@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_KKCC2_: (2014-08-17 )
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-.-......250.......260.......270.....-----..-280.......290.......300...-....310.......320--..---......330.......340.......350.......360.......370.......380.......390...-....400.......--410--.......420.......430...-----..------.-.440....-----...450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSCVSSQPSSNRAAP
Q
D
ELGGRGSSSSESQ
K
P
C
E
A
L
R
G
L
S
S
L
S
I
H
LG
M
E
S
F
I
V
V
TECEPG
C
A
V
DLGLARDRPLEADGQEVPLDTSGSQARPHLSG
R
K
L
S
L
Q
ERSQGGLAAGGSLDMNG
R
C
ICPSLPYSPVSSPQSSPRLPRRPTVESH
H
V
S
IT
G
M
Q
D
C
V
Q
L
NQY
T
L
K
DEIGKGS
Y
G
V
V
K
L
A
YNEND
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
QAGFPRRPPPRGTRPAPGGCIQPRG
P
I
E
Q
V
Y
Q
E
I
A
I
L
K
K-L-DH
P
N
V
V
K
L
V
E
V
LDDPNEDH
L
Y
M
V
F
E
L
VNQGPVME-----VP-TLKPL
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
RDIKPS
N
L
L
VG---ED---G
H
I
K
I
A
D
FGVSNEFKGS
D
A
L
L
SNTVGTPAFMA
P
E
S
L
S
E
T
R
K
I
FSGKA
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
FGQCPFM
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
LEF--PDQ--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
LDKNPES
R
I
-----
V
V
------
P
-E
I
K
LH
P
W
V-----TRHGAEPLPSEDEN
C
T
L
V
E
V
T
E
E
E
V
E
N
S
V
K
H
I
P
S
L
A
T
V
I
L
V
K
T
M
I
R
KRSFGNPFEGSRREERSLSAPGNLLTKK
P
T
R
E
C
E
S
L
S
E
L
K
E
A
R
Q
RRQPPGHRPAPRGGGGS
A
L
VRGS
P
C
V
E
SCWAPAPGSPARMHPLR
P
E
EAMEPE
1
PsiBlast_PDB
85.93
100%
-116
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------
E
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-----
V
P
-
T
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
G
---
E
D
---
G
H
I
K
I
A
D
F
G
V
S
N
E
F
K
G
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
D
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
------
P
-
E
I
K
L
H
P
W
V
-----
T
R
--------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.98
32%
-99
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[4-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
------------------------
Q
K
L
E
R
E
A
R
I
C
R
L
-
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
----
I
V
-
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
SKS
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
------
S
-
E
A
L
K
H
P
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
63.72
32%
-106
- C1 -
4GV1
5
AKT1_HUMAN
A:
[5-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-----------------------
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
--
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-----
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
---
K
D
---
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
--
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
-
E
K
L
F
E
L
I
L
M
E
E
I
R
F
--
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
-----
A
G
--------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
60.49
36%
-102
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[38-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-----------------------
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
--
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-----
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
---
Q
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
---
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
--
K
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
--
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
-----
A
T
--------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.78
32%
-101
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[4-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
------------------------
Q
K
L
E
R
E
A
R
I
C
R
L
-
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
----
I
V
-
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
SKS
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
PS
P
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
------
S
-
E
A
L
K
H
P
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
56.38
32%
-102
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
---------------------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
-
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
---
S
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
--
R
L
F
E
G
I
I
K
G
K
Y
K
M
--
N
P
R
QW
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
------
Y
-
E
A
L
N
H
P
W
L
-----
K
E
R
-------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
55.48
31%
-97
- C1 -
1XJD
1
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-----------------------
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
--
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
-----
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
---
K
D
---
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
--
Q
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
-
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
-----
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.56
31%
-95
- C1 -
2WTI
3
CHK2_HUMAN
A:
[16-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
--------------------------------------------------------------------------------------------------------------------------
36
HHSearch
49.30
33%
-99
- C1 -
3TXO
1
A:
[23-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
-----------------------
D
V
E
C
T
M
T
E
K
R
I
L
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
--
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
-----
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
---
H
E
---
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
---------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
--
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
-
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
--
P
T
----
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
-----
K
E
--------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.39
31%
-97
- C1 -
2CN8
1
CHK2_HUMAN
A:
[16-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
46.25
31%
-100
- C1 -
4BDB
10
CHK2_HUMAN
A:
[16-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
L
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
--------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.74
31%
-92
- C1 -
2XM9
1
CHK2_HUMAN
A:
[16-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
--------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.60
31%
-95
- C1 -
2WTC
1
CHK2_HUMAN
A:
[16-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
--------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
42.15
31%
-98
- C1 -
4BDA
8
CHK2_HUMAN
A:
[16-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------------
N
V
E
T
E
I
E
I
L
K
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
----
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
--
I
P
E
VW
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
QD
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
--------------------------------------------------------------------------------------------------------------------------