@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MINK1_HUMAN: (2014-08-17 )
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Atome Classification :
(13 SA)
.........10........20........30........40........50.......-.60.....--...70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGDPAPARSLDDI
D
L
S
A
LRD
P
A
G
I
F
E
L
V
E
V
VGNGTYGQVYKGRHVKTG
Q
L
A
A
I
K
V
M
DV-TED
E
E
E
E
I
--
K
Q
E
I
N
M
L
K
K
Y
SHHR
N
I
A
T
Y
Y
G
A
F
IKKSPPGNDD
Q
L
W
L
V
M
E
F
CGAG
S
V
T
D
L
V
KNTKGN
A
L
K
E
D
C
I
A
Y
I
C
R
E
I
L
R
G
L
A
H
L
H
A
H
K
V
I
H
R
DIKGQ
N
V
L
L
TENA
E
V
K
L
V
D
FGVS
A
Q
L
D
R
TVGRRNTFIGTPYWMA
P
E
V
I
A
CDENPDA
T
Y
D
Y
R
S
D
I
W
S
L
G
I
T
A
I
EMAEGAPPLCDMHP
M
R
A
L
F
L
I
PRNPPPRLK
S
-
K
K
W
S
K
K
F
I
D
F
I
D
T
C
L
I
K
T
Y
LSRP
P
T
E
Q
L
L
KFPFIRDQPTE
R
Q
V
R
I
Q
L
K
D
HI
D
R
S
R
K
KRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG
E
S
T
L
R
R
E
F
L
R
L
Q
QENKS
N
S
E
A
L
K
Q
Q
Q
Q
L
Q
Q
Q
QQR
D
P
E
A
H
I
K
H
L
L
H
Q
R
Q
R
R
I
E
E
Q
K
E
E
R
R
R
V
E
E
Q
Q
R
R
E
R
E
Q
R
K
L
Q
E
K
E
Q
Q
R
R
L
E
D
M
Q
A
L
R
R
E
E
E
R
R
Q
A
E
R
E
Q
E
Y
K
R
K
Q
L
E
E
Q
R
Q
S
E
R
L
Q
R
Q
L
Q
Q
E
H
A
Y
L
K
S
L
Q
Q
Q
Q
Q
Q
Q
Q
L
Q
K
Q
Q
Q
Q
QLLPGDRKP
L
Y
HYGRGMNPADK
P
A
W
A
R
E
V
E
E
R
T
RMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGP
H
K
S
L
V
AHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSAR
G
A
V
I
RQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP
Q
R
T
S
S
I
A
T
A
LNTSGAGGSR
P
A
Q
A
V
RARPRSN
S
A
W
Q
I
Y
L
Q
R
R
AERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA
D
F
V
L
L
KERTLDEAPRP
P
K
K
AMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDS
V
S
T
M
V
V
H
D
V
E
E
I
TGTQPPYGG
G
T
M
V
V
Q
RT
P
E
E
ER
N
L
LHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKS
S
F
T
M
F
V
D
L
G
I
YQPGGSGD
S
I
P
I
T
A
L
VGGEG
T
R
L
D
Q
L
Q
Y
DVRKG
S
V
V
NVNPTNTRAHSE
T
P
E
I
R
K
Y
K
K
R
FN
S
E
I
L
C
A
A
L
WG
V
N
L
L
V
GTEN
G
L
M
L
L
DRSGQG
K
V
Y
G
L
I
G
R
R
R
F
Q
Q
M
D
V
LEGL
N
L
L
I
T
ISGKR
N
K
L
R
V
Y
Y
L
S
W
L
R
N
K
ILHNDPEV
E
K
KQGWTTVGDMEGCGH
Y
R
V
V
K
Y
E
R
I
K
F
L
V
I
A
LKSS
V
E
V
Y
A
WAPK
P
Y
H
K
F
M
A
F
K
S
F
ADLPHR
P
L
L
V
D
L
TVEEG
Q
R
L
K
V
I
Y
GSSAG
F
H
A
V
D
VDSGN
S
Y
D
I
Y
I
P
V
H
I
QSQITP
H
A
I
I
F
L
PNTDG
M
E
M
L
L
C
YEDE
G
V
Y
V
N
T
Y
G
R
I
I
K
D
V
V
L
QWGEMP
T
S
V
A
Y
I
CSNQIMGWGE
K
A
I
E
I
R
S
VETGHL
D
G
V
F
M
H
K
R
A
Q
R
L
K
F
L
C
ERND
K
V
F
F
A
S
VRSGGS
S
Q
V
Y
F
M
TLNRNCIMNW
13
PsiBlast_PDB
63.42
44%
-72
- C1 -
3A7J
1
STK24_HUMAN
A:
[19-298]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
---
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.10
44%
-72
- C1 -
3A7I
1
STK24_HUMAN
A:
[19-298]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
---
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.22
44%
-71
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-293]
-------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
-
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
---
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
E
G
-
Q
H
-
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
---
I
D
R
Y
K
R
W
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.70
44%
-74
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-283]
--------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
-
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
---
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.49
44%
-76
- C1 -
4FZF
1
?
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.56
44%
-78
- C1 -
4FZD
1
MST4_HUMAN
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.45
44%
-69
- C1 -
3A7H
1
STK24_HUMAN
A:
[19-298]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
---
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.25
44%
-73
- C1 -
4FZA
3
MST4_HUMAN
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.32
45%
-74
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-298]
-----------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
48.07
41%
-80
* C1 *
4AOT
1
STK10_HUMAN
A:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
--
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
46.35
41%
-71
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
--
I
V
E
I
E
I
L
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
41.37
43%
-78
- C1 -
2J51
5
SLK_HUMAN
A:
[34-297]
-------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
--
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
41.05
43%
-77
- C1 -
2JFL
6
SLK_HUMAN
A:
[34-297]
-------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
--
M
V
E
I
D
I
L
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------