@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4720: (2016-02-29 )
MSRPQFDPSAYAAQLEDKKSRLAGLLAPFAAPAPEVFESPREHYRLRAEFRLWRETGNEKRHYAMFEQGDKHTPILLEDFPIASRRINELMPRLKAAWADPALGFKLFQVEFLTTLAGDALITLCYHRPIDDAWRQAAEKLAAELGVNLVGRSRGKRIVVGRDYVEEELSVAGRRFRYRQPEGAFTQPNGEVNQKMLGWAYEALGQRDDDLLELYCGNGNFTLPLATRVRKVLATEISKSSVNAALANLADNAVDNVSLVRLSAEELTQALNEVRPFRRLADIDLKSYAFGSVFVDPPRAGMDPDTCELARRFERILYISCNPETLAQNIAQLHDTHRISRCALFDQFPYTHHMESGVLLERR
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........-10........20.......-.30........40--.........50........60....-....70.......------.80........90.......-.-100.-.....-----.110------.......120......------.130--........140----....------.--...--150--.......160.......---170.......180.--.....--.190.....-.-.200...-..-..210.......220....-..--.---230........240.......250..-.-.--.--...260.......-------270.......280.......---290.......-300--...---------.-----------...-.310....--.-----..-----.------.320---...---.------....330---.-..----.....340----...-------------..---------..350.......360.----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRPQFD
P
S
-
A
Y
A
A
Q
L
E
D
K
K
S
R
L
A
G
L
LAP-FAAP
A
P
E
V
F
ES
P
---
R
E
H
Y
R
L
R
A
E
F
R
L
W
R
ETGNEK
R
H
Y
A
M-FEQGDKHT
P
I
L
L
E------DFP
I
A
S
R
R
I
N
E
L
M
P
R
L
K
A
AW-A-DPAL-
G
F
K
L
F
-----
Q
V
E
F
------
L
T
T
LAGD
A
L
I
T
L
C
YHR------PI
D
---
D
A
W
R
Q
A
A
E
K
L
-----
A
A
E
L------
G
--
V
N
L
--VGR--SRG
K
R
I
V
VG
R
D
Y
V
E
E
E
L
---
S
VAGRR
F
R
YRQPEG--AFTQP--NGE
V
N
Q
K
M
L
-
G
-
W
A
Y
E
A
LG-QR-DDD
L
L
E
L
Y
CGNG
N
F
T
L
P
L
A
-
T
R
--
V
---
R
-
K
V
L
A
T
E
IS
K
S
S
V
N
A
A
L
A
N
L
A
D-NA-V-D--
N
--
V
S
L
V
R
L
S
A
E
E
L
T
Q
-------
A
L
N
E
V
R
P
F
R
R
L
A
DIDLKSYA---FG
S
V
F
VDPPR-AG---MD
P
---------
D
-----------
T
C
E
-
L
A
--
R
R
F
E
--
R
-----
I
L
-----
Y
------
I
SC----
N
P
E
---
T
------
L
A
Q
N
I
-
A
---
Q
-
L
H
----
D
T
H
R
I
S
R
C
----
A
L
F-------------DQ---------FPYTHHMES
G
V
L
LERR----------------------------
48
Fugue
99.83
50%
-97
- C1 -
3BT7
1
TRMA_ECOLI
A:
[1-369]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
S
H
M
T
P
E
H
L
P
T
E
-
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
-
F
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L
V
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R
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---
V
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Y
R
M
R
A
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F
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D
--
G
D
D
L
Y
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I
I
-
F
D
Q
Q
T
-
K
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R
I
R
V
D
------
S
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
-
N
P
V
L
-
R
H
K
L
F
-----
Q
I
D
Y
------
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
------
K
L
D
---
D
E
W
R
Q
E
A
E
A
L
-----
R
D
A
L
R
A
Q
NL-
N
--
V
H
L
--
I
G
R
--
A
T
K
T
K
I
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L
D
Q
D
Y
I
D
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L
---
P
V
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K
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Q
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N
--
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F
T
Q
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A
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I
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L
-
E
-
W
A
L
D
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K
-
G
S
