@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5373: (2016-03-07 )
MARFEEQKLYIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTDGAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQDLARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSVQVELGDYASVF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAR
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
EASSG
A
T
F
E
TINPA
N
G
E
V
L
A
K
V
Q
RA
S
R
E
D
V
E
R
A
V
Q
S
A
VEG
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
ERNDEL
A
A
L
ETLDTGKPLAETR
S
V
D
I
VT
G
A
D
V
L
E
Y
Y
A
G
LVPAIEGEQIPLRET
S
F
V
Y
TRREP
L
G
V
V
A
GIGAWNY
P
V
Q
I
A
L
WKSAPALAAG
N
A
M
I
F
KPSEVTP
L
T
A
L
K
L
A
E
I
Y
T
EAGVP
D
G
V
F
N
V
LTGS
G
R
E
V
G
Q
W
L
T
EHP
L
I
E
K
I
SFTGGTSTGK
K
V
MASASS
S
S
L
K
E
V
T
M
E
LGGKS
P
L
I
I
FPDADL
D
R
A
A
D
I
A
V
M
A
N
F
FSSG
Q
V
CTNG
T
R
V
F
I
HRS
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
RLGDPQDENTNFGPLVSFP
H
M
E
S
V
L
G
Y
I
ESGKA
Q
K
A
R
L
L
CGGERVTDGAFGKG
A
Y
VA
P
T
VFTDCRD
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
YDDE
D
E
A
I
RRANDTEYGL
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
EA
G
I
C
W
I
NTWGESPAEMPVGGYKQSGVGREN
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
LGDYASVF
22
PsiBlast_CBE
99.26
100%
-84
- C4 -
2WME
21
BETB_PSEAE
H:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
1
PsiBlast_PDB
99.19
100%
-84
- C4 -
2WME
11
BETB_PSEAE
A:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
27
PsiBlast_CBE
99.16
100%
-83
- C4 -
4CBB
30
BETB_PSEAE
H:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
3
PsiBlast_PDB
99.15
100%
-83
- C4 -
2WOX
8
BETB_PSEAE
A:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
42
PsiBlast_CBE
99.12
99%
-84
- C4 -
2XDR
8
BETB_PSEAE
B:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
2
PsiBlast_PDB
98.92
100%
-81
- C4 -
4CAZ
23
BETB_PSEAE
A:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
26
PsiBlast_CBE
98.79
100%
-84
- C4 -
2WME
8
BETB_PSEAE
B:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
21
PsiBlast_CBE
98.75
100%
-82
- C4 -
4CAZ
9
BETB_PSEAE
B:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
34
PsiBlast_CBE
98.56
100%
-83
- C4 -
2WOX
9
BETB_PSEAE
D:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
36
PsiBlast_CBE
98.54
100%
-82
- C4 -
2WOX
11
BETB_PSEAE
B:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
4
PsiBlast_PDB
98.53
100%
-83
- C4 -
4CBB
10
BETB_PSEAE
A:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
33
PsiBlast_CBE
98.48
100%
-82
- C4 -
4CBB
12
BETB_PSEAE
B:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
28
PsiBlast_CBE
98.48
100%
-81
- C4 -
4CBB
30
BETB_PSEAE
G:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
35
PsiBlast_CBE
98.34
100%
-82
- C4 -
2WOX
5
BETB_PSEAE
C:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
39
PsiBlast_CBE
98.16
99%
-83
- C4 -
3ZQA
12
BETB_PSEAE
B:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
A
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
32
PsiBlast_CBE
98.11
100%
-82
- C4 -
4CBB
1
BETB_PSEAE
C:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
5
PsiBlast_PDB
98.00
99%
-83
- C4 -
3ZQA
13
BETB_PSEAE
A:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
A
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
40
PsiBlast_CBE
97.80
99%
-81
- C4 -
2XDR
6
BETB_PSEAE
D:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
6
PsiBlast_PDB
97.75
99%
-83
- C4 -
2XDR
6
BETB_PSEAE
A:
[1-489]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
A
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
C
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F
38
PsiBlast_CBE
97.33
99%
-82
- C4 -
3ZQA
9
BETB_PSEAE
C:
[2-490]
-
A
R
F
E
E
Q
K
L
Y
I
G
G
R
Y
V
E
A
S
S
G
A
T
F
E
T
I
N
P
A
N
G
E
V
L
A
K
V
Q
R
A
S
R
E
D
V
E
R
A
V
Q
S
A
V
E
G
Q
K
V
W
A
A
M
T
A
M
Q
R
S
R
I
L
R
R
A
V
D
I
L
R
E
R
N
D
E
L
A
A
L
E
T
L
D
T
G
K
P
L
A
E
T
R
S
V
D
I
V
T
G
A
D
V
L
E
Y
Y
A
G
L
V
P
A
I
E
G
E
Q
I
P
L
R
E
T
S
F
V
Y
T
R
R
E
P
L
G
V
V
A
G
I
G
A
W
N
Y
P
V
Q
I
A
L
W
K
S
A
P
A
L
A
A
G
N
A
M
I
F
K
P
S
E
V
T
P
L
T
A
L
K
L
A
E
I
Y
T
E
A
G
V
P
D
G
V
F
N
V
L
T
G
S
G
R
E
V
G
Q
W
L
T
E
H
P
L
I
E
K
I
S
F
T
G
G
T
S
T
G
K
K
V
M
A
S
A
S
S
S
S
L
K
E
V
T
M
E
L
G
G
K
S
P
L
I
I
F
P
D
A
D
L
D
R
A
A
D
I
A
V
M
A
N
F
F
S
S
G
Q
V
A
T
N
G
T
R
V
F
I
H
R
S
Q
Q
A
R
F
E
A
K
V
L
E
R
V
Q
R
I
R
L
G
D
P
Q
D
E
N
T
N
F
G
P
L
V
S
F
P
H
M
E
S
V
L
G
Y
I
E
S
G
K
A
Q
K
A
R
L
L
C
G
G
E
R
V
T
D
G
A
F
G
K
G
A
Y
V
A
P
T
V
F
T
D
C
R
D
D
M
T
I
V
R
E
E
I
F
G
P
V
M
S
I
L
V
Y
D
D
E
D
E
A
I
R
R
A
N
D
T
E
Y
G
L
A
A
G
V
V
T
Q
D
L
A
R
A
H
R
A
I
H
R
L
E
A
G
I
C
W
I
N
T
W
G
E
S
P
A
E
M
P
V
G
G
Y
K
Q
S
G
V
G
R
E
N
G
L
T
T
L
A
H
Y
T
R
I
K
S
V
Q
V
E
L
G
D
Y
A
S
V
F