@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MAPK2_: (2014-08-17 )
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
Atome Classification :
(14 SA)
.........10........20........30........40........50........60......-..70........80........90......--.-----.----100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPP
P
Q
Q
F
P
Q
F
H
V
KSG
L
Q
I
KKNAIID
D
Y
K
V
T
S
-
Q
V
LGLGIN
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D--
C
-----
P
----
K
AR
R
E
V
E
L
H
W
RASQC
P
H
I
V
R
I
V
D
V
Y
E
N
L
YAG
R
K
C
L
L
I
V
M
E
CL
D
G
G
E
L
F
S
R
I
Q
DRGD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
SINIAHRDVKPEN
L
L
Y
TSKRP
N
A
I
L
K
LTDFGFAKETTSHNSLTTPCYTPYYV
A
P
E
VL
G
P
E
K
YDKSCD
M
W
S
L
G
V
I
M
Y
I
L
LCGYPPFYSNH
G
L
A
ISPGMK
T
R
I
RMGQYEFPNP
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
LKTEPTQ
R
M
T
I
T
E
FMNHP
W
I
MQSTKVPQTPL
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
E
Q
I
K
I
K
K
IEDASN
P
L
L
L
K
R
R
K
K
A
R
A
L
E
A
A
ALAH
19
PsiBlast_PDB
84.39
99%
-124
- C1 -
3KA0
1
MAPK2_HUMAN
A:
[1-318]
----------------------------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
78
HHSearch
80.01
100%
-114
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[42-345]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
11
PsiBlast_PDB
80.01
100%
-116
- C1 -
3FYK
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
21
PsiBlast_CBE
78.80
100%
-122
- C1 -
1NY3
1
MAPK2_HUMAN
A:
[46-345]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
H
---------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
9
PsiBlast_PDB
78.79
100%
-115
- C1 -
2P3G
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
80
HHSearch
77.78
100%
-105
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[4-299]
-----------------------------------------------
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
---------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
12
PsiBlast_PDB
76.79
100%
-115
- C1 -
2PZY
1
MAPK2_HUMAN
A:
[2-306]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
------------------------------------------------------
18
PsiBlast_PDB
75.89
100%
-123
- C1 -
3R2Y
1
MAPK2_HUMAN
A:
[1-300]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
10
PsiBlast_PDB
74.96
100%
-108
- C1 -
3FYJ
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
--
C
-----
P
----
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
79
HHSearch
72.75
76%
-108
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[20-336]
----------------------------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
Y
D
--
S
-----
P
----
K
A
R
Q
E
V
D
H
H
W
Q
A
S
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
T
-----------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
---------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
S
M
V
V
P
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------
88
HHSearch
52.87
38%
-118
* C1 *
3LIJ
1
?
A:
[29-298]
----------------------------------------------------
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
SS
N
-----
S
----
K
L
L
E
E
V
A
V
L
K
-
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
----
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
--
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
----
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
------------------------------------------------------------------------
97
HHSearch
51.25
38%
-114
- C1 -
3Q5I
1
?
A:
[29-310]
-----------------------------------------------------
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------KF
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
-
D
H
P
N
I
I
K
L
F
D
V
F
E
----
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
--
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
-
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
----
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
----------------------------------------------------------------------
96
HHSearch
47.68
40%
-125
- C1 -
2W4O
1
KCC4_HUMAN
A:
[48-313]
-------------------------------------------------------
R
D
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------
I
G
V
L
L
R
L
-
S
H
P
N
I
I
K
L
K
E
I
F
E
T
----
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
----------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
---
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
-----------------------------------------------------------------------
98
HHSearch
41.55
32%
-115
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[78-348]
---------------------------------------------------
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
--
R
G
M
K
D
K
E
----
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
----
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-------------------------------------------------------------------------