@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3972: (2016-02-22 )
MNLHQYAETHEVTNQVPSLDGANLYRLDLPLQEWVRRYQGGWAEERLQRYGELAGGPLMAAGFLANQHKPEFHSHDRYGNRVDLVEFHPAYHELMRAAIEHELPSLPWTDPRPGAQVARAGLSYLHSQAEAGTGCPLTMTYASVPAIRLQADLAEKWLPKILSREYDPRNVPMEQKAGVTIGMAMTEKQGGTDVRANTTRAYPVGIPGPGQAYELVGHKWFCSAPMCDAFLTLAYTDKGLTCFLLPRHRPDGSRNQFYIQRLKDKLGNWSNASSEIEYRGALAWMVGEEGRGVPTIIEMVAMTRFDCMIGSSALMRQALTQAAHHCAYRKVGGRVLAEQPLMQNVLADLALESEAALALTLRMGHALDRAHDEQEEKFARLVTAVGKYWICKRAPAMINEASECMGGAGYVEETILPRLYREAPVNSIWEGSGNVQCLDVLRALSKEPGVLDALFAELGDGHGDARLAAHIGNLKAAFADTADIQYRARQLTEDVAIALQAKLLLEAGNSAVSDAFIGSRLGDGGRVYGTLPRGVEVEALLARATPHLT
Atome Classification :
(20 SA)
-----.........10........20........30.......----.40........50.-...-.-...60........70........80........90........100.......-110----...--...---.-.120.......130......-.140----....--------...-----150....--.....160.......170.......180.......190....-...200.......210.......-220....-...230....----------.-----.-----.240...-....250.......260.......270....---...280---.---......290.......300.......310.......320.......330.......340.......350.......360.......370----.----........--380.......390.......400.......410.......420.......430.......440.......450.......460-------...-----......470.......480......---------------.490.......500....-...510---.......520.......530...-....540.......---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
N
L
H
Q
Y
A
E
T
H
E
V
T
NQVPSLDGA
N
L
Y
R
LDL
P
L
Q
E
W
V
R
R
Y----QGG
W
A
E
E
R
L
Q
R
Y
G
E
-LAG-G-
P
L
M
A
A
G
F
LANQHKPEFHSHDRYGNR
V
D
L
VEF
H
P
A
Y
H
E
L
M
R
A
A
I
E
HELPSLPWT-DP-----RP
G
--
A
Q
V
---
A
-
R
A
G
L
S
Y
L
H
S
QAEAGTGC
P
L
T
-
M
T
YA----SV
P
A
--------
I
R
L
-----
Q
--
A
D
L
A
--
E
K
W
L
P
K
I
L
SREYDPRNVP
M
E
QKA
G
V
T
I
G
M
A
M
TEKQGGTDVRA-NTTRAYPVGIPGP
G
Q
A
Y
E
LVG
H
K
-
W
FCSAP
M
-
C
D
A
F
L
T
L
A
Y
T----------D-----K-----G
L
T
C
F
L
L
-PRHRPDGSR
N
Q
F
Y
I
Q
R
L
K
D
KLGNWSNASS
E
I
---
E
Y
R
G
A
L
---
A
---
W
M
VGEEGRG
V
P
T
I
I
E
M
V
A
M
T
R
F
D
C
MI
G
S
S
A
L
M
R
Q
A
L
T
Q
A
A
H
H
C
A
Y
R
K
VG
G
R
V
L
A
E
Q
P
L
M
Q
N
V
L
A
D
L
ALESE
A
A
L
A
L
T
L
RMGHALDRA------
H
----
D
E
Q
E
E
K
F
A
--
R
L
V
T
A
V
G
K
Y
W
I
CKRA
P
A
M
I
N
E
A
S
E
CMGGA
G
Y
V
E
E
T
I
L
P
R
L
Y
R
EAPV
N
S
IWEGSGNV
Q
C
L
D
V
L
R
A
LSKEP
G
V
L
D
A
L
F
A
E
LGD---------GHG-----
D
A
R
L
A
A
H
IGN
L
K
A
AFADTA
D
I
Q
Y
R
A
---------------
R
Q
L
T
E
D
V
A
I
A
L
Q
A
K
L
L
