@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_AAPK2_: (2014-08-14 )
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
Atome Classification :
(12 SA)
.........10........20........30........40........50.....---...60.......-.70.-........80....----....90........100.......110........120.......130-.......140.......---150---........160.-.-...---..170.......180.......190.......200.......210.......----220........230..--.----....240.......250.....-----..------260........-----270-------..-......-.280.....-..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEKQKHDG
R
V
K
I
G
H
Y
V
LGDTLGVG
T
F
G
K
V
K
IGEHQLT
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
---
V
V
G
K
I
K
R
E
I
Q
N
L
-
K
L
-F-RHP
H
I
I
K
L
Y
Q
V
IST----P
T
D
F
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KHG
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
HRDLKPE
N
V
L
L
DA---HM----NA
K
I
A
D
F
G
L
S
N
M-M-SDG---
E
F
L
R
TSCGSPNYAA
P
E
VISGRLYAGPE
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
CGTLPFDDE
H
V
----
P
-
T
L
F
K
K
IRG
G
V
F
Y
I
P
--
E
----
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
QVDPL
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
-----
Q
---------D
L
-
P
S
YLFP-EDPSYDANV-I
D
D
E
A
V
K
E
V
C
E
KFEC
T
E
S
E
V
M
N
S
L
YSGDP
Q
D
Q
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
N
Q
A
S
E
F
Y
LASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKS
L
A
V
K
K
A
K
W
H
LGIRSQSK
P
Y
D
I
M
A
E
V
Y
R
A
M
K
QLD
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
RKNPVTG
N
Y
V
K
M
S
L
Q
L
Y
L
VDN
R
S
Y
L
L
D
FKSI
D
D
E
V
V
E
QRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSG
S
L
TGSLTGS
T
L
S
SVSPRLGS
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
LAR
3
PsiBlast_PDB
80.56
80%
-127
- C1 -
4CFH
3
AAPK1_RAT
A:
[29-489]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
---
V
V
G
K
I
R
R
E
I
Q
N
L
-
K
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
----
N
A
K
I
A
D
F
G
L
S
N
M
-
M
-
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
--
Q
----
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
L
-
P
K
Y
L
F
P
-
E
D
-----------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-
S
F
L
D
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
----------------------------------------------------------------------------
6
PsiBlast_PDB
66.26
99%
-133
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[4-276]
------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
---
V
V
G
K
I
K
R
E
I
Q
N
L
-
K
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
----
N
A
K
I
A
D
F
G
L
S
N
M
-
M
-
S
D
G
---
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
----
P
-
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
--
E
----
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
L
-
P
S
Y
L
F
P
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.15
44%
-126
- C1 -
3IEC
1
MARK2_HUMAN
A:
[6-317]
------------
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-
S
---
S
L
Q
K
L
F
R
E
V
R
I
M
-
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
----
N
I
K
I
A
D
F
G
F
S
N
E
-
F
-
T
F
G
---
N
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
----
K
-
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
--
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
L
-
K
P
Y
V
E
P
-
L
-
P
D
Y
------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.32
42%
-114
- C1 -
4BKY
1
MELK_HUMAN
A:
[9-327]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-------
D
L
P
R
I
K
T
E
I
E
A
L
-
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
--
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
Y
-
N
Y
P
V
E
W
--
Q
S
K
N
P
F
I
H
-
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
-
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
52.99
37%
-116
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-302]
---------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
---
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
---
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
---
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
--
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
-----
G
I
V
W
Q
H
V
Y
EK
K
L
S
P
P
F
K
P
Q
-
V
T
S
E
T
D
T
R
Y
-
F
D
E
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.38
46%
-112
- C1 -
4BL1
1
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
L
P
R
I
K
T
E
I
E
A
L
-
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
--
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
----
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
49.68
34%
-107
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[35-298]
-------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
----
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
R
---
T
--
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
----
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
--
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
47.36
37%
-114
- C1 -
3TXO
1
A:
[23-286]
-------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
---
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
----
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
---
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
-
G
I
C
------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
----
D
-
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
--
T
----
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
-----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
46.99
34%
-110
- C1 -
1XJD
1
A:
[16-275]
------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
---
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
----
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
---
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
D--
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
-
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
--
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
-----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
46.05
34%
-108
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[11-277]
-------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
RGV
S
R
E
D
I
E
R
E
V
S
I
L
-
K
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
---
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
-
D
F
G
---
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
----
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
EYFS
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
------
Q
-
D
S
L
Q
H
P
W
I
K
-----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
43.93
35%
-104
- C1 -
2YEX
8
CHK1_HUMAN
A:
[6-270]
------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
D
---
C
P
E
N
I
K
K
E
I
C
I
N
-
K
M
-
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
-
F
-
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
----
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
PW
K
----
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
------
P
-
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
L
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
42.44
35%
-110
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[63-329]
--------------
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
-----------
P
K
A
R
R
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
--A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
KRP
N
A
----
I
L
K
L
T
D
F
G
F
A
K
E
-
T
-
T
--------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
LAIS
P
-
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
--
N
PEWS
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
------
T
-
E
F
M
N
H
P
W
I
M
-----
Q
---------
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------