@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_KPCD3_: (2014-08-17 )
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610..---.-....----620.......630.......640.......650...-.-.-..660.....--..670.......680.......690.......700.......710.......720.......730-.......740.......750-.........760.......770......---.780-.--..--......790-----------------.......---------..800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSANNSPPSAQKSV
L
P
T
A
I
P
A
VLPAASPCSSPKTG
L
S
A
RLSNGSFSAPSLTNSRGS
V
H
T
V
S
F
L
L
Q
IGLTRE
S
V
T
I
E
A
Q
E
L
S
L
S
A
V
K
D
L
V
C
S
I
V
Y
Q
KFPECG
F
F
G
M
Y
D
K
I
L
L
FRHDM
N
S
E
N
I
L
Q
L
I
T
S
A
D
EIHEG
D
L
V
E
V
V
L
S
A
L
A
T
V
EDFQIR
P
H
T
L
Y
V
H
SYKA
P
T
F
C
D
Y
C
G
E
M
L
W
G
L
V
RQGLKCEGCGLNYH
K
R
C
A
FKIPNNC
S
G
V
R
K
R
RLSNVSLPGPGLSVPRPLQPE
Y
V
ALPSEESHVHQE
P
S
KRIPSWSGR
P
I
W
M
E
K
M
V
M
C
R
VKV
P
H
T
F
A
VHSYT
R
P
T
I
C
Q
Y
C
K
R
L
L
K
G
L
F
RQGMQCKDCK
F
N
C
H
K
R
C
A
S
KV
P
R
D
C
LG
E
V
T
FNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPED
K
M
F
F
LDPSDLDV
E
R
D
E
E
A
V
K
TISPSTSNN
I
P
L
M
R
V
V
Q
S
I
K
H
TKRKSSTMVKEG
W
M
V
H
Y
TSRDNL
R
K
R
H
Y
W
RL
D
S
K
C
L
T
L
FQNESGS
K
Y
Y
K
EI
P
L
S
E
I
L
RISSPRDFTNISQGSNP
H
C
F
E
I
ITD
T
M
V
Y
F
V
GENNGDSSHN
P
V
L
A
ATGV
G
L
D
V
A
Q
S
W
E
K
A
I
R
Q
ALMPVTPQASVCTSPGQGKDHKDLS
T
S
I
SVSN
C
Q
I
QENV
D
I
S
T
V
Y
Q
I
F
A
D
E
VLGSG
Q
F
G
I
V
YGGKHRKTG
R
D
V
A
I
K
V
I
D
K
MRFP
T
---
K
-
Q
E
S
Q
----
L
R
N
E
V
A
I
L
Q
NLHHPG
I
V
N
L
E
C
M
FET
P
E
R
V
F
V
V
M
E
K
L
-
H
-
G
-
D
M
L
E
M
I
L
S
S
E
--
K
S
R
L
P
E
R
I
T
K
F
M
V
T
Q
I
L
V
A
L
R
NL
H
F
K
N
I
V
HCDLKPE
N
V
L
L
ASAEPFPQ
V
K
LCD
F
G
F
A
R
I
I
G
E
K
S
F
-
R
R
S
VVGT
P
A
Y
L
A
P
E
V
L
R
S---KGYNRSLD
M
W
S
V
G
V
I
I
Y
V
SLSGTFPFNE---DE---
D
--
I
N
--
D
Q
I
QN
A
A
-------------------FMYPPN
P
---------
W
R
E
ISG
E
A
I
D
L
I
N
N
L
L
Q
V
K
M
R
K
R
YSVDKSLS
H
P
W
L
Q
D
Y
Q
T
W
L
D
L
R
E
F
E
T
R
IGE
R
Y
ITHESDD
A
R
W
E
I
H
A
Y
THNLVY
P
K
H
F
I
MAPNPDDMEEDP
45
HHSearch
65.78
34%
-112
- C1 -
3Q5I
1
?
A:
[31-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------K
F
H
E
E
----
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
-
E
G
G
-
E
L
F
E
Q
I
I
N
----
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
K
-
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
----
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
QN-
D
Q
---
D
--
I
I
--
K
K
V
E
K
G
K
-------------------
Y
Y
F
D
F
N
D
---------
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
------------------------------------------------------
30
HHSearch
64.57
35%
-100
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
--
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SPG
L
-
S
T
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
A
-
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T--
K
E
---
R
--
L
F
--
E
G
I
I
K
G
K
-------------------
Y
K
M
N
P
R
Q
---------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
-----------------------------------------------------
18
PsiBlast_PDB
64.33
34%
-115
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------
S
----
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
-
S
-
G
G
E
L
F
D
R
I
V
--
E
--
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
---
D
A
K
L
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------------------------------------------------------
39
HHSearch
63.20
34%
-108
- C1 -
3LIJ
1
?
A:
[26-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
--------
S
-
S
N
S
K
----
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
-
K
G
G
-
E
L
F
D
E
I
I
H
----
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
K
-
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
----
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
QT-
D
Q
---
E
--
I
L
--
R
K
V
E
K
G
K
-------------------
Y
T
F
D
S
P
E
---------
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
------------------------------------------------------
20
PsiBlast_PDB
61.32
34%
-118
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
-
S
-
G
G
E
L
F
D
R
I
V
--
E
--
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
---
D
A
K
L
F
--
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
Y
---------
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----------------------------------------------------------
9
PsiBlast_PDB
60.37
39%
-106
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
7
PsiBlast_PDB
60.03
39%
-106
- C1 -
2YCS
1
CHK2_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
2
PsiBlast_PDB
59.86
39%
-107
- C1 -
2YCR
1
CHK2_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
12
PsiBlast_PDB
58.97
39%
-110
- C1 -
4BDG
2
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
11
PsiBlast_PDB
57.24
39%
-99
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
10
PsiBlast_PDB
57.18
39%
-104
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
-
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
---
H
R
TQV
S
--
L
K
--
D
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------------------------------------------------------
16
PsiBlast_PDB
56.64
37%
-105
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[15-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
-
S
-
G
G
E
L
F
D
R
I
L
--
E
--
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
M
-
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---
E
T
---
E
S
K
L
F
--
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
F
---------
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
----------------------------------------------------------
48
HHSearch
56.39
31%
-96
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[14-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
--
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-----------
V
K
E
T
----
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
-
E
-
K
-
N
M
L
E
L
L
E
E
M
---
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
---
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
---
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
---
E
S
---
E
--
I
D
Q
L
F
T
I
Q
K
V
L
GPLP
S
E
Q
M
K
L
F
Y
S
NPRFHG
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
-------------------------------------------------------
17
PsiBlast_PDB
54.16
37%
-105
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
-
G
-
E
L
F
D
R
I
V
--
E
--
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
-----------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
ERG
D
Q
---
F
--
M
F
--
R
R
I
L
N
C
E
-------------------
Y
Y
F
I
S
P
W
---------
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
----------------------------------------------------------