@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDK17_: (2014-08-15 )
MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210--.......220......-.-230.-......240.......250.....--.-----.------260---..------.......270.......-280--.---.-......290.......300.......310.......320---...-.....330.......--340.......350.......360.......370.......380.-.-----------.....390.-------.----.....400.......410.......420.----.-.--....430..-.-------.----...-.440.......450.......460.......470.......480.....---..490.......500.......510.......520.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
F
K
R
R
L
S
L
T
LRGS
Q
T
I
D
E
S
L
S
E
L
A
E
Q
MTIEENSSKDNEPIVKNGRPPT
S
H
S
M
H
S
F
L
H
Q
YTGSFKKPPLRR
P
H
S
V
IGGS
L
G
S
FMAMPRNG
S
R
L
D
I
V
H
E
NLKMGSDGESDQASGTSSDEVQS
P
T
G
V
C
L
R
N
R
I
H
R
RI
S
M
E
D
L
N
K
R
LSLP
A
D
I
RIPD
G
Y
L
E
K
L
QINSPPFD
Q
P
M
S
R
R
S
R
RA
S
L
S
EIGFG
K
M
E
T
Y
I
K
L
EKLGEG
T
Y
A
T
V
YK
G
R
S
K
--
L
T
E
N
L
V
A
L
K
E
I
R
L
EHE-E-GAP
C
-
T
A
I
R
E
V
S
L
L
K
D
L
K
HA
N
I
V
T
L
H
D
I
V--H-----T------D-----K
S
------
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
M
D
-
D
C
---
G
---
N
-
I
M
S
M
H
N
V
K
L
F
L
Y
Q
I
L
R
G
L
A
Y
C
H
R
R
K
V
L
H
RDLKPQ
N
L
L
I----NEK-G
E
L
K
L
ADFGLARAKS--VPTKTYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGSSEY
S
T
Q
ID
M
W
G
V
G
C
I
F
F
EMA-S-----------GRPLFPGST-------
V
----
E
D
E
L
H
L
I
F
R
L
LGTPSQETWPGISSNEEFK----N-Y--NFPKYK-PQ-P-------L----INH-APRLDSE
G
I
E
L
I
T
K
F
L
Q
Y
E
S
KKRV
S
A
E
E
A
M
K
H
V
Y
F
R
SLG
P
R
IHALPES
V
---
S
I
F
S
L
K
E
I
Q
LQKDPGFRNSSYPETGHGKN
R
R
QSMLF
12
PsiBlast_PDB
82.77
53%
-100
- C1 -
1OGU
1
CDK2_HUMAN
A:
[2-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
13
PsiBlast_PDB
82.56
53%
-103
- C1 -
1OI9
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
15
PsiBlast_PDB
82.03
53%
-99
- C1 -
1OIY
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
16
PsiBlast_PDB
82.00
53%
-102
- C1 -
4CFN
1
CDK2_HUMAN
A:
[2-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
19
PsiBlast_PDB
81.63
53%
-104
- C1 -
2IW9
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
11
PsiBlast_PDB
81.48
53%
-102
- C1 -
2IW8
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
14
PsiBlast_PDB
81.40
53%
-104
- C1 -
1OIU
1
CDK2_HUMAN
A:
[2-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---T
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
20
PsiBlast_PDB
80.67
53%
-100
- C1 -
4EOS
1
CDK2_HUMAN
A:
[1-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
E
-
G
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
46
HHSearch
80.42
52%
-103
- C1 -
3NIZ
1
?
