@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00067_CP51_M: (2014-08-13 )
MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV
Atome Classification :
(13 SA)
.........10........20........30..-......40........50........60........70......-..80........90...---.....100..--.....110.......120....-...130........140.......150.......160..-.....170.......180..-..---...190.......200.......210......-.220.......230.......240.......250.......260.......270.--......280.......290..-....-.300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420--........430.......440-.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAVALPRVSGGHDEHG
H
L
E
E
FRTD
P
I
G
L
M
Q
R
V
-
R
D
ECGDVG
T
F
Q
LAG
K
Q
V
V
L
L
SGSHA
N
E
F
F
F
RAGDDD
L
D
Q
AKAYP-FMTPIFGE
G
V
V
FDA
S
P
E
---
R
R
K
E
M
L
H
N
A
A--LRGEQMKGH
A
A
T
I
E
D
Q
V
R
R
M
I
A
-DWGE-AGE
I
D
L
L
D
F
F
A
E
L
T
I
YTS
S
A
C
L
I
G
K
K
F
R
D
Q
L
D
G
R
-
F
A
K
L
Y
H
E
L
E
RGTDPLAYVDP-YL---
P
I
E
S
F
R
R
R
D
E
ARN
G
L
V
A
L
V
A
D
I
MNGRIANPPT-DKS
D
R
D
M
L
D
V
L
I
A
V
KAETGTPRF
S
A
D
E
I
T
G
M
F
I
S
M
M
FAGHHTSSGT
A
S
W
T
L
I
E
L
M
--
R
HR
D
A
Y
A
A
V
I
D
E
L
D
E
L
YGDGR-S
V
S
F
-
H
A
L
R
Q
I
P
Q
L
E
N
V
L
K
E
T
L
RLHPP
L
I
I
L
M
R
VAKG
E
F
E
V
QG
H
R
IHEG
D
L
V
AASPAISNRIPEDFPDPHDFV
P
A
R
YEQP
R
Q
E
D
L
L
N
RWTWIPFGAGR
H
R
C
V
G
A
A
F
A
I
M
Q
I
K
A
I
F
S
V
L
L
R
E
Y
E
F
EMAQ---P
P
E
S
YR
N
D
H
S
K
M
V
V
Q
LA
Q
P
A
C
-
V
R
Y
R
R
RTGV
2
PsiBlast_PDB
99.26
100%
-110
- C1 -
1E9X
2
CP51_MYCTU
A:
[1-449]
M
S
A
V
A
L
P
R
V
S
G
G
H
D
E
H
G
H
L
E
E
F
R
T
D
P
I
G
L
M
Q
R
V
-
R
D
E
C
G
D
V
G
T
F
Q
L
A
G
K
Q
V
V
L
L
S
G
S
H
A
N
E
F
F
F
R
A
G
D
D
D
L
D
Q
A
K
A
Y
P
-
F
M
T
P
I
F
G
E
G
V
V
F
D
A
S
P
E
---
R
R
K
E
M
L
H
N
A
A
--
L
R
G
E
Q
M
K
G
H
A
A
T
I
E
D
Q
V
R
R
M
I
A
-
D
W
G
E
-
A
G
E
I
D
L
L
D
F
F
A
E
L
T
I
Y
T
S
S
A
C
L
I
G
K
K
F
R
D
Q
L
D
G
R
-
F
A
K
L
Y
H
E
L
E
R
G
T
D
P
L
A
Y
V
D
P
-
Y
L
---
P
I
E
