@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_M3K5_H: (2014-08-17 )
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFK
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680..----.....690.......700.......710.......720.......730.......740......-------.750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.--.....-.900.--......910.......920.......930.......940.......950...-....960.......970.......980.......990.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTEADE
G
I
T
F
SVPPFAPSG
F
C
TIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGS
R
R
T
T
V
A
Y
V
INEASQG
Q
L
V
V
A
E
S
E
A
L
Q
S
L
R
E
A
C
E
T
V
G
A
T
L
E
T
L
H
FGKLDFG
E
T
T
V
L
D
R
FYNA
D
I
A
V
V
E
M
S
D
AFRQP
S
L
F
Y
H
LGV
R
E
S
FSMAN
N
I
I
L
Y
CDTN
S
D
S
L
Q
S
L
K
E
I
I
CQKNTMCTG
N
Y
T
F
V
P
Y
M
ITPH
N
K
V
Y
CC
D
S
S
F
M
K
G
L
T
E
L
MQPN
F
E
L
L
LG
P
I
C
L
P
L
V
D
R
F
I
Q
L
L
K
V
A
QAS
S
S
Q
Y
F
R
E
S
I
L
N
D
I
R
K
A
RNLYT
G
K
E
L
A
A
E
L
A
R
I
R
Q
R
VDN
I
E
V
L
T
A
D
I
V
I
N
L
L
L
S
Y
R
D
I
Q
D
Y
D
S
I
V
K
L
V
E
T
L
E
KLPTFDLASH
H
H
V
K
F
H
Y
A
F
A
LNRRNLPGDRA
K
A
L
D
I
M
I
P
MVQSEG
Q
V
A
S
D
M
Y
C
L
V
G
R
I
Y
K
D
M
FLDSNFTDTESRD
H
G
A
S
W
F
K
K
A
FESEP
T
L
Q
SGI
N
Y
A
V
L
L
L
AAGHQFESS
F
E
L
R
K
V
G
V
K
L
S
S
L
LGKKG
N
L
E
K
L
Q
S
Y
W
E
V
G
F
F
L
G
A
S
V
LAND
H
M
R
V
I
Q
AS
E
K
L
F
KLKT
P
A
W
Y
L
K
S
I
V
E
T
I
L
I
Y
K
H
F
V
K
LTTEQP
V
A
K
Q
E
L
V
D
F
W
M
D
F
L
V
E
ATKT
D
V
T
V
V
R
F
P
V
L
I
LEPTKIYQP
S
Y
L
SINNEVEE
K
T
I
S
I
W
H
VLPDDKKGIHEWNFSASSVRGV
S
I
S
K
F
EER
C
C
F
L
Y
V
L
HNSD
D
F
Q
I
Y
F
C
T
E
L
H
C
K
K
F
F
E
M
V
N
T
I
T
E
EKGRSTEEGD
C
E
S
D
L
L
E
YDYEYDENG
D
R
V
----
V
LGKG
T
Y
G
I
V
Y
AGRDLS
N
Q
V
R
I
A
I
K
EIPERDSRYSQ
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
SFSEN
G
-------
F
I
K
I
F
M
E
QVPG
G
S
L
S
A
L
L
R
SKWGPLKDNE
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
HDN
Q
I
V
H
R
DIKG
D
N
V
L
I
N
TYS
G
V
L
K
I
SDFGTSKRLAGINP
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
IDKGPRGYGKA
A
D
I
W
S
LG
C
T
I
I
EMATGKPPFYELGEP
Q
A
A
M
F
K
--
V
G
M
F
K
-VHPEI--
P
E
SM
S
A
E
A
K
A
F
I
L
K
CFEPDPD
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
SSKKKKTQPK
L
S
ALS-AG
S
N
E
Y
L
R
SISLPV
P
V
L
V
EDTSSSSEYGSVSPDT
E
L
KVDPFSFK
3
PsiBlast_PDB
85.34
99%
-75
- C1 -
4BID
1
M3K5_HUMAN
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------
23
PsiBlast_CBE
84.29
99%
-74
- C1 -
4BIC
2
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------
21
PsiBlast_CBE
84.24
99%
-74
- C1 -
4BIE
2
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------
6
PsiBlast_PDB
84.24
100%
-67
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
22
PsiBlast_CBE
84.02
99%
-74
- C1 -
4BID
1
B:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
24
PsiBlast_CBE
83.76
99%
-74
- C1 -
4BIB
1
B:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
2
PsiBlast_PDB
83.59
99%
-71
- C1 -
4BIC
2
M3K5_HUMAN
A:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
27
PsiBlast_CBE
83.27
100%
-72
- C1 -
2CLQ
1
B:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
4
PsiBlast_PDB
83.18
99%
-69
- C1 -
4BIE
2
M3K5_HUMAN
A:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
25
PsiBlast_CBE
81.30
99%
-71
- C1 -
4BHN
2
B:
[27-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
--------------------------------------------------------------
26
PsiBlast_CBE
81.08
99%
-74
- C1 -
4BF2
1
B:
[28-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
---------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------
1
PsiBlast_PDB
81.02
99%
-69
- C1 -
4BIB
3
M3K5_HUMAN
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------
5
PsiBlast_PDB
79.27
99%
-69
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
--
V
G
M
F
K
-
V
H
P
E
I
--
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------
15
PsiBlast_PDB
48.22
31%
-48
- C1 -
3Q53
1
PAK1_HUMAN
A:
[29-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
--
I
A
T
N
G
-
T
-
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------
17
PsiBlast_PDB
47.20
31%
-44
- C1 -
4O0T
1
?
A:
[28-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
--
I
A
T
N
G
-
T
-
P
E
L
QN
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
-----------------------------------------------
55
HHSearch
37.91
31%
-43
- C1 -
4G3F
1
A:
[49-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
-----
V
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
-------
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
-
G
C
L
P
--
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
-------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
--
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
G
P
-
L
C
L
K
--
I
A
S
E
P
P
P
I
R
E
I
--
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
-----------------------------------------------------------------
42
HHSearch
22.42
30%
-52
- C1 -
1ZY4
1
GCN2_YEAST
A:
[13-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
-
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
N
L
N
Q
Q
--
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
-
S
R
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R
-----------
A
M
Y
V
A
T
E
V
L
D
G
-
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
---
P
F
S
T
G
M
E
R
V
N
I
L
K
K
L
R
S
V
S
I
E
-
F
P
P
D
F
--
D
D
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
-----------------------------------------------------------