@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00017_BMX_MO: (2014-08-09 )
MESKSILEELLLKKSQQKKKMSPNNYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERLLKIPRAVPVLKMDASSSGAILPQYDSYSKKSCGSQPTSNIRYIPREDCPDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPLREQDKP
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-....-...220...-..-..230.......240.......250.......260.......270.......280.....-.-.290........300........310.......320.......330.......340.......350.......360.......370.......--------------380--.......390.....-..400.......410.---.------.--------.---...420.....--..---430.........440.-......450.......-460.......470.......--480---------------.------.......490.......500.......510.......520..---.....530.......--540-.-......-.550.......560.......570.......580.......-590...-....600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
S
K
S
I
L
E
E
L
L
L
K
K
S
Q
Q
KKKMSPNNY
K
E
R
L
F
V
L
T
KTSL
S
Y
Y
E
Y
D
K
M
KRGSRKG
S
I
E
I
K
K
I
R
C
V
E
KVNLEEQTPVERQY
P
F
Q
I
V
YKD
G
L
L
Y
V
Y
ASN
E
E
S
R
C
Q
W
L
K
A
L
Q
K
E
IRGNP
H
L
L
I
K
YHS
G
F
F
VDG
K
F
L
C
C
Q
Q
SCKAAPG
C
T
L
W
E
AY
A
D
L
H
I
A
ISDEKHRAPT
F
P
E
R
L
L
KIPRAV
P
V
L
K
MDASSSGAILPQYDSYSKKSCGSQPTSN
I
R
Y-IPRE-DCP
D
W
W
Q
V
R
-KL-KSEEDI
A
C
S
N
Q
L
E
R
N
I
ASHSTSKMSWGFPESSSS
E
E
EENL
H
A
Y
D
WFAGNIS
R
S
Q
S
E
Q
L
L
R
-Q-KG-KE
G
A
F
M
V
RNS-SQM
G
M
Y
T
V
S
L
F
S
K
A
VNDKKG
T
V
K
H
Y
H
V
HTNAE
N
K
L
Y
L
AEN
Y
C
F
D
S
I
P
K
L
I
H
Y
HQHNSAG
M
I
T
R
LRHPVSTKANK
V
P
V
S
V
--------------ALG--S
G
I
W
E
L
K
R
E
E
I
T
L
L
K
-
E
LGNG
Q
F
G
V
V
Q
LGQWK---G------
Q
--------
Y
---
D
V
A
V
K
M
I
K
EGA--M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
KL-SH
P
K
L
V
K
F
Y
G
VCSKKY-
P
I
Y
I
V
T
E
Y
ITN
G
C
L
L
N
Y
L
K
S
--H-G---------------K------G
L
E
S
C
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
ARNCLVDSDL---
S
V
K
V
SDFG
M
T
R
Y
V
L
D
--
D
Q
--
Y
-
V
S
S
VGT-KFPVKWSAPE
V
F
H
Y
F
KYSSKS
D
V
W
A
F
G
I
L
M
W
E
V
F
S
LGKQPY-DLYDN
S
-
E
V
V
V
K
VSQG
H
R
LYRPQLAS
D
T
I
Y
Q
I
M
Y
S
C
W
H
ELPEKR
P
T
F
Q
Q
L
L
S
A
I
E
P
L
R
EQDKP
33
HHSearch
85.18
37%
-94
- C2 -
2H8H
1
SRC_HUMAN
A:
[87-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
E
G
D
W
W
L
A
H
-
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
----------------------
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
-
E
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
-
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
---
S
K
P
Q
T
Q
--------------
G
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
------
T
--------
T
---
R
V
A
I
K
T
L
K
P
G
T
--
M
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
-
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
T
G
---------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
---
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
E
--
Y
-
T
A
R
Q
G
A
-
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
-
41
HHSearch
79.85
93%
-124
- C2 -
3SXS
1
A:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
---
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
-
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
--
H
-
G
---------------
K
------
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
Q
--
Y
-
V
S
S
V
G
T
-
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
-
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
36
HHSearch
79.52
36%
-93
- C2 -
1OPK
3
ABL1_MOUSE
A:
[44-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
-
T
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
P
----------------------
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
-
S
--
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
--
N
K
P
T
I
Y
--------------
G
V
S
PN
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
---
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
--
C
-
N
R--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
T
--
Y
-
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---
34
HHSearch
79.39
35%
-88
- C2 -
1QCF
1
HCK_HUMAN
A:
[8-443]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
-
V
V
L
E
-
E
S
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
----------------------
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
-
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
---
K
P
Q
K
P
--------------
W
-
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
---
K
V
A
V
K
T
M
K
P
G
S
--
M
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
-
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
---------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
--
N
E
--
Y
-
T
A
R
E
G
A
-
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
---
1
PsiBlast_PDB
79.10
92%
-119
- C2 -
3SXR
1
BMX_HUMAN
A:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
----
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
---
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
-
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
--
H
-
G
---------------
K
------
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
Q
--
Y
-
V
S
S
V
G
T
-
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
-
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
21
PsiBlast_CBE
78.79
92%
-122
- C2 -
3SXR
1
B:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
------
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
---
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
-
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
--
H
-
G
---------------
K
------
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
Q
--
Y
-
V
S
S
V
G
T
-
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
-
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
39
HHSearch
74.57
31%
-108
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[155-598]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
-
S
-
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
------
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------MDTSVFESPFSDPE
E
L
K
--
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK
K
------
Q
--------
I
---
D
V
A
I
K
V
L
K
Q
G
T
EK
A
D
---
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
--
K
-
R
---------------
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
-
K
K
M
K
G
P
-
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
----
42
HHSearch
69.52
58%
-113
- C2 -
4HCU
1
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
-
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---
15
PsiBlast_PDB
68.95
58%
-113
- C2 -
4HCT
1
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
-
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
40
HHSearch
68.75
62%
-121
- C2 -
3GEN
1
A:
[16-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
-
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
17
PsiBlast_PDB
68.64
58%
-114
- C2 -
4HCV
1
A:
[5-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
-
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
8
PsiBlast_PDB
67.93
62%
-124
- C2 -
3PJ2
1
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
4
PsiBlast_PDB
67.85
62%
-113
- C2 -
3PIX
1
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
-
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
18
PsiBlast_PDB
67.49
58%
-115
- C2 -
3T9T
3
A:
[3-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
-
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
7
PsiBlast_PDB
67.47
62%
-126
- C2 -
3PJ1
2
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
-------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
-----------------------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
12
PsiBlast_PDB
67.26
63%
-116
- C2 -
3OCS
2
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
-
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
N
--
9
PsiBlast_PDB
66.74
62%
-123
- C2 -
3PJ3
1
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
--------------
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
-------------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
5
PsiBlast_PDB
66.50
62%
-112
- C2 -
3PIY
1
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
-----------
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
-
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
13
PsiBlast_PDB
66.00
64%
-130
- C2 -
3OCT
1
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
-----
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
6
PsiBlast_PDB
65.42
62%
-123
- C2 -
3PIZ
1
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
-------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
19
PsiBlast_PDB
63.67
59%
-118
- C2 -
3QGW
1
ITK_HUMAN
A:
[28-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
20
PsiBlast_PDB
63.29
59%
-119
- C2 -
3QGY
1
ITK_HUMAN
A:
[28-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
---
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
---------------
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
-
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
10
PsiBlast_PDB
63.03
61%
-118
- C2 -
3K54
1
A:
[16-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
---
D
V
A
I
K
M
I
K
--------------
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--
M
-
R
---------------
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
-
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
49
HHSearch
58.41
38%
-105
- C2 -
1T46
1
A:
[16-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
---
G
LIKSD
A
A
--------
M
---
T
V
A
V
K
M
L
K
P
S
A
--
H
L
T
E
-
R
--
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
-
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
--
K
-
R
---------------
D
SFL---
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
---
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
--
D
S
--
N
Y
V
V
K
G
N
A
-
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
-
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
---
47
HHSearch
58.25
39%
-108
* C2 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
---
N
LLP---
K
--------
M
---
L
V
A
V
K
A
L
K
E
A
S
--
E
S
A
--
R
--
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
-
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
--
H
-
G
---------------
P
DPG---
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
---
V
V
K
I
G
D
F
G
--------------------
T
-
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
-
Y
Q
L
S
N
T
-
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
---
50
HHSearch
58.04
38%
-107
- C2 -
3KUL
2
EPHA8_HUMAN
A:
[43-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
---
V
PGQ
R
--
D
--------
V
---
P
V
A
I
K
A
L
K
A
G
Y
--
T
E
R
Q
-
R
--
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
R
-
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
--
H
-
D
---------------
G
------
Q
F
T
I
M
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
---
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-----A-
A
-
Y
T
T
T
----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
-
W
N
M
T
N
R
-
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
--
23
Fugue
57.23
44%
-112
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
---
G
---------------
N
---
K
V
A
V
K
C
I
K
-----
N
D
---
A
--
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G--
R
---------------
S
------
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
---
V
A
K
V
S
D
F
G
----------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
-
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-
54
HHSearch
56.68
39%
-97
- C2 -
3L9P
4
A:
[63-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---
G
----------------S
P
L
Q
V
A
V
K
T
L
P
E
V
C
--
S
E
Q
D
-
E
--
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
-
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
--
T
-
R
---------------
P
RPSQPS
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
PG
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--
A
G
--
Y
-
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
-
P
S
K
S
N
Q
-
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
---
46
HHSearch
55.92
35%
-107
- C2 -
1U59
1
A:
[2-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
---
K
------
Q
--------
I
---
D
V
A
I
K
V
L
K
Q
G
T
--
E
K
A
D
-
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
E
--
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
--
K
-
R
---------------
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
DD
S
Y
--
Y
-
T
A
R
S
A
G
-
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
-
K
K
M
K
G
P
-
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
-----
52
HHSearch
55.55
36%
-98
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[54-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
--
Y
E
L
P
E
---------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
---
G
------
L
DKDKPN
R
V
T
---
K
V
A
V
K
M
L
K
S
D
A
--
T
E
---
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
-
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
--
R
-
R
PPGLEYSYNPSHNP
E
E
------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
---
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
--
I
D
Y-
Y
-
K
K
T
T
N
G
-
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
-
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
----
51
HHSearch
53.68
37%
-106
- C2 -
4FYO
1
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---
M
------
K
K
V
V
-----
K
---
T
V
A
V
K
I
L
--------P
A
L
K
--
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
--
N
-----------------
R
------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--
D
E
NY
Y
-
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
-
R
G
M
K
G
S
-
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---