S
F
R
R
R
D
E
A
R
N
G
L
V
A
L
V
A
D
I
M
N
G
R
I
A
N
P
P
T
-
D
K
S
D
R
D
M
L
D
V
L
I
A
V
K
A
E
T
G
T
P
R
F
S
A
D
E
I
T
G
M
F
I
S
M
M
F
A
G
H
H
T
S
S
G
T
A
S
W
T
L
I
E
L
M
--
R
H
R
D
A
Y
A
A
V
I
D
E
L
D
E
L
Y
G
D
G
R
-
S
V
S
F
-
H
A
L
R
Q
I
P
Q
L
E
N
V
L
K
E
T
L
R
L
H
P
P
L
I
I
L
M
R
V
A
K
G
E
F
E
V
Q
G
H
R
I
H
E
G
D
L
V
A
A
S
P
A
I
S
N
R
I
P
E
D
F
P
D
P
H
D
F
V
P
A
R
Y
E
Q
P
R
Q
E
D
L
L
N
R
W
T
W
I
P
F
G
A
G
R
H
R
C
V
G
A
A
F
A
I
M
Q
I
K
A
I
F
S
V
L
L
R
E
Y
E
F
E
M
A
Q
---
P
P
E
S
Y
R
N
D
H
S
K
M
V
V
Q
L
A
Q
P
A
C
-
V
R
Y
R
R
R
T
--
8
PsiBlast_PDB
98.69
99%
-112
- C1 -
2W0B
2
CP51_MYCTU
A:
[3-449]
--
A
V
A
L
P
R
V
S
G
G
H
D
E
H
G
H
L
E
E
F
R
T
D
P
I
G
L
M
Q
R
V
-
R
D
E
L
G
D
V
G
T
F
Q
L
A
G
K
Q
V
V
L
L
S
G
S
H
A
N
E
F
F
F
R
A
G
D
D
D
L
D
Q
A
K
A
Y
P
-
F
M
T
P
I
F
G
E
G
V
V
F
D
A
S
P
E
---
R
R
K
E
M
L
H
N
A
A
--
L
R
G
E
Q
M
K
G
H
A
A
T
I
E
D
Q
V
R
R
M
I
A
-
D
W
G
E
-
A
G
E
I
D
L
L
D
F
F
A
E
L
T
I
Y
T
S
S
A
C
L
I
G
K
K
F
R
D
Q
L
D
G
R
-
F
A
K
L
Y
H
E
L
E
R
G
T
D
P
L
A
Y
V
D
P
-
Y
L
---
P
I
E
S
F
R
R
R
D
E
A
R
N
G
L
V
A
L
V
A
D
I
M
N
G
R
I
A
N
--------
R
D
M
L
D
V
L
I
A
V
K
A
E
T
G
T
P
R
F
S
A
D
E
I
T
G
M
F
I
S
M
M
F
A
G
H
H
T
S
S
G
T
A
S
W
T
L
I
E
L
M
--
R
H
R
D
A
Y
A
A
V
I
D
E
L
D
E
L
Y
G
D
G
R
-
S
V
S
F
-
H
A
L
R
Q
I
P
Q
L
E
N
V
L
K
E
T
L
R
L
H
P
P
L
I
I
L
M
R
V
A
K
G
E
F
E
V
Q
G
H
R
I
H
E
G
D
L
V
A
A
S
P
A
I
S
N
R
I
P
E
D
F
P
D
P
H
D
F
V
P
A
R
Y
E
Q
P
R
Q
E
D
L
L
N
R
W
T
W
I
P
F
G
A
G
R
H
R
C
V
G
A
A
F
A
I
M
Q
I
K
A
I
F
S
V
L
L
R
E
Y
E
F
E
M
A
Q
---
P
P
E
S
Y
R
N
D
H
S
K
M
V
V
Q
L
A
Q
P
A
A
-
V
R
Y
R
R
R
T
--
1
PsiBlast_PDB
98.48
100%
-109
- C1 -
1EA1
2
CP51_MYCTU
A:
[3-449]
--
A
V
A
L
P
R
V
S
G
G
H
D
E
H
G
H
L
E
E
F
R
T
D
P
I
G
L
M
Q
R
V
-
R
D
E
C
G
D
V
G
T
F
Q
L
A
G
K
Q
V
V
L
L
S
G
S
H
A
N
E
F
F
F
R
A
G
D
D
D
L
D
Q
A
K
A
Y
P
-
F
M
T
P
I
F
G
E
G
V
V
F
D
A
S
P
E
---
R
R
K
E
M
L
H
N
A
A
--
L
R
G
E
Q
M
K
G
H
A
A
T
I
E
D
Q
