@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00067_CP2B6_: (2014-08-13 )
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
Atome Classification :
(18 SA)
.........10........20........30........40........50--........60........70.........80........90---------........100.......110.......120.......130.......140.......150.......160.......170-........180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......-380.......390.......400-.......410.......420.......430.......440.......450.......460.......470....--...480.......490-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
S
V
L
L
F
L
A
L
L
T
G
L
L
L
L
L
V
QRHPNTHDRLPPGPR
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
KYG
D
V
F
T
V
HL-GPR
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
FSGRG
K
I
A
M
VD
P
F
FRG
Y
G
V
I
F
ANGN
R
W
K
V
L
R
R
FSV
T
T
M
R
D
FGM
G
K
R
S
V
E
E
R
I
Q
E
E
A
Q
C
L
I
E
E
L
R
K
SKGALM
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
VFGKRFHY
Q
D
Q
E
F
L
K
M
L
N
L
F
Y
Q
T
F
S
L
I
S
S
V
F
G
Q
L
F
E
L
F
S
G
F
L
K
YFPG
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
A
Y
IGH
S
V
E
K
H
R
ETLDPSA
P
K
D
L
I
D
T
Y
L
L
H
M
E
KEKSNAHSEFSHQNLN
L
N
T
L
S
L
F
F
AGTETT
S
T
T
L
R
Y
G
F
L
L
M
LKY
P
H
V
A
E
R
V
Y
R
E
I
E
Q
V
IGPHRPP
E
L
HDRAKMP
Y
T
E
A
V
I
Y
E
I
Q
R
F
S
D
LLPMGV
P
H
I
V
TQHTSF
R
G
-
Y
I
IPKD
T
E
V
F
L
I
L
S
T
ALHDPHYF-EKPDAFNPDHFLDANGALKKT
E
A
F
IPFSLGK
R
I
CLGE
G
I
A
R
A
E
L
F
L
F
F
T
T
I
L
Q
NFSMASPVAPEDIDL
T
P
Q
ECG--VGKIPP
T
Y
Q
I
R
FLPR--
5
PsiBlast_PDB
94.62
98%
-123
- C7 -
4I91
6
CP2B6_HUMAN
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
R
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
L
-
G
P
R
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
F
S
G
R
G
K
I
A
M
V
D
P
F
F
R
G
Y
G
V
I
F
A
N
G
N
R
W
K
V
L
R
R
F
S
V
T
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
Q
C
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
M
L
N
L
F
Y
Q
T
F
S
L
I
S
S
V
F
G
Q
L
F
E
L
F
S
G
F
L
K
H
F
P
G
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
A
Y
I
G
H
S
V
E
K
H
R
E
T
L
D
P
S
A
P
R
D
L
I
D
T
Y
L
L
H
M
E
K
E
K
S
N
A
H
S
E
F
S
H
Q
N
L
N
L
N
T
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
A
E
R
V
Y
R
E
I
E
Q
V
I
G
P
H
R
P
P
E
L
H
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
I
Q
R
F
S
D
L
L
P
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
-
Y
I
I
P
K
D
T
E
V
F
L
I
L
S
T
A
L
H
D
P
H
Y
F
-
E
K
P
D
A
F
N
P
D
H
F
L
D
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
A
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
D
L
T
P
Q
E
C
G
--
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
--
2
PsiBlast_PDB
94.12
98%
-122
- C7 -
3QOA
4
CP2B6_HUMAN
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
R
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
L
-
G
P
R
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
F
S
G
R
G
K
I
A
M
V
D
P
F
F
R
G
Y
G
V
I
F
A
N
G
N
R
W
K
V
L
R
R
F
S
V
T
T
M
R
D
-----
R
S
V
E
E
R
I
Q
E
E
A
Q
C
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
M
L
N
L
F
Y
Q
T
F
S
L
I
S
S
V
F
G
Q
L
F
E
L
F
S
G
F
L
K
H
F
P
G
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
A
Y
I
G
H
S
V
E
K
H
R
E
T
L
D
P
S
A
P
R
D
L
I
D
T
Y
L
L
H
M
E
K
E
K
S
N
A
H
S
E
F
S
H
Q
N
L
N
L
N
T
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
A
E
R
V
Y
R
E
I
E
Q
V
I
G
P
H
R
P
P
E
L
H
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
I
Q
R
F
S
D
L
L
P
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
-
Y
I
I
P
K
D
T
E
V
F
L
I
L
S
T
A
L
H
D
P
H
Y
F
-
E
K
P
D
A
F
N
P
D
H
F
L
D
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
A
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
D
L
T
P
Q
E
C
G
--
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
--
4
PsiBlast_PDB
93.82
98%
-116
- C7 -
3UA5
3
CP2B6_HUMAN
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
R
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
L
-
G
P
R
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
F
S
G
R
G
K
I
A
M
V
D
P
F
F
R
G
Y
G
V
I
F
A
N
G
N
R
W
K
V
L
R
R
F
S
V
T
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
Q
C
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
M
L
N
L
F
Y
Q
T
F
S
L
I
S
S
V
F
G
Q
L
F
E
L
F
S
G
F
L
K
H
F
P
G
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
A
Y
I
G
H
S
V
E
K
H
R
E
T
L
D
P
S
A
P
R
D
L
I
D
T
Y
L
L
H
M
E
K
E
K
S
N
A
H
S
E
F
S
H
Q
N
L
N
L
N
T
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
A
E
R
V
Y
R
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I
E
Q
V
I
G
P
H
R
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L
H
D
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A
K
M
P
Y
T
E
A
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Y
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F
S
D
L
L
P
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
-
Y
I
I
P
K
D
T
E
V
F
L
I
L
S
T
A
L
H
D
P
H
Y
F
-
E
K
P
D
A
F
N
P
D
H
F
L
D
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
L
G
K
R
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C
L
G
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G
I
A
R
A
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L
F
L
F
F
T
T
I
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
D
L
T
P
Q
E
C
G
--
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
--
1
PsiBlast_PDB
93.70
98%
-115
- C7 -
3IBD
4
CP2B6_HUMAN
