@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CLK1_M: (2014-08-15 )
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....--..160.......170.......180.......190..--.--....200..--.....210.......220.......230-----.......240.......250.......260.......270.......280.......290.......300.......310...-----......320.......330..------..-...340.......350-..-.....360.......370.......380.......390......-----.400....---...410...--....420......--.430--.....-....440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRHSKRTYCPDWDERDWDYGTWRSSS
S
H
K
R
K
KRSH
S
S
A
R
E
Q
K
R
CRYDHSKTTD
S
Y
Y
L
ESRSI
N
E
K
A
Y
H
S
R
R
Y
V
D
E
Y
R
N
DYMGYEPGHPYGEPGS
R
Y
Q
MHSSKSSGRSG
R
S
S
Y
K
S
K
H
RSRHHT
S
Q
HHSH
G
K
S
H
R
R
K
RSRSVEDDEE
G
H
L
I
CQSGD
V
L
S
--
A
R
Y
E
I
V
D
T
LGE
G
A
F
G
K
V
V
E
C
I
DHKVGGR
R
V
A
V
K
I
V
K
N
--
V
--
D
R
Y
C
E
A
A
Q
S
--
E
I
Q
V
L
E
HLNTTDP
H
S
T
F
R
C
V
Q
M
L
E
W
F
E
H-----RG
H
I
C
I
V
F
E
L
LGL
S
T
Y
D
F
I
KENSFL
P
F
R
M
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
HSNKLTHTDLKPE
N
I
L
F
V
KSDYTEAYNPKMKR--DER-----TIVNPD
I
K
V
V
DFGSATYDDEH------
H
S
-
T
L
V
S
TRHYRAP
E
V
I
L
A-LG-WSQPC
D
V
W
S
I
G
C
I
L
I
E
Y
Y
LG
F
T
V
FPTHD
S
R
E
H
L
A
M
M
E
R
I
LGPL
P
-----
K
H
M
I
Q
K
T
R
---
K
R
R
Y
F
HHDR--LDWDEHSSA
G
R
Y
V
--
S
R
----
R
C
K
P
L
-
K
E
F
M
LSQDA
E
H
E
L
L
F
D
L
I
G
K
M
LEYDPAKR
I
T
L
K
E
A
LKHPFFYPLKKHT
1
PsiBlast_PDB
94.20
94%
-124
- C1 -
1Z57
1
CLK1_HUMAN
A:
[3-337]
--------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
--
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
--
V
--
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
-----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
----
R
--
D
E
R
-----
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
------
H
S
-
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
Q
K
T
R
---
K
R
K
Y
F
H
H
D
R
--
L
D
W
D
E
H
S
S
A
G
R
Y
V
--
S
R
----
A
C
K
P
L
-
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
2
PsiBlast_PDB
94.02
93%
-127
- C1 -
2VAG
1
CLK1_HUMAN
A:
[3-336]
--------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
--
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
--
V
--
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
-----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
---
K
R
--
D
E
R
-----
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
------
H
S
-
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
Q
K
T
R
---
K
R
K
Y
F
H
H
D
R
--
L
D
W
D
E
H
S
S
A
G
R
Y
V
--
S
R
----
A
C
K
P
L
-
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
3
PsiBlast_PDB
89.23
66%
-122
- C1 -
3NR9
1
CLK2_HUMAN
A:
[15-355]
-------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
--
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
--
V
--
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
-----
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
---------
D
E
R
-----
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
------
H
S
-
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
R
K
T
R
---
K
Q
K
Y
F
Y
R
G
R
--
L
D
W
D
E
N
T
S
A
G
R
Y
V
--
R
E
----
N
C
K
P
L
-
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
4
PsiBlast_PDB
87.07
60%
-120
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-372]
-----------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
--
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
--
V
--
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
-----
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
--
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
------
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
-
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
----
5
PsiBlast_PDB
86.22
60%
-120
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-372]
------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
--
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
--
V
--
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
-----
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
--
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
------
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
-
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
----
6
PsiBlast_PDB
85.59
60%
-119
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-372]
-----------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
--
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
--
V
--
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
-----
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
--
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
------
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
-
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
----
33
HHSearch
74.96
36%
-120
- C1 -
3LLT
1
?
A:
[20-360]
----------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
--
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
N
K
K
Y
Y
A
V
K
V
V
R
N
--
I
--
K
K
Y
T
R
S
A
K
I
--
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
-
N
N
I
V
K
Y
H
G
K
F
M
Y
-----
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
-
K
S
L
I
T
V
R
R
VT
D
G
K
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
------
H
G
-
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
G
-
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
-----
K
N
M
L
Y
E
A
T
K
T
N
G
S
K
Y
V
N
K
D
E
LK
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
----
K
C
L
P
L
-
Y
K
I
I
-----
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
------
49
HHSearch
55.65
35%
-109
- C1 -
2B9H
2
FUS3_YEAST
A:
[7-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
S
--
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
-
P
T
G
E
I
V
A
I
K
K
I
E
P
--
F
DK
P
L
F
A
L
R
T
L
R
--
E
I
K
I
L
K
H
F
K
H
E
N
I
I
-
T
I
F
N
I
Q
R
P
D
S
F
E
N
-----
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
---
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
--------------------------
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
---------
V
-
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
-----
S
D
----------------
N
D
--
L
R
C
I
E
S
P
R
A
R
E
Y
I
--
K
S
LPMY
P
A
A
P
L
-
E
K
M
F
P
R
V
N
---
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
---
39
HHSearch
54.84
31%
-120
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
---
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
--
E
L
K
M
L
R
T
L
K
Q
--
E
----
N
I
V
E
L
K
E
A
F
R
R
-----
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
--------------------------
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
-----
S
E
Q
M
K
L
F
Y
---
S
N
P
R
F
H
G
----
L
R
F
P
A
V
N
H
P
--------------
Q
S
L
E
R
R
Y
L
G
I
---
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
---
18
PsiBlast_PDB
54.75
31%
-105
- C1 -
2B9I
2
FUS3_YEAST
A:
[9-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
--
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
--
F
--
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
-
I
Q
R
P
D
S
F
E
N
-----
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
--------------------------
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
E
---------V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
E
S
P
R
---
A
R
E
Y
I
------------
K
S
L
P
M
Y
P
--
A
-------
A
P
L
-
E
K
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
52
HHSearch
54.65
31%
-113
- C1 -
3QYZ
13
MK01_RAT
A:
[17-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
-
Q
V
F
D
VG
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
-
L
N
K
V
R
V
A
I
K
K
I
S
P
FE
H
--
Q
T
Y
C
Q
R
T
L
R
--
E
I
K
I
L
L
R
F
R
H
--
E
----
N
I
I
G
I
N
D
I
I
R
A
PTIEQ
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
Q
---
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
--------------------------
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
T
G
F
L
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-----
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
----
L
P
-------------
H
K
----
N
K
V
P
W
-
N
R
L
F
P
N
A
D
---
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
----
19
PsiBlast_PDB
52.65
31%
-104
- C1 -
2B9J
2
FUS3_YEAST
A:
[9-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
--
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
--
F
--
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
-
I
Q
R
P
D
S
F
E
N
-----
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
--------------------------
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
-
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
E
S
P
R
---
A
R
E
Y
I
------------
K
S
L
P
M
Y
P
--
A
-------
A
P
L
-
E
K
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------