V
R
R
M
I
A
-
D
W
G
E
-
A
G
E
I
D
L
L
D
F
F
A
E
L
T
I
Y
T
S
S
A
C
L
I
G
K
K
F
R
D
Q
L
D
G
R
-
F
A
K
L
Y
H
E
L
E
R
G
T
D
P
L
A
Y
V
D
P
-
Y
L
---
P
I
E
S
F
R
R
R
D
E
A
R
N
G
L
V
A
L
V
A
D
I
M
N
G
R
I
A
N
P
P
T
-
D
K
S
D
R
D
M
L
D
V
L
I
A
V
K
A
E
T
G
T
P
R
F
S
A
D
E
I
T
G
M
F
I
S
M
M
F
A
G
H
H
T
S
S
G
T
A
S
W
T
L
I
E
L
M
--
R
H
R
D
A
Y
A
A
V
I
D
E
L
D
E
L
Y
G
D
G
R
-
S
V
S
F
-
H
A
L
R
Q
I
P
Q
L
E
N
V
L
K
E
T
L
R
L
H
P
P
L
I
I
L
M
R
V
A
K
G
E
F
E
V
Q
G
H
R
I
H
E
G
D
L
V
A
A
S
P
A
I
S
N
R
I
P
E
D
F
P
D
P
H
D
F
V
P
A
R
Y
E
Q
P
R
Q
E
D
L
L
N
R
W
T
W
I
P
F
G
A
G
R
H
R
C
V
G
A
A
F
A
I
M
Q
I
K
A
I
F
S
V
L
L
R
E
Y
E
F
E
M
A
Q
---
P
P
E
S
Y
R
N
D
H
S
K
M
V
V
Q
L
A
Q
P
A
C
-
V
R
Y
R
R
R
T
--
9
PsiBlast_PDB
97.91
99%
-110
- C1 -
1U13
1
CP51_MYCTU
A:
[2-449]
-
S
A
V
A
L
P
R
V
S
G
G
H
D
E
H
G
H
L
E
E
F
R
T
D
P
I
G
L
M
Q
R
V
-
R
D
E
L
G
D
V
G
T
F
Q
L
A
G
K
Q
V
V
L
L
S
G
S
H
A
N
E
F
F
F
R
A
G
D
D
D
L
D
Q
A
K
A
Y
P
-
F
M
T
P
I
F
G
-------------
R
R
K
E
M
L
H
N
A
A
--
L
R
G
E
Q
M
K
G
H
A
A
T
I
E
D
Q
V
R
R
M
I
A
-
D
W
G
E
-
A
G
E
I
D
L
L
D
F
F
A
E
L
T
I
Y
T
S
S
A
T
L
I
G
K
K
F
R
D
Q
L
D
G
R
-
F
A
K
L
Y
H
E
L
E
R
G
T
D
P
L
A
Y
V
D
P
-
Y
L
---
P
I
E
S
F
R
R
R
D
E
A
R
N
G
L
V
A
L
V
A
D
I
M
N
G
R
I
A
N
P
------
D
R
D
M
L
D
V
L
I
A
V
K
A
E
T
G
T
P
R
F
S
A
D
E
I
T
G
M
F
I
S
M
M
F
A
G
H
H
T
S
S
G
T
A
S
W
T
L
I
E
L
M
--
R
H
R
D
A
Y
A
A
V
I
D
E
L
D
E
L
Y
G
D
G
R
-
S
V
S
F
-
H
A
L
R
Q
I
P
Q
L
E
N
V
L
K
E
T
L
R
L
H
P
P
L
I
I
L
M
R
V
A
K
G
E
F
E
V
Q
G
H
R
I
H
E
G
D
L
V
A
A
S
P
A
I
S
N
R
I
P
E
D
F
P
D
P
H
D
F
V
P
A
R
Y
E
Q
P
R
Q
E
D
L
L
N
R
W
T
W
I
P
F
G
A
G
R
H
R
C
V
G
A
A
F
A
I
M
Q
I
K
A
I
F
S
V
L
L
R
E
Y
E
F
E
M
A
Q
---
P
P
E
S
Y
R
N
D
H
S
K
M
V
V
Q
L
A
Q
P
A
A
-
V
R
Y
R
R
R
T
--
11
PsiBlast_PDB
75.51
33%
-104
- C1 -
3JUS
4
CP51A_HUMAN
A:
[24-454]
----------------
G
H
A
I
A
F
G
K
S
P
I
E
F
L
E
N
A
-
Y
E
K
Y
G
P
V
F
S
F
T
M
V
G
K
T
F
T
Y
L
L
G
S
D
A
A
A