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
R
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
L
-
G
P
R
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
F
S
G
R
G
K
I
A
M
V
D
P
F
F
R
G
Y
G
V
I
F
A
N
G
N
R
W
K
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L
R
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F
S
V
T
T
M
R
D
F
G
M
G
K
R
S
V
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I
Q
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E
A
Q
C
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
M
L
N
L
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Q
T
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L
I
S
S
V
F
G
Q
L
F
E
L
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G
A
H
R
Q
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Y
K
N
L
Q
E
I
N
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Y
I
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H
S
V
E
K
H
R
E
T
L
D
P
S
A
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R
D
L
I
D
T
Y
L
L
H
M
E
K
E
K
S
N
A
H
S
E
F
S
H
Q
N
L
N
L
N
T
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
A
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R
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Y
R
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I
E
Q
V
I
G
P
H
R
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P
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L
H
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
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F
S
D
L
L
P
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
-
Y
I
I
P
K
D
T
E
V
F
L
I
L
S
T
A
L
H
D
P
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F
-
E
K
P
D
A
F
N
P
D
H
F
L
D
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
A
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
D
L
T
P
Q
E
C
G
--
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
--
21
PsiBlast_CBE
93.48
98%
-116
- C7 -
3UA5
3
CP2B6_HUMAN
B:
[10-472]
----------------------------
K
L
P
P
G
P
R
P
L
P
L
L
G
N
L
L
Q
M
D
R
R
G
L
--
L
K
S
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
L
-
G
P
R
P
V
V
M
L
C
G
V
E
A
I
R
E
A
L
V
D
K
---------
A
E
A
F
S
G
R
G
K
I
A
M
V
D
P
F
F
R
G
Y
G
V
I
F
A
N
G
N
R
W
K
V
L
R
R
F
S
V
T
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
Q
C
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
T
F
L
F
--
Q
S
I
T
A
N
I
I
C
S
I
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
M
L
N
L
F
Y
Q
T
F
S
L
I
S
S
V
F
G
Q
L
F
E
L
F
S
G
F
L
K
H
F
P
G
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
A
Y
I
G
H
S
V
E
K
H
R
E
T
L
D
P
S
A
P
R
D
L
I
D
T
Y
L
L
H
M
E
K
E
K
S
N
A
--
E
F
S
H
Q
N
L
N
L
N
T
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
A
E
R
V
Y
R
E
I
E
Q
V
I
G
P
H
R
P
P
E
L
H
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
I
Q
R
F
S
D
L
L
P
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
-
Y
I
I
P
K
D
T
E
V
F
L
I
L
S
T
A
L
H
D
P
H
Y
F
-
E
K
P
D
A
F
N
P
D
H
F
L
D
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
A
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
D
L
T
P
Q
E
C
G
--
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
--
20
PsiBlast_PDB
91.44
77%
-110
- C7 -
1PO5
1
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
H
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
7
PsiBlast_PDB
89.05
77%
-111
- C7 -
1SUO
2
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
16
PsiBlast_PDB
88.33
77%
-117
- C7 -
3TMZ
4
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
-
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
-
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
19
PsiBlast_PDB
88.29
76%
-120
- C7 -
4H1N
5
CP2B4_RABIT
A:
[10-472]
----------------------------
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
---
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
A
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
--
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
18
PsiBlast_PDB
88.12
77%
-117
- C7 -
4JLT
6
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
-----
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
--
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
13
PsiBlast_PDB
88.03
77%
-115
- C7 -
3MVR
3
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
--
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
11
PsiBlast_PDB
87.95
77%
-116
- C7 -
3KW4
5
CP2B4_RABIT
A:
[8-472]
--------------------------
K
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
43
PsiBlast_CBE
87.93
77%
-116
- C7 -
3MVR
3
CP2B4_RABIT
B:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
--
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
17
PsiBlast_PDB
87.29
77%
-115
- C7 -
3UAS
5
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
----
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
8
PsiBlast_PDB
86.42
77%
-109
- C7 -
2BDM
8
CP2B4_RABIT
A:
[9-472]
---------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
--
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
-
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
---------
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
--
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
-
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
-
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
--
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
