@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00017_FER_HU: (2014-08-09 )
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..----.----.----...480.......490.......-----500------.......-510--....-...520.......530....--------...-------540..----.-----....-----550..-----.....560.....-..570.......580----.------.-------..-...590.......600..-.....610...-....620.......630........640.......650.------.-------.---.-....660.......670.......680.......690.-----......700.......--710.-......-..720.......730.......740.......750.......760...-.-...770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGF
G
S
DLK
N
S
H
E
A
V
L
K
LQ
D
W
E
L
R
L
L
E
T
V
K
K
F
M
A
L
RIKS
D
K
E
Y
A
S
T
L
Q
N
L
C
N
QVDKES
T
V
Q
M
N
Y
V
S
NV
S
K
S
W
L
L
M
IQ
Q
T
E
Q
L
S
R
I
M
K
T
H
A
E
DLNSG
P
L
H
R
L
T
M
M
IK
D
K
Q
Q
V
K
K
S
Y
I
G
V
H
Q
Q
I
E
A
E
M
I
K
V
T
K
T
E
L
E
K
L
K
C
S
Y
R
Q
L
I
K
E
M
N
S
A
K
E
K
Y
K
E
A
L
AKGK
E
T
E
K
A
K
E
R
Y
D
K
A
T
M
K
L
H
M
L
HN
Q
Y
V
L
A
LKGAQLHQN
Q
Y
Y
D
I
T
L
P
L
L
L
D
S
L
Q
K
M
Q
E
E
M
I
K
A
L
K
G
I
F
D
E
Y
S
Q
I
T
S
L
V
T
E
E
I
V
N
V
H
K
E
I
Q
M
S
V
E
QIDPSTEYN
N
F
I
D
V
HRTTAAKEQEIEF
D
T
S
L
L
EENENLQAN
E
I
MWNNL
T
A
E
S
L
Q
V
M
L
K
T
L
A
E
E
L
M
Q
T
Q
Q
M
L
LN
K
E
E
A
V
L
E
L
E
K
R
I
E
E
S
S
E
T
C
EKKS
D
I
V
L
L
L
S
Q
K
Q
A
L
E
E
L
K
Q
S
V
Q
Q
L
RC
T
E
A
K
F
S
A
Q
K
E
L
L
E
Q
K
V
Q
ENDGKEPPPVV
N
Y
E
E
D
A
R
S
V
T
S
M
E
R
K
E
R
L
S
K
F
E
S
I
R
H
S
I
A
G
I
IR
S
P
K
S
AL
G
S
S
A
L
S
D
M
I
S
ISEKPLAEQDWYHGAIP
R
I
E
A
Q
E
L
L
----
K
----K----QG
D
F
L
V
RESHGKPG
E
Y
V
L
S
VYSD-----GQ
R
------
R
H
F
I
I
Q
Y-VD
N
--
M
Y
R
F-EGTGF
S
N
I
P
Q
L
I
D
HHY
T
T
K
Q
--------
V
I
T-------KKS
G
V
----
V
-----
L
LNP-----IPKDK-----
K
W
I
LSHE
D
V
I
L
G
E
-
L
LGKGNF
G
E
V
Y
K
GTL----K------D-------K
T
-
S
V
A
V
K
T
C
K
E
DL
P
Q
E
L
K
I
K
-
F
L
Q
E
A
K
I
L
K
QY-DH
P
N
I
V
K
L
I
G
V
CTQR-Q
P
V
Y
I
I
M
E
L
VSGG
D
F
L
T
F
L
R
R-
K
------
K
-------
D
---
E
-
L
K
L
K
Q
L
V
K
F
S
LDAAA
G
M
L
Y
LESKN
C
I
H
R
D
L
A
ARNCLVG-----EN
N
V
L
K
I
SDFGMSRQE--D--G-GVYSSS-G
L
K
QI
P
I
K
WTAPEALNYGRYSSES
D
V
W
S
F
G
I
L
L
W
E
TFSLGVCPYPGMT-
N
-
Q
Q
A
R
E
Q
V
E
RGYRMSAPQH
C
P
E
D
I
S
K
I
M
M
K
CWDYKPENRP
K
F
S
E
L
Q
K
E
L
T
I
I
K
RKLT
1
PsiBlast_PDB
98.81
66%
-89
- C2 -
3BKB
9
A:
[4-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
F
L
V
R
E
S
Q
G
K
-
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
------
R
H
F
I
I
Q
S
-
L
D
N
--
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
--------
P
L
T
-------
K
K
S
G
V
----
V
-----
L
H
R
A
-----
V
P
K
D
K
------
W
V
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A-----
D
-------
N
T
-
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
------
G
-------
A
---
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--
A
--
D
-
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
-
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
2
PsiBlast_PDB
84.23
40%
-84
- C2 -
1OPK
3
ABL1_MOUSE
A:
[102-473]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
------
Y
H
Y
R
I
N
T
-
A
S
D
G
K
L
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G-------
L
I
T
TLHYPAP
K
R
N
K
P
----
T
-----
I
Y
G
V
-----
S
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
4
PsiBlast_PDB
83.72
40%
-84
- C2 -
1OPL
2
ABL1_HUMAN
A:
[141-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
------
Y
H
Y
R
I
N
T
-
A
S
D
G
K
L
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G-------
L
I
T
TLHYPAP
K
R
N
K
P
----
T
-----
V
Y
G
V
-----
S
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
3
PsiBlast_PDB
83.54
40%
-83
- C2 -
2FO0
4
ABL1_HUMAN
A:
[99-470]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
------
Y
H
Y
R
I
N
T
-
A
S
D
G
K
L
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G-------
L
I
T
TLHYPAP
K
R
N
K
P
----
T
-----
V
Y
G
V
-----
S
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
9
PsiBlast_PDB
80.97
40%
-84
- C2 -
1Y57
1
SRC_HUMAN
A:
[53-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
----
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
