@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00067_CP3A2_: (2014-08-13 )
MDLLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYKGLGRFDMECYKKYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQAILEPEKPIVLKVLPRDAVINGA
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
L
L
S
A
L
T
L
E
T
W
V
L
L
A
V
I
L
V
L
L
Y
R
LGTHRHGIFKKQGIPGPKPL
P
F
L
G
T
V
L
N
Y
Y
K
G
LGRF
D
M
E
C
Y
K
K
Y
G
K
I
W
G
LFDGQT
P
V
F
A
I
M
D
T
E
M
I
K
N
V
L
V
K
E
C
F
S
V
F
TNRRDFGPVGIMGKAVSVA
K
D
E
E
W
K
R
Y
R
A
L
LSPTFTSG
R
L
K
E
M
F
P
I
I
E
Q
Y
G
D
I
L
V
K
Y
L
K
Q
EAETGKP
V
T
M
K
K
V
F
G
AY
S
M
D
V
I
TSTSF
G
V
N
VDSLNNPKD
P
F
V
E
K
T
K
K
L
L
R
FDFF
D
P
L
F
L
S
V
V
L
F
P
F
L
T
P
I
Y
E
M
L
N
I
CMFP
K
D
S
I
A
F
F
Q
K
F
V
H
R
I
K
E
TRLD
S
K
H
K
H
R
V
D
F
L
Q
L
M
L
NAHNN
S
K
D
E
V
S
H
KAL
S
D
V
E
I
I
A
Q
S
V
I
F
I
F
AGYETT
S
S
T
L
S
F
V
L
Y
F
L
AT
H
P
D
I
Q
K
K
L
Q
E
E
IDGALPSKAPP
T
Y
D
I
V
M
E
M
E
Y
L
D
M
V
L
NE
T
L
R
LYPI
G
N
R
L
E
R
V
C
K
KDIELD
G
L
FIPKG
S
V
V
T
I
P
T
YALHHDPQHWPKPEEF
H
P
E
RFSKENKGSID
P
Y
V
Y
L
PFGNGP
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
T
K
V
L
Q
NFSFQPCKETQI
P
L
K
L
S
R
Q
AILEPEK
P
I
V
L
K
VLPRDAVINGA
4
PsiBlast_PDB
99.22
72%
-121
- C1 -
4I4G
2
CP3A4_HUMAN
A:
[7-476]
--------------------------
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
1
PsiBlast_PDB
98.78
72%
-125
- C1 -
3UA1
2
CP3A4_HUMAN
A:
[8-476]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
---
E
D
T
Q
---
V
D
F
L
Q
L
M
I
D
S
Q
--------
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
38
HHSearch
98.61
73%
-124
- C1 -
3NXU
6
CP3A4_HUMAN
A:
[7-474]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
---------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
16
PsiBlast_PDB
98.51
72%
-118
- C1 -
1TQN
1
CP3A4_HUMAN
A:
[7-478]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
S
----
S
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
T
----
3
PsiBlast_PDB
98.24
72%
-121
- C1 -
4I3Q
1
CP3A4_HUMAN
A:
[8-477]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
S
-----
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
------
5
PsiBlast_PDB
97.98
72%
-121
- C1 -
4I4H
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
6
PsiBlast_PDB
97.91
72%
-124
- C1 -
4K9T
3
CP3A4_HUMAN
A:
[9-477]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
-----
D
F
L
Q
L
M
I
D
S
Q
----------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
------
8
PsiBlast_PDB
97.43
72%
-124
- C1 -
4K9V
2
CP3A4_HUMAN
A:
[8-476]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
----
V
D
F
L
Q
L
M
I
D
S
Q
----------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
24
PsiBlast_CBE
97.19
72%
-123
- C1 -
3NXU
4
CP3A4_HUMAN
B:
[7-474]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
12
PsiBlast_PDB
96.70
72%
-118
- C1 -
1W0F
2
CP3A4_HUMAN
A:
[4-476]
-------------------------
G
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
-------
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
-----
2
PsiBlast_PDB
95.91
72%
-119
- C1 -
3TJS
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
-------
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
----
H
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
10
PsiBlast_PDB
95.81
72%
-122
- C1 -
4K9X
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
------
N
T
K
K
L
L
--
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
13
PsiBlast_PDB
95.71
72%
-117
- C1 -
1W0G
2
CP3A4_HUMAN
A:
[4-476]
-------------------------
G
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
-------
F
L
Q
L
M
I
-------------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
-----
7
PsiBlast_PDB
95.61
72%
-123
- C1 -
4K9U
3
CP3A4_HUMAN
A:
[7-476]
--------------------------
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
F
V
E
N
T
K
K
------
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
------
D
F
L
Q
L
M
I
D
S
Q
-
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
I
P
K
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------