L
L
F
N
S
K
N
E
D
L
N
A
E
D
V
Y
S
R
L
T
T
P
V
F
G
K
G
V
A
Y
D
V
P
N
P
V
F
L
E
Q
K
K
M
L
-
K
S
G
--
L
N
I
A
H
F
K
Q
H
V
S
I
I
E
K
E
T
K
E
Y
F
E
-
S
W
G
E
-
S
G
E
K
N
V
F
E
A
L
S
E
L
I
I
L
T
A
S
H
C
L
H
G
K
E
I
R
S
Q
L
N
E
K
-
V
A
Q
L
Y
A
D
L
D
G
G
F
S
H
A
A
W
L
L
P
G
W
L
---
P
L
P
S
F
R
R
R
D
R
A
H
R
E
I
K
D
I
F
Y
K
A
I
Q
K
R
R
Q
S
--
Q
-
E
K
I
D
-
D
I
L
Q
T
L
L
D
A
T
Y
K
D
G
R
P
-
L
T
D
D
E
V
A
G
M
L
I
G
L
L
L
A
G
Q
H
T
S
S
T
T
S
A
W
M
G
F
F
L
A
--
R
D
K
T
L
Q
K
K
C
Y
L
E
Q
K
T
V
C
G
E
N
L
P
P
L
T
Y
-
D
Q
L
K
D
L
N
L
L
D
R
C
I
K
E
T
L
R
L
R
P
P
I
M
I
M
M
R
M
A
R
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
V
C
V
S
P
T
V
N
Q
R
L
K
D
S
W
V
E
R
L
D
F
N
P
D
R
Y
L
Q
D
N
P
A
S
-
G
E
K
F
A
Y
V
P
F
G
A
G
R
H
R
C
I
G
E
N
F
A
Y
V
Q
I
K
T
I
W
S
T
M
L
R
L
Y
E
F
D
L
I
D
GYF
P
T
V
N
Y
T
T
-----
M
I
H
T
P
E
N
P
V
-
I
R
Y
K
R
R
S
--
12
PsiBlast_PDB
74.89
33%
-104
- C1 -
3JUV
1
CP51A_HUMAN
A:
[24-454]
----------------
G
H
A
I
A
F
G
K
S
P
I
E
F
L
E
N
A
-
Y
E
K
Y
G
P
V
F
S
F
T
M
V
G
K
T
F
T
Y
L
L
G
S
D
A
A
A
L
L
F
N
S
K
N
E
D
L
N
A
E
D
V
Y
S
R
L
T
T
P
V
F
G
K
G
V
A
Y
D
V
P
N
P
V
F
L
E
Q
K
K
M
L
-
K
S
G
--
L
N
I
A
H
F
K
Q
H
V
S
I
I
E
K
E
T
K
E
Y
F
E
-
S
W
G
E
-
S
G
E
K
N
V
F
E
A
L
S
E
L
I
I
L
T
A
S
H
C
L
H
G
K
E
I
R
S
Q
L
N
E
K
-
V
A
Q
L
Y
A
D
L
D
G
G
F
S
H
A
A
W
L
L
P
G
W
L
---
P
L
P
S
F
R
R
R
D
R
A
H
R
E
I
K
D
I
F
Y
K
A
I
Q
K
R
R
Q
S
--
Q
-
E
K
I
D
-
D
I
L
Q
T
L
L
D
A
T
Y
K
D
G
R
P
-
L
T
D
D
E
V
A
G
M
L
I
G
L
L
L
A
G
Q
H
T
S
S
T
T
S
A
W
M
G
F
F
L
A
--
R
D
K
T
L
Q
K
K
C
Y
L
E
Q
K
T
V
C
G
E
N
L
P
P
L
T
Y
-
D
Q
L
K
D
L
N
L
L
D
R
C
I
K
E
T
L
R
L
R
P
P
I
M
I
M
M
R
M
A
R
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
V
C
V
S
P
T
V
N
Q
R
L
K
D
S
W
V
E
R
L
D
F
N
P
D
R
Y
L
Q
D
N
P
A
S
-
G
E
K
F
A
Y
V
P
F
G
A
G
R
H
R
C
I
G
E
N
F
A
Y
V
Q
I
K
T
I
W
S
T
M
L
R
L
Y
E
F
D
L
I
D
GYF
P
T
V
N
Y
T
T
-----
M
I
H
T
P
E
N
P
V
-
I
R
Y
K
R
R
S
--