D
-----
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
-
L
D
S
GG
F
Y
I
T
-
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
--------
G
L
C
-------
H
R
L
T
T
----
V
-----
C
P
T
S
-----
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
------
G
-------
T
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
------
T
-------
G
---
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--
D
-
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
33
HHSearch
78.57
40%
-80
- C2 -
1QCF
1
HCK_HUMAN
A:
[65-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
PGNM
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
------
K
H
Y
K
I
R
T
-
L
D
N
G
G
F
Y
I
S
-
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
--------
G
L
C
-------
Q
K
L
S
V
----
P
CMSSK
P
Q
K
P
-----
W
E
K
D
------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
------
K
-------
H
T
-
K
V
A
V
K
T
M
K
P
G
S
M
--
S
V
E
A
-
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-------
S
---
K
-
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
--
D
-
N
E
Y
T
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
---
8
PsiBlast_PDB
78.30
40%
-79
- C2 -
2SRC
1
SRC_HUMAN
A:
[53-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
----
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
D
-----
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
-
L
D
S
G
G
F
Y
I
T
-
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
--------
G
L
C
-------
H
R
L
T
T
----
V
-----
C
P
T
S
-----
K
P
Q
T
Q
GLAKD
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
------
G
-------
T
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
------
T
-------
G
---
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--
D
-
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
10
PsiBlast_PDB
77.30
40%
-77
- C2 -
1KSW
1
SRC_HUMAN
A:
[53-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
----
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
D
-----
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
-
L
D
S
GG
F
Y
I
T
-
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
--------
G
L
C
-------
H
R
L
T
T
----
V
-----
C
P
T
S
-----
K
P
Q
T
Q
GLAKD
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
------
G
-------
T
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
------
T
-------
G
---
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--
D
-
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
37
HHSearch
76.72
35%
-83
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[158-599]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
----
Y
SGAQ
T
----
D
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
G
-----
K
T
V
------
Y
H
Y
L
I
S
Q
D
K
A
G
--
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
GLIYCLKE
A
C
P
-------
N
----MDTS
V
-----
F
E
S
P
FSDPE
E
L
K
D
K
-----
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
----
R
M
RK---
K
-------
Q
I
-
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
------
R
-------
E
---
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
--
G
----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
14
PsiBlast_PDB
59.97
45%
-87
- C2 -
3PYY
1
ABL1_HUMAN
A:
[18-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
-----
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
53
HHSearch
59.76
42%
-79
- C2 -
3ZBF
1
A:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--------
E
------------
N
------------
L
P
A
-----
F
P
-------------
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
----
V
------
D
ILGVGSG
E
I
-
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-
A
R
M
ATFY
G
-------
P
---
L
-
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
--
Y
---------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
-
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
--
12
PsiBlast_PDB
59.72
45%
-86
- C2 -
2Z60
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
----