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L
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C
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N
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L
A
-
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N
--
F
---
D
-
R
V
L
A
T
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I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
-
N
H
-
I
-
D
--
N
--
V
Q
I
I
R
M
A
A
E
E
F
T
Q
-------
A
M
N
G
V
R
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F
N
R
L
Q
G
I
D
L
K
S
Y
Q
---
C
E
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F
V
D
P
P
R
-
S
G
---
L
D
S
---------
E
-----------
T
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K
-
M
V
--
Q
A
Y
P
--
R
-----
I
L
-----
Y
------
I
S
C
----
N
P
E
---
T
------
L
C
K
N
L
-
E
---
T
-
L
S
----
Q
T
H
K
V
E
R
L
----
A
L
F
-------------
D
Q
---------
F
P
Y
T
H
H
M
Q
C
G
V
L
L
T
A
K
----------------------------
26
HHSearch
99.09
50%
-97
- C1 -
3BT7
1
TRMA_ECOLI
A:
[4-369]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
E
H
L
P
T
E
-
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
-
F
S
D
L
V
P
E
V
F
R
S
P
---
V
S
H
Y
R
M
R
A
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F
R
I
W
H
D
G
--
D
D
L
Y
H
I
I
-
F
D
Q
-
Q
T
K
S
R
I
R
V
D
------
S
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
-
R
N
N
P
V
L
-
R
H
K
L
F
-----
Q
I
D
Y
------
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
------
K
L
D
---
D
E
W
R
Q
E
A
E
A
L
-----
R
D
A
L
R
A
Q
---
N
LN
V
H
L
--
I
G
R
--
A
T
K
T
K
I
E
L
D
Q
D
Y
I
D
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R
L
---
P
V
A
G
K
E
M
I
Y
R
Q
V
E
N
--
S
F
T
Q
P
--
N
A
A
M
N
I
Q
M
L
-
E
-
W
A
L
D
V
T
K
-
G
S
-
K
G
D
L
L
E
L
Y
C
G
N
G
N
F
S
L
A
L
A
-
R
N
--
F
---
D
-
R
V
L
A
T
E
I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
-
N
H
-
I
-
D
--
N
--
V
Q
I
I
R
M
A
A
E
E
F
T
Q
-------
A
M
N
G
V
R
E
F
N
R
L
Q
G
I
D
L
K
S
Y
Q
---
C
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F
V
D
P
P
R
-
S
G
---
L
D
S
---------
E
-----------
T
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K
-
M
V
--
Q
A
Y
P
--
R
-----
I
L
-----
Y
------
I
S
C
----
N
P
E
---
T
------
L
C
K
N
L
-
E
---
T
-
L
S
----
Q
T
H
K
V
E
R
L
----
A
L
F
-------------
D
Q
---------
F
P
Y
T
H
H
M
Q
C
G
V
L
L
T
A
K
----------------------------
21
PsiBlast_CBE
98.57
50%
-93
- C1 -
3BT7
1
TRMA_ECOLI
B:
[6-366]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
H
L
P
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
-
F
S
D
L
V
P
E
V
F
R
S
P
---
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
D
-
G
D
D
L
Y
H
-
I
I
-
F
D
Q
Q
T
K
-
S
R
I
R
V
D
------
S
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
-
N
P
V
L
-
R
H
K
L
F
-----
Q
I
D
Y
------
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
------
K
L
D
---
D
E
W
R
Q
E
A
E
A
L
RDALR
A
Q
N
L
------
N
--
V
H
L
--
I
G
R
--
A
T
K
T
K
I
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L
D
Q
D
Y
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L
---
P
V
A
G
K
E
M
I
Y
R
Q
V
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N
--
S
F
T
Q
P
--
N
A
A
M
N
I
Q
M
L
-
E
-
W
A
L
D
V
T
K
-
G
S
-
K
G
D
L
L
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L
Y
C
G
N
G
N
F
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A
L
A
-
R
N
--
F
---
D
-
R
V
L
A
T
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I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
-
N
H
-
I
-
D
--
N
--
V
Q
I
I
R
M
A
A
E
E
F
T
Q
-------
A
M
N
G
V
R
E
F
N
R
L
Q
G
I
