@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_M3K15_: (2014-08-17 )
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740....--...750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860......-.870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGG
G
P
R
R
A
L
R
A
V
Y
V
RSESSQGGAAGG
P
E
A
G
A
R
Q
C
L
L
R
A
CEAEG
A
H
LTSVPFGELDFG
E
T
A
V
L
D
AFYDA
D
V
A
V
V
D
M
S
DVSRQP
S
L
F
Y
H
LGVRESFDMAN
N
V
I
L
Y
HDTDAD
T
A
L
S
L
K
D
M
V
TQKNTASSG
N
Y
Y
F
I
P
Y
IVTPCADYFCCE
S
D
A
Q
R
R
A
S
E
YMQP
N
W
D
N
I
L
G
P
L
C
M
P
L
V
D
R
F
I
S
L
L
K
DIHV
T
S
C
V
Y
Y
K
E
T
L
L
N
D
I
R
K
A
R
E
KYQ
G
E
E
L
A
K
E
L
A
R
I
K
L
RMDN
T
E
V
L
T
S
D
I
I
I
N
L
L
L
S
YRDI
Q
D
Y
D
A
M
V
K
L
V
E
T
L
E
MLPTCDLADQH
N
I
K
F
H
Y
A
F
A
LNRRNSTG
D
R
E
K
A
L
Q
I
M
L
Q
V
L
Q
SCDHPGP
D
M
F
C
L
C
G
R
I
Y
K
D
I
FLDSDCKDDTSR
D
S
A
I
E
W
Y
R
K
G
F
E
L
Q
S
S
L
YSGI
N
L
A
V
L
L
I
VAGQ
Q
F
E
T
S
L
E
L
R
K
I
G
V
R
L
N
S
L
LGRKG
S
L
E
K
M
N
N
YW
D
V
G
Q
F
F
S
V
S
M
L
A
H
D
V
G
K
A
V
Q
A
A
E
R
L
FKLKP
P
V
W
Y
L
R
S
L
V
Q
N
L
L
L
I
R
R
F
K
K
T
I
I
EHS
P
R
Q
E
R
L
N
F
W
L
D
I
I
F
E
A
T
N
E
VTNGLRF
P
V
L
V
IEPTKVYQ
P
S
Y
V
S
INNEAE
E
R
T
V
S
L
W
HV
S
P
T
E
M
K
Q
M
H
EWNFTASSIKGISLSKFDE
R
C
C
F
L
Y
V
HDNSD
D
F
Q
I
Y
FS
T
E
E
Q
C
S
R
F
F
S
L
V
K
E
M
I
TNTAG
S
T
V
E
L
EGETDG
D
T
L
E
Y
EYDHDANG
E
R
V
V
LGKG
T
Y
G
I
V
Y
AGRDLS
N
Q
V
R
I
A
I
K
EIPERDSRYSQ
P
L
H
E
E
I
A
L
H
K
Y
L
K
H
R
N
I
V
Q
Y
L
G
SVSEN
G
Y
I
K
I
F
M
EQVPG
G
S
L
S
A
L
L
R
SKWGPMK--E
P
T
I
K
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
ENQ
I
V
H
R
DIKG
D
N
V
L
V
N
TYS
G
V
V
K
I
SDFGTSKRLAGVNP
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
IDQGPRGYGAP
A
D
I
W
S
L
G
C
T
I
I
EMATSKP
P
F
H
ELGEP
Q
A
A
M
F
K
V
G
M
F
K
-IHPEI
P
E
A
L
S
A
E
A
R
A
F
I
L
S
CFEPDPHKRA
T
T
A
E
L
L
R
E
G
F
L
R
Q
VNKGKKN
R
I
A
FKPSEGP
R
G
V
V
L
A
LPTQGEPMATSSSEHGSVSPDSDAQ
P
D
A
L
F
E
RTRA
P
R
H
H
L
G
H
L
LSVPDESSALEDRGLASSPEDRDQ
G
L
F
L
L
RKDSE
R
R
A
I
L
Y
K
I
L
WE
E
Q
N
Q
V
A
S
N
L
Q
E
C
V
A
QSSE
E
L
H
L
S
V
G
H
I
K
Q
I
I
G
I
L
R
D
F
IRSPE
H
R
V
M
A
T
T
I
S
K
L
K
V
D
L
DFDSSS
I
S
Q
I
H
L
V
L
FG
F
Q
D
A
V
N
K
I
L
R
NHLIR
P
H
W
M
F
A
M
D
N
I
I
R
R
A
V
Q
A
A
V
T
I
L
I
P
E
L
R
A
HFEPTCETEGVDK
D
M
D
E
A
EEGYPPATGPGQEAQ
P
H
Q
Q
H
L
S
L
Q
L
G
E
L
R
Q
E
T
N
R
L
L
E
H
L
V
E
K
E
R
E
Y
Q
N
L
L
R
Q
T
L
E
Q
K
T
Q
E
L
Y
H
L
Q
L
K
L
KSNCITENPAGPYGQR
T
D
K
E
L
I
D
W
L
R
LQGA
D
A
K
T
I
E
K
I
V
EEGY
T
L
S
D
I
L
N
E
I
T
K
E
D
L
R
Y
L
R
L
R
G
G
L
L
C
R
L
W
S
A
V
S
Q
Y
R
R
A
Q
E
ASETKDKA
26
PsiBlast_CBE
88.60
82%
-62
- C1 -
4BIC
2
B:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.29
82%
-64
- C1 -
4BIB
1
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.88
82%
-61
- C1 -
4BIC
2
M3K5_HUMAN
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.56
82%
-59
- C1 -
4BIE
2
M3K5_HUMAN
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.33
83%
-57
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[14-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.30
83%
-61
- C1 -
2CLQ
1
B:
[14-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
86.26
82%
-60
- C1 -
4BID
1
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.71
82%
-64
- C1 -
4BIE
2
B:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.47
82%
-61
- C1 -
4BIB
3
M3K5_HUMAN
A:
[11-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.20
82%
-62
- C1 -
4BID
1
M3K5_HUMAN
A:
[11-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.74
82%
-64
- C1 -
4BF2
1
B:
[28-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
---------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.04
82%
-60
- C1 -
4BHN
2
B:
[27-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.57
82%
-60
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
-
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
41.50
30%
-37
- C1 -
4G3F
1
A:
[65-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
-----
V
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
-
G
C
L
P
--
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
-------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
--
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
G
P
-
L
C
L
K
I
A
S
E
P
P
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------