@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5425: (2016-03-07 )
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAASLGEHIRADYGDQEHLRQLADEVDLVTFEFESVPAETVAFLSQFVPVYPNAESLRIARDRWFEKSMFKDLGIPTPDFADVQSQADLDAAAAAIGLPAVLKTRTLGYDGKGQKVLRQPADVQGAFAELGSVPCILEGFVPFTGEVSLVAVRARDGETRFYPLVHNTHDSGILKLSVASSGHPLQALAEDYVGRVLARLDYVGVLAFEFFEVDGGLKANEIAPRVHNSGHWTIEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGAVPPVAQVVAVADCHLHHYGKAFKNGRKVGHATLRCADRATLQARIAEVEALIEA
Atome Classification :
(28 SA)
.........10........20.....--...30....-....40.-.-......50........60........70........-80-...-......90........100.......110.......120.......130---.......140..-......150..------.....160.......--170.......-180.......190.......200.......210..--.---...-.--.220....---...230..-.....240....-..-.-250.......260.......270.......280.......290-.......300...-..-.------------..-----310.....-....320....-.-..330.......340.-......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
G
V
IGGGQL
G
R
M
L
A
LAGTPLG
M
N
F
--
A
FLDPA
P
D
A
-
C
A
A
S
L
G
E
-
H
-
I
R
ADYG
D
Q
E
H
L
R
Q
L
A
D
EV
D
L
V
T
F
E
FESV
P
A
E
T
V
A
F
L
-
S
--
Q
F
V-PVYP
N
A
E
S
L
R
I
A
R
D
R
W
F
E
K
S
M
F
K
DLGIPTP
D
F
A
D
V
Q
S
QA
D
L
D
A
A
A
A
A
IG---
L
P
A
V
L
K
T
R
-TLG-YDGK
G
Q
K
V
LRQ------PA
D
V
Q
G
A
F
A
E
LGSV
P
--
C
I
L
EGFVPFT-G
E
V
S
L
V
A
V
R
ARDGE
T
R
F
Y
P
L
V
HNTHDS
G
I
L
K
-
L
S
V--A---SSG-H--
P
L
Q
A
L
A
E
D
---
Y
V
G
R
V
L
A
R
-
L
D
Y
V
G
V
L
A
F
E
F
F
-EV-D-GGL
K
A
N
EIAPRVHNSG
H
W
T
I
EG
A
E
C
S
Q
F
E
N
H
L
R
A
V
AGLPLGST-AKV
G
E
S
A
M
-
L
N
F
I-GA-V------------P
P
-----
V
--
A
Q
V
V
A
-
V
A
D
C
H
L
H
H
Y
G
K
-
A
-
F
KNGRKVG
H
A
T
L
RCA
D
-
R
A
T
L
Q
A
R
I
A
E
V
E
A
L
IEA
65
HHSearch
97.83
55%
-96
* C2 *
3AW8
2
?
A:
[1-361]
-
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
--
R
F
L
D
P
S
P
E
A
-
C
A
G
Q
V
G
E
-
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
-
E
GR
L
P
---
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
-------
G
Q
A
L
V
R
T
------
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
--
A
---
P
A
P
G
A
S
E
A
L
Q
K
K
A
E
A
---
Y
A
L
R
A
M
E
A
-
L
D
Y
V
G
V
L
A
L
E
F
F
-
Q
V
-
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
P
R
G
Q
S
A
M
-
V
N
L
I
-
G
E
-
K
------------
P
P
-----
F
---
A
E
V
L
K
V
E
G
A
H
L
H
W
Y
G
K
-
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
-
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
S
-
1
PsiBlast_PDB
94.27
54%
-96
- C2 -
3AW8
2
?
A:
[12-360]
------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
--
R
F
L
D
P
S
P
E
A
-
C
A
G
Q
V
G
E
-
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
-
E
--
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
------
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
--
A
PAP
G
A
S
-
E
--
A
L
Q
K
K
A
E
A
---
Y
A
L
R
A
M
E
A
-
L
D
Y
V
G
V
L
A
L
E
F
F
-
Q
V
-
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
P
R
G
Q
S
A
M
-
V
N
L
I
-
G
E
-
K
------------
P
P
-----
F
--
A
E
V
L
K
-
V
E
G
A
H
L
H
W
Y
G
K
-
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
-
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
--
21
PsiBlast_CBE
93.84
54%
-97
- C2 -
3AW8
3
?
