@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CDKL5_: (2014-08-15 )
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK
Atome Classification :
(23 SA)
.........10........20........30.-.......40........50........60........70------.......-----.80-----.-----.------.......90........100---..-.-....110.......120.......130.......140...---------------.-...150.......160..--.---....170.......180..-.-.-.-..190.......200....-----------...210...-------....220.......230.----------......--------240--....--.--..250....--------...260.--......270.......280.......290.......300...-....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKIP
N
I
G
N
V
M
N
K
F
E
I
L
G
V
VGEG
A
Y
G
V
V
L
K
C
RH-KET
H
E
I
V
A
I
KKFKDSEE
N
E
E
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
------
I
V
E
L
K
E
A
-----
F
R
------R-----R------G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E---MP-N-GV
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
HKNDIVHRDIKPE
N
L
L
ISH---------------N-
D
V
L
K
L
CDFGFARNLSEGN--N---A
N
Y
T
E
Y
V
A
T
R
WYRSPE
L
L
L
-G-A-P-YGKSVD
M
W
S
V
G
C
I
LGELSD-----------GQPLFP
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
LGPL
P
S
E
----------
Q
M
K
L
FY--------SNP--RFHG--L--RFPAVNH
P
Q
--------
S
L
E
R
R
Y
L
--
G
I
L
N
S
V
L
L
D
L
M
K
N
L
LKLDPA
D
R
Y
L
T
E
Q
C
LNHPT
F
Q
T
Q
R
L
L
DR-SPSRSAKRK
P
Y
H
VESSTLSNRNQAGKS
T
A
L
Q
S
HHRSNSK
D
I
Q
N
LSVGLPRADEGLPANESFLNGNLAGASLSP
L
H
T
K
T
YQASSQPGSTSKDLTNNNIPHLL
S
P
K
EAKSKT
E
F
D
FNIDPKPSEGPGT
K
Y
LKSNSR
S
Q
Q
N
R
H
S
F
M
E
SSQSKAGTLQPNEK
Q
S
R
H
S
Y
I
DTIPQSSRSPSYRTKAKSHGALSDSKSV
S
N
L
S
E
A
R
A
QIAEPSTSRYF
P
S
S
CLDLNSPTSPTPTRHSDT
R
T
LLSPSGRNNRNEGTLDSRRTTT
R
H
S
K
T
M
E
E
LKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHS
M
Y
V
T
R
D
K
V
RAKGLDGSLSIGQGMAARAN
S
L
Q
LLSPQPGEQLPP
E
M
T
V
A
R
S
S
V
K
E
T
S
REGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPV
P
R
R
VGSFYRVPSPRPDNSFHEN
N
V
S
T
R
V
SSLPSESSSGTNHSKRQPAFDPWKSPENI
S
H
S
E
Q
L
K
E
K
E
K
Q
G
F
F
R
S
M
K
K
K
K
KKSQTVPNSDSP
D
L
L
T
L
Q
K
S
IHSASTPSSRPKEWRP
E
K
I
S
D
L
QT
Q
S
Q
P
L
K
S
L
R
K
L
L
H
LSSASNHPASSDPRFQPL
T
A
Q
Q
TKNSFS
E
I
R
I
H
PLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQD
R
R
F
M
L
R
TTEQQG
E
Y
F
CCGDPKKPHTPCVPN
R
A
LHRPISSPAPY
P
V
L
Q
VRGTSMC
P
T
L
Q
V
RGTDAFSCPTQQS
G
F
S
F
F
V
R
H
V
M
R
E
A
L
I
H
R
A
QVN
Q
A
A
L
L
T
Y
HENAALTGK
31
HHSearch
96.61
99%
-112
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-303]
--------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
------
I
V
E
L
K
E
A
-----
F
R
------
R
-----
R
------
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
---
M
P
-
N
-
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
---------------
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
----------
Q
M
K
L
F
Y
--------
S
N
P
--
R
F
H
G
--
L
--
R
F
P
A
V
N
H
P
Q
--------
S
L
E
R
R
Y
L
--
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
78.03
46%
-98
- C1 -
4AAA
7
CDKL2_HUMAN
A:
[22-325]
-------
Q
S
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
------
L
V
N
L
L
E
V
-----
C
K
------
K
-----
K
------
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
---
F
P
-
N
-
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
---------------
S
-
G
V
V
K
L
C
D
F
G
F
A
------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
-
G
-
D
V
K
-
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
----------
H
Q
E
L
F
N
--------
K
N
P
--
V
F
A
G
--
V
--
R
L
P
E
I
K
E
R
E
--------
P
L
E
R
R
Y
P
--
K
-
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
-
F
S
Q
E
L
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.36
47%
-96
- C1 -
4BBM
3
CDKL2_HUMAN
A:
[24-318]
---------
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
------
L
V
N
L
L
E
V
-----
C
K
------
K
-----
K
------
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
---
F
P
-
N
-
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
---------------
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
--
E
---
V
-
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
-
G
D
V
-
K
-
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-----------
G
E
P
L
F
P
G
D
S
-------
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
----------
H
Q
E
L
F
N
--------
K
N
P
--
V
F
A
G
--
V
--
R
L
P
E
I
K
E
R
E
--------
P
L
E
R
R
Y
P
--
K
-
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