L
E-AGNS
A
V
---
S
D
A
F
I
GSRLGDG
G
R
V
Y
GTLPRGV-
E
V
E
A
L
L
A
RATPHLT---------------------------
52
Fugue
99.04
44%
-77
- C2 -
3DJL
2
AIDB_ECOLI
A:
[3-540]
-----------
W
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
-
Q
L
G
T
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
L
Q
M
----
L
--
P
A
P
F
--
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
E
----
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
Q----
D
R
Y
F
D
R
A
V
R
R
L
Q
Q
Q
L
R
K
P
A
--
E
E
L
G
---------------
R
E
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
-
Y
A
S
P
P
M
---
A
Q
A
W
C
Q
V
M
L
D
T
R
G
---
G
V
R
L
S
E
Q
-
I
Q
N
D
L
L
L
R
A
T
G
G
V
C
---------------------------
2
PsiBlast_PDB
88.84
48%
-78
- C2 -
3U33
4
AIDB_ECOLI
A:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
88.59
48%
-79
- C2 -
3U33
3
AIDB_ECOLI
E:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.37
48%
-77
- C2 -
3U33
2
AIDB_ECOLI
H:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
88.29
48%
-79
- C2 -
3U33
4
AIDB_ECOLI
C:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
88.20
42%
-72
- C2 -
3DJL
2
AIDB_ECOLI
A:
[4-539]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
-
Q
L
G
-
T
A
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
-
E
D
-----
A
R
S
--
G
A
F
---
V
A
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
L
L
Q
M
LPAP
F
Q
D
-----
W
T
T
P
L
L
S
--
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
---------
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
Q----
D
R
Y
F
D
R
A
V
R
R
L
Q
Q
Q
L
R
--
K
P
A
E
E
L
G
---------------
R
E
I
T
H
Q
L
F
L
L
G
C
G
A
Q
M
L
K
-
Y
A
S
P
P
M
---
A
Q
A
W
C
Q
V
M
L
D
T
R
----
G
G
V
R
L
S
E
Q
I
Q
N
D
L
L
L
R
A
T
G
G
V
----------------------------
27
PsiBlast_CBE
88.09
48%
-77
- C2 -
3U33
4
AIDB_ECOLI
F:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.62
48%
-78
- C2 -
3U33
10
AIDB_ECOLI
K:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.61
48%
-77
- C2 -
3DJL
2
AIDB_ECOLI
A:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
87.59
48%
-77
- C2 -
3U33
4
AIDB_ECOLI
B:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.33
48%
-78
- C2 -
3U33
3
AIDB_ECOLI
G:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
87.25
48%
-76
- C2 -
3U33
4
AIDB_ECOLI
D:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.21
48%
-77
- C2 -
3U33
10
AIDB_ECOLI
L:
[4-461]