R
--
70
HHSearch
79.98
47%
-107
- C7 -
3E6I
2
CP2E1_HUMAN
A:
[10-471]
----------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
--
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
-
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
---------
K
D
E
F
S
G
R
G
D
L
P
A
F
H
A
-
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
-
G
K
Q
G
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
--
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
-
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
-
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
--
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
R
--
67
HHSearch
79.67
48%
-105
- C7 -
1R9O
3
CP2C9_HUMAN
A:
[9-473]
--------------------------
R
G
K
L
P
P
G
P
T
P
L
P
-----
L
Q
I
G
I
K
D
I
--
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
-
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
---------
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
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N
G
K
K
W
K
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R
R
F
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L
M
T
L
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N
F
G
M
G
K
R
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R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
--
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
K
I
L
S
S
P
W
I
-------
P
I
I
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
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S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
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K
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N
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P
S
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L
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N
T
A
V
D
L
F
G
A
G
T
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T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
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V
T
A
K
V
Q
E
E
I
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R
V
I
G
R
N
R
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P
C
M
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D
R
S
H
M
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Y
T
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A
V
V
H
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V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
-
Y
L
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P
K
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T
T
I
L
I
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L
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S
V
L
H
D
N
K
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F
-
P
N
P
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M
F
D
P
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H
F
L
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G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
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V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
--
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
I
--
57
Fugue
68.43
44%
-105
- C7 -
1DT6
1
CP2C5_RABIT
A:
[12-471]
-------------------------
P
P
G
P
T
P
F
P
I
-
I
G
N
I
---
L
Q
I
D
A
-
K
--D
I
S
K
S
L
T
K
F
S
E
C
Y
G
P
V
F
T
V
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L
G-
M
K
P
T
V
V
L
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Y
E
A
V
K
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A
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D
L
GEEF
A
G
R
G
S
-------
V
P
I
L
E
K
V
S
K
G
L
G
I
A
F
S
N
A
--
K
T
W
K
E
M
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
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D
R
I
Q
E
E
A
R
C
L
V
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E
L
R
K
T
N
-
A
-
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
I
F
H
N
R
F
D
Y
-
K
D
E
E
F
L
K
L
M
E
S
L
H
E
N
V
E
---
L
L
G
T
P
L
-------
D
Y
F
P
G
I
H
K
T
L
L
K
N
A
D
Y
I
K
N
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I
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E
K
V
K
E
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--
L
L
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-
V
N
N
P
R
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F
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M
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N
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L
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A
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L
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A
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Y
F
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K
G
T
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L
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L
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N
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G
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L
A
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L
F
L
F
L
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L
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N
F
-
K
L
Q
S
L
V
E
P
K
D
L
D
I
T
A
V
V
N
GF
V
S
V
P
P
S
-
Y
Q
L
C
F
I
P
I
H
H