@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00018_BLK_HU: (2014-08-10 )
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90-.-........100.......110.......120.......130.......140.......150.......160.....-..170.......180.......190.......200.......210.......220.-.....-.----------------230.......240...-....250.......260------.-.......270...--.--.--.---.--280.......290........300..-.-.-...310.......320......-----.--330.......340.......350.......360.......-----370.......380...--.---.---..--390.......400.......410.......420.......430.......440.-......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGLVSSKKPDKEKPIKEKDKGQWS
P
L
K
V
SAQDKDAPPLP
P
L
V
VFNHLTPPPPDEHLDEDK
H
F
V
V
A
L
Y
D
Y
TAMNDR
D
L
Q
MLKGE
K
L
Q
V
L
KG--T-
G
D
W
W
L
A
R
S
LVTGREGYV
P
S
N
F
V
A
R
V
E
S
L
E
M
E
R
W
F
F
R
SQG
R
K
E
A
E
R
Q
L
L
A
P
INKA
G
S
F
L
I
R
ESETNK
G
A
F
S
L
S
V
K
DV-TT
Q
G
E
L
I
K
H
Y
K
I
R
C
LDEG
G
Y
Y
I
SPRIT
F
P
S
L
Q
A
L
V
Q
H
Y
SKKGD
G
L
C
Q
RLTLPCVRP-APQNP-W----------------AQ
D
E
WEI
P
R
Q
S
L
R
L
V
R
-
K
LGSGQ
F
G
E
V
W
M
G
Y
YK-------N-N
M
K
V
A
I
K
T
L
K
EGT--M--
S
--
P
---
E
--
A
FL
G
E
A
N
V
M
K
A
L
-
Q
H
E
R
L
V
R
L
Y
A
V
VT-K-E-P
I
Y
I
V
T
E
Y
M
A
R
G
C
L
L
D
F
L
KTDE-----G--SRLSL
P
R
L
I
D
M
S
A
Q
I
A
E
G
M
A
Y
I
E
R
M
N
S
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
E
A
L
C
C
K
I
A
D
F
G
L
A
R
I
I--D---S---EY--TAQEGAKF
P
I
K
WTAPE
A
I
H
F
G
V
F
T
I
K
A
D
V
W
S
F
G
V
L
L
M
E
V
V
TYGRVPYPGMS
N
P
E
-
V
I
R
N
L
E
R
GYRMPRPDTC
P
P
E
L
Y
R
G
V
I
A
E
C
W
RSRPEER
P
T
F
E
F
L
Q
S
V
L
E
D
F
Y
T
A
T
E
R
Q
YELQP
1
PsiBlast_PDB
92.93
62%
-114
- C2 -
1Y57
1
SRC_HUMAN
A:
[6-447]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
--
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
Q
G
L
----------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-------
G
-
T
T
R
V
A
I
K
T
L
K
P
G
T
--
M
--
S
--
P
---
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E-
D
---
N
---
E
Y
--
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
36
HHSearch
84.90
43%
-111
- C2 -
1OPK
3
ABL1_MOUSE
A:
[44-480]
------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
NH
N
-
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
-
G
VSP-------------
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
--
M
--
E
--
V
---
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-----
R
--
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T-
G
---
D
---
T
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
-
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
-
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
39
HHSearch
74.26
35%
-115
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[155-603]
----------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------MDTSVFESPFSDPEEL
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK----
K
-
Q
I
D
V
A
I
K
V
L
K
Q
G
T
EK
A
--
D
--
T
---
E
--
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
-
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-----
R
--
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G---------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
-
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
-
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
-----
9
PsiBlast_PDB
72.29
71%
-128
- C2 -
2OF2
1
LCK_HUMAN
A:
[2-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E-
D
---
N
---
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
4
PsiBlast_PDB
72.11
74%
-135
- C2 -
2HK5
1
HCK_HUMAN
A:
[2-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
-
W
----------------
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
--
M
--
S
--
V
---
E
--
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
--
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-
D
---
N
---
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
-
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
------------
10
PsiBlast_PDB
71.41
71%
-129
- C2 -
2OF4
1
LCK_HUMAN
A:
[2-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E-
D
---
N
---
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
6
PsiBlast_PDB
71.08
72%
-136
- C2 -
3B2W
1
LCK_HUMAN
A:
[13-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E-
D
---
N
---
E
Y
--
T
A
--
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
14
PsiBlast_PDB
70.31
72%
-132
- C2 -
2ZVA
1
LYN_MOUSE
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
L
V
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
-
S
T
K
V
A
V
K
T
L
K
P
G
T
--
M
--
S
--
V
---
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
--
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E-------------
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
-
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------
15
PsiBlast_PDB
69.79
71%
-132
- C2 -
3MPM
2
LCK_HUMAN
A:
[4-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
---
N
---
E
Y
--
T
A
R
----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
7
PsiBlast_PDB
69.67
71%
-130
- C2 -
3BYU
1
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
17
PsiBlast_PDB
69.64
68%
-135
- C2 -
2HWO
2
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
N
-------
G
-
T
T
R
V
A
I
K
T
L
K
P
------------------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
19
PsiBlast_PDB
69.57
68%
-130
- C2 -
3F3T
2
SRC_CHICK
A:
[10-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-------
G
-
T
T
R
V
A
I
K
T
L
K
P
G
T
--
M
--
S
--
P
---
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
12
PsiBlast_PDB
69.19
72%
-132
- C2 -
2ZV8
1
LYN_MOUSE
A:
[7-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
L
V
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
-
S
T
K
V
A
V
K
T
L
K
P
G
T
--
M
--
S
--
V
---
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
--
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------------
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
-
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
5
PsiBlast_PDB
69.00
72%
-131
- C2 -
2OFV
1
LCK_HUMAN
A:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
------------------
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
13
PsiBlast_PDB
68.94
72%
-135
- C2 -
2ZV9
1
LYN_MOUSE
A:
[7-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
L
V
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
-
S
T
K
V
A
V
K
T
L
K
P
G
T
--
M
--
S
--
V
---
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
--
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
-
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
16
PsiBlast_PDB
68.91
71%
-130
- C2 -
4C3F
1
LCK_HUMAN
A:
[4-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
---
N
---
E
Y
--
T
A
R
----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
3
PsiBlast_PDB
68.71
71%
-124
- C2 -
2PL0
1
LCK_HUMAN
A:
[11-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
---
N
---
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
22
PsiBlast_CBE
68.45
72%
-129
- C2 -
2OG8
1
?
B:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
--
P
---
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
-
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
18
PsiBlast_PDB
68.29
68%
-140
- C2 -
2QLQ
2
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-------
G
-
T
T
R
V
A
I
K
T
L
------------------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
-
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
20
PsiBlast_PDB
67.87
68%
-123
- C2 -
3F3U
2
SRC_CHICK
A:
[10-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-------
G
-
T
T
R
V
A
I
K
T
L
K
P
G
T
--
M
--
S
--
P
---
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
21
PsiBlast_CBE
66.42
72%
-130
- C2 -
2OFV
1
?
B:
[7-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
W
----------------
W
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
G
-
H
T
K
V
A
V
K
S
L
K
Q
G
----------------
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
--
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
--------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------
8
PsiBlast_PDB
65.45
71%
-122
- C2 -
3A4O
1
LYN_HUMAN
X:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
I
K
L
V
K
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
-
S
T
K
V
A
V
K
T
L
K
P
G
T
--
M
--
S
--
V
---
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
R
-
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
--
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
-
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
-------
42
HHSearch
62.04
37%
-117
- C2 -
1U59
1
A:
[2-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
-------
K
-
Q
I
D
V
A
I
K
V
L
K
Q
G
T
--
E
K
A
D
--
T
---
E
--
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
-
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
------
R
--
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
--
G
ADD
S
---
Y
Y
--
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
-
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
-
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
-----
52
HHSearch
61.56
42%
-130
- C2 -
3GEN
1
A:
[16-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
-------
G
-
Q
Y
D
V
A
I
K
M
I
K
E
G
S
--
M
--
S
--
E
---
D
--
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
R
-
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
------
R
--
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
-----
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L-
D
---
D
---
E
Y
--
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
-
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
-
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
----------
51
HHSearch
61.12
43%
-125
- C2 -
3SXS
1
A:
[2-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
-------
G
-
Q
Y
D
V
A
V
K
M
I
K
E
G
S
--
M
--
S
--
E
---
D
--
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
E
Y
-
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
------
G
--
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
-----
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
-
D
---
D
---
Q
Y
--
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
-
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
-
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----------
49
HHSearch
60.56
44%
-122
- C2 -
4HCU
1
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-------
N
-
K
D
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
--
E
---
E
--
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
-
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
--------
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L-
D
---
D
---
Q
Y
--
T
S
S
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
-
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
-
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------
58
HHSearch
60.23
43%
-127
* C2 *
3ZBF
1
A:
[29-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
DILGVGS
G
-
E
I
K
V
A
V
K
T
L
K
K
G
S
--
T
--
D
--
Q
---
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
-
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
ATFY
G
--
P
L
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y--------------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
-
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
-
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
------------
59
HHSearch
59.28
40%
-120
- C2 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
PGQ---
R
-
D
V
P
V
A
I
K
A
L
K
A
G
Y
--
T
--
E
R
Q
R
---
R
--
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
-
R
G
R
-
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
D
--------
G
Q
F
T
I
M
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
-----
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--
E
---------A
A
Y
T
T
T
---
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
-
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
-
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
-------
43
HHSearch
59.11
39%
-126
- C2 -
4FYO
1
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
KK----
V
-
V
K
T
V
A
V
K
I
L
------------
P
A
L
K
D
--
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-
E
-
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-------
N
--
R
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
--
R
---
A
DEN
Y
Y
--
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
-
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
-
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
E
-----
46
HHSearch
58.82
38%
-108
- C2 -
1T46
1
A:
[7-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
P
T
Q
L
-
P
----------------
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
GLIKSD-
A
-
A
M
T
V
A
V
K
M
L
K
P
S
A
--
H
L
T
E
--
R
---
E
--
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
G
G
-
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-----
D
SF
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
KN
D
---
S
---
N
Y
--
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
-
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
--------