@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00018_SRC_HU: (2014-08-10 )
GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Atome Classification :
(63 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....-...120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......-250......--.260.......270.-......280......-------.290.-----------------.......300..--.--..--..310.......320.......330-.-......340.......350...----.-----...360.......370.......380.......390.....-----..400.......410....--...420.-......430.......440.......450.......-460.......470.......-------480.......490.......500.......510.......520.......530...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
GSNKSKPK
D
A
S
Q
R
RRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP
K
L
F
GGFNSSDTVTSPQRAGPLAGG
V
T
T
F
V
A
L
Y
DYESRTETDLSFKKG
E
R
L
Q
I
V
NNT-EG
D
W
W
L
A
H
SLSTGQTGYIPSNYVAPSDSIQAE
E
W
Y
F
G
K
ITRRES
E
R
L
L
L
NAENP
R
G
T
F
L
V
R
ESETTK
G
A
Y
C
L
S
VSDFDNAKGL
N
V
K
H
Y
K
I
R
K
LDSG
G
F
Y
I
T
SR
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
KHA
D
G
L
C
H
R
L
T
TVCPT-SKPQTQG
L
A
--
K
D
A
W
EI
P
R
E
S
L
R
L
E
V
-
K
LGQGCFG
E
V
W
M
GTW-------NG-
T
T
-----------------
R
V
A
I
K
TLKPGTM--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
VVS-E-E
P
I
Y
I
V
T
E
Y
MSKG
S
L
L
D
F
L
KGE----T-----G
K
Y
LR
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
LVG-----EN
L
V
C
K
V
A
D
F
G
L
A
R
L
IEDN--EYTARQG-AKF
P
I
K
WTAPEA
A
L
Y
G
R
F
T
IKS
D
V
W
S
F
G
I
L
L
T
E
LTT-KGRVPYPGMV
N
R
E
V
L
D
Q
V
E
R-------GYRMPCPPE
C
P
E
S
L
H
D
L
M
C
Q
C
W
RKEPEER
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
FTSTEPQYQPGENL
1
PsiBlast_PDB
96.23
100%
-115
- C4 -
1Y57
1
SRC_HUMAN
A:
[2-452]
------------------------------------------------------------------------------------
V
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
K
P
Q
T
Q
G
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
--
E
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
74
HHSearch
75.57
44%
-105
- C4 -
1OPK
3
ABL1_MOUSE
A:
[44-481]
-------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
G
V
S
PN
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
-----------------
T
V
A
V
K
T
L
K
E
D
T
M
--
E
--
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
----
N
-----
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
---------
21
PsiBlast_CBE
69.12
100%
-123
- C4 -
4MXO
1
SRC_HUMAN
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
4
PsiBlast_PDB
68.99
100%
-124
- C4 -
4MXO
1
SRC_HUMAN
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
34
PsiBlast_CBE
68.93
99%
-123
- C4 -
3EN4
1
SRC_CHICK
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
29
PsiBlast_CBE
68.89
99%
-123
- C4 -
3G6G
2
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
-----------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
15
PsiBlast_PDB
68.71
99%
-121
- C4 -
3G6G
3
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
----------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
35
PsiBlast_CBE
68.62
99%
-122
- C4 -
3DQX
1
SRC_CHICK
B:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
32
PsiBlast_CBE
68.57
99%
-122
- C4 -
3F6X
1
SRC_CHICK
B:
[8-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
5
PsiBlast_PDB
68.51
99%
-125
- C4 -
4MXX
1
SRC_HUMAN
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
30
PsiBlast_CBE
68.23
99%
-119
- C4 -
3F6X
1
SRC_CHICK
D:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
9
PsiBlast_PDB
68.17
99%
-122
- C4 -
3EN4
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
--
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
40
PsiBlast_CBE
68.16
99%
-123
- C4 -
4MXY
1
SRC_HUMAN
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
38
PsiBlast_CBE
68.16
99%
-123
- C4 -
4MXZ
1
SRC_HUMAN
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
42
PsiBlast_CBE
68.12
98%
-122
- C4 -
3QLG
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
8
PsiBlast_PDB
68.11
99%
-123
- C4 -
3DQX
1
SRC_CHICK
A:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
48
PsiBlast_CBE
68.07
98%
-118
- C4 -
3GEQ
1
SRC_CHICK
B:
[4-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
Q
G
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
17
PsiBlast_PDB
67.98
99%
-123
- C4 -
3UQF
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
39
PsiBlast_CBE
67.97
99%
-123
- C4 -
4MXY
1
SRC_HUMAN
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
37
PsiBlast_CBE
67.97
99%
-123
- C4 -
4MXZ
1
SRC_HUMAN
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
41
PsiBlast_CBE
67.95
98%
-124
- C4 -
3QLG
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
-----
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
50
PsiBlast_CBE
67.83
98%
-122
- C4 -
3TZ9
1
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
55
PsiBlast_CBE
67.73
98%
-126
- C4 -
3G5D
2
SRC_CHICK
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
---
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
22
PsiBlast_CBE
67.71
99%
-121
- C4 -
4MXX
1
SRC_HUMAN
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
T
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
53
PsiBlast_CBE
67.63
98%
-122
- C4 -
3TZ7
1
SRC_CHICK
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
45
PsiBlast_CBE
67.63
98%
-119
- C4 -
3OEZ
2
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
44
PsiBlast_CBE
67.61
98%
-120
- C4 -
3OEZ
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
23
PsiBlast_CBE
67.47
99%
-120
- C4 -
1YOL
2
SRC_HUMAN
B:
[9-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
26
PsiBlast_CBE
67.46
99%
-121
- C4 -
4AGW
3
SRC_CHICK
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
18
PsiBlast_PDB
67.41
99%
-120
- C4 -
3UQG
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
31
PsiBlast_CBE
67.33
99%
-119
- C4 -
3F6X
1
SRC_CHICK
C:
[8-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
--------
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
60
PsiBlast_CBE
67.29
98%
-122
- C4 -
3F3T
2
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
52
PsiBlast_CBE
67.25
98%
-121
- C4 -
3TZ8
1
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
51
PsiBlast_CBE
67.18
98%
-119
- C4 -
3TZ8
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
27
PsiBlast_CBE
67.13
99%
-122
- C4 -
3UQG
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
----
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
------
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
46
PsiBlast_CBE
67.05
98%
-123
- C4 -
1YOM
1
SRC_HUMAN
B:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
54
PsiBlast_CBE
67.03
98%
-118
- C4 -
3TZ7
1
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
6
PsiBlast_PDB
67.00
99%
-119
- C4 -
1YOL
1
SRC_HUMAN
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
19
PsiBlast_PDB
66.96
99%
-119
- C4 -
4DGG
1
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
28
PsiBlast_CBE
66.95
99%
-119
- C4 -
3UQF
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
-----------
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
59
PsiBlast_CBE
66.88
98%
-116
- C4 -
3F3U
2
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
33
PsiBlast_CBE
66.87
99%
-130
