A
Y
S
-----
S
L
K
A
D
W
A
K
K
V
S
A
-
K
A
N
P
V
I
I
D
-
G
R
N
V
I
E
P
--
D
-
E
F
I
G
K
G
F
V
Y
K
G
I
G
R
-------
6
PsiBlast_PDB
66.91
35%
-80
- C2 -
2Y0E
10
?
A:
[9-368]
----
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
---
E
-
D
-----
G
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
---
R
---
Y
M
T
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
--
R
A
A
V
A
E
E
L
A
K
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
----
V
------
P
---
G
E
R
A
R
E
L
M
K
K
L
------
Y
---
A
--
P
F
N
R
N
HER
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
--
H
F
L
Y
---
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
----
E
--
H
G
Q
---
S
--
L
Q
I
L
---------
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
A
---------
R
FGEDL---
T
G
R
--
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
-----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.79
26%
-77
- C2 -
3PJG
3
?
A:
[37-414]
----
M
K
I
T
I
S
G
T
G
Y
V
G
-
L
S
N
G
V
L
I
A
Q
N
--
H
--
E
V
V
A
L
D
I
V
Q
----
A
K
V
D
M
L
N
Q
K
I
S
P
I
--
V
D
K
E
I
Q
E
Y
L
A
E
K
P
L
N
F
R
--
A
T
T
D
K
H
D
A
Y
R
N
A
D
--
Y
V
I
I
A
T
P
T
D
YDP
K
-
T
-----
N
-----
Y
F
N
T
S
T
V
E
A
V
I
R
D
V
T
-------
E
I
N
P
N
A
V
M
I
I
K
S
T
I
P
V
G
F
T
R
D
I
-----------
K
E
R
L
G
I
D
-
N
V
I
F
S
P
E
F
L
R
E
G
R
A
L
Y
D
N
L
H
P
S
R
I
V
I
G
E
R
S
A
----
R
------
A
E
R
F
A
D
L
L
K
E
G
A
I
K
Q
------
D
---
I
--
P
T
L
F
T
-------
D
S
T
E
A
E
A
I
K
L
F
A
N
T
Y
L
A
L
R
V
A
Y
F
N
E
L
D
S
Y
A
E
S
Q
G
L
N
S
K
Q
I
I
E
G
V
C
L
D
P
R
--
I
G
N
H
Y
N
N
---
P
S
F
G
Y
G
G
Y
C
L
P
K
D
T
K
Q
L
L
--
A
N
----
Y
--
E
S
V
---
P
--
N
N
I
I
---------
A
A
I
V
D
A
N
R
T
R
K
D
F
I
A
D
S
I
L
A
---------
R
--------
K
P
K
--
V
V
G
V
Y
R
L
I
M
K
S
G
S
D
N
F
R
A
S
S
I
Q
G
I
M
K
R
I
K
A
K
G
I
P
V
I
I
Y
E
-
P
V
M
Q
--------
E
D
E
F
-
F
--
N
S
R
-
V
----------
V
R
D
L
N
A
F
K
Q
E
A
D
V
I
I
S
N
R
M
A
E
E
L
A
-----
D
V
A
-
D
K
------------------------------------------------
7
PsiBlast_PDB
66.70
33%
-78
- C2 -
3GG2
4
?
A:
[5-362]
------
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
----
N
K
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
A
G
---
E
-
D
-----
G
-----
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
---
R
---
A
M
S
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
--
R
K
A
I
Q
E
E
L
D
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
D
----
R
------
A
---
R
E
L
I
T
S
L
Y
K
P
M
LLN---
N
---
F
--
R
V
L
F
M
-------
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
--
F
L
Y
---
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
----
D
--
N
G
Y
---
R
--
M
E
V
L
---------
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
T
---------
Y
Y
K
GNV---
Q
G
R
--
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
-----------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.02
37%
-68
- C2 -
4A7P
1
?
A:
[9-381]
----
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
--
H
--
E
V
V
C
V
D
K
D
A
----
R
K
I
E
L
L
H
Q
N
V
M
P
I
--
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
S
R
---
R
G
D
-----
G
-----
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
---
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
E
R
I
I
A
E
V
A
P
N
S
G
A
K
------
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
E
----
F
------
A
---
R
Q
V
M
R
E
I
Y
R
P
L
S------------
P
V
L
F
T
-------
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
---
P
G
--
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
--------
D
N
---
E
--
T
P
L
R
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
K
A
----
M
G
---------
G
--------
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
E
G
V
E
Q
A
S
-
K
M
L
T
D
V
E
F
-
V
--
E
N
------------------------------------------------------------------------------------------------