------------
Q
T
H
T
V
F
N
Q
P
I
P
L
N
N
S
N
L
Y
L
S
D
G
A
L
C
E
A
V
T
R
E
----
G
A
G
W
D
S
D
F
L
A
S
I
G
Q
Q
L
G
T
-
A
-
E
S
L
E
L
G
R
L
A
N
V
N
P
P
E
L
L
R
Y
D
A
Q
G
R
R
L
D
D
V
R
F
H
P
A
W
H
L
L
M
Q
A
L
C
T
N
R
V
H
N
L
A
W
E
E
D
A
-----
R
S
G
--
A
F
V
---
A
-
R
A
A
R
F
M
L
H
A
Q
V
E
A
G
S
L
C
P
I
T
-
M
T
F
A
----
A
T
P
L
--------
L
-
L
-----
Q
--
M
L
P
A
PF
Q
D
W
T
T
P
L
L
S
D
R
Y
D
S
H
L
L
P
G
G
Q
K
R
G
L
L
I
G
M
G
M
T
E
K
Q
G
G
S
D
V
M
S
-
N
T
T
R
A
E
R
L
----
E
D
G
S
Y
R
L
V
G
H
K
-
W
F
F
S
V
P
Q
-
S
D
A
H
L
V
L
A
Q
T
----------
A
-----
G
-----
G
L
S
C
F
F
V
-
P
R
F
L
P
D
G
Q
R
N
A
I
R
L
E
R
L
K
D
K
L
G
N
R
S
N
A
S
C
E
V
---
E
F
Q
D
A
I
---
G
---
W
L
L
G
L
E
G
E
G
I
R
L
I
L
K
M
G
G
M
T
R
F
D
C
A
L
G
S
H
A
M
M
R
R
A
F
S
L
A
I
Y
H
A
H
Q
R
H
V
F
G
N
P
L
I
Q
Q
P
L
M
R
H
V
L
S
R
M
A
L
Q
L
E
G
Q
T
A
L
L
F
R
L
A
R
A
W
D
R
R
------
A
----
D
A
K
E
A
L
W
A
--
R
L
F
T
P
A
A
K
F
V
I
C
K
R
G
M
P
F
V
A
E
A
M
E
V
L
G
G
I
G
Y
C
E
E
S
E
L
P
R
L
Y
R
E
M
P
V
N
S
I
W
E
G
S
G
N
I
M
C
L
D
V
L
R
V
L
N
K
Q
A
G
V
Y
D
L
L
S
E
A
F
V
E
---------
V
K
G
-----
Q
D
R
----------------------------------------------------------------------------------------------------------------------------------
53
Fugue
80.75
29%
-75
- C2 -
4Y9J
4
?
A:
[1-592]
TITAR
H
T
Q
Y
S
H
A
K
T
G
G
F
S
Q
T
G
P
T
L
H
--
N
P
Y
K
D
D
P
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
-
R
I
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
-
D
S
-----
V
D
P
F
V
R
R
I
---
H
-
Q
V
A
K
L
F
L
F
S
P
S
A
G
L
V
S
C
P
M
A
-
M
T
D
G
----
A
V
K
T
--------
L
T
S
L
NLYG
K
--
H
K
L
A
--
T
E
A
V
D
R
L
R
S
R
--
D
P
S
K
A
W
-------
T
S
G
Q
W
M
T
E
K
K
G
G
S
D
V
A
G
G
C
D
T
Y
A
V
Q
I
D
----
K
D
T
Y
R
L
H
G
Y
K
-
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
SDG
N
A
L
E
G
S
-----
R
-----
G
L
S
L
F
L
L
-
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
---
L
L
D
G
A
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
------
E
A
GKS
S
D
V
E
A
M
M
L
--
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
S
G
K
E
N
I
L
L
A
F
G
K
R
V
E
Q
---------
L
L
G
NTKTE
D
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
A
S
DSAIQGETRIDSV
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
D
S
S
V
AN
Q
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
P
L
I
D
L
R
W
E
W
F
-
A
S
E
R
V
K
A
D
R
E
I
V
F
D
NFT------------------------
3
PsiBlast_PDB
74.77
30%
-75
- C2 -
4Y9J
4
?
