@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MK04_H: (2014-08-18 )
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
Atome Classification :
(12 SA)
.........10..--......20........30........40-.........50.--.--...-..-.-60........70........80........90........100.......110......-----.120.......130.......140.......150......---.160.......170......-.180.......190.......200.......210.......220.......230..----.....240.......250..--...--.--.--.-260.-------......270-.....----..280.........290.......300.......310.......320...----....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEKGD
C
I
A
S
V
Y
G--YDLG
G
R
F
V
D
F
Q
PLGFGVN
G
L
V
L
SA
V
D
S
--
R
A
C
R
K
V
A
V
K
K
I
A--L--
S
D
A
-
R
S
-
M
-
K
H
A
L
R
E
I
K
I
I
R
RLDH
D
N
I
V
K
V
Y
E
V
LGPKGTDLQ
G
E
L
F
K
F
S
V
A
Y
I
V
Q
E
Y
M
E
T
D
L
A
R
L
L
E
Q-----GT
L
A
E
E
H
A
K
L
F
M
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
RDLKP
A
N
I
F
I
S---TE
D
L
V
L
K
IGD
F
G
L
A
R
I
V
D
Q
H-YSHKGYLSE
G
L
V
T
K
W
YRSP
R
L
L
LSPNNY
T
K
A
I
D
M
W
A
A
G
C
I
L
A
E
M
L
TG
R
M
L
FA
G
A
H
E
----
L
E
Q
M
Q
L
I
L
E
TIPVIREE-
D
K
--
D
E
L
--
L
--
R
--
V
-
M
P
S
F
-------
V
S
S
T
W
E
V
K
R
-
P
L
R
K
L
----
L
P
E--VN
S
E
A
I
D
F
L
E
K
I
LTFN
P
M
D
R
L
T
A
E
MGLQHPYMSPYSCPEDEPTSQ----HPFRIEDEID
D
I
V
L
M
AA
N
Q
S
QLSNWDTCSSRYPVSLSSDLEWR
P
D
RCQ
D
A
S
E
V
QRDPRAGSAPL
A
E
DVQVDPRKDSH
S
S
S
E
R
F
L
E
Q
S
H
S
S
M
E
R
A
F
E
ADYGRSCDYKVG
S
P
S
Y
L
D
K
L
L
WRDNKPHHYSE
P
K
L
I
L
D
L
S
H
W
K
Q
AAGAPPTATGLADTGARED
E
P
A
S
L
F
L
E
I
A
Q
W
V
K
STQGGPEHASPPAD
D
P
E
RRLSASPPGRPAPVDGGASPQ
F
D
L
D
V
F
I
S
R
A
L
K
L
CTKPEDLPDNKLGDLNGACIPEHPG
D
L
V
Q
T
E
AFSKERW
3
PsiBlast_PDB
75.89
42%
-105
- C1 -
4FMQ
2
MK01_HUMAN
A:
[21-340]
---------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
S
--
P
--
F
E
H
-
Q
T
-
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
V
------
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
--
N
C
I
IN
L
--
K
--
A
-
R
N
Y
L
-------
L
S
L
P
H
K
N
K
V
-
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
----
A
P
F
K
F
D
M
E
L
D
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.59
35%
-97
* C1 *
4IC7
1
MK07_HUMAN
A:
[50-393]
------------
T
--
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
P
--
N
AF
D
V
V
-
T
N
-
A
-
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
-----
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
---
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
-
V
I
--
Q
A
V
--
G
--
A
ER
V
-
R
A
Y
I
-------
Q
S
L
P
P
R
Q
P
V
-
P
W
E
T
V
----
Y
P
G
--
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
----
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
75.03
41%
-99
- C1 -
3QYZ
13
MK01_RAT
A:
[23-360]
---------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
K
K
I
S
--
P
--
F
E
H
Q
T
Y
-
C
-
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
------
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
--
N
C
I
--
I
--
N
L
K
A
-
R
N
Y
L
-------
L
S
L
P
H
K
N
K
V
-
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
----
A
P
F
K
F
-----
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.56
41%
-103
- C1 -
1TVO
1
MK01_HUMAN
A:
[19-338]
---------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
S
--
P
--
F
E
H
-
Q
T
Y
C
-
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
--
N
C
I
--
I
N
L
K
--
A
-
R
N
Y
L
-------
L
S
L
P
H
K
N
K
V
-
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
----
A
P
F
K
F
D
M
E
L
D
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
73.90
36%
-102
- C1 -
4O2Z
1
?