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
20
PsiBlast_PDB
59.65
45%
-82
- C2 -
3QRK
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
50
HHSearch
59.39
38%
-85
* C2 *
4AOJ
1
NTRK1_HUMAN
A:
[36-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----
H
NLLP----------
K
M
-
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
------
G
-------
P
DPG
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
---------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
---
46
HHSearch
59.39
40%
-73
- C2 -
2IVS
5
RET_HUMAN
A:
[14-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
-----
K
W
E
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
----
F
HLKGRA
G
-------
Y
T
-
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
------
R
K
VGPGYL
R
---
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y-
E
--
E
-
D
S
Y
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
-
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
--
19
PsiBlast_PDB
59.30
45%
-86
- C2 -
3QRI
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
6
PsiBlast_PDB
59.18
44%
-83
- C2 -
3CS9
1
ABL1_HUMAN
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
-----
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
13
PsiBlast_PDB
59.14
45%
-87
- C2 -
3IK3
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
54
HHSearch
58.68
42%
-74
- C2 -
3SXS
1
A:
[2-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
----
K
------
G
-------
Q
Y
-
D
V
A
V
K
M
I
K
E
G
S
M
S
--
E
D
E
-
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
------
G
-------
K
---
G
-
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
-----
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
--
L
--
D
-
D
Q
Y
V
S
S
-
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
43
HHSearch
58.64
42%
-73
- C2 -
1T46
1
A:
[13-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
H
-----
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
GLI
K
SD----
A
-------
A
M
-
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
------
R
-------
D
SFL
A
-
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
--
K
--
N
D
S
N
Y
V
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
--
5
PsiBlast_PDB
58.57
44%
-83
- C2 -
2HZI
1
ABL1_HUMAN
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
16
PsiBlast_PDB
58.55
45%
-80
- C2 -
3UE4
1
ABL1_HUMAN
A:
[8-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
11
PsiBlast_PDB
58.10
45%
-77
- C2 -
3OY3
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
15
PsiBlast_PDB
57.88
45%
-79
- C2 -
2G1T
2
ABL1_HUMAN
A:
[7-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
39
HHSearch
56.83
38%
-84
- C2 -
1U59
1
A:
[2-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
----
R
------
K
-------
Q
I
-
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
------
R
-------
E
---
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
GA
D
--
D
-
S
Y
Y
T
A
R
-
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
----
17
PsiBlast_PDB
56.23
45%
-82
- C2 -
2HYY
1
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
------
K
-------
Y
S
L
T
V
A
V
K
T
L
K
-
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-------
Q
---
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
--
G
-
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
42
HHSearch
56.10
39%
-83
- C2 -
4FYO
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
----
Q
M
KK---
V
-------
V
K
-
T
V
A
V
K
I
L
-----
P
A
L
K
D
E
-
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
--------------
R
---
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
--
R
AD
E
-
N
Y
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
23
Fugue
56.10
44%
-93
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG------------------
N
-
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
------
G
R------
S
---
V
-
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
-----
E
D
N
V
A
K
V
S
D
F
G
----------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L