10
PsiBlast_PDB
74.79
33%
-104
- C1 -
3LD6
4
CP51A_HUMAN
A:
[24-454]
----------------
G
H
A
I
A
F
G
K
S
P
I
E
F
L
E
N
A
-
Y
E
K
Y
G
P
V
F
S
F
T
M
V
G
K
T
F
T
Y
L
L
G
S
D
A
A
A
L
L
F
N
S
K
N
E
D
L
N
A
E
D
V
Y
S
R
L
T
T
P
V
F
G
K
G
V
A
Y
D
V
P
N
P
V
F
L
E
Q
K
K
M
L
-
K
S
G
--
L
N
I
A
H
F
K
Q
H
V
S
I
I
E
K
E
T
K
E
Y
F
E
-
S
W
G
E
-
S
G
E
K
N
V
F
E
A
L
S
E
L
I
I
L
T
A
S
H
C
L
H
G
K
E
I
R
S
Q
L
N
E
K
-
V
A
Q
L
Y
A
D
L
D
G
G
F
S
H
A
A
W
L
L
P
G
W
L
---
P
L
P
S
F
R
R
R
D
R
A
H
R
E
I
K
D
I
F
Y
K
A
I
Q
K
R
R
Q
S
--
Q
-
E
K
I
D
-
D
I
L
Q
T
L
L
D
A
T
Y
K
D
G
R
P
-
L
T
D
D
E
V
A
G
M
L
I
G
L
L
L
A
G
Q
H
T
S
S
T
T
S
A
W
M
G
F
F
L
A
--
R
D
K
T
L
Q
K
K
C
Y
L
E
Q
K
T
V
C
G
E
N
L
P
P
L
T
Y
-
D
Q
L
K
D
L
N
L
L
D
R
C
I
K
E
T
L
R
L
R
P
P
I
M
I
M
M
R
M
A
R
T
P
Q
T
V
A
G
Y
T
I
P
P
G
H
Q
V
C
V
S
P
T
V
N
Q
R
L
K
D
S
W
V
E
R
L
D
F
N
P
D
R
Y
L
Q
D
N
P
A
S
-
G
E
K
F
A
Y
V
P
F
G
A
G
R
H
R
C
I
G
E
N
F
A
Y
V
Q
I
K
T
I
W
S
T
M
L
R
L
Y
E
F
D
L
I
D
G
Y
F
P
T
V
N
Y
T
T
-----
M
I
H
T
P
E
N
P
V
-
I
R
Y
K
R
R
S
--
20
PsiBlast_PDB
73.07
32%
-107
- C1 -
2WUZ
2
CP51_TRYCC
A:
[29-462]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
A
V
F
M
P
-
W
L
LRL
P
L
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
E
------
N
T
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---
16
PsiBlast_PDB
72.43
32%
-104
- C1 -
3ZG2
2
CP51_TRYCC
A:
[16-449]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
A
V
F
M
P
-
W
L
LR--
L
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
E
E
A
S
K
D
N
N
T
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---
17
PsiBlast_PDB
72.22
32%
-105
- C1 -
3ZG3
2
CP51_TRYCC
A:
[16-449]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
A
V
F
M
P
-
W
L
-----
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
E
E
A
S
K
D
N
N
T
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---
14
PsiBlast_PDB
71.82
32%
-103
- C1 -
4BY0
2
?
