@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_AURKB_: (2014-08-14 )
MAQKENAYPWPYGSKTSQSGLNTLSQRVLRKEPATTSALALVNRFNSQSTAAPGQKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRANSRRVLPPSAL
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130....-.-..140.......150.......160.......170.......180.......190......-.200.......210.......220.......230.........240.......250.......260.......270.......280.......290.......300.......310.......320----..------.-.....330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAQKENAYPWPYGSKT
S
Q
S
G
L
N
T
L
S
Q
R
V
L
RKEPA
T
T
S
A
L
A
L
V
N
RFNSQSTAAP
G
Q
K
L
AENKSQGSTASQGSQNKQ
P
F
T
IDNFEIGRPLGKGKFG
N
V
Y
L
A
REKKS
R
F
I
V
A
L
K
I
L
F
K
S
Q
I
E
KE
G
V
E
H
Q
L
R
R
E
I
E
I
Q
A
H-L-KHP
N
I
L
Q
L
Y
N
Y
F
YDQ
Q
R
I
Y
L
I
L
E
YAP
R
G
E
L
Y
K
E
L
Q
KSRTF
D
E
Q
R
T
A
T
I
M
E
E
L
S
D
A
L
T
Y
C
H
K
-
K
K
V
I
HRDIKPE
N
L
L
L
GLQG
E
L
K
I
A
D
FGWSVHA--P
S
L
R
R
KTMCGTLDYL
P
P
E
M
I
E
G
R
M
H
N
E
M
V
D
L
W
C
I
G
V
L
C
Y
E
L
MVGNPPFESP
S
H
S
E
T
Y
R
R
I
V
K
V
D
L
KFPSSVPS
G
A
Q
D
L
I
S
K
L
L
KHNPWQRL-----
P
L
------
A
-
E
V
AAHPWVRANSRRVLPPSAL
6
PsiBlast_PDB
81.90
77%
-114
- C1 -
2VGO
1
AUKBA_XENLA
A:
[10-276]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
45
HHSearch
81.42
77%
-112
- C1 -
4C2V
1
?
A:
[12-280]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
-
8
PsiBlast_PDB
80.64
77%
-114
- C1 -
2VRX
1
AUKBA_XENLA
A:
[11-277]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
2
PsiBlast_PDB
79.77
77%
-116
- C1 -
4B8M
1
AUKBA_XENLA
A:
[11-277]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
7
PsiBlast_PDB
79.71
77%
-112
- C1 -
3ZTX
1
AUKBA_XENLA
A:
[10-276]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
10
PsiBlast_PDB
79.03
77%
-112
- C1 -
4C2W
1
?
A:
[11-276]
----------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
11
PsiBlast_PDB
77.97
76%
-109
- C1 -
2BFY
1
AUKBA_XENLA
A:
[9-276]
--------------------------------------------------------------------------
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
5
PsiBlast_PDB
77.58
77%
-115
- C1 -
2VGP
1
AUKBA_XENLA
A:
[11-276]
----------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
1
PsiBlast_PDB
77.31
91%
-117
- C1 -
4AF3
1
AURKB_HUMAN
A:
[20-286]
----------------------------------------------------------------------------
F
T
I
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
K
S
H
F
I
V
A
L
K
V
L
F
K
S
Q
I
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
A
H
-
L
-
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
C
T
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
L
K
G
E
L
K
I
A
D
F
G
------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
N
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
A
S
H
N
E
T
Y
R
R
I
V
K
V
D
L
K
F
P
A
S
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
R
L
-----
P
L
------
A
-
Q
V
S
A
H
P
W
V
R
A
N
S
R
R
V
L
P
P
S
--
15
PsiBlast_PDB
76.84
71%
-117
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[7-269]
--------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
--------
19
PsiBlast_PDB
75.09
70%
-110
- C1 -
4JAJ
1
AURKA_HUMAN
A:
[13-277]
-------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------
9
PsiBlast_PDB
74.39
77%
-115
- C1 -
4B8L
1
AUKBA_XENLA
A:
[11-275]
---------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
-----
12
PsiBlast_PDB
74.03
72%
-118
- C1 -
2WTW
1
AURKA_HUMAN
A:
[10-271]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------
17
PsiBlast_PDB
73.31
71%
-122
- C1 -
3D2I
1
AURKA_MOUSE
A:
[8-269]
---------------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
--------
31
PsiBlast_CBE
72.80
71%
-123
- C1 -
3W16
1
?
A:
[3-263]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
-------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
--------
13
PsiBlast_PDB
72.58
71%
-125
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[9-269]
----------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
--------
14
PsiBlast_PDB
71.77
71%
-121
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[9-269]
----------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
--------
16
PsiBlast_PDB
71.67
71%
-116
- C1 -
3D15
1
AURKA_MOUSE
A:
[7-269]
--------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
-------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
--------
18
PsiBlast_PDB
70.87
70%
-115
- C1 -
4JAI
1
AURKA_HUMAN
A:
[14-277]
--------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------
20
PsiBlast_PDB
70.42
70%
-118
- C1 -
1MUO
1
AURKA_HUMAN
A:
[22-282]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
--------
29
PsiBlast_CBE
66.46
71%
-120
- C1 -
3W18
1
?
B:
[3-263]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-----------
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
--------
30
PsiBlast_CBE
64.45
71%
-124
- C1 -
3W18
1
?
A:
[3-263]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
-------
R
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
--------
25
PsiBlast_CBE
62.40
77%
-90
- C1 -
2VGP
1
AUKBA_XENLA
B:
[8-276]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
48
HHSearch
62.30
36%
-112
* C1 *
4GV1
5
AKT1_HUMAN
A:
[4-270]
---------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
IK
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
G
-----------
22
PsiBlast_CBE
61.53
77%
-88
- C1 -
4C2V
1
?
B:
[10-278]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
27
PsiBlast_CBE
61.36
77%
-89
- C1 -
4C2W
1
?
B:
[8-276]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
21
PsiBlast_CBE
60.89
77%
-90
- C1 -
4B8M
1
AUKBA_XENLA
B:
[9-277]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
23
PsiBlast_CBE
59.57
77%
-87
- C1 -
3ZTX
1
AUKBA_XENLA
B:
[8-276]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
-----
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
28
PsiBlast_CBE
59.25
76%
-81
- C1 -
2BFY
1
AUKBA_XENLA
B:
[8-276]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
24
PsiBlast_CBE
59.23
77%
-86
- C1 -
2VRX
1
AUKBA_XENLA
B:
[9-277]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
----
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
52
HHSearch
59.15
32%
-105
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[36-299]
--------------------------------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
-
G
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
A
T
-----------
26
PsiBlast_CBE
58.38
77%
-87
- C1 -
2VGO
1
AUKBA_XENLA
B:
[8-276]
-------------------------------------------------------------------------
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
--
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
-
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
---
34
PsiBlast_CBE
56.54
71%
-132
- C1 -
3W2C
1
?
A:
[1-260]
----------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
------------
E
V
E
I
Q
S
H
-
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
-------------------
T
L
D
Y
L
P
P
E
M
I
E
-------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
E
F
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-----------------------
H
P
W
I
T
A
N
S
---------
53
HHSearch
49.78
31%
-94
- C1 -
1XJD
1
A:
[16-275]
------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
ML
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
-----------
49
HHSearch
49.02
34%
-107
- C1 -
3TXO
1
A:
[23-286]
-------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
IC---------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
E
-----------
58
HHSearch
42.62
30%
-110
- C1 -
4BKY
1
MELK_HUMAN
A:
[8-268]
-----------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
--
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
D
Y
---------