@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDKL1_: (2014-08-15 )
MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........-----70------..-----.------.....80........90.-.---..-....100.......110.......120.......130.....-..140.......150...----....160.......170.......180.......190.....-----------..200....-------...210.......----------220.----------...-...230.---......-..240.......250..-.....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
K
Y
E
K
IGKIGEG
S
Y
G
V
V
F
K
CRNRDTG
Q
I
V
A
I
K
K
F
L
ESED
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
LKHP
N
L
V
N
L
L
E
V
-----
F
R
------RK-----
R
------
R
L
H
L
V
F
E
YC
D
H
T
V
L
H
E
L
D
-
R
---
Y
Q-RG
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
KHNCIHRDVKPE
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
LAGP
S
----
D
Y
Y
T
D
Y
V
A
T
R
WYRSPE
L
L
V
GDTQYGPP
V
D
V
W
A
I
G
C
V
F
A
E
L
LS-----------GVPLWPGKS-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
----------
R
H
Q
-
Q
V
FS--T---NQYFSG-VKIPDPEDMEP
L
E
L
KFP-NISY
P
A
L
G
L
L
K
G
C
LHMDPTQRL
T
C
E
Q
L
LH
H
P
Y
F
E
N
I
R
E
I
E
D
L
A
K
E
HNK
P
T
R
K
T
L
R
K
SRKHHCFTET
S
K
L
Q
Y
L
P
Q
LTGSSILPALDNK
K
Y
Y
CDTKKLNYRFPNI
21
PsiBlast_CBE
97.02
98%
-133
- C1 -
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
---
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
----------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
----------
R
H
Q
-
Q
V
F
S
--
T
---
N
Q
Y
F
S
G
-
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
32
HHSearch
96.86
98%
-134
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
---
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
----------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
----------
R
H
Q
-
Q
V
F
S
--
T
---
N
Q
Y
F
S
G
-
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
22
PsiBlast_CBE
95.37
98%
-135
- C1 -
4AGU
1
CDKL1_HUMAN
B:
[4-293]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
---
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
----------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
----------
R
H
Q
-
Q
V
F
S
--
T
---
N
Q
Y
F
S
G
-
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
-----------------------------------------------------------------
33
HHSearch
80.18
56%
-129
- C1 -
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
K
------
K
K
-----
K
------
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
---
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
----------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
----------
R
H
Q
-
E
L
F
N
--
K
---
N
P
V
F
A
G
-
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-------------------------------------------------------
3
PsiBlast_PDB
78.34
57%
-134
- C1 -
4BBM
3
CDKL2_HUMAN
A:
[24-311]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
K
------
K
K
-----
K
------
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
---
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
----
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
----------
R
H
Q
-
E
L
F
N
--
K
---
N
P
V
F
A
G
-
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
---------------------------------------------------------------------
40
HHSearch
77.73
34%
-114
- C1 -
3N9X
2
?
A:
[26-371]
-
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
-----
I
I
------
P
D
DLLKF
D
------
E
L
Y
I
V
L
E
I
A
D
S
D
-
L
K
K
L
F
-
K
---
T
P
-
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
-------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
----------
T
P
T
E
----------
D
D
L
-
K
N
I
N
--
K
---
P
E
V
I
K
Y
-
I
K
L
F
P
H
R
K
P
I
N
L
K
Q
K
Y
P
-
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
----------------------------------------------------------------
4
PsiBlast_PDB
75.40
48%
-115
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-299]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
-----
F
R
------
Q
K
-----
K
------
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
-
H
---
Y
C
-
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
I
T
K
L
C
D
F
G
F
A
R
T
---------
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
-------
D
L
D
L
L
H
K
I
V
L
K
V
G
----------
N
L
S
P
----------
H
L
Q
-
N
I
F
S
--
K
---
S
P
I
F
A
G
-
V
V
L
P
Q
V
Q
H
P
K
N
A
R
K
K
Y
P
-
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
----------------------------------------------------------
34
HHSearch
71.04
47%
-127
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
-----
F
R
------
R
R
-----
G
------
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-
E
---
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----------
P
L
P
S
----------
E
Q
M
-
K
L
F
Y
--
S
---
N
P
R
F
H
G
-
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
------------------------------------------------------------------
11
PsiBlast_PDB
69.88
38%
-122
- C1 -
3NIZ
1
?