D
L
K
S
Y
Q
---
C
E
T
I
F
V
D
P
P
R
-
S
G
---
L
D
S
---------
E
-----------
T
E
K
-
M
V
--
Q
A
Y
P
--
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-----
I
L
-----
Y
------
I
S
C
----
N
P
E
---
T
------
L
C
K
N
L
-
E
---
T
-
L
S
----
Q
T
H
K
V
E
R
L
----
A
L
F
-------------
D
Q
---------
F
P
Y
T
H
H
M
Q
C
G
V
L
L
-------------------------------
1
PsiBlast_PDB
98.31
50%
-92
- C1 -
3BT7
1
TRMA_ECOLI
A:
[6-366]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
H
L
P
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
-
F
S
D
L
V
P
E
V
F
R
S
P
---
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
D
-
G
D
D
L
Y
H
-
I
I
-
F
D
Q
Q
T
K
-
S
R
I
R
V
D
------
S
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
-
N
P
V
L
-
R
H
K
L
F
-----
Q
I
D
Y
------
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
------
K
L
D
---
D
E
W
R
Q
E
A
E
A
L
R
D
A
L
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A
Q
N
L
------
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H
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G
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--
A
T
K
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K
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L
---
P
V
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K
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N
--
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F
T
Q
P
--
N
A
A
M
N
I
Q
M
L
-
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A
L
D
V
T
K
-
G
S
-
K
G
D
L
L
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A
L
A
-
R
N
--
F
---
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R
V
L
A
T
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A
K
P
S
V
A
A
A
Q
Y
N
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A
A
-
N
H
-
I
-
D
--
N
--
V
Q
I
I
R
M
A
A
E
E
F
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-------
A
M
N
G
V
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N
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L
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I
S
C
----
N
P
E
---
T
------
L
C
K
N
L
-
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---
T
-
L
S
----
Q
T
H
K
V
E
R
L
----
A
L
F
-------------
D
Q
---------
F
P
Y
T
H
H
M
Q
C
G
V
L
L
-------------------------------
2
PsiBlast_PDB
78.16
28%
-87
- C1 -
2BH2
2
RLMD_ECOLI
A:
[101-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
S
K
S
A
A
L
A
R
L
-
M
K
H
D
V
S
E
V
I
A
D
V
---
P
W
G
Y
R
R
R
A
R
L
S
L
N
Y
L
P
K
T
Q
Q
L
Q
M
G
--
F
R
K
A
G
S
S
D
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D
V
K
------
Q
C
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I
L
A
P
Q
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A
L
L
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A
C
L
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G
-
S
L
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A
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H
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-----
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------
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Q
A
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S
G
-
T
L
M
I
L
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------
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---
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A
D
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-----
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Y
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----
