@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_AVR2A_: (2014-08-14 )
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190-........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310........320.......330.......340.......350..--.--.--...360.......370....---..-.-380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
A
A
A
K
L
A
F
A
V
F
L
I
SCSS
G
A
I
LGRSET
Q
E
C
L
F
FNANWEKDRTNQTGVEPCYGD
K
D
K
R
R
H
C
F
A
T
W
KNISG
S
I
E
I
V
KQGCWLDDINCYDRTDCVEKKDSP
E
V
Y
F
C
CCEGNMCN
E
K
F
SYFPE
M
E
VTQPTSNPVTPKPP
Y
Y
N
I
L
L
Y
S
L
V
P
L
M
L
I
A
G
I
V
I
C
A
F
W
V
Y
R
HHKMAYPPVLVPTQDPGPPPPSPLLGLKP--
L
Q
L
L
E
V
KARGRFG
C
V
W
K
A
Q
L
L
NE
Y
V
A
V
K
I
F
PIQD
K
Q
S
W
Q
NEY
E
V
YSLPGM
K
H
E
N
I
L
Q
F
IGAEKRGT
S
V
D
V
D
L
W
L
I
T
A
FHEKG
S
L
S
D
F
L
K
A
NVV
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
EDIPGLK-DGHKPAISHRDIKSK
N
V
L
LKNN
L
T
A
C
I
A
DFG
L
A
L
K
F
EAGKSAG--D--T--HGQVGTRRYM
A
P
E
V
L
E
G
A
IN---FQ-R-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
CTAADG
P
V
D
E
YML
P
F
E
E
E
IGQHP
S
L
E
D
M
Q
E
V
V
V
HKKKR
P
V
L
R
D
Y
W
Q
K
HA
G
M
A
M
L
C
E
T
I
E
E
C
WDH
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
N
II
T
T
E
D
I
V
T
V
V
T
M
V
TNVDFPPKESSL
23
PsiBlast_CBE
98.78
100%
-106
- C1 -
3Q4T
10
AVR2A_HUMAN
B:
[25-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
------
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
----------------------------
22
PsiBlast_CBE
98.20
100%
-105
- C1 -
3SOC
5
AVR2A_HUMAN
B:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
------
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
21
PsiBlast_CBE
97.26
100%
-101
- C1 -
4ASX
6
AVR2A_HUMAN
B:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
--
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
3
PsiBlast_PDB
97.21
100%
-106
- C1 -
4ASX
4
AVR2A_HUMAN
A:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
-----
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
1
PsiBlast_PDB
95.33
100%
-99
- C1 -
3Q4T
13
AVR2A_HUMAN
A:
[25-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
--
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-----------------------------
37
HHSearch
95.25
97%
-96
- C1 -
3SOC
7
AVR2A_HUMAN
A:
[16-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
N
L
Y
F
Q
S
M
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
--
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
4
PsiBlast_PDB
86.94
76%
-101
- C1 -
2QLU
1
AVR2B_HUMAN
A:
[15-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GS
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
D
F
V
A
V
K
I
F
P
L
Q
D
K
Q
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
E
K
R
G
S
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
P
W
C
R
G
E
G
H
K
P
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
E
P
G
K
P
P
G
--
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
Q
-
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
L
K
H
P
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
----------------------------
13
PsiBlast_PDB
74.22
40%
-93
- C1 -
2WOT
2
TGFR1_HUMAN
A:
[6-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
--------------------------
8
PsiBlast_PDB
72.76
40%
-94
- C1 -
3TZM
1
TGFR1_HUMAN
A:
[9-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
AP--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
------------------------------
14
PsiBlast_PDB
72.63
40%
-94
- C1 -
2WOU
2
TGFR1_HUMAN
A:
[6-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
------------------------------
18
PsiBlast_PDB
72.47
40%
-93
- C1 -
3H9R
4
ACVR1_HUMAN
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-----------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
D
C
F
-
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
19
PsiBlast_PDB
72.29
40%
-89
- C1 -
4C02
11
ACVR1_HUMAN
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
--
D
V-----
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
D
C
F
-
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
11
PsiBlast_PDB
72.29
40%
-93
- C1 -
1RW8
1
TGFR1_HUMAN
A:
[4-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
40
HHSearch
72.02
40%
-90
- C1 -
3Q4U
7
ACVR1_HUMAN
A:
[9-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
--
G
-
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
DV
G
--
N
--
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
D
-
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
10
PsiBlast_PDB
71.90
40%
-95
- C1 -
3HMM
1
TGFR1_HUMAN
A:
[3-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
A-----
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
----------------------------
15
PsiBlast_PDB
71.64
40%
-98
- C1 -
3MDY
1
BMR1B_HUMAN
A:
[37-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
--
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
--
F
S
-
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
------------P-
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
RNH
F
Q
----
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
-------------------------
9
PsiBlast_PDB
71.58
40%
-91
- C1 -
3GXL
1
TGFR1_HUMAN
A:
[3-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
---
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
-------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
----
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
----------------------------
20
PsiBlast_PDB
71.49
40%
-82
- C1 -
3MTF
12
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
--
D
VG
N
--
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
D
C
F
-
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
12
PsiBlast_PDB
69.94
40%
-90
- C1 -
1PY5
1
TGFR1_HUMAN
A:
[29-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
--
D
--
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
K
-
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------