@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_M3K2_H: (2014-08-17 )
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360........370.......380.......390...-....400.......410.......420.......430.......440.......450..----.....--.460.......470....-...480.......490.-..-....500.......510.......520.......530...--....540.......550.......560-----..-....-------.-570.......580.--..-.....590......-.-600.......610.......-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
D
Q
Q
A
L
N
S
I
M
Q
D
L
A
V
L
H
KASRPA
L
S
L
Q
E
T
R
KAKSSSPKKQN
D
V
R
V
K
F
EHRGE
K
R
I
LQFPRPV
K
L
E
D
L
R
S
K
A
K
I
AFGQ
S
M
D
L
H
YTNN
E
L
V
I
P
LT
T
Q
D
D
L
D
K
A
V
E
L
L
D
R
SIH
M
K
S
L
K
I
L
L
V
INGSTQATNLEPLP
S
L
E
D
L
D
N
T
VF
G
A
E
R
K
K
R
L
S
I
IGPTSRDRSSPPPGY
I
P
D
E
L
H
Q
V
A
RNGSFTSINSEGEF
I
P
E
S
M
D
Q
M
LDPLSLSSPENSGSGSCPSLDSPLDGESY
P
K
SRMPRAQSYPDN
H
Q
E
FSDYD
N
P
I
F
E
KFGKGGTY
P
R
R
Y
H
V
S
Y
H
HQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGS
S
I
FTPEY
D
D
S
R
I
R
RRGSDIDNP
T
L
T
V
M
DISPPSRSPRAPTN
W
R
L
G
K
L
-LGQGAF
G
R
V
Y
L
C
Y
DVDTGR
E
L
A
V
K
Q
V
QFDPDSPE-TSKEV
N
A
L
E
C
E
I
Q
L
L
K
N
L
L
H
E
R
I
V
Q
Y
Y
G
CLRDP
Q
E
K
T
L
S
I
F
M
E
YMPGG
S
I
K
D
Q
L
K
A
-
Y
G
----
A
L
T
E
N
--
V
T
R
K
Y
T
R
Q
I
L
E
G
V
H
Y
L
H
S-N
M
I
V
H
RDIKG
A
N
I
LRDS-TG-
N
V
K
LGDFGASK
R
L
Q
T
I
C
LSGTGMKSVTGTPYWMSPEVISG--EGYGRK
A
D
I
W
S
V
A
C
T
V
V
E
M
L
TEKPP
W
A
-----
E
F
-
E
A
M
A
-------
A
-
I
F
K
IATQPTNPK-L--PP-H
V
S
D
Y
T
R
D
F
L
K
R
I
F
-
V
-
E
AKLRP
S
A
D
E
L
L
R
H
M
F
VHYH-------------------
6
PsiBlast_PDB
76.89
40%
-88
- C1 -
4BIE
2
M3K5_HUMAN
A:
[26-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
F
K
V
H
P
E
-
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------
3
PsiBlast_PDB
76.79
40%
-85
- C1 -
4BF2
2
M3K5_HUMAN
A:
[42-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
F
K
V
H
P
E
-
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------
43
HHSearch
75.56
33%
-82
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[33-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-----
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
--
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
-----
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
--
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
-
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
E
P
-
P
P
K
-
L
--
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
-
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
---------------------
5
PsiBlast_PDB
75.15
40%
-86
- C1 -
4BIC
2
M3K5_HUMAN
A:
[26-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
F
K
V
H
P
E
-
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------
4
PsiBlast_PDB
74.28
40%
-85
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[29-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
--------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
F
K
V
H
P
E
-
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------
14
PsiBlast_PDB
72.91
36%
-85
- C1 -
4O0R
1
?
A:
[28-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
-----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
----------------------
11
PsiBlast_PDB
71.74
36%
-85
- C1 -
3FXZ
1
?
A:
[28-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
----------------------
21
Fugue
70.42
30%
-58
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
-----------
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
-
Q
G
----
C
L
P
E
D
--
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
-----------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
--
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
-----
Q
F
-
F
R
G
P
-------
L
-
C
L
K
I
A
S
E
P
P
P
V
R
E
I
--
P
P
-
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
-
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP
32
HHSearch
70.30
30%
-83
- C1 -
2W5A
5
NEK2_HUMAN
A:
[3-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
A
E
D
Y
E
V
L
Y
T
-
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
----
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
-
G
T
K
E
R
Q
Y
L
D
E
E
--
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L
------
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
-----
A
F
-
S
Q
K
E
-------
L
-
A
G
K
I
R
E
G
-
K
F
R
R
-
I
--
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
-
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
---------------------
17
PsiBlast_PDB
69.69
36%
-82
- C1 -
3Q53
1
PAK1_HUMAN
A:
[29-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
----------------------
12
PsiBlast_PDB
69.04
36%
-81
- C1 -
3FY0
1
PAK1_HUMAN
A:
[28-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
----------------------
15
PsiBlast_PDB
68.77
36%
-78
- C1 -
4O0T
1
?
A:
[28-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
-----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
----------------------
18
PsiBlast_PDB
68.47
36%
-83
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[29-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
-------
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
D
E
G
--
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
N
G
T
-
P
E
-
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
----------------------