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N
A
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V
N
Q
K
M
V
-
A
-
R
A
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W
L
D
V
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P
-
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D
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D
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F
T
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P
L
A
-
T
Q
--
A
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A
-
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A
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V
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L
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N
--
V
T
F
Y
H
E
N
L
E
E
----------------------
D
V
T
K
Q
P
W
A
KNG
F
D
K
V
L
L
D
P
A
R
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A
G
---
A
-
A
---------
G
-----------
V
M
Q
-
Q
I
--
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PI
R
-----
I
V
-----
Y
------
V
S
C
----
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P
A
---
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------
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A
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---
L
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L
K
----
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I
A
R
L
----
A
M
L
-------------
D
M
---------
F
P
H
T
G
H
L
E
S
M
V
L
F
S
R
-----------------------------
3
PsiBlast_PDB
72.12
30%
-81
- C1 -
1UWV
5
RLMD_ECOLI
A:
[148-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
K
A
G
S
S
D
I
V
D
V
K
------
Q
C
P
I
L
A
P
Q
L
E
A
L
L
P
K
V
R
A
C
L
-
G
-
S
L
Q
A
-
M
R
H
L
G
-----
H
V
E
L
------
V
Q
A
T
S
G
-
T
L
M
I
L
R
H
T
A
------
P
L
S
---
S
A
D
R
E
K
L
E
R
F
-----
S
H
S
E
------
G
--
L
D
L
Y
L
A
P
D
--
S
E
I
L
E
T
V
S
G
E
M
P
W
Y
D
S
------
N
G
L
R
L
T
F
S
P
R
D
----
F
I
Q
V
--
N
A
G
V
N
Q
K
M
V
-
A
-
R
A
L
E
W
L
D
V
Q
P
-
E
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
L
A
-
T
Q
--
A
---
A
-
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
L
-
N
G
-
L
-
Q
--
N
--
V
T
F
Y
H
E
N
L
E
E
----------------------
D
V
T
K
Q
P
W
A
KNG
F
D
K
V
L
L
D
P
A
R
-
A
G
---
A
A
G
---------
V
-----------
M
Q
Q
-
I
I
---
K
L
E
PI
R
-----
I
V
-----
Y
------
V
S
C
----
N
P
A
---
T
------
L
A
R
D
S
E
A
---
L
-
L
K
----
A
G
Y
T
I
A
R
L
----
A
M
L
-------------
D
M
---------
F
P
H
T
G
H
L
E
S
M
V
L
F
S
R
-----------------------------
27
HHSearch
69.62
29%
-24
- C- -
1UWV
5
RLMD_ECOLI
A:
[87-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
G
C
Q
Q
Q
H
A
-
S
V
D
L
Q
Q
R
S
K
S
A
A
L
A
R
L
M
K
H
-
D
---
V
S
E
V
I
A
D
V
---
P
W
G
Y
R
R
R
A
R
L
S
L
N
Y
L
P
-
K
T
Q
Q
L
Q
M
G
-
F
R
K
A
G
S
S
D
I
V
D
V
K
------
Q
C
P
I
L
A
P
Q
L
E
A
L
L
P
K
V
R
A
C
L
-
G
S
L
Q
A
M
-
R
-
H
L
G
-----
H
V
E
L
------
V
Q
A
T
S
G
T
L
M
I
L
R
H
T
A
P
-------
L
S
---
S
A
D
R
E
K
L
E
R
F
-----
S
H
S
E
------
G
--
L
D
L
--
Y
L
A
PD
S
E
I
L
E
T
V
S
G
E
M
P
W
Y
-
D
S
-------
N
G
L
R
L
T
F
S
P
R
--
D
F
I
Q
V
--
N
A
G
V
N
Q
K
M
V
-
A
-
R
A
L
E
W
L
D
-
V
Q
P
E
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
L
A
-
T
Q
--
A
---
A
-
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
L
-
N
G
-
L
-
Q
--
N
--
V
T
F
Y
H
E
N
L
E
E
D
V
T
-------
K
Q
P
------------
W
A
K
N
G
---
F
D
K
V
L
L
D
P
A
R
-
A
G
---
A
A
G
---------------------
V
M
Q
Q
I
I
K
-
L
E
P
I
--
R
-----
I
V
-----
Y
------
V
S
C
----
N
P
A
---
T
------
L
A
R
D
S
-
E
---
A
-
L
L