73.68
46%
-90
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
----------
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
------
L
V
N
L
L
E
V
-----
F
R
------
R
-----
K
------
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
---
Y
Q
-
R
-
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
---------------
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------------
R
W
Y
R
S
P
E
L
L
V
-
G
-
D
T
Q
-
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
----------
H
Q
Q
V
F
S
--------
T
N
Q
--
Y
F
S
G
--
V
--
K
I
P
D
P
E
D
M
E
--------
P
L
E
L
K
F
P
--
N
-
I
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.30
40%
-88
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-303]
---------
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
------
L
V
N
L
I
E
V
-----
F
R
------
Q
-----
K
------
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
---
Y
C
-
H
-
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
---------------
S
-
G
I
T
K
L
C
D
F
G
F
A
R
T
-------
D
---
I
-
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
-
T
-
S
-
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
-------
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
----------
L
Q
N
I
F
S
--------
K
S
P
--
I
F
A
G
--
V
--
V
L
P
Q
V
Q
H
P
K
--------
N
A
R
K
K
Y
P
--
K
-
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
71.57
33%
-82
- C1 -
3N9X
2
?
A:
[23-372]
-------
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
-
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
------
I
I
R
L
Y
D
L
-----
I
I
------
P
-----
D
DLLKF-
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
----
P
-
I
-
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
---------------
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
---------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
-
L
-
Q
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
----------
D
L
K
N
I
N
--------
K
P
E
--
V
I
K
Y
--
I
K
-
L
F
P
-
H
R
K
P
I
--------
N
L
K
Q
K
Y
P
--
S
-
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
69.44
37%
-93
- C1 -
2B9H
2
FUS3_YEAST
A:
[6-313]
-----
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
-
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
-
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
------
I
I
T
I
F
N
I
QRPDS
F
E
------
N
-----
F
------
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
---
Q
----
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
---------------
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
-
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
NDLRCIES
P
R
A
R
E
Y
I
K
--------
S
L
P
--
M
Y
-------------
P
A
A
--------
P
L
E
K
M
F
P
--
R
-
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.17
40%
-85
- C1 -
1UNL
1
CDK5_HUMAN
A:
[1-286]
---------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
H
D
V
-----
L
H
------
S
-----
D
------
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
---------------
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
--
R
---
C
-
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
----------
Q
W
P
S
M
T
--------
K
L
P
--
D
Y
K
P
--
Y
P
-
M
Y
P
A
T
T
S
L
V
--------
N
V
V
P
K
------
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
68.99
37%
-84
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[54-345]
----------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
------
I
V
R
L
R
Y
F
-----
F
Y
S
S
GEKK
D
-----
E
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
-
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
---------------
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
----------
Q
I
R
E
----------
M
N
P
--
N
Y
T
E
--
F
--
K
F
P
Q
I
K
-
A
H
--------
P
W
T
K
V
F
R
--
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
68.27
30%
-87
- C1 -
1Z57
1
CLK1_HUMAN
A:
[13-336]
---------
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
---
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
NSTFR
C
V
Q
M
L
E
W
-----
F
E
------
H
-----
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
---
N
G
-
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
NR
D
E
R
T
L
I
N
-
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
---------
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
-
A
-
L
-
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
-----------
G
F
