@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDKL2_: (2014-08-15 )
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70------..------......80......---..90...---.-.-...100.......110.......120.......130.....-..140.......150.......160.......170.......180.......190.....-----------..200....-------...210.......220.......230---......-.240..------.....250..-.-....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKYENL
G
L
VGEGSY
G
M
V
M
K
CRNKDTG
R
I
V
A
I
K
K
F
L
ESD
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------KK------K
R
W
Y
L
V
F
E
F
V
D
H
T
I
---
L
D
D
L
E
LF---P-N-GL
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
IGFCHSHN
I
I
HRDIKPE
N
I
L
VSQS-G
V
V
K
L
CDFG
F
A
R
TLAAP
G
E
V
Y
T
D
Y
V
A
T
R
WYRAPE
L
L
V
GDVKYG
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
FM-----------GEPLFPGDS-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
LI
P
R
H
Q
E
L
FNKN---PVFAGV-RLPEIK------ERE
P
L
E
R
RY
P
-
K
-
L
S
E
V
V
I
D
L
A
K
K
C
LHIDPDKR
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
QKDARNVSLSKKSQNRKKEKEK
D
D
S
L
V
E
ER
K
T
L
V
V
Q
DTNADPKIK
D
Y
K
L
F
K
I
KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTH
N
L
S
AVAPSINSGMGTE
T
I
P
IQ
G
Y
RVDEKTKKCSIPFVKPNRHSPS
G
I
Y
N
I
N
V
T
T
L
VSGPPLSDDSGADLPQMEHQH
1
PsiBlast_PDB
94.93
99%
-149
- C1 -
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
K
------
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
---
L
D
D
L
E
L
F
---
P
-
N
-
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
---
P
V
F
A
G
V
-
R
L
P
E
I
K
------
E
R
E
P
L
E
R
R
Y
P
-
K
-
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.75
99%
-140
- C1 -
4BBM
3
CDKL2_HUMAN
A:
[24-331]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
K
------
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
---
L
D
D
L
E
L
F
---
P
-
N
-
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
---
P
V
F
A
G
V
-
R
L
P
E
I
K
------
E
R
E
P
L
E
R
R
Y
P
-
K
-
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.01
99%
-143
- C1 -
4BBM
3
CDKL2_HUMAN
B:
[24-331]
M
E
K
Y
E
N
L
G
-----
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
---------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
------------------
Y
L
V
F
E
F
V
D
H
T
I
---
L
D
D
L
E
L
F
---
P
-
N
-
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
---
P
V
F
A
G
V
-
R
L
P
E
I
K
------
E
R
E
P
L
E
R
R
Y
P
-
K
-
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.48
57%
-123
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
------
Q
K
------
K
K
I
H
L
V
F
E
F
I
D
H
T
V
---
L
D
E
L
Q
H
Y
---
C
-
H
-
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
-------
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
S
---
P
I
F
A
G
V
-
V
L
P
Q
V
Q
------
H
P
K
N
A
R
K
K
Y
P
-
K
-
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
76.63
56%
-132
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
------
R
K
------
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
---
L
H
E
L
D
R
Y
---
Q
-
R
-
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
---
Q
Y
F
S
G
V
-
K
I
P
D
P
E
------
D
M
E
P
L
E
L
K
F
P
-
N
-
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
70.69
49%
-141
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
------
R
R
------
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
---
L
E
L
L
E
E
M
---
P
-
N
-
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
---
P
R
F
H
G
L
-
R
F
P
A
V
N
------
H
P
Q
S
L
E
R
R
Y
L
-
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.86
40%
-122
- C1 -
4EON
1
CDK2_HUMAN
A:
[3-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.01
40%
-124
- C1 -
3PXY
1
CDK2_HUMAN
A:
[9-296]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.00
40%
-124
- C1 -
4EOK
1
CDK2_HUMAN
A:
[4-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.98
40%
-127
- C1 -
4EOM
1
CDK2_HUMAN
A:
[5-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.85
40%
-122
- C1 -
3PXF
7
CDK2_HUMAN
A:
[9-296]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.81
40%
-130
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[2-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.35
41%
-121
- C1 -
4EOI
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
D
F
M
D
A
S
---
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------
P
D
E
---
V
V
W
P
G
V
T
S
M
P
D
Y
K
PS
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.28
40%
-119
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[9-296]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.28
40%
-124
- C1 -
3NIZ
1
?
A:
[20-305]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
-
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
------
S
E
------
R
C
L
T
L
V
F
E
F
M
E
K
D
L
---
K
K
V
L
D
E
N
---
K
-
T
-
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
---
P
L
W
K
-
Q
-
R
T
F
Q
V
F
------
E
K
K
P
W
S
S
I
I
P
-
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
65.91
34%
-117
- C1 -
3N9X
2
?
A:
[26-368]
-
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
------
P
D
DLLKF-
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
---
K
-
K
L
F
K
T
---
P
-
I
-
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
---------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
P
---
E
V
I
K
Y
I
-
K
L
F
P
H
R
------
K
P
I
N
L
K
Q
K
Y
P
-
S
-
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.60
40%
-121
- C1 -
4EOL
1
CDK2_HUMAN
A:
[4-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
-----
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.33
40%
-118
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[9-296]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
---
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
---
P
D
Y
K
P
--
S
F
P
K
W
-------
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.15
41%
-132
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
------
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------
P
D
E
---
V
V
W
P
G
V
T
S
M
P
D
Y
K
PSF
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
61.84
40%
-120
* C1 *
4AU8
2
CDK5_HUMAN
A:
[6-292]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
---------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
---
K
K
Y
F
D
S
C
---
N
-
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
---
P
D
Y
K
---
P
Y
P
M
Y
P
------
A
T
T
S
L
V
N
V
V
P
-
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
59.56
34%
-127
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-342]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
GEKK
D
E
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
---
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
-
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
--
E
Q
I
R
E
M
N
---
P
N
Y
T
E
F
-
K
F
P
Q
I
K
-------
A
H
P
W
T
K
V
F
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.78
41%
-131
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
------
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------
P
D
E
---
V
V
W
P
G
V
T
S
M
P
D
Y
K
PSF
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
53.63
35%
-131
- C1 -
2FST
3
MK14_HUMAN
X:
[29-318]
-
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
------
P
A
RSLEEF
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
---
N
-----------
Q
-
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
C
E
L
K
I
L
D
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
SAR
N
Y
I
--
Q
-
S
L
T
Q
M
-------
P
K
M
N
F
A
N
V
F
I
-
G
-
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------