@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_DCLK2_: (2014-08-16 )
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.-----.-.-..-...440.......450.......460.......470.......480...-------------------------------..--------..490.......500.......510.......520.......530.......540...-----.---.---..550.......560....--..-.570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAST
R
S
I
E
L
E
H
F
E
E
RDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHS
A
H
C
S
F
Y
R
T
R
T
L
Q
A
L
S
S
E
K
K
A
K
K
A
R
FYRN
G
D
R
Y
F
K
G
L
V
F
A
ISSDRF
R
S
F
D
A
L
L
I
E
L
T
R
S
LSDNVNLPQG
V
R
T
I
Y
T
IDGSRKV
T
S
L
D
E
L
LEGE
S
Y
V
CASNEP
F
R
KVDYTKNINPN
W
S
V
N
IKGGT
S
R
A
L
A
A
A
S
S
V
K
S
E
V
K
E
S
K
DFI
K
P
K
L
V
T
V
I
R
SGV
K
P
R
K
A
V
R
I
L
LNKK
T
A
H
S
F
E
Q
V
L
T
D
I
T
E
A
I
KL
D
S
G
V
V
K
R
L
C
TLDG
K
Q
V
T
C
L
Q
D
FFGDD
D
V
F
I
A
CG
P
E
KFRYAQD
D
F
V
L
D
H
S
E
C
R
V
L
K
S
SYSRS
S
A
V
KYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPG
S
F
R
G
L
K
Q
I
S
AHGRSSSNVNGGPE
L
D
RCISPEGVNGNRCS
E
S
S
T
L
L
E
K
YKI
G
K
V
IGDG
N
F
A
V
V
K
E
C
I
D
RST
G
K
E
F
A
L
K
I
I
D
K
A
K
CC-
G
-----
K
-
E
-
H
L
-
I
E
N
E
V
S
I
L
R
R
VKHP
N
I
I
M
L
V
E
E
M
E
T
A
T
E
L
F
L
V
M
E
L
VKGG
D
L
F
D
A
I
TSST-------------------------------KY--------TERDG
S
A
M
V
Y
N
L
A
N
A
L
R
Y
L
H
G
L
S
I
V
H
RDIKPE
N
L
L
V
C
EYPDGTKSLKLGDF
G
L
A
T
VVE-----G---P---
L
Y
T
VCGTPTY
V
A
P
E
I
I
AET--GY-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
LCGFPPFRSEN
N
L
Q
E
D
L
F
D
Q
I
L
AGKLEFPAPYWDNI
T
D
S
A
K
E
L
I
S
Q
M
L
QVN
V
E
A
R
CTAGQILSHPWVSDDASQENNM
Q
A
E
V
T
G
K
L
K
Q
H
F
N
N
ALPKQNSTT
T
G
V
S
V
I
M
N
TALDKEG
Q
I
F
C
S
KHCQDSGRPGMEPISPVPP
S
V
E
EIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
40
HHSearch
91.13
38%
-108
- C1 -
3HKO
2
?
A:
[22-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
K
-----
D
-
V
-
E
R
-
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
--
N
K
S
F
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
KLNN-
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
--
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
--------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.21
39%
-118
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
-----
R
-
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
DQQ
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.89
40%
-106
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
-----
R
-
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
DQQ
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
--
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
--
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
--------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.28
37%
-94
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[15-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
N
L
Y
F
Q
S
M
A
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
-----
R
-
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
EQQ
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
--
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
41
HHSearch
85.19
44%
-117
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------
S
-
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
-----
P
G------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
-----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.79
39%
-103
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
-----
R
-
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
DQQ
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
--------------------------------------------------------------------------------------------
45
HHSearch
83.38
40%
-100
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[6-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
---------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
-------------------------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
-
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
----
G
---
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
--
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.35
37%
-90
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[11-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
-
A
-----
R
-
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
E
-----
G
E
Q
Q
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
--
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
V
R
K
Q
--------------------------------------------------------------------
3
PsiBlast_PDB
82.18
42%
-108
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
--------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------
38
HHSearch
81.76
37%
-109
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
SRRGV
S
-
R
-
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
FG---
N
---
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
--
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
---------------------------------------------------------------------------------------------------------------
51
HHSearch
80.96
43%
-112
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
-
P
A
P
D
A
P
L
K
I
A
D
F
-------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
-
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
V
H
M
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.29
42%
-97
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
---------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
43
HHSearch
79.21
38%
-114
* C1 *
3LIJ
1
?
A:
[32-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------S----
S
-
N
-
S
K
-
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
-------------------------------
K
F
--------
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
-----
N
Q
K
-
K
---
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
---
K
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
--
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
----------------------------------------------------------------------------------------------------------------
37
HHSearch
79.07
37%
-115
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
-
S
SPGL-
S
-
T
-
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
---------------------------
V
Y
--------
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
-----
E
---
S
GLV
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
--
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
---------------------------------------------------------------------------------------------------------------
48
HHSearch
77.82
40%
-108
- C1 -
3MWU
1
?
A:
[18-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
-----
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
QN-------------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
---
T
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
--
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
----------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.77
39%
-106
- C1 -
3IGO
8
?
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
-----
K
--T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-----
Q
N
T-----------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
---
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
--
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-------------------------------------------------------------------------------------------------------------
44
HHSearch
75.71
38%
-110
- C1 -
4BKY
1
MELK_HUMAN
A:
[6-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
D
-
L
-
P
R
-
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-------------------------------
R
L
--------
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
----
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
--
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.44
39%
-104
- C1 -
2WEI
1
?
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
-----
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-----
Q
NT-
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
---
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
--
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-------------------------------------------------------------------------------------------------------------
52
HHSearch
63.68
30%
-93
- C1 -
2YEX
8
CHK1_HUMAN
A:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-
D
-----
C
-
P
-
E
N
-
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
-------------------------------
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
----
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
YNN
R
E
R
---
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
--
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
-
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------