B:
[12-360]
------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
--
R
F
L
D
P
S
P
E
A
-
C
A
G
Q
V
G
E
-
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
-
E
--
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
------
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
-
L
S
L
--
A
PAP
G
A
S
-
E
--
A
L
Q
K
K
A
E
A
---
Y
A
L
R
A
M
E
A
-
L
D
Y
V
G
V
L
A
L
E
F
F
-
Q
V
-
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
P
R
G
Q
S
A
M
-
V
N
L
I
-
G
E
-
K
------------
P
P
-----
F
--
A
E
V
L
K
-
V
E
G
A
H
L
H
W
Y
G
K
-
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
-
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
--
3
PsiBlast_PDB
89.93
41%
-91
- C2 -
4MA0
4
?
A:
[2-359]
-
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
--
H
C
L
G
K
N
G
D
C
-
A
E
E
V
V
K
T
-
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
------
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
--
A
---
P
F
E
-
N
--
V
V
L
A
E
K
A
Q
---
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
-
V
K
-
G
-
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
S
-
R
K
T
V
M
-
L
N
C
I
-
G
G
-
M
------------
P
A
-----
T
--
K
D
L
A
A
-
L
D
R
V
K
I
H
S
Y
N
K
-
E
-
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
-
E
-
T
D
E
Y
Q
L
L
Q
V
K
K
L
I
--
4
PsiBlast_PDB
89.76
41%
-92
- C2 -
4MA5
5
?
A:
[2-359]
-
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
--
H
C
L
G
K
N
G
D
C
-
A
E
E
V
V
K
T
-
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
------
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
--
A
---
P
F
E
-
N
--
V
V
L
A
E
K
A
Q
---
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
-
V
K
----
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
S
-
R
K
T
V
M
-
L
N
C
I
-
G
G
-
M
------------
P
A
-----
T
--
K
D
L
A
A
-
L
D
R
V
K
I
H
S
Y
N
K
-
E
-
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
-
E
-
T
D
E
Y
Q
L
L
Q
V
K
K
L
I
--
2
PsiBlast_PDB
89.71
41%
-90
- C2 -
4M9U
13
?
A:
[2-359]
-
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
--
H
C
L
G
K
N
G
D
C
-
A
E
E
V
V
K
T
-
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
------
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
--
A
---
P
F
E
-
N
--
V
V
L
A
E
K
A
Q
---
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
-
V
K
-
G
-
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
S
-
R
K
T
V
M
-
L
N
C
I
-
G
G
-
M
------------
P
A
-----
T
--
K
D
L
A
A
-
L
D
R
V
K
I
H
S
Y
N
K
-
E
-
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
-
E
-
T
D
E
Y
Q
L
L
Q
V
K
K
L
I
--
5
PsiBlast_PDB
89.38
41%
-91
- C2 -
4MAM
3
?
A:
[2-359]
-
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
--
H
C
L
G
K
N
G
D
C
-
A
E
E
V
V
K
T
-
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
------
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
-
E
S
E
--
A
---
P
F
E
-
N
--
V
V
L
A
E
K
A
Q
---
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
-
V
K
-
G
-
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
S
-
R
K
T
V
M
-
L
N
C
I
-
G
G
-
M
------------
P
A
-----
T
--
K
D
L
A
A
-
L
D
R
V
K
I
H
S
Y
N
K
-
E
-
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
-
E
-
T
D
E
Y
Q
L
L
Q
V
K
K
L
I
--
6
PsiBlast_PDB
87.33
39%
-88
- C2 -
4E4T
3
?
A:
[38-392]
--
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
--
A
V
L
D
P
D
P
A
S
-
P
A
G
A
V
A
D
R
H
-
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
-
A
--
R
T
T
-
F
V
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
L
G
-
Y
D
G
K
G
Q
V
R
V
S
T
------
A
R
E
A
R
D
A
H
A
A
L
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
-
L
T
I
--
V
---
P
A
P
-
A
--
A
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
-
L
G
Y
V
G
V
L
C
V
E
F
F
-
V
L
E
D
-
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
Q
H
S
P
A
A
M
-
L
N
I
L
-
G
D
-
V
WFPNGAAA
G
A
V
T
P
P
-----
W
--
D
T
V
A
A
-
M
P
A
A
H
L
H
L
Y
G
K
E
E
-
A
R
V
G
R
K
M
G
H
-------------------------
22
PsiBlast_CBE
86.96
39%
-91
- C2 -
4E4T
2
?
B:
[38-392]
--
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
--
A
V
L
D
P
D
P
A
S
-
P
A
G
A
V
A
D
R
H
-
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
-
A
--
R
T
T
-
F
V
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
------
K
G
Q
V
R
V
S
T
------
A
R
E
A
R
D
A
H
A
A
L
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
-
L
T
I
--
V
---
P
A
P
-
A
--
A
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
-
L
G
Y
V
G
V
L
C
V
E
F
F
-
V
L
E
D
-
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
Q
H
S
P
A
A
M
-
L
N
I
L
-
G
D
-
V
WFPNGAAA
G
A
V
T
P
P
-----
W
--
D
T
V
A
A
-
M
P
A
A
H
L
H
L
Y
G
K
E
E
-
A
R
V
G
R
K
M
G
H
-------------------------
66
HHSearch
86.41
38%
-89
- C2 -
3Q2O
1
?
