@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_DMPK_H: (2014-08-16 )
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Atome Classification :
(18 SA)
.........10.....------...-20........30........40........50.-.......60........70........80........90.---.......100.......110.......120...-.-...130.......140.......150.......160.......170.......180......-.190.......200.......210.......220.......230.......240.......250.......260.......270.......280---.......290--.........300.......310.......-320.-...--.---..330.......340-......--.--.--350.......360.......370.......380......-.390.......400...---....410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
A
E
V
R
L
R
R
L
Q
Q
L
VLD------PGF-L
G
L
E
P
L
L
D
L
L
L
G
V
H
Q
EL
G
A
S
E
L
A
Q
D
K
Y
V
A
D
F
L
Q
-
W
A
E
P
I
V
V
R
L
K
E
V
RLQRD
D
F
E
I
L
K
V
I
GRGAFS
E
V
A
V
V
K
M
KQ---TGQ
V
Y
A
M
K
I
M
N
K
W
D
M
L
KRGE
V
S
C
F
R
EER
D
V
L
VN-G-
D
R
R
W
I
T
Q
L
H
F
A
FQDE
N
Y
L
Y
L
V
M
E
Y
YVG
G
D
L
L
T
L
L
S
K
F
G
E
R
I
P
A
E
M
A
R
F
Y
L
A
E
I
V
M
A
I
D
S
V
H
R
-
L
G
Y
V
HRDIKPD
N
I
L
L
DRCG
H
I
R
LADF
G
S
C
L
K
LRADG
T
V
R
S
L
V
AVGTPDYL
S
P
E
I
L
Q
A
VGGGPGTGSYGPEC
D
W
W
A
L
G
V
F
A
Y
E
M
F
YGQTPFYADS---
T
A
E
T
Y
G
K
I
----
V
H
Y
K
E
HLSLPLVDEGV
P
E
E
A
R
D
F
I
Q
R
LLC-PPET-RLG--R---GGAGDFRTH
P
F
F
F
G--LDWDGL--R--D--SVPPFTPDFEGATDTC
N
F
D
L
V
E
D
G
L
T
A
M
VSGGG
E
T
L
S
D
I
-REGAP
L
G
V
H
LPFVGYS
Y
---
S
C
M
A
L
RDSEVPGPTPMEL
E
A
E
Q
L
L
E
PHVQAPSLEPSVSPQDETAEVAVPAAVPAAE
A
E
A
E
V
T
L
R
E
L
Q
E
A
L
E
E
E
V
L
T
R
Q
S
L
S
R
E
M
E
A
I
RTD
N
Q
N
F
A
S
Q
L
R
E
A
E
ARNR
D
L
E
A
H
V
R
Q
L
Q
E
R
M
E
L
L
QAEGA
T
A
VTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMH
R
R
H
L
LLPARVPRP
G
L
S
E
A
L
S
L
L
L
F
A
V
V
L
S
R
A
A
A
L
G
C
I
G
L
V
AHAG
Q
L
T
A
V
WRRPGAARAP
3
PsiBlast_PDB
87.52
59%
-119
- C1 -
3QFV
2
MRCKB_HUMAN
A:
[2-414]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
GPWRN-
E
S
A
-
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
-
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
--
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
----
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
-
S
R
E
R
-
R
L
G
--
Q
---
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
--
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
86.95
61%
-120
- C1 -
4AW2
5
MRCKA_RAT
A:
[1-408]
-
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTN
G
Q
C
-
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
-
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
-
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
--
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
----
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
-
R
L
G
--
Q
---
N
G
I
E
D
F
K
K
H
P
F
F
S
G
--
I
D
W
D
N
I
--
R
--
N
--
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
------------------------
S
G
H
H
L
P
F
V
G
F
T
Y
---
T
S
S
C
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.86
59%
-113
- C1 -
3TKU
3
MRCKB_HUMAN
A:
[18-430]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
GPWRN-
E
S
A
-
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
-
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
--
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
----
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
-
S
R
E
R
-
R
L
G
--
Q
---
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
--
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------------
S
G
L
H
L
P
F
I
G
F
T
F
TTE
S
C
F
S
D
R
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.46
43%
-120
- C1 -
2F2U
1
ROCK2_BOVIN
A:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
------
P
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
-
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
---
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
D
H
K
N
S
L
C
F
P
-
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
N
I
--
R
--
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
----------
V
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.05
44%
-116
- C1 -
2ETR
1
ROCK1_HUMAN
A:
[6-399]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
------
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
-
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
N
H
K
N
S
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
--
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
-----
K
G
E
E
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.55
44%
-118
- C1 -
3D9V
1
ROCK1_HUMAN
A:
[6-399]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
------
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
-
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
N
H
K
N
S
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
--
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
-----
K
G
E
E
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.32
44%
-115
- C1 -
2ESM
1
ROCK1_HUMAN
A:
[6-399]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
------
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
-
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
N
H
K
N
S
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
--
