@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDK4_H: (2014-08-15 )
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
Atome Classification :
(17 SA)
.........10........20....-....30........40........50........60........70........80..-......90........100.....--..110.......120.......130.......140.......150........160.......-----170.......180.......-190........200.......-----------210......-------.220.......230.......240-...----.----...250-.-.....-.260........270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATSRYE
P
V
A
E
IGVGAYG
T
V
Y
KARD-PHSG
H
F
V
A
L
K
S
V
RVPNGGGGGGGL
P
I
S
T
V
R
E
V
A
L
L
R
R
L
E
A
FEHP
N
V
V
R
L
M
D
V
CATSRT-D
R
E
I
K
V
T
L
V
F
E
HV
D
Q
D
L
R
T
Y
L
DKA--PPPGL
P
A
E
T
I
K
D
L
M
R
Q
F
L
R
G
L
D
F
L
H
A
N
C
I
V
HRDLKPE
N
I
L
V
TSG-
G
T
V
K
L
A
D
F
G
L
A
R
I
Y
S
Y
Q
M
-----
A
L
T
P
V
V
V
T
L
W
YR
A
P
E
V
L
L
Q
S-T-YAT
P
V
D
M
W
S
V
G
C
I
F
A
E
M
F
R-----------RKPLFCGNS-------
E
A
D
Q
L
G
K
I
F
D
LIGLPPEDDWPRDV-SLP----R----GAFPPR-G-PR
P
V
Q
-
S
V
V
-
P
E
M
E
E
S
G
A
Q
L
L
L
E
M
LTFNP
H
K
R
I
S
A
F
R
A
L
Q
H
S
Y
LHKDEGNPE
7
PsiBlast_PDB
86.96
69%
-131
- C1 -
1XO2
1
CDK6_HUMAN
B:
[11-305]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
----
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
-
A
L
P
----
R
----
Q
A
F
H
-----
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
8
PsiBlast_PDB
86.71
69%
-132
- C1 -
2EUF
2
CDK6_HUMAN
B:
[10-305]
--
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
-
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------------------------
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
9
PsiBlast_PDB
85.04
69%
-133
- C1 -
2F2C
2
CDK6_HUMAN
B:
[9-305]
-
A
D
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
---
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
-
T
-
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
----------------
Q
A
F
------
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---
16
PsiBlast_PDB
84.36
70%
-138
- C1 -
4EZ5
1
CDK6_HUMAN
A:
[11-301]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
-
A
L
P
----
R
----
Q
A
F
H
S
----
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
14
PsiBlast_PDB
83.89
70%
-133
- C1 -
3NUX
1
CDK6_HUMAN
A:
[10-301]
--
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
-
A
L
P
----
R
----
Q
A
F
H
-
K
-
S
-
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
15
PsiBlast_PDB
82.34
70%
-135
- C1 -
4AUA
1
CDK6_HUMAN
A:
[11-301]
---
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
---------------
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
-
G
Q
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
-
A
L
P
----
R
----
Q
A
F
H
S
K
-
S
-
A
Q
P
I
E
-
K
F
V
-
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------
20
PsiBlast_PDB
81.31
45%
-126
- C1 -
2IW8
1
CDK2_HUMAN
A:
[4-291]
-
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-
S
M
P
DY--
K
----
P
S
F
P
K
W
-
A
-
R
Q
D
F
S
-
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------
17
PsiBlast_PDB
77.12
46%
-132
- C1 -
1GII
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-
S
M
P
DY--
K
----
P
S
F
P
K
W
-
A
-
R
Q
D
F
S
-
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------
18
PsiBlast_PDB
75.11
46%
-128
- C1 -
1GIJ
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-
S
M
P
DY--
K
----
P
S
F
P
K
W
-
A
-
R
Q
D
F
S
-
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------
48
HHSearch
73.70
46%
-120
- C1 -
4AU8
2
CDK5_HUMAN
A:
[4-293]
-
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
---------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
--
N
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
-----
R
-
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-
K
L
P
----
D
Y
---
K
P
Y
P
M
Y
-
P
A
T
T
S
L
V
-
N
V
V
-
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----
33
HHSearch
70.79
39%
-101
- C1 -
3N9X
2
?
A:
[26-369]
---
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
-
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
---
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
---
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
-
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
----
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
-------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
-
K
P
E
V
I
K
Y
I
----
K
L
F
P
H
R
-
K
-
P
I
N
L
K
-
Q
K
Y
-
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
----
50
HHSearch
70.07
36%
-108
- C1 -
3QYZ
13
MK01_RAT
A:
[27-320]
---
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
-
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
-
E
H
Q
---
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
---
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
T
G
-
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
-
N
L
K
----
A
R
N
Y
L
L
S
L
P
H
K
-
N
-
K
V
P
W
N
-
R
L
F
-
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
-----
51
HHSearch
69.11
30%
-121
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-343]
----
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
--
R
F
-------
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
----
E
----
F
K
F
P
Q
I
-
K
-
A
H
P
W
T
-
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
-----
52
HHSearch
66.94
35%
-109
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-301]
--
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
------
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
--
P
N
-
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
-
S
N
P
----
R
FHG-
L
R
F
P
A
V
N
H
-
P
Q
S
L
E
R
R
Y
L
-
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
-----
39
HHSearch
64.52
35%
-110
* C1 *
4IC7
1
MK07_HUMAN
A:
[55-352]
---
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
---
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
AEHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
-
A
E
R
VRAY
I
----
Q
S
L
P
P
R
-
Q
-
P
V
P
W
E
-
T
V
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
-----
34
HHSearch
62.67
38%
-108
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-299]
------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
I
------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
H
K
------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
--
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
-
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
-
S
L
P
D
---
Y
----
V
T
F
K
S
F
-
P
-
G
I
P
L
H
-
H
I
F
-
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----
46
HHSearch
61.46
36%
-114
- C1 -
2FST
3
MK14_HUMAN
X:
[29-318]
---
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
-
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
---
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
---
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
-
S
E
S
ARNY
I
----
Q
S
L
T
Q
M
-
P
-
K
M
N
F
A
-
N
V
F
-
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
-----