@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MELK_H: (2014-08-17 )
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Atome Classification :
(13 SA)
.........10........20........30........40......--.--.-----50........60..-.-.....70........80........90........100--------------.----------------.--------......110.......120...-....130.......140..----.....150....-.---.-.-160.......170.......180.-......190.......200.......210..-.....220......--.230--.--........240.......250-----..------.-....260....---...270.......280---........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
IGTG
G
F
A
K
V
K
L
A
C
H
I
LTG
E
M
V
A
I
K
I
M
DKNTL--G--S-----D
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
TAN
K
I
F
M
V
L
E
YCPG
G
E
L
F
D
Y
I
I
S
Q
---------------
D
----------------R--------L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
HS-QGYAHRDLKPEN
L
L
F
D
EYH----
K
L
K
L
I
D
F
GLCAK-P---K-G-NKDY
H
L
Q
T
C
C
G
S
L
A
Y
A
A
P
E
L
IQGK-SYLGSEA
D
V
W
S
M
G
I
L
L
Y
V
L
M
CGFLPFDDD
N
V
-
M
A
L
Y
K
K
I
MRGKYDV--PK----W--LS
P
S
S
I
L
L
L
Q
Q
M
L
QVD
P
K
K
R
I
-----
S
M
------
K
-
N
LLNHP
W
I
MQD---YNYP
V
E
WQSKNP
F
I
H
----LDD
D
C
V
T
E
L
S
V
HHRNN
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
KARGK
P
V
R
L
R
L
SSFSCGQASATPFTDIKSNNWSLEDVTASDKN
Y
V
A
G
LIDYDWCE
D
D
L
STGAATPRT
S
Q
F
T
K
YWTESNGVESKSL
T
P
A
L
C
RT
P
A
N
KLKNKENVYTPKSAVKNE
E
Y
F
MFPEPKTPVNK
N
Q
H
K
R
E
ILTTPNRYTT
P
S
K
A
R
N
Q
C
L
KETP
I
K
I
PVNSTG
T
D
K
L
M
T
G
VI
S
P
E
R
RC
R
S
V
E
LDL
N
Q
A
H
M
E
ETPKR
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
V
I
T
V
L
T
RSKRKGSARDG
P
R
R
L
K
L
H
Y
NV
T
T
T
RLV
N
P
D
Q
L
L
N
E
I
M
S
IL
P
K
K
H
V
D
F
V
QKG
Y
T
L
K
C
Q
TQSDF
G
K
V
T
M
Q
F
E
L
E
V
C
QLQKPD
V
V
G
I
R
R
Q
RLKG
D
A
W
V
Y
K
R
L
V
E
D
I
L
S
SCKV
2
PsiBlast_PDB
97.18
99%
-132
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-334]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-----------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
----------------
R
--------
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.30
99%
-134
- C1 -
4BKZ
1
MELK_HUMAN
A:
[3-335]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
------------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
----------------
R
--------
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.10
99%
-129
- C1 -
4BL1
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
------------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
----------------
R
--------
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
K
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.43
43%
-116
- C1 -
3IEC
1
MARK2_HUMAN
A:
[9-317]
----------
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N-
S
--
S
-----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
---------------
G
----------------
W
--------
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
----
N
I
K
I
A
D
F
G
F
S
N
E
F
T
---
F
-
G
-
N
K
---
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
-
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
-
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
-------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
P
LPD
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
64.52
37%
-127
- C1 -
3HKO
2
?
A:
[20-336]
--
S
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
--
R
Q-
K
-----
D
V
E
R
I
K
T
E
V
R
L
M
K
K
-
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI-F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
-
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
SF--
E
I
K
L
V
D
F
G
L
S
K
E
-
F
YKL
N
-
N
-
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
-
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
EN
P
N
----
Y
NV
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
-----
D
A
------
M
-
R
A
L
Q
H
P
W
I
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.54
47%
-117
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[10-275]
-------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
--
R
--
S
L
D---
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
---------------
G
----------------
R
--------
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
----
N
A
K
I
A
D
F
G
L
S
N
M
-
M
---
S
-
D
-
G
E
--
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
-
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
D
LPS
Y
L
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
58.48
35%
-116
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[40-298]
-------
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
--
V
KL
K
-----
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
---------------
G
----------------
R
--------
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
-
G
-
R
----
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
57.99
33%
-117
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[7-276]
----
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--
K
--
S
SRRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------------
E
----------------
S
--------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
---
D
-
F
-
G
--
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
--
E
D
EYFS
N
--
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
------
Q
-
D
S
L
Q
H
P
W
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
57.33
34%
-125
- C1 -
4GV1
5
AKT1_HUMAN
A:
[7-269]
-------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--
V
A
K
D
-----
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
---------------
R
----------------
V
--------
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
-
G
---
I
-
K
--
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
-
E
K
L
F
E
L
I
L
M
E
E
I
R
F
--
P
R
----
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
50.83
34%
-109
- C1 -
3TKI
1
CHK1_HUMAN
A:
[4-271]
-----
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
----------------
G
--------
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
-
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
P
----
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
------
P
-
D
I
K
K
D
R
W
Y
N
K
P
---
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
50.82
32%
-108
- C1 -
3TXO
1
A:
[23-285]
--------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
--
L
Q
D
D
-----
D
V
E
C
T
M
T
E
K
R
I
L
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
---------------
R
----------------
R
--------
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
-
G
---
I
-
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
-
L
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
-
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
--
P
T
----
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
50.81
34%
-102
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-270]
-----
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
--
D
-----
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
----------------
G
--------
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
-
F
---
R
-
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
P
----
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
------
P
-
D
I
K
K
D
R
W
Y
N
K
P
---
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
50.23
30%
-104
- C1 -
1XJD
1
A:
[16-274]
-------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
--
D
-----
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
---------------
H
----------------
K
--------
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
---
M
-
L
-
G
-
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
-
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
R
----
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------