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
-----
K
G
E
E
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.03
43%
-120
- C1 -
4L6Q
1
ROCK2_HUMAN
A:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
------
P
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
-
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
---
G
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
D
H
K
N
S
L
C
F
P
-
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
DQ
W
H
W
D
N
I
--
R
--
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
--------
V
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.74
44%
-118
- C1 -
2ETK
1
ROCK1_HUMAN
A:
[6-399]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
------
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
-
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
N
H
K
N
S
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
--
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
-----
K
G
E
E
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.04
43%
-109
- C1 -
2H9V
1
ROCK2_BOVIN
A:
[11-400]
-----
R
Q
R
K
L
E
A
L
I
R
D
------
P
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
-
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
---
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
D
H
K
N
S
L
C
F
P
-
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
N
I
--
R
--
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
---------------
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.55
44%
-113
- C1 -
2V55
1
ROCK1_HUMAN
A:
[6-399]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
------
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
-
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
----
M
N
H
K
N
S
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
-
R
L
G
--
R
---
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
--
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----------
E
E
T
F
P
I
P
-
K
--
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
66.93
38%
-114
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
---
H
E
K
L
F
E
L
I
----
L
M
--
E
E
I
R
F
P
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
-
R
L
G
--
G
GS-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
--
I
V
W
Q
H
V
--
Y
--
E
KK
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
---
E
F
T
A
Q
M
----
I
T
I
T
P
-S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
---
S
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.68
36%
-104
- C1 -
2GNH
3
KAPCA_BOVIN
A:
[10-332]
--------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
--
E
D
F
L
K
K
W
E
N
P
A
-----
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-------
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
VSGK
V
R
F
P
S
H
F
S
S
D
L
---------
K
D
L
L
R
N
L
L
Q
-
V
D
L
T
K
R
F
G
NL
K
---
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
--
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
63.42
37%
-113
* C1 *
1RDQ
4
KAPCA_MOUSE
E:
[37-331]
------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
----
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
---
S
----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
----
V
S
G
--
K
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-
R
F
G
NL
K
---
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
--
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.99
36%
-101
- C1 -
2GNI
2
KAPCA_BOVIN
A:
[10-332]
--------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
--
E
D
F
L
K
K
W
E
N
P
A
-----
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-------
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
VSGK
V
R
F
P
S
H
F
S
S
D
L
---------
K
D
L
L
R
N
L
L
Q
-
V
D
L
T
K
R
F
G
NL
K
---
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
--
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
59.44
40%
-106
- C1 -
3TXO
1
A:
[23-316]
----------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-------
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
---
E
D
D
L
F
E
A
I
----
L
N
--
D
E
V
V
Y
P
T
---
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
-
R
L
G
--
S
LTQ
G
G
E
H
A
I
L
R
H
P
F
F
K
E
--
I
D
W
A
Q
L
N
H
R
--
Q
--
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
57.61
38%
-103
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-354]
-------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
SNT
E
D
Y
L
F
Q
V
I
----
L
E
--
K
Q
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
-
R
L
G
--
C
HPQ
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
--
V
D
W
D
M
M
--
E
Q
K
Q
--
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
54.05
39%
-113
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
-------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
------
D
I
L
V
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-----
E
K
K
-
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
M
I
----
L
K
--
A
K
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
-
R
L
G
--
A
GP-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
--
E
--
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------