@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_AUKBA_: (2014-08-14 )
MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQSK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140......-.150.......160.......170.......180...-....190.......200.......-210.......220.......230.......240-........250.......260.......270.......280.......290.......300.......310.......320.......330-----..------.....340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSYKENLNPSSYTSKFTTPS
S
A
T
A
A
Q
R
V
L
RKEP
Y
V
S
TFTTPS
D
N
L
L
A
Q
R
T
Q
L
SRITPSASSSVP
G
R
V
A
V
S
TEMPSQN
T
A
L
A
EMPKRKFTIDDFDIGRPLGKGKFG
N
V
Y
L
A
REKQN
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
KE
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
HL-RH
P
N
I
L
R
M
Y
N
Y
F
HD
R
K
R
I
Y
L
M
L
E
FAPR
G
E
L
Y
K
E
L
Q
KH-GRF
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
RDIKPE
N
L
L
MGYKG
E
L
K
I
A
DFGWSVHA--P
S
L
R
R
R
TMCGTLDYL
P
P
E
M
IEGKTHDE
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
LVGMPPFDSPSH
T
E
T
H
R
R
I
V
N
V
DLKFPPFLSDG
S
K
D
L
I
S
K
L
L
R
YHPPQRL-----
P
L
------
K
G
VMEHPWVKANSRRVLPP
V
Y
Q
STQSK
7
PsiBlast_PDB
93.02
99%
-112
- C1 -
4B8M
1
AUKBA_XENLA
A:
[11-281]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
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R
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R
S
A
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M
E
E
L
A
D
A
L
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Y
C
H
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-
R
K
V
I
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I
K
P
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L
M
G
Y
K
G
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L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
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M
I
E
G
K
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D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
----
40
HHSearch
92.57
100%
-110
- C1 -
4C2V
1
?
A:
[12-282]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
----
5
PsiBlast_PDB
92.03
99%
-111
- C1 -
2VGO
1
AUKBA_XENLA
A:
[10-278]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
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M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
10
PsiBlast_PDB
91.60
99%
-110
- C1 -
4C2W
1
?
A:
[11-279]
---------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
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M
I
E
G
K
T
H
D
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K
V
D
L
W
C
A
G
V
L
C
Y
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F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
-----
2
PsiBlast_PDB
91.14
99%
-110
- C1 -
2VRX
1
AUKBA_XENLA
A:
[11-279]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
6
PsiBlast_PDB
90.99
99%
-108
- C1 -
3ZTX
1
AUKBA_XENLA
A:
[10-279]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
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A
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P
S
L
R
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R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
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E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
-----
4
PsiBlast_PDB
90.97
99%
-113
- C1 -
2VGP
1
AUKBA_XENLA
A:
[11-279]
---------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
---
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
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V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
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R
H
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N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
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Q
R
S
A
T
F
M
E
E
L
A
D
A
L
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C
H
E
-
R
K
V
I
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R
D
I
K
P
E
N
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M
G
Y
K
G
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L
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S
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--
P
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L
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P
S
H
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K
F
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P
F
L
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D
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S
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L
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R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
-----
8
PsiBlast_PDB
84.96
99%
-111
- C1 -
4B8L
1
AUKBA_XENLA
A:
[11-275]
--------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
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F
A
P
R
G
E
L
Y
K
E
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H
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G
R
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A
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F
M
E
E
L
A
D
A
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R
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H
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D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
----------
19
PsiBlast_PDB
80.97
70%
-108
- C1 -
2XNG
1
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
14
PsiBlast_PDB
80.08
72%
-110
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[7-269]
-------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-------------
16
PsiBlast_PDB
79.08
72%
-114
- C1 -
3D2I
1
AURKA_MOUSE
A:
[8-269]
--------------------------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-------------
17
PsiBlast_PDB
78.95
71%
-107
- C1 -
2WTW
1
AURKA_HUMAN
A:
[10-271]
---------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
15
PsiBlast_PDB
77.58
72%
-110
- C1 -
3D15
1
AURKA_MOUSE
A:
[7-269]
-------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
-------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-------------
18
PsiBlast_PDB
75.79
70%
-114
- C1 -
1MUO
1
AURKA_HUMAN
A:
[22-282]
---------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------
21
PsiBlast_CBE
75.50
99%
-82
- C1 -
4C2V
1
?
B:
[1-281]
---------------------------------------------------------------------------
Q
N
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
-----
11
PsiBlast_PDB
75.25
80%
-108
- C1 -
4AF3
1
AURKB_HUMAN
A:
[18-285]
-------------------------------------------------------------------------------------
R
H
F
T
I
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
K
S
H
F
I
V
A
L
K
V
L
F
K
S
Q
I
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
A
H
L
-
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
-
C
T
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
L
K
G
E
L
K
I
A
D
F
G
------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
N
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
A
S
H
N
E
T
Y
R
R
I
V
K
V
D
L
K
F
P
A
S
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
R
L
-----
P
L
------
A
Q
V
S
A
H
P
W
V
R
A
N
S
R
R
V
L
P
P
--------
12
PsiBlast_PDB
75.20
72%
-117
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[9-269]
---------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-------------
13
PsiBlast_PDB
74.55
72%
-115
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[9-269]
---------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-------------
26
PsiBlast_CBE
73.88
99%
-83
- C1 -
4B8M
1
AUKBA_XENLA
B:
[2-281]
-----------------------------------------------------------------------------
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
----
24
PsiBlast_CBE
73.75
99%
-83
- C1 -
2VGP
1
AUKBA_XENLA
B:
[1-278]
-----------------------------------------------------------------------------
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
28
PsiBlast_CBE
73.35
99%
-83
- C1 -
4C2W
1
?
B:
[1-278]
-----------------------------------------------------------------------------
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
20
PsiBlast_PDB
72.93
70%
-110
- C1 -
4B0G
1
AURKA_HUMAN
A:
[6-269]
-------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
----
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
22
PsiBlast_CBE
72.90
99%
-81
- C1 -
2VRX
1
AUKBA_XENLA
B:
[1-279]
----------------------------------------------------------------------------
N
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
----
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
25
PsiBlast_CBE
72.72
99%
-82
- C1 -
2VGO
1
AUKBA_XENLA
B:
[1-280]
-----------------------------------------------------------------------------
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
--
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
----
23
PsiBlast_CBE
71.55
99%
-80
- C1 -
3ZTX
1
AUKBA_XENLA
B:
[1-278]
-----------------------------------------------------------------------------
T
A
L
A
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
-----
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
------
42
HHSearch
67.64
33%
-108
* C1 *
4GV1
5
AKT1_HUMAN
A:
[4-270]
--------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
IK
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
E
I
M
Q
H
R
F
F
A
G
----------------
47
HHSearch
64.78
31%
-101
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[36-299]
-------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
-
G
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
D
I
K
N
H
K
W
F
A
T
----------------
29
PsiBlast_CBE
63.94
71%
-124
- C1 -
3W2C
1
?
A:
[1-260]
---------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
------------
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
-------------------
T
L
D
Y
L
P
P
E
M
I
E
-------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------------
H
P
W
I
T
A
N
S
--------------
60
HHSearch
58.60
37%
-120
- C1 -
3COK
1
PLK4_HUMAN
A:
[9-267]
----------------------------------------------------------------------------------------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K----------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
L
A
D
Y
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
------
S
S
V
L
D
H
P
F
M
S
-----------------
44
HHSearch
55.28
32%
-97
- C1 -
3TXO
1
A:
[23-286]
------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
IC---------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
A
I
L
R
H
P
F
F
K
E
----------------