K
---
A
G
Y
T
I
A
R
L
----
A
M
L
-------------
D
M
---------
F
P
H
T
G
H
L
E
S
M
V
L
F
S
R
V
----------------------------
5
PsiBlast_PDB
52.14
32%
-74
- C1 -
2JJQ
2
ATRMA_PYRAB
A:
[292-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
L
D
M
Y
S
G
V
G
T
F
G
I
Y
L
A
-
K
R
--
G
---
F
-
N
V
K
G
F
D
S
N
E
F
A
I
E
M
A
R
R
N
V
E
I
-
N
N
-
V
-
D
------------
A
E
------------------
F
E
V
A
S
D
R
E
V
S
V
K
G
---
F
D
T
V
I
V
D
P
P
R
-
A
G
---
L
H
P
-----------------------
R
-
L
V
--
K
R
L
N
--
R
E
KPG
V
I
V
-----
Y
------
V
S
C
----
N
P
E
---
T
------
F
A
R
D
V
-
K
---
M
-
L
------
D
Y
R
I
D
E
I
----
V
A
L
-------------
D
M
---------
F
P
H
T
P
H
V
E
------------------------------------
39
HHSearch
49.48
24%
-76
- C1 -
2PWY
2
TRMI_THET2
A:
[97-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
R
V
L
E
A
G
T
G
S
G
G
L
T
L
F
L
A
-
R
A
--
V
GEK
G
-
L
V
E
S
Y
E
A
R
P
H
H
L
A
Q
A
E
R
N
V
R
A
-
F
W
Q
V
-
E
--
N
--
V
R
F
H
L
G
K
L
E
E
A
E
L
-----------------------
E
E
A
A
---
Y
D
G
V
A
L
D
L
M
E
-
P
------
W
---------
K
-----------
V
L
E
K
A
A
L
A
L
K
P
D
--
R
-----
F
L
-----
V
------
A
Y
L
----
P
N
I
---
T
------
Q
V
L
E
L
-
V
---
R
A
A
E
A
---
H
P
F
R
L
E
R
V
----
L
E
V
G
W
R
E
W
E
V
RLPVAH
P
R
---------
F
Q
Q
V
G
H
T
A
F
L
V
A
L
R
R
-----------------------------
57
Fugue
49.13
18%
-44
- C1 -
3A25
1
TYW2_PYRHO
A:
[29-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
P
-
R
I
R
E
I
L
S
K
E
-------------
L
P
E
E
L
V
K
L
L
P
---
K
R
W
V
R
I
---------------------------------------------------------------------------------------------
G
D
V
L
L
L
P
L
R
P
------
E
L
E
---
P
Y
K
H
R
I
A
E
V
Y
-----
A
E
V
L
------
G
--
V
K
T
--
V
L
R
--
K
G
D
Y
E
L
L
Y
G
S
D
-
T
V
T
V
H
---
V
E
N
G
I
K
Y
K
L
D
V
A
K
I
--
M
F
S
P
A
--
N
V
K
E
R
V
R
M
A
-
K
-
V
A
------
K
P
-
D
E
L
V
V
D
M
F
A
G
I
G
H
L
S
L
P
I
A
-
V
Y
--
G
---
K
A
K
V
I
A
I
E
K
D
P
Y
T
F
K
F
L
V
E
N
I
H
L
-
N
K
-
V
-
E
--
D
R-
M
S
A
Y
N
M
D
N
R
D
F
P
G
ENIAD
R
I
L
M
G
Y
V
V
R
T
H
E
F
I
P
K
A
L
S
I
A
K
---
D
G
A
I
I
H
Y
H
N
T
-
V
P
---
E
K
L
---------
M
-----------
P
R
E
-
P
F
--
E
T
F
K
--
R
-----
I
T
-----
K
------
E
Y
--------------------
G
Y
D
-
V
---
E
-
K
L
----
N
E
L
K
I
K
R
Y
----
A
---------------------------
P
G
V
W
H
V
V
L
D
L
R
V
F
K
S
----------------------------
55
Fugue
48.59
13%
-53
- C1 -
3TM4
1
?
A:
[1-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
F
L
L
T
-
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
-
L
G
I
S
-
F
Q
I
E
E
K
P
LGI
E
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
E
K
G
R
K
R
E
L
S
I
-
S
T
Y
L
N
E
N
S
R
L
L
H
R
------
V
I
I
E
I
A
S
E
K
F
N
G
I
E
K
D
E
S
E
E
-
A
-
L
K
R
I
-
K
D
F
V
S
-----
S
L
P
V
------
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
F
R
K
G
DHNI
T
S
I
---
D
I
A
R
T
V
G
E
A
I
-----
F
E
R
L
S
R
F
G
T
P
L
--
V
N
L
--
D
H
P
--
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
---
D
T
T
G
D
S
S
L
H
K
R
P
W
R
--
V
Y
D
H
P
--
A
-
H
L
K
A
S
I
A
-
N
-
A
M
I
E
L
A
E
-
L
D
-
G
G
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
-
L
R
RY
S
---
G
-
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
-
L
-
D
--
K
--
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-------
Y
V
D
S
-------------------
V
D
F
A
I
S
N
L
P
Y
G
S
M
---
I
P
D
---------
L
-----------
Y
M
K
-
F
F
--
N
E
L
A
--
K
-----
V
L
E
K
R
G
V
F
------
I
T
T
----
E
K
K
---
A
------
I
E
E
A
I
-
A
---
E
-
N
G
----
F
E
I
I
H
H
R
V
----
I
G
H
-------------
G
G
---------
L
M
V
H
L
Y
V
V
K
L
E
H
H
H
------------------------------
51
Fugue
48.12
15%
-48
- C1 -
2CWW
3
?
