@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDK9_H: (2014-08-15 )
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
Atome Classification :
(18 SA)
.........10........20........30........40-.........50........60........70........80........90........100.......110...------....120.......130.......140.......150.....----..160.......170.......180.......190.......200.......210.......220..-----------..-...230.-------.----.....240.......250.......260...-.--...--270..--......280-........290.......300.......310....--...320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKQYDSVECPF
C
D
E
V
S
K
Y
E
K
L
A
K
IGQG
T
F
G
E
V
F
K
A
R
H
RK--T
G
Q
K
V
A
L
K
K
V
L
M
ENEKEGFP
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
HE
N
V
V
N
L
I
E
I
CRTKASPYNRCK
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
DMKA
A
N
V
L
I
----TRDG
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
AKNSQPNRYT
N
R
V
V
T
L
W
YR
P
P
E
L
LLGERDYGPPIDLWG
A
G
C
I
M
A
E
M
WT-----------RS-PIMQGN
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
SI
T
P
E
VWPNVD
N
Y
E
L
Y
E
K
L
-
E
--
L
VK--G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
VRDP
Y
A
L
D
L
I
D
K
L
L
VL
D
P
A
Q
RIDSDDALNHDFFW--SDPM
P
S
D
L
K
G
M
L
S
T
H
L
T
S
M
F
E
Y
LAPPRRKGS
Q
I
T
Q
QSTNQSRNPATTN
Q
T
E
F
E
RVF
13
PsiBlast_PDB
96.49
99%
-131
- C1 -
4BCG
2
CDK9_HUMAN
A:
[8-328]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
4
PsiBlast_PDB
95.52
99%
-125
- C1 -
3MIA
1
CDK9_HUMAN
A:
[8-340]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
L
S
T
H
L
T
S
M
F
E
Y
L
A
--------------------------------
5
PsiBlast_PDB
93.92
99%
-136
- C1 -
3BLQ
1
CDK9_HUMAN
A:
[8-326]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
-----------
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
-----------------------------------------------
7
PsiBlast_PDB
92.61
99%
-123
- C1 -
3MY1
3
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
11
PsiBlast_PDB
92.50
99%
-127
- C1 -
4BCI
1
CDK9_HUMAN
A:
[6-327]
----
Y
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
---------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
12
PsiBlast_PDB
91.83
99%
-126
- C1 -
4BCJ
1
CDK9_HUMAN
A:
[7-327]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
6
PsiBlast_PDB
91.74
99%
-128
- C1 -
3BLR
1
CDK9_HUMAN
A:
[8-327]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
----------
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
8
PsiBlast_PDB
91.54
99%
-129
- C1 -
3LQ5
1
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
-
E
--
L
V
K
--
G
Q
-
K
R
--
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
9
PsiBlast_PDB
91.42
99%
-136
- C1 -
3TNH
1
CDK9_HUMAN
A:
[9-329]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
--
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
-----------------------
K
V
K
D
R
L
K
A
--
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
L
--------------------------------------------
35
HHSearch
63.79
31%
-105
- C1 -
3N9X
2
?
A:
[25-371]
---------------
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
--
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
---
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
------
T
P
-
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
-------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
-
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
P
E
V
I
K
Y
I
-
K
L
-
F
P
H
--
R
K
-
P
I
--
N
L
K
Q
K
Y
P
S
--
I
--
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
--
D
V
R
K
K
---------------------------------------------------
15
PsiBlast_PDB
63.47
40%
-118
- C1 -
3NIZ
1
?
A:
[20-304]
---------------
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
---
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
E
-----
R
C
---
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
------
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
-
P
L
F
P
G
V
T
-------
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
-
T
--
F
Q
V
--
F
E
-
K
K
--
P
W
S
S
I
I
P
G
--
F
C
Q
E
--
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
-----------------------------------------------------------
34
HHSearch
61.36
41%
-99
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-305]
-------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
--
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
K
--------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
------
D
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
----
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
-
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
F
-
K
--
S
F
----
P
-
G
I
--
P
L
H
H
I
F
S
A
--
A
--
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
--
N
R
P
G
P
T
P
G
C
-----------------------------------------------
40
HHSearch
58.95
35%
-117
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-345]
----------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
GK
D
D
K
D
Y
A
L
K
Q
I
E
----
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
------
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
-
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
-
M
K
D
F
R
R
NT
Y
T
-
N
C
--
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
--
E
D
P
L
P
T
S
-------------------------------------------------
19
PsiBlast_PDB
58.79
39%
-105
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-296]
---------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
--
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
-----
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
--
F
P
K
--
W
A
-
R
Q
--
D
F
S
K
V
V
P
P
----
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
17
PsiBlast_PDB
58.33
41%
-106
- C1 -
4AU8
2
CDK5_HUMAN
A:
[7-293]
-----------------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
--
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
-----------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-----
P
V
R
-
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
-
P
--
M
Y
P
--
A
T
-
T
S
LV
N
V
V
P
K
L
N
A
--
T
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
F
-----------------------------------------------------
20
PsiBlast_PDB
58.07
39%
-101
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-296]
---------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
--
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
-----
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
--
F
P
K
--
W
A
-
R
Q
--
D
F
S
K
V
V
P
P
----
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
45
HHSearch
55.06
36%
-112
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
---------------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
--
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
--------
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
------
E
M
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
-
P
L
F
P
G
E
S
-------
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
--
F
P
A
--
V
N
H
P
Q
--
S
L
E
R
R
Y
L
G
--
I
-
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
--
T
Q
R
-----------------------------------------------------
46
HHSearch
49.84
33%
-109
- C1 -
2FST
3
MK14_HUMAN
X:
[29-322]
----------------
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
--
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
--
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
-----------
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
-
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
--
L
T
Q
--
M
P
-
K
M
--
N
F
A
N
V
F
I
G
--
A
--
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
--
Q
Y
H
D
P
D
--------------------------------------------------