@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_KCC2D_: (2014-08-17 )
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
Atome Classification :
(13 SA)
.........10........20........30........40........50-..---.----......60........70........80........90........100..--------------------------------------..----...110.......120.......130.......140......-.150.......160....----...170.......180......--.190.......200.......210.......220........230.......240.......250.......260.......270....----..---.--280....---...290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAST
T
T
C
T
RF
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
KIPT
G
Q
E
Y
A
A
K
I
I
NTKKL--S
A
---
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
LKHP
N
I
V
R
LHDSISEEG
F
H
Y
L
V
F
D
LVT
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
YSEA
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
CHLN
G
I
V
HRDLKPE
N
L
L
L
ASKS-K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
QG----DQ
Q
A
W
FGFAGTPGYL
S
P
E
V
LRK--DPYGK
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
VGYPPFWD
E
D
Q
H
R
-
L
Y
Q
Q
I
K
AGAYDFPSPEWDTVTP
E
A
K
D
L
I
N
K
M
LTINPAKRI
T
A
S
E
ALKHPWIC
Q
R
S
----
T
V
---
A
--
S
M
M
H
R
Q
E
---
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
ATR
N
F
S
A
A
K
S
L
LKKPDGVKESTESSNTTIE
D
E
D
V
K
A
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
NNG
D
F
E
A
Y
T
KICDPGLTAF
E
P
E
A
L
G
N
L
V
E
G
M
D
F
H
R
F
Y
F
E
N
A
LSKSNK
P
I
H
T
I
I
LNP
H
V
H
L
VGD
D
A
A
C
I
A
Y
I
R
L
T
Q
YMDGSGMPKTMQSEET
R
V
W
HRRDGKWQ
N
V
H
F
HRSGSPTVPIKPPCIPNGKENFSG
G
T
S
L
W
QNI
63
HHSearch
92.32
88%
-95
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-444]
-------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
--
S
A
---
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
----
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
----
T
V
---
A
--
S
C
M
H
R
Q
E
---
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
-----------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
-------------------------
23
PsiBlast_CBE
73.90
92%
-111
- C1 -
2VZ6
3
KCC2A_HUMAN
B:
[20-311]
---------
F
Q
S
M
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
--
S
A
---
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
----
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
--
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
----
T
V
---
A
--
S
C
M
H
R
Q
E
---
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.89
83%
-124
- C1 -
3KL8
1
KCC2D_CAEEL
C:
[3-268]
--------
K
F
S
D
N
Y
D
V
K
E
E
L
-----
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
---------------
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
-----
D
S
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
--
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.77
83%
-120
- C1 -
3KL8
1
KCC2D_CAEEL
G:
[2-268]
-------
T
K
F
S
D
N
Y
D
V
K
E
E
------
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
-----
S
A
---
R
----
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
-----
D
S
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
--
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
62.41
49%
-100
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
-------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
SPG
L
----
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
---
A
--
Y
K
I
H
L
P
E
---
T
V
E
Q
L
R
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
57.80
40%
-110
- C1 -
3LIJ
1
?
A:
[33-338]
-------
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----------
S
----
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
----
Q
-
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
---
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
----
S
K
---
K
E
S-
L
P
S
L
A
N
---
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
56.48
35%
-104
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-302]
--------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--
K
S
---
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
----
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----
T
Q
---
Q
---
A
L
S
R
K
A
SAV
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
56.11
34%
-107
- C1 -
3HKO
2
?
A:
[22-337]
-------
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-----
K
----
D
V
E
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
----
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
--
S
F
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
LNNG--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
55.54
37%
-115
* C1 *
3F3Z
5
?
A:
[6-267]
--------
D
I
N
Q
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
F
----
V
---
E
----
D
V
D
R
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
--------------------------------------
K
R
----
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
S
-
P
D
S
P
L
K
L
I
D
F
G
L
A
A
R
F
K
P
----
G
K
-
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
54.25
40%
-95
- C1 -
3MWU
1
?
A:
[19-324]
--------
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
--
K
N
---
K
----
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--------------------------------------
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
----
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
---
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
---
S
--
D
L
P
S
L
E
S
---
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
53.15
35%
-109
- C1 -
3Q5I
1
?
A:
[33-346]
--------
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
----------
K
----
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
--------------------------------------
R
H
----
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
----
D
Y
-
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
---
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
----
N
N
INK
S
--
D
Q
K
T
L
C
G
---
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
52.86
41%
-98
- C1 -
3NYV
1
?
A:
[22-326]
-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
--
K
Q
---
K
T---
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
----
S
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
---
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----
K
-------
D
V
P
S
L
D
N
---
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
52.84
44%
-103
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-345]
--------
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
-----------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
---------
A
--
N
F
V
H
M
D
T
---
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------