A:
[1-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
Q
V
N
A
K
G
A
A
R
L
L
S
R
H
L
-
W
V
F
-
R
R
D
V
V
S
G
P
---
E
T
P
G
L
Y
P
V
Y
W
------
G
R
R
F
L
A
L
A
L
-
Y
N
P
H
T
D
L
A
V
R
A
Y
R
FAPAED
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
-
R
Q
D
P
E
G
-
G
Y
R
L
V
-----
H
A
E
G
DLLPG
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
H
------
A
W
E
---
G
L
L
P
Q
V
A
E
A
L
-----
R
P
H
V
------
Q
--
S
V
L
--
A
K
N
--
D
A
R
T
R
E
L
E
G
L
P
L
Y
V
R
P
L
---
L
G
E
V
P
E
R
V
Q
V
Q
E
G
R
--
V
R
Y
L
V
--
D
L
G
A
Y
L
D
Q
R
-
E
-
N
R
L
Y
M
E
R
-
F
R
-
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
-
L
G
--
F
---
R
-
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
-
N
G
-
L
-
G
--
N
--
V
R
V
L
E
A
N
A
F
D
L
L
R
-------
R
L
E
K
------------
E
G
E
R
---
F
D
L
V
V
L
D
P
P
A
F
A
K
---
G
K
K
---------
D
-----------
V
E
R
-
A
Y
--
R
A
Y
K
--
E
-----
V
N
-----
L
------
R
A
I
----
K
L
L
---
K
------
E
G
G
I
L
-
A
---
T
-
A
S
----
C
S
H
H
M
T
E
P
----
L
F
Y
-------------
A
M
---------
V
A
E
A
A
Q
D
A
H
R
L
L
R
V
V
E
K
R
G
Q
PFDHPVLLNHPETHY
L
K
F
A
V
F
Q
V
L
47
HHSearch
46.35
23%
-64
- C1 -
2ESR
-
?
A:
[32-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
R
V
L
D
L
F
A
G
S
G
G
L
A
I
E
A
V
-
S
R
G-
M
---
S
-
A
A
V
L
V
E
K
N
R
K
A
Q
A
I
I
Q
D
N
I
I
M
-
T
K
-
A
-
E
N-
R
--
F
T
L
L
K
M
E
A
E
R
A
I
D
-------
C
---------------
L
T
G
R
---
F
D
L
V
F
L
D
P
P
Y
-
A
K
---
E
T
I
V
--------
A
-----------
T
I
E
A
L
A
A
K
N
L
L
S
--
E
-----
Q
V
-----
M
------
V
V
C
----
E
T
D
KT
V
L
------
L
P
K
E
I
-
A
---
T
-
L
G
I
W
K
E
K
I
Y
G
I
S
K
V
----
T
V
Y
-------------
V
N
---------
E
G
H
H
H
H
--------------------------------------
32
HHSearch
45.41
15%
-58
- C1 -
3V97
3
RLMKL_ECOLI
A:
[503-702]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
--
D
Y
L
D
T
--
G
L
F
L
D
H
R
I
A
R
R
-
M
L
G
Q
M
S
--
K
--
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
-
L
G
--
G
A--
R
-
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
-
N
G
-
L
-
T
GR
A
--
H
R
L
I
Q
A
D
C
L
A
W
L
R
-------
E
---------------
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
-
F
S
------AFDVQRD
H
L
A
-----------
L
M
K
D
L
K
R
L
L
R
A
G
--
G
-----
T
I
-----
M
------
F
S
N
----
N
K
R
---
G
------
F
R
M
D
L
-
D
---
G
-
L
A
K
---
L
G
L
K
A
Q
E
I
TQKT
L
S
Q
-------------
D
----------
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
-----------------------------
45
HHSearch
44.86
19%
-53
- C1 -
2YXD
1
CBIT_METJA
A:
[4-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
D
E
--
E
F
I
R
R
E
G
V
P
I
T
K
E
E
I
R
-
A
-
V
S
I
G
K
L
N
-
L
N
K
D
D
V
V
V
D
V
G
C
G
S
G
G
M
T
V
E
I
A
-
K
R
--
C
---
K
-
F
V
Y
A
I
D
Y
L
D
G
A
I
E
V
T
K
Q
N
L
A
K
-
F
N
-
I
-
K
--
N
--
C
Q
I
I
K
G
R
A
E
D
V
L
------------------------
D
K
L
E
---
F
N
K
A
F
I
G
G
T
K
-
N
----
I
E
K
---------------------
I
I
E
-
I
---
L
D
K
K
--
K
-----
I
N
-----
H
------
I
V
A
----
N
T
I
---
V
------
L
E
N
A
A
-
K
I
I
N
E
-
F
E
S
---
R
G
Y
N
V
D
A
V
----
N
V
F
-------------
I
------------------------------------------------------
29
HHSearch
44.25
14%
-63
- C1 -
3VSE
1
?