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
---
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
-----
R
C
------
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
-
E
N
---
K
---
T
-
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
----
Q
-
R
--
T
F
Q
V
F
E
-
K
K
-
P
-------
W
----
S
S
I
-
I
P
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
-----------------------------------------------
44
HHSearch
80.35
57%
-102
* C1 *
4AU8
2
CDK5_HUMAN
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
-
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-------------------
K
------
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
C
---
N
---
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
-
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
-----
Y
P
M
Y
P
-
A
T
T
S
-------
L
----
V
N
V
-
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
--------------------------------------------------
5
PsiBlast_PDB
79.54
55%
-104
- C1 -
1UNL
1
CDK5_HUMAN
A:
[1-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
-
G
V
P
S
-
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
-----
K
K
------
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
C
---
N
---
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-----------
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
---------------
L
P
D
Y
K
-
P
Y
-
P
MYPATTS
L
----
V
N
V
-
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
------------------------------------------------
3
PsiBlast_PDB
79.43
55%
-107
- C1 -
1UNG
1
CDK5_HUMAN
A:
[1-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
-
G
V
P
S
-
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
-----
K
K
------
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
C
---
N
---
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-----------
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
---------------
L
P
D
Y
K
-
P
Y
-
P
MYPATTS
L
----
V
N
V
-
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
------------------------------------------------
18
PsiBlast_PDB
77.87
53%
-109
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
17
PsiBlast_PDB
76.62
53%
-113
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
---
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------
35
HHSearch
74.58
35%
-95
- C1 -
3N9X
2
?
A:
[22-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
--
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
-
D
-
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
--
I
-----
P
------
D
DLLKF
D
E
------
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
-
T
P
---
I
-----
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
-----------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
-
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
P
E
V
I
K
----
Y
I
K
--
L
F
P
H
R
K
-
P
I
-
N
-------
L
----
K
Q
K
-
Y
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
-------------------------------------------------
40
HHSearch
73.20
31%
-94
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[54-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
-------
R
-
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
--
Y
-----
S
S
GEKKD
E
-----
V
Y
------
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
-
H
Y
S
R
A
K
---
Q
-
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
RG
E
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
--
N
P
N
Y
T
----
E
-
F
--
K
F
P
Q
I
K
-
A
H
-
P
-------
W
----
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
DTP
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
------------------
50
HHSearch
72.23
34%
-98
- C1 -
2B9H
2
FUS3_YEAST
A:
[4-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
-
P
-
L
F
A
L
-
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
--
R
PDSFE
N
------
F
-----
N
E
------
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
-
T
--------
Q
-
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
--------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
-
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
----
E
-
Y
I
K
S
L
P
M
Y
P
-
A
A
-
P
-------
L
----
E
K
M
-
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
------------------------------------------------
34
HHSearch
64.79
39%
-94
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
-
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
--
G
-----
H
------
K
-----
S
N
------
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
-
D
N
---
S
---
L
-
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
--
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---------
T
F
K
S
F
P
-
G
I
-
P
-------
L
----
H
H
I
-
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
--------------------------------------------------
52
HHSearch
64.59
37%
-101
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
-
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
-----
R
------
R
-----
G
K
------
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-
E
M
---
P
---
N
-
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
--
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
----
G
-
L
--
R
F
P
A
V
N
H
P
Q
-
S
-------
L
----
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
---------------------------------------------------
51
HHSearch
64.23
38%
-105
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
---
G
-
T
-
G
I
S
M
-
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
-----
A
------
D
-----
R
K
------
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
-
F
H
---
R
A
S
K
V
-
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
-
G
R
V
K
I
A
D
M
G
F
----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
-
T
-----------
S
E
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
-
F
--
R
R
N
T
Y
T
-
N
C
-
S
-------
L
I
K
Y
M
E
K
H
-
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
---------------------------------------------------
49
HHSearch
61.44
36%
-110
- C1 -
2FST
3
MK14_HUMAN
X:
[25-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
-
S
I
I
H
A
K
-
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
--
T
-----
P
------
A
-----
R
S
LEEFND
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
-----
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
D
-
C
E
L
K
I
L
D
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
-
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
-
S
A
R
----
N
-
Y
IQ
S
L
T
Q
M
P
-
K
M
-
N
-------
F
----
A
N
V
-
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
-------------------------------------------------
39
HHSearch
34.37
53%
22
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
-
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-----
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-
A
S
---
A
---
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
----
S
F
P
K
W
A
-
R
Q
-
D
-------
F
----
S
K
V
-
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
-------------------------------------------------