- C4 -
3EN6
1
SRC_CHICK
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
-------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
-----------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
16
PsiBlast_PDB
66.86
99%
-121
- C4 -
4AGW
3
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
57
PsiBlast_CBE
66.82
98%
-119
- C4 -
3F3V
1
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
20
PsiBlast_PDB
66.71
99%
-123
- C4 -
4FIC
1
SRC_CHICK
A:
[8-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
--------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
12
PsiBlast_PDB
66.59
99%
-128
- C4 -
3EN7
1
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
-------
N
---
T
-----------------
R
V
A
I
K
T
L
K
P
-------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
49
PsiBlast_CBE
66.57
98%
-118
- C4 -
3TZ9
1
SRC_CHICK
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
25
PsiBlast_CBE
66.51
99%
-118
- C4 -
4DGG
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
------------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
24
PsiBlast_CBE
66.33
99%
-121
- C4 -
4FIC
1
SRC_CHICK
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
--------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
47
PsiBlast_CBE
66.22
98%
-119
- C4 -
1YOM
1
SRC_HUMAN
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
----
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
56
PsiBlast_CBE
66.04
98%
-119
- C4 -
3F3V
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
14
PsiBlast_PDB
65.85
99%
-119
- C4 -
3EL8
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
10
PsiBlast_PDB
65.85
99%
-125
- C4 -
3EN5
1
SRC_CHICK
A:
[13-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
--------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
13
PsiBlast_PDB
65.77
99%
-118
- C4 -
3EL7
1
SRC_CHICK
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
-
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
---
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
43
PsiBlast_CBE
65.58
98%
-121
- C4 -
3QLF
1
SRC_CHICK
A:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
---------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
58
PsiBlast_CBE
65.12
98%
-113
- C4 -
3F3U
1
SRC_CHICK
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
----
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
7
PsiBlast_PDB
61.63
99%
-120
- C4 -
3D7T
1
SRC_CHICK
B:
[11-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
G
-
T
T
-----------------
R
V
A
I
K
T
L
K
P
G
T
M
--
S
--
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
----
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
86
HHSearch
57.32
44%
-113
- C4 -
3SXS
1
A:
[2-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
-------
K
G
-
Q
Y
-----------------
D
V
A
V
K
M
I
K
E
G
S
M
--
S
--
E
D
--
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
----------
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
-----
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
--
Q
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
-
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
-------
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
------------
82
HHSearch
57.18
41%
-114
- C4 -
3GEN
1
A:
[16-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
-------
R
G
-
Q
Y
-----------------
D
V
A
I
K
M
I
K
E
G
S
M
--
S
--
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
----
R
------
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
-----
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
-
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
-------
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
-----------
85
HHSearch
56.12
42%
-112
- C4 -
4HCU
1
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-------
L
N
-
K
D
-----------------
K
V
A
I
K
T
I
R
E
G
A
M
--
S
--
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
----
R
-----
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
-
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
-------
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
-----------
91
HHSearch
54.44
45%
-109
* C4 *
3ZBF
1
A:
[24-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
E
N
L
P
A
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
DILGVG
S
G
-
E
I
-----------------
K
V
A
V
K
T
L
K
K
G
S
T
--
D
--
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
----
R
M
ATFY
G
P
L
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
---------------
80
HHSearch
53.69
37%
-108
- C4 -
1U59
1
A:
[2-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-------
R
K
-
Q
I
-----------------
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
--
T
E
--
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
----
R
-----
E
-
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
-
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
-
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
-------
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
----------
89
HHSearch
52.86
39%
-101
- C4 -
4BKJ
10
DDR1_HUMAN
A:
[4-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
D
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
-------
D
S
-
P
Q
DLVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
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--
K
N
A
R
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--
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F
L
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K
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M
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R
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K
D
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L
L
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C
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D
-
D
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L
C
M
I
T
D
Y
M
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N
G
D
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N
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F
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A
H
QLED-------
P
T
I
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Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
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T
L
N
F
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L
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T
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N
C
L
V
G
-----
E
N
F
T
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K
I
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F
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M
S
R
N
L
Y
A
G
--
D
Y
Y
----R
A
V
L
P
I
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W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
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Q
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I
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N
A
G
E
F
F
R
DQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
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C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
---------------