T
V
F
P
T
H
D
-------
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
----------
M
I
Q
K
T
R
--------
K
R
K
--
Y
F
H
H
--
D
RL
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
SQ
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.23
40%
-88
- C1 -
4AU8
2
CDK5_HUMAN
A:
[7-290]
-----------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
H
D
V
-----
L
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
---------------
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--
R
------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
----------
Q
W
P
S
M
T
--------
K
L
P
--
D
Y
K
P
--
Y
P-
M
Y
P
A
T
T
S
L
V
--------
N
V
V
P
K
------
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
65.38
36%
-90
* C1 *
4IC7
1
MK07_HUMAN
A:
[53-354]
--------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
------
I
I
A
I
K
D
I
-----
L
R
PTVPYG
E
-----
F
------
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
--
Q
-
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
---------------
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
--
A
EHQ
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
-
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
----------
V
I
Q
A
V
G
--------
A
-
E
--
R
V
R
A
YI
Q
--
S
L
P
P
-
R
Q
P
V
--------
P
W
E
T
V
Y
P
--
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.21
40%
-88
- C1 -
1UNG
1
CDK5_HUMAN
A:
[1-286]
---------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
H
D
V
-----
L
H
------
S
-----
D
------
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
-
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
---------------
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
--
R
---
C
-
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
----------
Q
W
P
S
M
T
--------
K
L
P
--
D
Y
K
P
--
Y
P
-
M
Y
P
A
T
T
S
L
V
--------
N
V
V
P
K
------
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
64.49
35%
-79
- C1 -
3QYZ
13
MK01_RAT
A:
[24-321]
-------
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
-
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
-
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
------
I
I
G
I
N
D
I
-----
I
R
------
A
PTIEQ
M
------
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
------
Q
-
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
---------------
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
T
---
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
-
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
----------
D
L
N
C
I
I
--------
N
L
K
A
R
N
Y
-
L
--
L
--
S
L
P
H
K
-
N
K
V
--------
P
W
N
R
L
F
---
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.72
38%
-82
- C1 -
3PXY
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.54
38%
-77
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.45
38%
-79
- C1 -
3PY0
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
60.18
34%
-88
- C1 -
2FST
3
MK14_HUMAN
X:
[24-320]
-----
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
-
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
------
V
I
G
L
L
D
V
-----
F
T
------
P
-----
A
RSLEEF
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
-----------
Q
-
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
---------------
D
-
C
E
L
K
I
L
D
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
----------
L
L
K
K
I
S
--------
S
-
E
--
S
A
R
N
YI
Q
--
S
L
T
Q
M
P
-
K
M
--------
N
F
A
N
V
F
I
--
G
-
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.46
38%
-74
- C1 -
3PXF
7
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.33
38%
-87
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
58.27
38%
-66
- C1 -
3PY1
4
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.59
38%
-88
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
------------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.29
38%
-71
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
L
D
V
-----
I
H
------
T
-----
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
-
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
---------------
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
--
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-
P
D
E
----------
V
V
W
P
G
V
TSMPDYKP
S
F
P
--
K
W
A
R
--
Q
--
D
F
S
K
V
V
P
P
L
--------
D
E
D
G
R
------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------