@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_M3K3_H: (2014-08-17 )
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400........410.......420.......430...-----....440.......450.....-..----460-..-......470.......480-.......490.......-500........510.......520.......530.......540-.-.......550.......560......-----.570...-------.-....580-....-...--.590........600..-.-....610.......620....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
E
Q
E
A
L
N
S
I
M
N
D
L
V
A
L
Q
MNRRHRMPGYETMKNKDTGHSNRQS
D
V
R
I
K
F
EHNG
E
R
R
I
I
A
FSRPVK
Y
E
D
V
E
H
K
V
T
T
VFGQP
L
D
L
H
Y
MNN
E
L
S
I
L
LKN
Q
D
D
L
D
K
A
I
D
I
L
DRSSSM
K
S
L
R
I
L
L
L
SQDRNHNSSSPHSGV
S
R
Q
V
R
I
K
ASQSAGDINTIYQPPEPRS
R
H
L
SVSSQNPGRSSPPPGYV
P
E
R
Q
Q
H
I
A
RQGSYTSINSEGEFIPETS
E
Q
C
MLDPL
S
S
A
ENSLSG
S
C
Q
S
L
DRSADS
P
S
F
R
K
S
R
M
S
R
A
QSFPD
N
R
Q
EYS
D
R
E
T
Q
L
Y
DKGVKGGTY
P
R
R
Y
H
V
S
V
HHKDYSDG
R
R
T
F
P
R
I
R
R
HQG
N
L
F
T
LVPSSRSLSTNGENM
G
L
A
V
Q
Y
LDPRGRLRSADSENA
L
S
V
Q
ERNVPTKSPSAPINWRRG
K
L
LGQGAF
G
R
V
Y
L
C
Y
DVDT
G
R
E
L
A
S
K
Q
V
Q
FDPDSPE-TSKE
V
S
A
L
E
C
E
I
Q
L
L
K
NL
Q
H
E
R
I
V
Q
Y
Y
G
C
L
R
D
RA-----
E
K
T
L
T
I
F
M
EYMPGG
S
V
K
D
Q
L
K
A
-
Y
G
----
A
L
--
T
E
-
S
V
T
R
K
Y
T
R
Q
I
L
E
G
M
S
Y
L
H
S-N
M
I
V
H
RDIKG
A
N
I
LRDS-AG-N
V
K
LGDFGAS
K
R
L
Q
T
I
CMSGTGMRSVTGTPYWMSPEVISG--E-GYGRKA
D
V
W
S
L
G
C
T
V
V
E
M
L
TEKPP
W
A
-----
E
Y
-
E
A
M
A
-------
A
-
I
F
K
IAT--QPTN-PQ
L
--
P
S
-
H
I
S
E
H
G
R
D
F
L
R
R
I
F
-
V
-
E
A
RQRP
S
A
E
E
L
L
T
H
H
F
A
Q
L
MY
7
PsiBlast_PDB
85.67
40%
-75
- C1 -
4BID
1
M3K5_HUMAN
A:
[26-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
42
HHSearch
85.56
32%
-75
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[33-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
-----
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
-------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
-
A
G
----
R
I
--
P
E
-
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-----
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
--
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
-
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
--
E
P
-
P
-
P
K
L
--
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
-
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
---
3
PsiBlast_PDB
85.28
40%
-73
- C1 -
4BF2
2
M3K5_HUMAN
A:
[42-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
6
PsiBlast_PDB
85.05
40%
-76
- C1 -
4BIC
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
8
PsiBlast_PDB
84.76
40%
-77
- C1 -
4BIE
2
M3K5_HUMAN
A:
[26-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
4
PsiBlast_PDB
82.81
40%
-76
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[29-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
--------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--
5
PsiBlast_PDB
81.98
40%
-68
- C1 -
4BIB
3
M3K5_HUMAN
A:
[26-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
------
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
----
P
L
KD
N
E
-
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
GP
R
-
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
-----
E
L
G
E
P
Q
A
-------
A
-
M
F
K
V
G
M
--
F
K
V
H
-
P
E
I
--
P
E
-
S
M
S
A
E
A
K
A
F
I
L
K
C
F
-
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---
18
PsiBlast_PDB
79.79
36%
-72
- C1 -
4O0R
1
?
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
--
N
G
T
--
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--
15
PsiBlast_PDB
75.89
36%
-72
- C1 -
3FXZ
1
?
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
--
N
G
T
--
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--
19
PsiBlast_PDB
74.06
36%
-65
- C1 -
4O0T
1
?
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
--
N
G
T
--
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--
16
PsiBlast_PDB
74.01
36%
-68
- C1 -
3FY0
1
PAK1_HUMAN
A:
[22-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
-
Q
Q
P
K
-
K
E
L
I
I
N
----
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-----
E
--
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--
T
----
C
M
--
D
E
-
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
---
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-----
N
E
-
N
P
L
R
-------
A
-
L
Y
L
I
A
T
--
N
G
T
--
P
E
L
QN
P
E
-
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
-
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--
31
HHSearch
72.02
31%
-70
- C1 -
2W5A
5
NEK2_HUMAN
A:
[3-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
----
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
-----
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
-
G
T
K
E
R
Q
Y
L
--
D
E
-
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L
------
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
-----
A
F
-
S
Q
K
E
-------
L
-
A
G
K
I
R
E
--
G
-
K
F
-
R
R
I
--
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
-
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
---
54
HHSearch
71.77
33%
-62
- C1 -
4G3F
1
A:
[62-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
----------
V
F
R
-
V
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
-------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
-
M
G
----
C
L
--
P
E
-
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
----------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
--
K
-
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
-----
Q
Y
-
F
R
G
P
-------
L
-
C
L
K
I
A
S
--
E
P
P
P
I
R
E
I
--
P
P
-
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
-
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
-----
32
HHSearch
71.27
31%
-69
- C1 -
1ZY4
1
GCN2_YEAST
A:
[7-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
------
H
-
T
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
-
E
N
----
L
N
--
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
-
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
-
S
R
-
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R
--------------
A
M
Y
V
A
T
E
V
L
D
G
--
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
--
P
F
S
T
-----
G
M
-
E
R
V
N
-------
I
-
L
K
K
L
R
S
VS
I
E
F
P
-
P
D
F
--
D
D
-
N
K
M
K
V
E
K
K
I
I
R
L
L
I
-
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
---