A:
[32-514]
---------------------
P
I
L
D
-
R
T
L
R
R
L
-
L
P
E
S
E
Y
M
R
----------
V
A
A
D
L
S
K
F
G
D
-
R
I
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
-
D
S
VD
P
F
V
R
R
I
--
H
Q
V
---
A
-
K
L
---
F
L
F
S
P
S
A
G
L
V
S
C
P
M
A
-
M
T
D
G
----
A
V
K
T
--------
L
T
S
L
NLYG
K
--
H
K
L
A
--
T
E
A
V
D
R
L
R
S
R
--
D
P
S
K
-------
A
W
T
S
G
Q
W
M
T
E
K
K
G
G
S
D
V
-
A
-
G
G
C
D
T
Y
A
V
Q
I
D
K
--
D
T
Y
R
L
H
G
Y
K
-
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
SDG
N
A
L
E
G
S
-----
R
-----
G
L
S
L
F
L
L
-
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
---
L
L
D
G
A
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
------
E
A
GKS
S
D
V
E
A
M
M
L
--
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
S
G
K
E
N
I
L
L
A
F
-----------------------
G
K
R
V
E
Q
L
L
G
N
T
K
-----
T
E
D
E
K
L
K
K
---------------
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
-
A
S
D
S
A
I
--------------------------------------------------------------------
4
PsiBlast_PDB
73.51
30%
-75
- C2 -
4Y9L
2
?
A:
[32-514]
---------------------
P
I
L
D
-
R
T
L
R
R
L
-
L
P
E
S
E
Y
M
R
----------
V
A
A
D
L
S
K
F
G
D
-
R
I
T
-
S
-
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
R
V
D
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
-
D
S
VD
P
F
V
R
R
I
--
H
Q
V
---
A
-
K
L
---
F
L
F
S
P
S
A
G
L
V
S
C
P
M
A
-
M
T
D
G
----
A
V
K
T
--------
L
T
S
L
NLYG
K
--
H
K
L
A
--
T
E
A
V
D
R
L
R
S
R
--
D
P
S
K
-------
A
W
T
S
G
Q
W
M
T
E
K
K
G
G
S
D
V
-
A
-
G
G
C
D
T
Y
A
V
Q
I
D
K
--
D
T
Y
R
L
H
G
Y
K
-
W
F
S
S
A
V
D
-
A
D
V
A
L
T
L
A
R
I
V
D
SDG
N
A
L
E
G
S
-----
R
-----
G
L
S
L
F
L
L
-
K
I
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
---
L
L
D
G
A
I
---
A
---
E
R
I
G
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
------
E
A
GKS
S
D
V
E
A
M
M
L
--
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
V
F
S
G
K
E
N
I
L
L
A
F
-----------------------
G
K
R
V
E
Q
L
L
G
N
T
K
-----
T
E
D
E
K
L
K
K
---------------
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
-
A
S
D
S
A
I
--------------------------------------------------------------------
55
Fugue
53.66
19%
-63
- C2 -
2Z1Q
2
?
B:
[5-577]
--------------------
K
K
L
W
Q
K
G
G
G
W
L
L
E
V
P
E
R
V
Y
T
P
E
D
----
F
D
----------
E
S
-
V
K
E
-
I
-
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
--------
G
E
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
-
E
E
-----
Y
G
G
--
L
D
L
---
P
-
K
V
I
S
T
V
V
A
E
E
L
S
G
S
G
G
F
S
V
T
-
Y
G
A
H
T
S
IG
T
L
P
L
--------
V
Y
F
G----
T
--
E
E
Q
K
--
R
K
Y
L
P
K
L
A
S
G
E
W
-------------
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
-
A
K
T
R
A
T
L
---
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
-
A
H
L
F
T
V
F
A
K
V
----------
D
G----
E
-----
H
F
T
A
F
L
V
-
E
R
D
T
P
G
-----
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
---
I
L
E
D
V
K
---
V
P
VE