A:
[15-377]
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
-
P
C
A
Q
V
A
D
-
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
K
H
A
Y
L
---
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
-
G
G
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
--
V
---
P
A
R
-
I
T
E
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
-
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
G
E
H
I
E
------------
G
V
-----
L
---
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
-
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
-
I
E
V
A
L
E
K
A
K
S
L
H
I
----
69
HHSearch
83.70
33%
-90
- C2 -
3AX6
1
?
A:
[2-369]
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
--
I
V
L
D
P
T
P
R
S
-
P
A
G
Q
V
A
D
-
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
K
L
-
Y
N
-
E
G
Y
-
K
I
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
S
---
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
-
G
-----
G
V
F
I
I
K
N
------
E
K
D
L
E
N
A
I
K
----
G
E
--
T
Y
L
E
E
F
V
E
-
I
E
K
E
L
A
V
M
V
A
R
N
E
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
-
T
V
I
--
A
---
P
A
R
-
I
E
E
K
Y
S
K
I
A
R
E
---
I
A
T
S
V
V
E
A
-
L
E
G
V
G
I
F
G
I
E
M
F
-
L
T
-
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
S
T
-
E
L
L
I
P
A
V
M
-
V
N
L
L
-
G
E
-
E
------------
G
Y
Y
G
K
P
A
L
I
G
L
E
E
A
L
A
I
E
G
L
S
L
H
F
Y
G
K
-
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
D
-
V
E
R
A
L
E
K
A
L
R
A
K
K
I
L
K
-
64
HHSearch
81.84
33%
-87
- C2 -
3ORQ
3
?
A:
[13-374]
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
--
V
V
L
D
P
S
E
D
C
-
P
C
R
Y
V
A
H
-
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
K
-
Y
N
I
-
P
--
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
-
G
G
Y
D
G
K
G
Q
V
L
I
N
N
------
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
-
K
T
I
--
V
---
P
A
R
-
I
--
D
K
T
A
E
A
K
E
---
Q
V
N
K
I
I
Q
S
-
I
H
F
I
G
T
F
T
V
E
F
F
-
I
D
-
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
L
K
P
A
V
M
-
M
N
L
L
-
G
K
D
L
------------
D
L
-----
L
--
E
N
E
F
N
E
H
P
E
W
H
L
H
I
Y
G
K
-
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
-
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
----
7
PsiBlast_PDB
81.71
39%
-85
- C2 -
4DLK
7
?
A:
[18-354]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
11
PsiBlast_PDB
81.15
39%
-84
- C2 -
3V4S
3
?
A:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
10
PsiBlast_PDB
81.14
39%
-84
- C2 -
3R5H
3
?
A:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
24
PsiBlast_CBE
80.87
39%
-86
- C2 -
3R5H
3
?
B:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
VP
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
GV---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
9
PsiBlast_PDB
80.76
39%
-86
- C2 -
3QFF
1
?
A:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
26
PsiBlast_CBE
80.55
39%
-86
- C2 -
3Q2O
1
?
B:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
VP
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
GV---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
8
PsiBlast_PDB
80.39
39%
-86
- C2 -
3Q2O
1
?
A:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
27
PsiBlast_CBE
80.24
39%
-85
- C2 -
3V4S
4
?
B:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
V
P
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
G
V
---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
17
PsiBlast_PDB
80.01
32%
-84
- C2 -
3ORQ
3
?
A:
[22-374]
---------
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
--
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
A
H
E
-
F
-
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
-
C
--
E
K
Y
-
N
I
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
-
Y
D
G
K
G
Q
V
L
I
N
N
------
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
-
K
T
I
--
V
---
P
A
R
-
I
--
D
K
T
A
E
A
K
E
---
Q
V
N
K
I
I
Q
S
-
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
-
N
-
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
-
I
E
L
L
K
P
A
V
M
M
N
L
L
-
G
K
-
D
------------
L
D
-----
L
LE
N
E
F
N
E
-
H
P
E
W
H
L
H
I
Y
G
K
-
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
-----
25
PsiBlast_CBE
79.92
39%
-87
- C2 -
3QFF
1
?
B:
[24-360]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
VP
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
GV---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
23
PsiBlast_CBE
79.79
39%
-85
- C2 -
4DLK
4
?