A:
[23-456]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
A
V
F
M
P
-
W
L
LRL
P
L
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
E
E
------
T
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---
15
PsiBlast_PDB
70.92
32%
-109
- C1 -
3KHM
2
CP51_TRYCC
A:
[20-453]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
-------
L
LR
L
P
L
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
---------
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---
19
PsiBlast_PDB
70.36
32%
-101
- C1 -
3KSW
2
CP51_TRYCC
A:
[14-447]
----------------
G
H
I
V
Q
F
G
K
N
P
L
E
F
M
Q
R
C
K
R
D
L
K
S
G
V
F
T
I
S
I
G
G
Q
R
V
T
I
V
G
D
P
H
E
H
S
R
F
F
S
P
R
N
E
I
L
S
P
R
E
V
Y
T
-
I
M
T
P
V
F
G
E
G
V
A
Y
A
A
P
Y
P
---
R
M
R
E
Q
L
N
F
L
A
E
E
L
T
I
A
K
F
Q
N
F
V
P
A
I
Q
H
E
V
R
K
F
M
A
E
N
W
K
E
D
E
G
V
I
N
L
L
E
D
C
G
A
M
I
I
N
T
A
C
Q
C
L
F
G
E
D
L
R
K
R
L
N
A
R
H
F
A
Q
L
L
S
K
M
E
S
S
L
I
P
A
A
V
F
M
P
---L--
P
L
P
Q
S
A
R
C
R
E
A
R
A
E
L
Q
K
I
L
G
E
I
I
V
A
R
E
K
E
E
A
S
K
D
N
N
T
S
D
L
L
G
G
L
L
K
A
V
Y
R
D
G
T
-
R
M
S
L
H
E
V
C
G
M
I
V
A
A
M
F
A
G
Q
H
T
S
T
I
T
T
S
W
S
M
L
H
L
M
HP
K
N
K
K
W
L
D
K
L
H
K
E
I
D
E
F
P
A
----
Q
L
N
Y
D
N
V
M
D
E
M
P
F
A
E
R
C
V
R
E
S
I
R
R
D
P
P
L
L
M
V
M
R
M
V
K
A
E
V
K
V
G
S
Y
V
V
P
K
G
D
I
I
A
C
S
P
L
L
S
H
H
D
E
E
A
F
P
N
P
R
L
W
D
P
E
R
D
E
K
V
D
G
-------
A
F
I
G
F
G
A
G
V
H
K
C
I
G
Q
K
F
A
L
L
Q
V
K
T
I
L
A
T
A
F
R
E
Y
D
F
Q
L
L
R
----
D
E
V
P
D
P
D
Y
H
T
M
V
V
G
P
T
L
N
Q
C
L
V
K
Y
T
R
K
---