A:
[34-371]
--------
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
--
D
T
G
E
K
V
S
I
K
K
C
R
DV
F
--
R
D
V
-
E
D
-
G
-
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
P
L
K
R
E
----
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R----
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
---
I
-
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
-
Y
---
S
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
----
M
D
Q
L
R
M
I
A
Q
H
I
G
K
P
P
A
S
-
I
V
EH
R
E
A
--
L
--
E
--
K
----
L
-------
N
-
E
L
P
D
G
S
L
-
N
I
P
K
L
----
V
P
G
LA
G
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
P
----
C
P
F
L
W
A
H
E
S
T
P
M
G
V
S
E
L
R
R
A
F
W
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
72.60
35%
-100
- C1 -
2B9H
2
FUS3_YEAST
A:
[5-350]
-----------
I
V
--
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
--
P
--
F
D
K
P
L
F
-
A
-
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
P
D
S
F
E
------
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
-----
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
---
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
--
R
C
I
--
E
S
P
R
--
A
-
R
E
Y
I
-------
K
S
L
P
M
Y
P
A
A
-
P
L
E
K
M
----
F
P
R
--
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.31
41%
-101
- C1 -
1WZY
1
MK01_HUMAN
A:
[27-346]
---------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
S
--
P
--
F
E
H
-
Q
T
Y
C
-
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
--
N
C
I
--
I
N
L
K
--
A
-
R
N
Y
L
-------
L
S
L
P
H
K
N
K
V
-
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
----
A
P
F
K
F
D
M
E
L
D
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.43
30%
-107
- C1 -
4FA2
3
MK14_HUMAN
A:
[32-376]
----
Y
R
Q
E
L
N
K
T
I
--
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
RP
F
--
Q
S
I
-
I
H
-
A
-
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
--
K
K
I
--
S
--
S
--
E
S
A
R
N
Y
-------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
----
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
----
P
---
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
-
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.89
30%
-106
- C1 -
4F9Y
6
MK14_HUMAN
A:
[32-376]
----
Y
R
Q
E
L
N
K
T
I
--
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
RP
F
--
Q
S
I
-
I
H
-
A
-
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
--
K
K
I
--
S
--
S
--
E
S
A
R
N
Y
-------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
----
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
----
P
---
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
-
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.04
30%
-102
- C1 -
3KQ7
1
MK14_HUMAN
A:
[29-372]
----
Y
R
Q
E
L
N
K
T
I
--
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
RP
F
--
Q
S
I
-
I
H
-
A
-
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
--
K
K
I
--
S
--
S
--
E
S
A
R
N
Y
-------
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
----
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
----
P
---
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
-
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
65.02
33%
-105
- C1 -
2FST
3
MK14_HUMAN
X:
[25-355]
---------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
--
R
PF
Q
S
I
-
I
H
-
A
-
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
---
E
-
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
--
K
K
I
--
S
--
S
ES
A
-
R
N
Y
I
-------
Q
S
L
T
Q
M
P
K
M
-
N
F
A
N
V
----
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-----
P
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
54.59
33%
-99
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-348]
-------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
--
G
--
T
G
I
----
S
-
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
---------
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
-
D
W
--
E
D
I
--
K
--
K
----
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
Y
-
T
N
C
-
S
L
I
K
Y
M
E
K
H
K
V
K
--
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------