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
LGKKG
P
----
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
-----
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
---------------
Y
A
A
E
S
A
L
L
R
A
R
R
L
G
G
L
A
P
-
V
L
A
R
I
Y
---
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
-
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
REPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
7
PsiBlast_PDB
53.39
26%
-76
- C2 -
3MPI
3
ACD_DESML
A:
[96-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
A
Y
T
I
L
T
Y
G
----
S
E
A
----------------------
L
K
--
K
K
Y
V
P
K
L
S
S
A
E
F
-------------
L
G
G
F
G
I
T
E
P
D
A
G
S
D
V
M
A
-
M
S
S
T
A
-----
E
D
K
G
D
H
W
L
L
N
G
S
K
T
W
I
S
N
A
A
Q
-
A
D
V
L
I
Y
Y
A
Y
T
----------
D
-----
K
AAGSR
G
L
S
A
F
V
I
E
P
R
N
F
P
G
I
K
T
S
N
L
------
E
K
L
G
S
H
A
S
P
T
G
E
L
F
L
D
N
V
K
V
P
K
---
E
---
N
I
L
G
K
P
G
D
G
A
R
I
V
F
G
S
L
N
H
T
R
L
S
A
A
A
G
G
V
G
L
A
Q
A
C
L
D
A
A
I
K
Y
C
N
E
R
R
Q
F
G
K
P
I
G
D
F
Q
M
N
Q
D
M
I
A
Q
M
A
V
E
V
E
A
A
R
L
L
A
Y
K
A
A
A
A
K
D
E
G
------
R
----
L
N
N
-------
G
L
D
V
A
M
A
K
Y
A
A
G
E
A
V
S
K
C
A
N
Y
A
M
R
I
L
G
A
Y
G
Y
S
T
E
Y
P
V
A
R
F
Y
R
D
A
P
T
Y
Y
M
V
E
G
S
A
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.24
26%
-74
- C2 -
3MPJ
3
ACD_DESML
A:
[96-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
A
Y
T
I
L
T
Y
G
----
S
E
A
----------------------
L
K
--
K
K
Y
V
P
K
L
S
S
A
E
F
-------------
L
G
G
F
G
I
T
E
P
D
A
G
S
D
V
M
A
-
M
S
S
T
A
-----
E
D
K
G
D
H
W
L
L
N
G
S
K
T
W
I
S
N
A
A
Q
-
A
D
V
L
I
Y
Y
A
Y
T
----------
D
-----
K
AAGSR
G
L
S
A
F
V
I
E
P
R
N
F
P
G
I
K
T
S
N
L
------
E
K
L
G
S
H
A
S
P
T
G
E
L
F
L
D
N
V
K
V
P
K
---
E
---
N
I
L
G
K
P
G
D
G
A
R
I
V
F
G
S
L
N
H
T
R
L
S
A
A
A
G
G
V
G
L
A
Q
A
C
L
D
A
A
I
K
Y
C
N
E
R
R
Q
F
G
K
P
I
G
D
F
Q
M
N
Q
D
M
I
A
Q
M
A
V
E
V
E
A
A
R
L
L
A
Y
K
A
A
A
A
K
D
E
G
------
R
----
L
N
N
-------
G
L
D
V
A
M
A
K
Y
A
A
G
E
A
V
S
K
C
A
N
Y
A
M
R
I
L
G
A
Y
G
Y
S
T
E
Y
P
V
A
R
F
Y
R
D
A
P
T
Y
Y
M
V
E
G
S
A
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
51.48
23%
-69
- C2 -
1UKW
2
?
A:
[25-378]
--------------------------------------------------------------------------------
L
P
V
A
Q
E
Y
D
E
K
E
E
------
V
P
---
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
-
E
E
-----
Y
G
G
--
M
G
L
K
M
L
D
-
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
-
A
S
D
L
----
G
I
T
P
--------
V
L
L
-----
A
GT
E
E
Q
K
--
E
R
F
L
R
P
L
T
E
K
----
P
A
L
A
---------
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
-
L
K
T
R
A
I
R
Q
-----
G
D
H
Y
V
L
N
G
T
K
-
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
----------
N
PELRH
K
-----
G
V
V
A
L
V
V
-
E
R
G
T
P
-
G
----
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
---
V
F
E
D
V
K
V
P
V
E
---
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
------
L
----------
P
H
--
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------