A:
[20-307]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
Q
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
-----
I
H
------
S
E
-----
R
------
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
-
E
---
N
K
-
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
D
D
Q
L
P
K
I
F
S
I
L
G
----------
T
P
N
P
----------
R
E
W
-
P
Q
V
Q
--
E
---
L
P
L
W
K
Q
-
R
T
F
-
Q
V
F
E
K
K
P
W
S
S
I
I
P
-
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
-------------------------------------------------------------------
12
PsiBlast_PDB
69.61
38%
-123
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[2-293]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
16
PsiBlast_PDB
69.41
38%
-119
- C1 -
3PXY
1
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
13
PsiBlast_PDB
68.64
38%
-113
- C1 -
3PXF
7
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
20
PsiBlast_PDB
68.06
38%
-116
- C1 -
3QL8
2
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
18
PsiBlast_PDB
67.65
38%
-116
- C1 -
3PY0
2
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
17
PsiBlast_PDB
66.95
38%
-109
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
19
PsiBlast_PDB
66.32
38%
-105
- C1 -
3PY1
4
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
51
HHSearch
65.95
36%
-117
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-345]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
GEKK
D
E
-----
V
------
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
-
H
Y
S
R
A
K
-
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
----
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
----------
T
P
T
------------
R
E
-
Q
I
R
E
--
M
---
N
P
N
Y
T
E
-
F
K
F
P
Q
I
K
-
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-----------------------------------------------------------------
9
PsiBlast_PDB
65.83
39%
-113
- C1 -
2IW8
1
CDK2_HUMAN
A:
[5-293]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
-
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
----------
D
Y
K
-
P
S
F
P
K
W
A
---
R
Q
D
F
S
K
-
V
V
P
P
L
D
E
D
---------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-------------------------------------------------------------------
14
PsiBlast_PDB
65.30
38%
-110
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[9-300]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
-
P
G
V
T
--
S
---
M
P
D
Y
-
K
-
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
----------------------------------------------------------------
8
PsiBlast_PDB
65.27
39%
-119
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
----------
D
Y
K
-
P
S
F
P
K
W
A
---
R
Q
D
F
S
K
-
V
V
P
P
L
D
E
D
---------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-------------------------------------------------------------------
39
HHSearch
65.09
34%
-116
- C1 -
4IC7
1
MK07_HUMAN
A:
[55-354]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
-----
L
R
PTVPYG
E
F
-----
K
------
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-----
S
S
-
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
AEHQ
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
----------
T
P
S
P
----------
A
V
I
-
Q
A
V
G
--
A
---
E
R
V
R
A
Y
I
Q
S
L
P
P
-
R
Q
P
V
P
W
E
T
V
Y
P
-
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
-----------------------------------------------------------------
47
HHSearch
65.00
34%
-127
- C1 -
2B9H
2
FUS3_YEAST
A:
[11-314]
-
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
-
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
QRPDS
F
E
------
N
F
-----
N
------
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
-
T
------
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
----------
T
P
H
S
DNDLRCIES
P
R
A
R
-
E
Y
I
K
--
S
------------
L
P
M
Y
-
P
A
A
P
L
E
K
M
F
P
-
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
-----------------------------------------------------------------
7
PsiBlast_PDB
64.18
39%
-119
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
----------
D
Y
K
-
P
S
F
P
K
W
A
---
R
Q
D
F
S
K
-
V
V
P
P
L
D
E
D
---------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-------------------------------------------------------------------
6
PsiBlast_PDB
63.43
39%
-120
- C1 -
1OIT
1
CDK2_HUMAN
A:
[3-289]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
----------
D
Y
K
-
P
S
F
P
K
W
A
---
R
Q
D
F
S
K
-
V
V
P
P
L
D
E
D
---------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-------------------------------------------------------------------
52
HHSearch
63.37
40%
-112
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
-----
L
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
---
C
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
----------
T
P
T
E
----------
E
Q
W
-
P
S
M
T
--
K
---
L
P
D
Y
---
K
P
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
-
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-------------------------------------------------------------------
48
HHSearch
54.70
33%
-118
- C1 -
2FST
3
MK14_HUMAN
X:
[29-320]
-
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
-----
F
T
------
P
A
-----
R
SLEEFN
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
----------
T
P
G
A
----------
E
L
L
-
K
K
I
S
--
S
ESA
R
N
Y
I
Q
S
---
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
-
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
-----------------------------------------------------------------
53
HHSearch
23.65
41%
-4
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------
T
P
D
E
----------
V
V
W
P
G
V
T
S
--
M
---
P
D
Y
K
---
P
S
F
P
K
W
-
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
------------------------------------------------------------------