@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MARK3_: (2014-08-17 )
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90.-...----...-.100.......110.......120.......130.......140.......150.......160.......170........180.......---190--.........200..-..-.---..210.......220.......230.......240.......250.......-260.......270..----.....280.......290....-----...300.....----..310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTRTPLPTVNERDTENHTSHGD
G
R
Q
E
V
T
S
RTSRS
G
A
R
C
R
N
S
I
A
S
C
ADEQPHIG
N
Y
R
L
L
K
T
IGKGNF
A
K
V
K
L
A
R
H
I
LTG
R
E
V
A
I
K
I
I
DKTQL-
N
P
T
----
S
L
Q
-
K
L
F
R
E
V
R
I
M
K
I
LNHP
N
I
V
K
L
F
E
V
I
ETE
K
T
L
Y
L
I
M
E
YASG
G
E
V
F
D
Y
L
V
AHGRM
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
DLKAE
N
L
L
LDAD---M----
N
I
K
I
A
DFGFSN
E
F
T-VG-G---KLDTFCGSPPYAA
P
E
LFQGKKYDGPEV
D
V
W
S
L
G
V
I
L
Y
T
L
VSGSLPFD
G
Q
N
L
K
-
E
L
R
E
R
V
LRGK
Y
R
I
P
F
----
Y
MST
D
C
E
N
L
L
K
R
F
L
V
LNPIK
R
G
-----
T
L
E
Q
I
M
K
D
RWI----NAGH
E
E
D
ELKPFVEPELDISDQ
K
R
I
D
I
M
V
GMGY
S
Q
E
E
I
Q
E
S
L
S
KM
K
Y
D
E
I
T
A
T
Y
L
L
LGRKSSELDASDSSSSSN
L
S
L
A
K
VRPSSDLNNSTGQS
P
H
H
K
V
Q
R
S
V
F
S
S
Q
K
Q
R
RYSDHAGPAIP
S
V
VAYPKRSQTSTAD
S
D
L
K
EDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRR
N
T
Y
V
CSERTT
A
D
R
H
S
V
I
QNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATP
L
S
Q
TRSRGS
T
N
L
F
S
K
L
T
S
K
L
T
RRN
M
S
F
R
F
I
K
RL
P
T
E
Y
ERNGRYEGSSRNVSAEQKDENKEAKP
R
S
L
R
F
T
W
SMKTTSSM
D
P
G
D
M
M
R
E
I
R
K
V
LDANNC
D
Y
E
Q
R
E
R
F
L
L
F
C
VHGDG
H
A
E
N
L
V
Q
W
E
M
E
V
CKLPRLSLN
G
V
R
F
K
RISGT
S
I
A
F
K
N
I
A
S
K
I
A
N
ELKL
22
PsiBlast_CBE
90.33
87%
-111
- C1 -
3IEC
1
MARK2_HUMAN
C:
[5-318]
---------------------------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
----
S
L
Q
-
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
----
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-
F
G
-
N
---
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
-
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
----
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.94
87%
-110
- C1 -
3IEC
1
MARK2_HUMAN
D:
[5-318]
---------------------------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
----
S
L
Q
-
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
----
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-
F
G
-
N
---
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
-
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
----
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.88
87%
-110
- C1 -
3IEC
1
MARK2_HUMAN
B:
[5-318]
---------------------------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
----
S
L
Q
-
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
----
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-
F
G
-
N
---
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
-
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
----
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
70.36
42%
-87
- C1 -
4BKY
1
MELK_HUMAN
A:
[7-326]
--------------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
D
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
---
H
----
K
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.43
46%
-95
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[5-276]
-----------------------------------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
----
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
---
M
----
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-
D
G
-
E
---
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
-
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
----
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
---------
K
Q
D
L
P
S
Y
L
F
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.96
41%
-92
- C1 -
4BL1
1
MELK_HUMAN
A:
[12-313]
-------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---------
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
---
H
----
K
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
MQDY
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
60.08
37%
-101
- C1 -
4GV1
5
AKT1_HUMAN
A:
[5-274]
--------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
----
E
V
A
-
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-
A
---
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
----
A
-
G
I
V
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
59.17
36%
-96
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[11-276]
-----------------------------------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
S
S
RRGV
S
R
E
-
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
-
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
EYFS
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
58.78
38%
-90
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[10-272]
----------------------------------------------------
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
-
S
A
R
----
D
H
Q
-
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
LKG
A
----
A
V
K
L
A
D
F
G
L
A
I
E
V
E
-
G
E
Q
Q
---
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
PEWD
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
----
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
57.93
34%
-90
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[36-303]
------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
----
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
-
G
---
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----
A
-
T
T
D
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.38
36%
-96
- C1 -
3TKI
1
CHK1_HUMAN
A:
[3-272]
-------------------------------------------------
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
---
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
WK--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
55.71
36%
-89
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-270]
--------------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
D
----
C
P
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
---
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
WK--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------