A:
[163-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
F
V
E
G
D
A
P
-
E
F
P
I
---
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
--
D
G
L
M
T
--
G
I
F
L
D
Q
K
E
V
-
R
K
K
L
R
G
Q
Y
A
-
K
--
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
--
A
---
S
-
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
-
N
A
-
I
-
D
--
P
KS
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
-------
Y
A
A
R
------------
H
G
H
S
---
Y
D
T
I
V
I
D
P
P
S
-
F
A
---
R
N
K
---------
K
R
T
F
S
VQKD
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
--
G
-----
T
L
-----
L
------
L
C
T
----
N
A
S
---
V
YP
L
K
Q
-
F
K
N
T
I
-
K
---
K
-
T
L
E
E
--
S
G
V
D
Y
E
L
T
E
V
M
G
L
P
K
-------------
D
----------
F
K
T
H
P
H
Y
K
------------------------------------
54
Fugue
43.75
11%
-45
- C1 -
2B78
-
?
A:
[1-385]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
S
F
-
A
E
K
K
L
K
R
G
V
----------------
Q
L
L
S
S
R
D
---
Y
P
N
L
N
L
D
N
Q
V
V
Q
L
Y
S
D
A
D
I
F
L
G
T
A
Y
-
L
S
K
Q
N
K
G
V
G
W
L
I
S
PKKVSL
N
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
-
H
-
S
K
L
T
T
A
Y
R
L
F
-----
N
Q
D
G
DSFGG
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
------
F
V
Y
Q
I
R
D
E
I
V
A
A
F
R
Q
V
-----
Y
P
N
F
------
L
--
G
A
Y
--
E
K
I
--
R
F
N
V
S
A
H
L
Y
G
Q
E
A
P
E
Q
F
---
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
--
D
G
L
M
T
--
G
I
F
L
D
Q
R
Q
V
-
R
-
N
E
L
I
N
G
S
-
A
A
-
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
-
M
G
G-
A
---
M
-
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
-
N
H
-
L
-
D
MA
N
--
H
Q
L
V
V
M
D
V
F
D
Y
F
K
-------
Y
A
R
R
H
H
L
T
Y
D
I
I
I
I
D
P
P
S
F
E
---
V
F
S
--
V
S
K
D
Y
-
H
K
---
L
I
R
---------
Q
-----------
G
L
E
-
I
L
--
S
E
N
G
--
L
-----
I
I
-----
A
------
S
T
N
AANM
T
V
S
---
Q
------
F
K
K
Q
I
-
E
---
K
-
G
F
----
G
K
Q
K
H
T
Y
L
----
D
L
Q
-------------
Q
L
PSDFAVNVQ
D
E
S
S
N
Y
L
K
V
F
T
I
K
V
------------------------------
34
HHSearch
43.73
13%
-62
- C1 -
3A27
1
TYW2_METJA
A:
[73-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
K
I
L
Y
G
K
E
T
E
T
------
I
H
K
E
Y
G
C
L
F
K
L
D
V
A
K
I
M
W
S
Q
G
--
N
I
E
E
R
K
R
M
A
-
F
-
I
----
S
N
-
E
--
N
E
V
V
V
D
M
F
A
G
I
G
Y
F
T
I
P
L
A
-
K
Y
SK
P
---
K
-
L
V
Y
A
I
E
K
N
P
T
A
Y
H
Y
L
C
E
N
I
K
L
-
N
K
-
L
-
N
--
N
--
V
I
P
I
L
A
D
N
R
D
V
E
L
------------------------
K
D
V
---
A
D
R
V
I
M
G
Y
V
H
-
K
----
T
-
H
---------
K
-----------
F
L
D
K
T
F
E
F
L
K
D
R
--
G
-----
V
I
-----
H
------
Y
H
E
----
T
V
A
---
E
KIMYE
R
P
I
E
R
L
-
K
---
F
-
Y
A
E
K
--
N
G
Y
K
L
I
D
Y
E
V
R
-
K
I
K
-------------
K
Y
---------
A
P
G
V
W
H
V
V
V
D
A
K
--------------------------------
44
HHSearch
43.66
15%
-48
- C1 -
3NJR
2
?
