@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4458: (2016-02-27 )
MSDTHSAAELPVRASRIRLAIFDVDGVLTDGKLYFLVDGSEFKTFNTLDGHGIKMLIASGVRTAIITGRDTPVVERRARNLGIQHLYQGREDKLAVLDELLGELGLGYEQVAYLGDDLPDLPVIRRVGLGMAVASADPFVRQHAHGVTAARGGEGAAREFCELIMRAQGTLEAAQSAYL
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDTH
S
A
AELPV
R
A
S
R
I
R
L
A
I
F
D
VD
G
V
LTD
G
K
L
Y
F
L
V
DGSE
F
K
T
F
NTLDGH
G
I
K
M
L
I
ASG
V
R
T
A
I
I
TGRDT
P
V
V
E
R
R
A
R
NL
G
I
Q
H
L
YQGRE
D
K
L
A
V
L
D
E
L
L
G
E
LGL
G
Y
E
Q
V
A
Y
LGDDLP
D
L
P
V
I
R
R
VGL
G
M
A
VASA
D
P
F
V
R
Q
HAHGVTAARGGE
G
A
A
R
E
F
C
E
L
I
M
RAQG
T
L
E
A
A
Q
SAYL
30
PsiBlast_CBE
96.55
76%
-110
- C3 -
3NRJ
4
?
C:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
41
PsiBlast_CBE
96.48
76%
-111
- C3 -
3MN1
1
?
C:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
31
PsiBlast_CBE
96.17
76%
-115
- C3 -
3NRJ
4
?
B:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
42
PsiBlast_CBE
95.84
76%
-109
- C3 -
3MN1
2
?
B:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
37
PsiBlast_CBE
95.38
76%
-109
- C3 -
3MN1
2
?
G:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
34
PsiBlast_CBE
95.06
76%
-110
- C3 -
3MN1
2
?
J:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
40
PsiBlast_CBE
95.05
76%
-110
- C3 -
3MN1
2
?
D:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
38
PsiBlast_CBE
94.87
76%
-104
- C3 -
3MN1
2
?
F:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
35
PsiBlast_CBE
94.81
76%
-109
- C3 -
3MN1
2
?
I:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
36
PsiBlast_CBE
94.65
76%
-107
- C3 -
3MN1
2
?
H:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
24
PsiBlast_CBE
94.61
76%
-107
- C3 -
3NRJ
22
?
I:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
29
PsiBlast_CBE
94.35
76%
-108
- C3 -
3NRJ
4
?
D:
[11-181]
--------
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
1
PsiBlast_PDB
94.34
76%
-107
- C3 -
3MN1
2
?
A:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
39
PsiBlast_CBE
94.22
76%
-109
- C3 -
3MN1
1
?
E:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
137
HHSearch
94.10
75%
-105
- C3 -
3MN1
2
?
A:
[6-180]
---
E
T
M
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
-
2
PsiBlast_PDB
93.83
76%
-106
- C3 -
3NRJ
4
?
A:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
33
PsiBlast_CBE
93.65
76%
-109
- C3 -
3MN1
2
?
K:
[9-181]
------
S
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
22
PsiBlast_CBE
93.50
76%
-108
- C3 -
3NRJ
1
?
K:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
32
PsiBlast_CBE
93.29
76%
-108
- C3 -
3MN1
2
?
L:
[10-181]
-------
Q
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
25
PsiBlast_CBE
92.87
76%
-107
- C3 -
3NRJ
2
?
H:
[11-181]
--------
D
L
M
Q
R
G
K
A
I
K
L
A
V
F
D
V
D
G
V
L
T
D
G
R
L
Y
F
M
E
D
G
S
E
I
K
T
F
N
T
L
D
G
Q
G
I
K
M
L
I
A
S
G
V
T
T
A
I
I
S
G
R
K
T
A
I
V
E
R
R
A
K
S
L
G
I
E
H
L
F
Q
G
R
E
D
K
L
V
V
L
D
K
L
L
A
E
L
Q
L
G
Y
E
Q
V
A
Y
L
G
D
D
L
P
D
L
P
V
I
R
R
V
G
L
G
M
A
V
A
N
A
A
S
F
V
R
E
H
A
H
G
I
T
R
A
Q
G
G
E
G
A
A
R
E
F
C
E
L
I
L
S
A
Q
G
N
L
E
A
A
H
S
V
Y
L
9
PsiBlast_PDB
82.04
49%
-102
- C3 -
3I6B
3
KDSC_ECOL6
A:
[16-179]
------
S
A
D
V
M
A
K
A
E
N
I
R
L
L
I
L
D
V
D
G
V
L
S
D
G
L
I
Y
M
G
N
N
G
E
E
L
K
A
F
N
V
R
D
G
Y
G
I
R
C
A
L
T
S
D
I
E
V
A
I
I
T
G
R
K
A
K
L
V
E
D
R
C
A
T
L
G
I
T
H
L
Y
Q
G
Q
S
N
K
L
I
A
F
S
D
L
L
E
K
L
A
I
A
P
E
N
V
A
Y
V
G
D
D
L
I
D
W
P
V
M
E
K
V
G
L
S
V
A
V
A
D
A
H
P
L
L
I
P
R
A
D
Y
V
T
R
I
A
G
G
R
G
A
V
R
E
V
C
D
L
L
L
L
A
Q
G
K
---------
95
PsiBlast_CBE
80.27
49%
-102
- C3 -
3I6B
3
KDSC_ECOL6
C:
[16-180]
------
S
A
D
V
M
A
K
A
E
N
I
R
L
L
I
L
D
V
D
G
V
L
S
D
G
L
I
Y
M
G
N
N
G
E
E
L
K
A
F
N
V
R
D
G
Y
G
I
R
C
A
L
T
S
D
I
E
V
A
I
I
T
G
R
K
A
K
L
V
E
D
R
C
A
T
L
G
I
T
H
L
Y
Q
G
Q
S
N
K
L
I
A
F
S
D
L
L
E
K
L
A
I
A
P
E
N
V
A
Y
V
G
D
D
L
I
D
W
P
V
M
E
K
V
G
L
S
V
A
V
A
D
A
H
P
L
L
I
P
R
A
D
Y
V
T
R
I
A
G
G
R
G
A
V
R
E
V
C
D
L
L
L
L
A
Q
G
K
L
--------
99
PsiBlast_CBE
79.31
43%
-105
- C3 -
4UMF
5
?
B:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
17
PsiBlast_PDB
78.39
43%
-96
- C3 -
4UMF
4
?
A:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
14
PsiBlast_PDB
78.36
43%
-100
- C3 -
4UM7
3
?
A:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
98
PsiBlast_CBE
77.72
43%
-100
- C3 -
4UMF
4
?
C:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
15
PsiBlast_PDB
77.47
43%
-103
- C3 -
4UMD
1
?
A:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
16
PsiBlast_PDB
77.16
43%
-101
- C3 -
4UME
2
?
A:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
97
PsiBlast_CBE
76.85
43%
-102
- C3 -
4UMF
5
?
D:
[23-187]
--------
E
I
Y
Q
K
A
K
H
I
K
L
F
A
M
D
V
D
G
I
L
S
D
G
Q
I
I
Y
N
S
E
G
T
E
T
K
A
F
Y
V
Q
D
G
L
G
L
Q
A
L
K
Q
S
G
I
I
L
A
I
I
T
G
R
S
S
A
M
V
D
R
R
A
K
E
L
G
I
S
H
I
I
Q
G
Q
D
D
K
L
T
A
L
V
G
L
T
K
K
L
G
I
E
L
S
H
C
A
Y
I
G
D
D
L
P
D
L
K
A
V
R
E
A
G
F
G
I
S
V
P
N
G
C
E
Q
T
R
A
V
S
D
Y
I
T
T
K
T
G
G
N
G
A
V
R
E
V
C
E
L
I
L
K
A
Q
N
N
F
D
A
------
117
PsiBlast_CBE
75.16
43%
-97
- C3 -
4HGO
3
?
D:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
124
PsiBlast_CBE
75.12
43%
-98
- C3 -
3E84
2
?
D:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
120
PsiBlast_CBE
74.96
43%
-97
- C3 -
4HGO
3
?
A:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
118
PsiBlast_CBE
74.59
43%
-97
- C3 -
4HGO
2
?
C:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
20
PsiBlast_PDB
74.24
43%
-96
- C3 -
3E81
10
?
A:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
119
PsiBlast_CBE
73.50
43%
-96
- C3 -
4HGO
4
?
B:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
126
PsiBlast_CBE
73.30
43%
-97
- C3 -
3E84
3
?
B:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------
19
PsiBlast_PDB
73.23
40%
-96
- C3 -
4HGP
3
KDSC_HAEIN
A:
[4-160]
------------
K
L
E
N
I
K
F
V
I
T
D
V
D
G
V
L
T
D
G
Q
L
H
Y
D
A
N
G
E
A
I
K
S
F
H
V
R
D
G
L
G
I
K
M
L
M
D
A
D
I
Q
V
A
V
L
S
G
R
D
S
P
I
L
R
R
R
I
A
D
L
G
I
K
L
F
F
L
G
K
L
E
K
E
T
A
C
F
D
L
M
K
Q
A
G
V
T
A
E
Q
T
A
Y
I
G
D
D
S
V
D
L
P
A
F
A
A
C
G
T
S
F
A
V
A
D
A
P
I
Y
V
K
N
A
V
D
H
V
L
S
T
H
G
G
K
G
A
F
R
E
M
S
D
M
I
L
Q
A
Q
G
----------
125
PsiBlast_CBE
71.92
43%
-96
- C3 -
3E84
3
?
C:
[2-152]
--------------
K
E
I
K
L
I
L
T
D
I
D
G
V
W
T
D
G
G
M
F
Y
D
Q
T
G
N
E
W
K
K
F
N
T
S
D
S
A
G
I
F
W
A
H
N
K
G
I
P
V
G
I
L
T
G
E
K
T
E
I
V
R
R
R
A
E
K
L
K
V
D
Y
L
F
Q
G
V
V
D
K
L
S
A
A
E
E
L
C
N
E
L
G
I
N
L
E
Q
V
A
Y
I
G
D
D
L
N
D
A
K
L
L
K
R
V
G
I
A
G
V
P
A
S
A
P
F
Y
I
R
R
L
S
T
I
F
L
E
K
R
G
G
E
G
V
F
R
E
F
V
E
K
V
L
--------------