B:
[18-354]
---------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
--
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
-
E
-
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
------
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
-
E
S
I
VP
A
---
R
I
T
-
E
--
E
L
S
Q
K
A
I
A
---
Y
A
K
V
L
A
D
E
-
L
E
L
V
G
T
L
A
V
E
M
F
-
A
T
A
D
-
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
L
L
K
P
V
V
M
-
V
N
I
L
-
G
E
-
H
------------
I
E
GV---
L
--
R
Q
V
N
R
-
L
T
G
C
Y
L
H
L
Y
G
K
E
E
-
A
K
A
Q
R
K
M
G
H
V
N
I
----------------------
14
PsiBlast_PDB
79.49
38%
-83
- C2 -
3ETH
3
PURK_ECOLI
A:
[3-336]
-
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
A
A
-
V
P
F
-----------------------
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
NETEQL
P
A
E
C
Y
G
E
----------
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
--
A
F
P-
Q
A
N
-
A
--
Q
Q
Q
A
R
A
E
E
---
M
L
S
A
I
M
Q
E
-
L
G
Y
V
G
V
M
A
M
E
C
F
-
V
T
-
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
V
N
N
P
S
V
M
-
I
N
L
I
-
G
S
--------------
D
V
-----
N
--
Y
D
W
L
K
-
L
P
L
V
H
L
H
W
Y
D
K
-
E
-
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
-
T
S
R
L
T
A
T
L
---
E
A
L
I
--
15
PsiBlast_PDB
79.22
38%
-84
- C2 -
3ETJ
5
PURK_ECOLI
A:
[3-336]
-
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
A
A
-
V
P
F
-----------------------
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
NETEQL
P
A
E
C
Y
G
E
----------
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
--
A
F
P-
Q
A
N
-
A
--
Q
Q
Q
A
R
A
E
E
---
M
L
S
A
I
M
Q
E
-
L
G
Y
V
G
V
M
A
M
E
C
F
-
V
T
-
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
V
N
N
P
S
V
M
-
I
N
L
I
-
G
S
--------------
D
V
-----
N
--
Y
D
W
L
K
-
L
P
L
V
H
L
H
W
Y
D
K
-
E
-
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
-
T
S
R
L
T
A
T
L
---
E
A
L
I
--
29
PsiBlast_CBE
78.39
38%
-85
- C2 -
3ETH
3
PURK_ECOLI
B:
[3-336]
-
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
WP
V
G
L
D
A
E
P
A
A
-
V
P
F
-----------------------
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
NETEQL
P
A
E
C
Y
G
E
----------
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
--
A
FP-
Q
A
N
-
A
--
Q
Q
Q
A
R
A
E
E
---
M
L
S
A
I
M
Q
E
-
L
G
Y
V
G
V
M
A
M
E
C
F
-
V
T
-
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
V
N
N
P
S
V
M
-
I
N
L
I
-
G
S
--------------
D
V
-----
N
--
Y
D
W
L
K
-
L
P
L
V
H
L
H
W
Y
D
K
-
E
-
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
-
T
S
R
L
T
A
T
L
---
E
A
L
I
--
28
PsiBlast_CBE
78.08
38%
-89
- C2 -
3ETJ
4
PURK_ECOLI
B:
[3-336]
-
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
A
A
-
V
P
F
-----------------------
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-----
G
Q
W
R
L
R
A
NETEQL
P
A
E
C
Y
G
E
----------
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
-
T
S
V
--
A
F
P-
Q
A
N
-
A
--
Q
Q
Q
A
R
A
E
E
---
M
L
S
A
I
M
Q
E
-
L
G
Y
V
G
V
M
A
M
E
C
F
-
V
T
-
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
V
N
N
P
S
V
M
-
I
N
L
I
-
G
S
--------------
D
V
-----
N
--
Y
D
W
L
K
-
L
P
L
V
H
L
H
W
Y
D
K
-
E
-
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
-
T
S
R
L
T
A
T
L
---
E
A
L
I
--
72
HHSearch
77.88
39%
-79
- C2 -
3ETH
3
PURK_ECOLI
A:
[2-340]
K
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
--
W
P
V
G
L
D
A
E
P
--
A
A
V
------
P
--------------
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
---
E
T
A
L
T
R
Q
-
L
A
R
H
P
A
F
V
N
R
D
V
F
P
I
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A
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R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
T
G
-
G
-
Y
D
G
R
G
Q
W
R
L
R
A
------
N
E
T
E
-
Q
L
P
A
-
E
C
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
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G
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T
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F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
--
F
---
P
Q
A
-
N
A
-
Q
Q
Q
A
R
A
E
E
---
M
L
S
A
I
M
Q
E
-
L
G
Y
V
G
V
M
A
M
E
C
F
-
V
T
-
P
-
Q
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
V
N
N
P
S
V
M
-
I
N
L
I
-
G
S
-
D
------------
V
N
-----
Y
---
D
W
L
K
-
L
P
L
V
H
L
H
W
Y
D
K
-
E
-
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
D
-
T
S
R
L
T
A
T
L
E
A
L
I
P
L
L
P
-