A:
[23-184]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
P
G
R
P
E
S
--
A
F
A
H
D
--
G
Q
I
T
K
S
P
M
R
-
A
-
L
T
L
A
A
L
A
-
P
R
R
G
E
L
L
W
D
I
G
G
G
S
G
S
V
S
V
E
W
C
-
L
A
--
G
---
G
-
R
A
I
T
I
E
P
R
A
D
R
I
E
N
I
Q
K
N
I
D
T
-
Y
G
-
L
S
P
--
R
--
M
R
A
V
Q
G
T
A
P
A
A
L
A
-----------------------
D
L
P
L
---
P
E
A
V
F
I
G
G
G
G
-
S
-----
Q
A
---------------------
L
Y
D
R
L
W
E
W
L
A
P
G
--
T
-----
R
I
-----
V
------
A
N
A
----
V
T
L
---
E
------
S
E
T
L
L
-
T
---
Q
-
L
H
A
R
--
H
G
G
Q
L
L
R
I
----
D
I
A
-------------
Q
A
---------
E
P
------------------------------------------
50
Fugue
43.60
17%
-32
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
RGL
E
E
L
L
K
T
E
L
E
N
L
GAVE
C
Q
V
V
QG
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
M
W
SRLAS
R
I
M
L
P
L
G
E
C
K
V
YS
D
L
D
L
Y
L
G
V
Q
AINWTEMFNPG
A
T
F
A
V
H
F
S
G
L
N
DTIRN
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
NLP
R
P
N
V
D
RDAPD
I
R
V
N
V
W
L
H
KE
T
A
S
I
A
L
D
LSGDGLHLRGYRDRAGIAPIK
E
T
L
A
A
A
I
V
M
R
SGWQPG
T
P
L
L
D
PMCGSG
T
L
L
I
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGWAQHD
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
YS
S
H
F
Y
G
S
D
SD
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
GIGEL
I
T
F
E
VKDVAQLTNPLPKGP
Y
G
T
V
L
S
N
P
P
Y
G
E
S
-
E
--
P
A
L
I
A
L
H
S
L
L
G
R
I
M
K
N
Q
F
G
G
W
N
L
S
L
F
S
A
S
---
P
D
L
L
S
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
M
V
------
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
-
Q
-
E
G
I
E
-
C
Y
R
L
Y
DADLP
E
Y
N
V
------
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
H
------------
K
A
R
Q
R
L
F
D
I
I
-----
A
A
T
I
------
S
--
V
L
----
G
I
--
A
P
N
K
L
V
L
K
T
R
E
E
K
G
E
F
L
---
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
--
D
Y
L
D
T
--
G
L
F
L
D
H
R
I
A
-
R
-
R
M
L
G
Q
M
S
--
K
-
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
--
A
---
R
-
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
-
N
G
-
L
-
T
--
G
--------
R
A
H
R
L
I
Q
-------
A
-------
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
-
F
S
AFD
V
Q
R
---------
D
-----------
H
L
A
-
L
M
--
K
D
L
K
--
R
-----
L
L
-----
R
AG
G
T
I
M
F
S
N
----
N
K
R
---
G
------
F
R
M
D
L
-
D
---
G
-
L
A
K
L
G
L
K
A
Q
E
I
T
Q
K
----
T
L
S
-------------
Q
D
---------
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
----------------------------