@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_CLK3_M: (2014-08-15 )
MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....-..450.....-----..460.......470.......480.......490.......500.......510.......520.......530.......540.......550-.........--560.......570.........580.......590.......600.......610.......620.--......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
V
L
S
A
R
R
K
R
L
A
STAGPRRGSGP
S
L
A
V
R
WVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSP
R
V
C
E
F
G
A
R
A
V
RPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAA
G
A
W
E
T
M
H
H
C
K
RYRSPEPDP
Y
L
S
Y
R
W
K
R
RRSYSREHEGRLRYPSRREPPPRRSRSRSHDRI
P
Y
Q
R
R
Y
R
E
HRDSD
T
Y
R
CEERSPSFGEDCYGS
S
R
S
R
H
R
R
RSRERAPYR
T
R
K
H
A
H
H
C
H
K
R
R
TRSCSSASSR
S
Q
Q
SSKRSSRSVEDDKE
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
VGNLGE
G
T
F
G
K
V
V
E
C
L
D
H
ARG
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
KDKEN
K
F
L
C
V
L
M
S
D
W
F
N
FHG
H
M
C
I
A
F
E
L
LG
K
N
T
F
E
F
L
K
ENNFQPYPL
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
ENQLTHTDLKPE
N
I
L
F
VN
S
E
F
E
T
L
-
Y
N
E
H
K
S
C
E
E
K-----SVKNT
S
I
R
V
A
DFGSATFDHEH
H
T
T
I
V
A
TRHYR
P
P
E
V
I
LELGWAQPC
D
V
W
S
I
G
C
I
L
F
E
Y
YRG
F
T
L
F
Q
THEN
R
E
H
L
V
M
M
E
K
I
LGPI
P
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
YKG
G
--
L
V
WDENSSDGR--
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
LEFDPA
Q
R
I
T
L
A
E
A
L
L
H
P
F
FAGL--
T
P
E
E
R
SFHSSRNPSR
1
PsiBlast_PDB
97.02
99%
-122
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
-
Y
N
E
H
K
S
C
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
--
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
-------
3
PsiBlast_PDB
96.34
99%
-118
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
-
Y
N
E
H
K
S
C
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
--
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
2
PsiBlast_PDB
95.11
99%
-120
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
-
Y
N
E
H
K
S
C
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
--
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
--------
21
PsiBlast_CBE
94.09
99%
-115
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
-
Y
N
E
H
K
S
C
E
E
K
-----
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
---
K
Q
K
Y
F
Y
K
G
G
--
L
V
W
D
E
N
S
S
D
G
R
--
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
6
PsiBlast_PDB
87.54
70%
-122
- C1 -
3NR9
1
CLK2_HUMAN
A:
[15-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
--------
D
E
R
-----
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
---
K
Q
K
Y
F
Y
R
G
R
--
L
D
W
D
E
N
T
S
A
G
R
--
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
RA---------------
7
PsiBlast_PDB
80.60
61%
-116
- C1 -
1Z57
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
-
Y
N
----
R
D
E
R
-----
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
---
K
R
K
Y
F
H
H
D
R
--
L
D
W
D
E
H
S
S
A
G
R
--
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
8
PsiBlast_PDB
80.07
60%
-117
- C1 -
2VAG
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
-
Y
N
---
K
R
D
E
R
-----
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
---
K
R
K
Y
F
H
H
D
R
--
L
D
W
D
E
H
S
S
A
G
R
--
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
34
HHSearch
70.95
38%
-113
- C1 -
3LLT
1
?
A:
[20-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
D
N
-
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
-
I
V
K
Y
H
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
I
T
V
R
R
V
T
D
G
K
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
S
K
Y
V
N
K
D
E
LK
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
K
C
L
P
L
Y
K
I
I
-----
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-------------------
40
HHSearch
56.38
32%
-112
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
-
H
E
I
V
A
I
K
K
F
K
----
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
--
E
----
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-------------------------
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
---
S
N
P
R
F
H
G
----
L
R
F
P
A
V
N
H
P
Q
S
---------
L
E
R
R
Y
L
G
I
---
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
------------------